Publication Information

{'id': 'https://openalex.org/W2768451125', 'doi': 'https://doi.org/10.1021/acs.biochem.7b00765', 'title': 'Deuterated Drug Molecules: Focus on FDA-Approved Deutetrabenazine', 'display_name': 'Deuterated Drug Molecules: Focus on FDA-Approved Deutetrabenazine', 'publication_year': 2017, 'publication_date': '2017-11-21', 'ids': {'openalex': 'https://openalex.org/W2768451125', 'doi': 'https://doi.org/10.1021/acs.biochem.7b00765', 'mag': '2768451125', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29160059'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1021/acs.biochem.7b00765', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104038378', 'display_name': 'Biochemistry', 'issn_l': '0006-2960', 'issn': ['0006-2960', '1520-4995', '1943-295X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': 'https://doi.org/10.1021/acs.biochem.7b00765', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5064085290', 'display_name': 'Sheila H. DeWitt', 'orcid': 'https://orcid.org/0000-0003-0354-177X'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sheila H. DeWitt', 'raw_affiliation_strings': ['DeuteRx LLC, 300 Brickstone Square,\rSuite 201, Andover, Massachusetts 01810, United States'], 'affiliations': [{'raw_affiliation_string': 'DeuteRx LLC, 300 Brickstone Square,\rSuite 201, Andover, Massachusetts 01810, United States', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5070787633', 'display_name': 'Bruce E. Maryanoff', 'orcid': 'https://orcid.org/0000-0003-3590-2357'}, 'institutions': [{'id': 'https://openalex.org/I4210157427', 'display_name': 'Baruch S. Blumberg Institute', 'ror': 'https://ror.org/05evayb02', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210157427']}, {'id': 'https://openalex.org/I123431417', 'display_name': 'Scripps Research Institute', 'ror': 'https://ror.org/02dxx6824', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I123431417']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Bruce E. Maryanoff', 'raw_affiliation_strings': ['Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States', 'Department\rof Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States'], 'affiliations': [{'raw_affiliation_string': 'Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States', 'institution_ids': ['https://openalex.org/I4210157427']}, {'raw_affiliation_string': 'Department\rof Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States', 'institution_ids': ['https://openalex.org/I123431417']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.042, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 119, 'citation_normalized_percentile': {'value': 0.756494, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '57', 'issue': '5', 'first_page': '472', 'last_page': '473'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13561', 'display_name': 'Chemical Reactions and Isotopes', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/3003', 'display_name': 'Pharmaceutical Science'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13561', 'display_name': 'Chemical Reactions and Isotopes', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/3003', 'display_name': 'Pharmaceutical Science'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12770', 'display_name': 'Amino Acid Enzymes and Metabolism', 'score': 0.9894, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12191', 'display_name': 'Chemical Reaction Mechanisms', 'score': 0.972, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/web-site', 'display_name': 'Web site', 'score': 0.4472106}], 'concepts': [{'id': 'https://openalex.org/C2778805511', 'wikidata': 'https://www.wikidata.org/wiki/Q1713', 'display_name': 'Citation', 'level': 2, 'score': 0.6874003}, {'id': 'https://openalex.org/C161191863', 'wikidata': 'https://www.wikidata.org/wiki/Q199655', 'display_name': 'Library science', 'level': 1, 'score': 0.60292447}, {'id': 'https://openalex.org/C2984519610', 'wikidata': 'https://www.wikidata.org/wiki/Q35127', 'display_name': 'Web site', 'level': 3, 'score': 0.4472106}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.38243085}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.36046487}, {'id': 'https://openalex.org/C136764020', 'wikidata': 'https://www.wikidata.org/wiki/Q466', 'display_name': 'World Wide Web', 'level': 1, 'score': 0.30626702}, {'id': 'https://openalex.org/C110875604', 