Publication Information

{'id': 'https://openalex.org/W2767935554', 'doi': 'https://doi.org/10.1186/s13072-017-0160-2', 'title': 'Ubiquitin C-terminal hydrolase isozyme L1 is associated with shelterin complex at interstitial telomeric sites', 'display_name': 'Ubiquitin C-terminal hydrolase isozyme L1 is associated with shelterin complex at interstitial telomeric sites', 'publication_year': 2017, 'publication_date': '2017-11-10', 'ids': {'openalex': 'https://openalex.org/W2767935554', 'doi': 'https://doi.org/10.1186/s13072-017-0160-2', 'mag': '2767935554', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29126443', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5681776'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/s13072-017-0160-2', 'pdf_url': 'https://epigeneticsandchromatin.biomedcentral.com/track/pdf/10.1186/s13072-017-0160-2', 'source': {'id': 'https://openalex.org/S155115555', 'display_name': 'Epigenetics & Chromatin', 'issn_l': '1756-8935', 'issn': ['1756-8935'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://epigeneticsandchromatin.biomedcentral.com/track/pdf/10.1186/s13072-017-0160-2', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5024686169', 'display_name': 'Aleksandar Ilić', 'orcid': 'https://orcid.org/0000-0002-8594-3539'}, 'institutions': [{'id': 'https://openalex.org/I4210091102', 'display_name': "Children's Hospital Research Institute of Manitoba", 'ror': 'https://ror.org/00ag0rb94', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210091102', 'https://openalex.org/I4391767879']}, {'id': 'https://openalex.org/I46247651', 'display_name': 'University of Manitoba', 'ror': 'https://ror.org/02gfys938', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I46247651']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Aleksandar Ilic', 'raw_affiliation_strings': ['Children’s Hospital Research Institute of Manitoba, University of Manitoba, 715 McDermot Avenue, Room 600A, Winnipeg, MB, R3E 3P4, Canada'], 'affiliations': [{'raw_affiliation_string': 'Children’s Hospital Research Institute of Manitoba, University of Manitoba, 715 McDermot Avenue, Room 600A, Winnipeg, MB, R3E 3P4, Canada', 'institution_ids': ['https://openalex.org/I4210091102', 'https://openalex.org/I46247651']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110966836', 'display_name': 'Sumin Lu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210091102', 'display_name': "Children's Hospital Research Institute of Manitoba", 'ror': 'https://ror.org/00ag0rb94', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210091102', 'https://openalex.org/I4391767879']}, {'id': 'https://openalex.org/I46247651', 'display_name': 'University of Manitoba', 'ror': 'https://ror.org/02gfys938', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I46247651']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Sumin Lu', 'raw_affiliation_strings': ['Children’s Hospital Research Institute of Manitoba, University of Manitoba, 715 McDermot Avenue, Room 600A, Winnipeg, MB, R3E 3P4, Canada'], 'affiliations': [{'raw_affiliation_string': 'Children’s Hospital Research Institute of Manitoba, University of Manitoba, 715 McDermot Avenue, Room 600A, Winnipeg, MB, R3E 3P4, Canada', 'institution_ids': ['https://openalex.org/I4210091102', 'https://openalex.org/I46247651']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031075467', 'display_name': 'Vikram Bhatia', 'orcid': 'https://orcid.org/0000-0001-8416-8596'}, 'institutions': [{'id': 'https://openalex.org/I4210091102', 'display_name': "Children's Hospital Research Institute of Manitoba", 'ror': 'https://ror.org/00ag0rb94', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210091102', 'https://openalex.org/I4391767879']}, {'id': 'https://openalex.org/I46247651', 'display_name': 'University of Manitoba', 'ror': 'https://ror.org/02gfys938', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I46247651']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Vikram Bhatia', 'raw_affiliation_strings': ['Children’s Hospital Research Institute of Manitoba, University of Manitoba, 715 McDermot Avenue, Room 600A, Winnipeg, MB, R3E 3P4, Canada'], 'affiliations': [{'raw_affiliation_string': 'Children’s Hospital Research Institute of Manitoba, University of Manitoba, 715 McDermot Avenue, Room 600A, Winnipeg, MB, R3E 3P4, Canada', 'institution_ids': ['https://openalex.org/I4210091102', 'https://openalex.org/I46247651']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021204832', 'display_name': 'Farhana Begum', 'orcid': 'https://orcid.org/0000-0002-8211-8998'}, 'institutions': [{'id': 'https://openalex.org/I46247651', 'display_name': 'University of Manitoba', 'ror': 'https://ror.org/02gfys938', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I46247651']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Farhana Begum', 'raw_affiliation_strings': ['Department of Human Anatomy and Cell Science, University of Manitoba, 130-745 Bannatyne Ave, Winnipeg, MB, R3E 0J9, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Human Anatomy and Cell Science, University of Manitoba, 130-745 Bannatyne Ave, Winnipeg, MB, R3E 0J9, Canada', 'institution_ids': ['https://openalex.org/I46247651']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034855480', 