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'critical': [18], 'role': [19], 'in': [20, 49], 'the': [21, 29, 50, 91, 97, 102, 108, 111, 132, 138, 146, 158, 163, 173, 179], 'development': [22], 'cardiac': [24, 43, 65, 71], 'ischemia-reperfusion': [25], '(IR)': [26], 'injury.': [27, 73], 'However,': [28, 162], 'precise': [30], 'upstream': [31], 'molecular': [32], 'mechanism': [33], 'fission/mitophagy': [35, 176], 'remains': [36], 'unclear.': [37], 'Dual-specificity': [38], 'protein': [39], 'phosphatase1': [40], '(DUSP1)': [41], 'regulates': [42], 'metabolism,': [44], 'but': [45], 'its': [46, 54, 201], 'physiological': [47], 'contribution': [48], 'reperfused': [51], 'heart,': [52], 'particularly': [53], 'influence': [55], 'on': [56], 'homeostasis,': [58], 'is': [59], 'unknown.': [60], 'Here,': [61], 'we': [62], 'demonstrated': [63, 85], 'DUSP1': [66, 80, 99, 135, 166, 199], 'was': [67, 122], 'downregulated': [68], 'following': [69, 189], 'acute': [70], 'IR': [72, 190, 212], 'In': [74, 95], 'vivo,': [75], 'compared': [76], 'to': [77, 145, 186], 'wild-type': [78], 'mice,': [79], 'transgenic': [81], 'mice': [82], '(DUSP1TG': [83], 'mice)': [84], 'smaller': [87], 'infarcted': [88], 'area': [89], 'improved': [92], 'myocardial': [93, 187], 'function.': [94], 'vitro,': [96], 'IR-induced': [98], 'deficiency': [100], 'promoted': [101], 'activation': [103, 141, 147, 169], 'JNK': [105, 180, 203], 'which': [106], 'upregulated': [107], 'expression': [109, 118], 'factor': [114], '(Mff).': [115], 'A': [116], 'higher': [117], 'level': [119], 'Mff': [121], 'associated': [123], 'with': [124], 'elevated': [125], 'apoptosis.': [130], 'Additionally,': [131], 'loss': [133], 'also': [136], 'amplified': [137], 'Bnip3': [139], 'phosphorylated': [140], 'via': [142], 'JNK,': [143], 'leading': [144], 'mitophagy.': [149, 221], 'Increased': [150], 'mitophagy': [151], 'overtly': [152], 'consumed': [153], 'mass': [155], 'resulting': [156], 'into': [157], 'metabolism': [160], 'disorder.': [161], 'reintroduction': [164], 'blunted': [167], 'Mff/Bnip3': [168], 'therefore': [171], 'alleviated': [172], 'fatal': [174], 'by': [177, 214], 'inactivating': [178], 'pathway,': [181], 'providing': [182], 'survival': [184], 'advantage': [185], 'tissue': [188], 'stress.': [191], 'The': [192], 'results': [193], 'our': [195], 'study': [196], 'suggest': [197], 'downstream': [202], 'pathway': [204], 'are': [205], 'therapeutic': [206], 'targets': [207], 'for': [208], 'conferring': [209], 'protection': [210], 'against': [211], 'injury': [213], 'repressing': [215], 'Mff-mediated': [216], 'Bnip3-required': [220]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2768024671', 'counts_by_year': [{'year': 2024, 'cited_by_count': 30}, {'year': 2023, 'cited_by_count': 51}, {'year': 2022, 'cited_by_count': 52}, {'year': 2021, 'cited_by_count': 54}, {'year': 2020, 'cited_by_count': 54}, {'year': 2019, 'cited_by_count': 81}, {'year': 2018, 'cited_by_count': 51}], 'updated_date': '2024-09-15T14:33:10.114094', 'created_date': '2017-11-17'}