'wikidata': 'https://www.wikidata.org/wiki/Q75', 'display_name': 'The Internet', 'level': 2, 'score': 0.23083898}], 'mesh': [{'descriptor_ui': 'D018759', 'descriptor_name': 'Adrenergic Uptake Inhibitors', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D003903', 'descriptor_name': 'Deuterium', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D017277', 'descriptor_name': 'Drug Approval', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D055808', 'descriptor_name': 'Drug Discovery', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D013747', 'descriptor_name': 'Tetrabenazine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D018759', 'descriptor_name': 'Adrenergic Uptake Inhibitors', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D018759', 'descriptor_name': 'Adrenergic Uptake Inhibitors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018759', 'descriptor_name': 'Adrenergic Uptake Inhibitors', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D018759', 'descriptor_name': 'Adrenergic Uptake Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001671', 'descriptor_name': 'Biochemistry', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D001671', 'descriptor_name': 'Biochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002819', 'descriptor_name': 'Chorea', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D002819', 'descriptor_name': 'Chorea', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003903', 'descriptor_name': 'Deuterium', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D003903', 'descriptor_name': 'Deuterium', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003903', 'descriptor_name': 'Deuterium', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D003903', 'descriptor_name': 'Deuterium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017277', 'descriptor_name': 'Drug Approval', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D055808', 'descriptor_name': 'Drug Discovery', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D004335', 'descriptor_name': 'Drug and Narcotic Control', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004335', 'descriptor_name': 'Drug and Narcotic Control', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071057', 'descriptor_name': 'Tardive Dyskinesia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071057', 'descriptor_name': 'Tardive Dyskinesia', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D013747', 'descriptor_name': 'Tetrabenazine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013747', 'descriptor_name': 'Tetrabenazine', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D013747', 'descriptor_name': 'Tetrabenazine', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D013747', 'descriptor_name': 'Tetrabenazine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013747', 'descriptor_name': 'Tetrabenazine', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1021/acs.biochem.7b00765', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104038378', 'display_name': 'Biochemistry', 'issn_l': '0006-2960', 'issn': ['0006-2960', '1520-4995', '1943-295X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29160059', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1021/acs.biochem.7b00765', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104038378', 'display_name': 'Biochemistry', 'issn_l': '0006-2960', 'issn': ['0006-2960', '1520-4995', '1943-295X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 6, 'referenced_works': ['https://openalex.org/W1972733339', 'https://openalex.org/W2313227787', 'https://openalex.org/W2465528651', 'https://openalex.org/W2589012331', 'https://openalex.org/W2622138635', 'https://openalex.org/W2749434344'], 'related_works': ['https://openalex.org/W4245697572', 'https://openalex.org/W291827334', 'https://openalex.org/W277486614', 'https://openalex.org/W2766007331', 'https://openalex.org/W2748952813', 'https://openalex.org/W255623911', 'https://openalex.org/W2419063854', 'https://openalex.org/W2027911892', 'https://openalex.org/W1606752009', 'https://openalex.org/W1601617767'], 'abstract_inverted_index': {'ADVERTISEMENT': [0], 'RETURN': [1], 'TO': [2], 'ISSUEPREVViewpointNEXTDeuterated': [3], 'Drug': [4], 'Molecules:': [5], 'Focus': [6], 'on': [7, 203, 231], 'FDA-Approved': [8], 'DeutetrabenazinePublished': [9], 'as': [10], 'part': [11], 'of': [12, 53, 106, 131, 166, 192], 'the': [13, 128, 159, 164, 193, 204, 217, 220, 225, 232, 238], 'Biochemistry': [14, 73], 'series': [15], '"Biochemistry': [16], 'to': [17, 115, 153, 158], 'Bedside"Sheila': [18], 'H.': [19], 'DeWitt†': [20], 'and': [21, 141, 146, 175, 219, 236, 252, 254], 'Bruce': [22], 'E.': [23], 'Maryanoff*‡§View': [24], 'Author': [25], 'Information†': [26], 'DeuteRx': [27], 'LLC,': [28], '300': [29], 'Brickstone': [30], 'Square,': [31], 'Suite': [32], '201,': [33], 'Andover,': [34], 'Massachusetts': [35], '01810,': [36], 'United': [37, 50, 68], 'States‡': [38], 'Baruch': [39], 'S.': [40], 'Blumberg': [41], 'Institute,': [42, 58], '3805': [43], 'Old': [44], 'Easton': [45], 'Road,': [46, 63], 'Doylestown,': [47], 'Pennsylvania': [48], '18902,': [49], 'States§': [51], 'Department': [52], 'Chemistry,': [54], 'The': [55], 'Scripps': [56], 'Research': [57], '10550': [59], 'North': [60], 'Torrey': [61], 'Pines': [62], 'La': [64], 'Jolla,': [65], 'California': [66], '92037,': [67], 'States*E-mail:': [69], '[email': [70], 'protected]Cite': [71], 'this:': [72], '2018,': [74], '57,': [75], '5,': [76], '472–473Publication': [77], 'Date': [78], '(Web):November': [79], '21,': [80], '2017Publication': [81], 'History': [82], 'Received9': [83], 'August': [84], '2017Published': [85, 88], 'online21': [86], 'November': [87, 137], 'inissue': [89], '6': [90], 'February': [91], '2018https://pubs.acs.org/doi/10.1021/acs.biochem.7b00765https://doi.org/10.1021/acs.biochem.7b00765editorialACS': [92], 'PublicationsCopyright': [93], '©': [94], '2017': [95], 'American': [96], 'Chemical': [97], 'Society.': [98], 'This': [99, 111], 'publication': [100, 112], 'is': [101, 113, 188, 240], 'available': [102], 'under': [103], 'these': [104], 'Terms': [105], 'Use.': [107], 'Request': [108], 'reuse': [109], 'permissions': [110], 'free': [114], 'access': [116], 'through': [117], 'this': [118, 170], 'site.': [119], 'Learn': [120], 'MoreArticle': [121], 'Views14952Altmetric-Citations99LEARN': [122], 'ABOUT': [123], 'THESE': [124], 'METRICSArticle': [125], 'Views': [126], 'are': [127, 150, 163], 'COUNTER-compliant': [129], 'sum': [130], 'full': [132], 'text': [133], 'article': [134, 198], 'downloads': [135], 'since': [136], '2008': [138], '(both': [139], 'PDF': [140, 260], 'HTML)': [142], 'across': [143], 'all': [144], 'institutions': [145], 'individuals.': [147], 'These': [148], 'metrics': [149], 'regularly': [151], 'updated': [152, 176], 'reflect': [154], 'usage': [155], 'leading': [156], 'up': [157], 'last': [160], 'few': [161], 'days.Citations': [162], 'number': [165], 'other': [167], 'articles': [168], 'citing': [169], 'article,': [171], 'calculated': [172], 'by': [173], 'Crossref': [174, 182], 'daily.': [177], 'Find': [178, 228], 'more': [179, 229], 'information': [180, 230], 'about': [181, 216], 'citation': [183], 'counts.The': [184], 'Altmetric': [185, 233], 'Attention': [186, 234], 'Score': [187, 235], 'a': [189, 196, 209], 'quantitative': [190], 'measure': [191], 'attention': [194], 'that': [195], 'research': [197], 'has': [199], 'received': [200], 'online.': [201], 'Clicking': [202], 'donut': [205], 'icon': [206], 'will': [207], 'load': [208], 'page': [210], 'at': [211], 'altmetric.com': [212], 'with': [213, 248], 'additional': [214], 'details': [215], 'score': [218, 239], 'social': [221], 'media': [222], 'presence': [223], 'for': [224], 'given': [226], 'article.': [227], 'how': [237], 'calculated.': [241], 'Share': [242, 257], 'Add': [243], 'toView': [244], 'InAdd': [245], 'Full': [246], 'Text': [247], 'ReferenceAdd': [249], 'Description': [250], 'ExportRISCitationCitation': [251], 'abstractCitation': [253], 'referencesMore': [255], 'Options': [256], 'onFacebookTwitterWechatLinked': [258], 'InRedditEmail': [259], '(271': [261], 'KB)': [262], 'Get': [263, 268], 'e-AlertscloseSUBJECTS:Hydrogen': [264], 'isotopes,Molecular': [265], 'structure,Molecules,Pharmaceuticals,Reaction': [266], 'mechanisms': [267], 'e-Alerts': [269]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2768451125', 'counts_by_year': [{'year': 2024, 'cited_by_count': 32}, {'year': 2023, 'cited_by_count': 25}, {'year': 2022, 'cited_by_count': 23}, {'year': 2021, 'cited_by_count': 12}, {'year': 2020, 'cited_by_count': 13}, {'year': 2019, 'cited_by_count': 10}, {'year': 2018, 'cited_by_count': 4}], 'updated_date': '2025-01-06T07:01:10.639288', 'created_date': '2017-12-04'}