'display_name': 'Thomas Klonisch', 'orcid': 'https://orcid.org/0000-0003-0448-6741'}, 'institutions': [{'id': 'https://openalex.org/I46247651', 'display_name': 'University of Manitoba', 'ror': 'https://ror.org/02gfys938', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I46247651']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Thomas Klonisch', 'raw_affiliation_strings': ['Department of Human Anatomy and Cell Science, University of Manitoba, 130-745 Bannatyne Ave, Winnipeg, MB, R3E 0J9, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Human Anatomy and Cell Science, University of Manitoba, 130-745 Bannatyne Ave, Winnipeg, MB, R3E 0J9, Canada', 'institution_ids': ['https://openalex.org/I46247651']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067957722', 'display_name': 'Prasoon Agarwal', 'orcid': 'https://orcid.org/0000-0003-1813-7606'}, 'institutions': [{'id': 'https://openalex.org/I4210091102', 'display_name': "Children's Hospital Research Institute of Manitoba", 'ror': 'https://ror.org/00ag0rb94', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210091102', 'https://openalex.org/I4391767879']}, {'id': 'https://openalex.org/I46247651', 'display_name': 'University of Manitoba', 'ror': 'https://ror.org/02gfys938', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I46247651']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Prasoon Agarwal', 'raw_affiliation_strings': ['Children’s Hospital Research Institute of Manitoba, University of Manitoba, 715 McDermot Avenue, Room 600A, Winnipeg, MB, R3E 3P4, Canada'], 'affiliations': [{'raw_affiliation_string': 'Children’s Hospital Research Institute of Manitoba, University of Manitoba, 715 McDermot Avenue, Room 600A, Winnipeg, MB, R3E 3P4, Canada', 'institution_ids': ['https://openalex.org/I4210091102', 'https://openalex.org/I46247651']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039548719', 'display_name': 'Wayne Wenzhong Xu', 'orcid': 'https://orcid.org/0000-0003-0484-7340'}, 'institutions': [{'id': 'https://openalex.org/I4210091102', 'display_name': "Children's Hospital Research Institute of Manitoba", 'ror': 'https://ror.org/00ag0rb94', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210091102', 'https://openalex.org/I4391767879']}, {'id': 'https://openalex.org/I46247651', 'display_name': 'University of Manitoba', 'ror': 'https://ror.org/02gfys938', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I46247651']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Wayne Xu', 'raw_affiliation_strings': ['Children’s Hospital Research Institute of Manitoba, University of Manitoba, 715 McDermot Avenue, Room 600A, Winnipeg, MB, R3E 3P4, Canada'], 'affiliations': [{'raw_affiliation_string': 'Children’s Hospital Research Institute of Manitoba, University of Manitoba, 715 McDermot Avenue, Room 600A, Winnipeg, MB, R3E 3P4, Canada', 'institution_ids': ['https://openalex.org/I4210091102', 'https://openalex.org/I46247651']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5048849645', 'display_name': 'James Davie', 'orcid': 'https://orcid.org/0000-0002-0420-6888'}, 'institutions': [{'id': 'https://openalex.org/I4210091102', 'display_name': "Children's Hospital Research Institute of Manitoba", 'ror': 'https://ror.org/00ag0rb94', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210091102', 'https://openalex.org/I4391767879']}, {'id': 'https://openalex.org/I46247651', 'display_name': 'University of Manitoba', 'ror': 'https://ror.org/02gfys938', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I46247651']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'James R. Davie', 'raw_affiliation_strings': ['Children’s Hospital Research Institute of Manitoba, University of Manitoba, 715 McDermot Avenue, Room 600A, Winnipeg, MB, R3E 3P4, Canada'], 'affiliations': [{'raw_affiliation_string': 'Children’s Hospital Research Institute of Manitoba, University of Manitoba, 715 McDermot Avenue, Room 600A, Winnipeg, MB, R3E 3P4, Canada', 'institution_ids': ['https://openalex.org/I4210091102', 'https://openalex.org/I46247651']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 1890, 'currency': 'GBP', 'value_usd': 2318, 'provenance': 'doaj'}, 'apc_paid': {'value': 1890, 'currency': 'GBP', 'value_usd': 2318, 'provenance': 'doaj'}, 'fwci': 0.407, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 6, 'citation_normalized_percentile': {'value': 0.618236, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 81, 'max': 82}, 'biblio': {'volume': '10', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin and proteasome pathways', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin and proteasome pathways', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11772', 'display_name': 'Genetics and Neurodevelopmental Disorders', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/shelterin', 'display_name': 'Shelterin', 'score': 0.92124027}, {'id': 'https://openalex.org/keywords/immunoprecipitation', 'display_name': 'Immunoprecipitation', 'score': 0.6824305}, {'id': 'https://openalex.org/keywords/deubiquitinating-enzyme', 'display_name': 'Deubiquitinating enzyme', 'score': 0.61274534}, {'id': 'https://openalex.org/keywords/chromatin-immunoprecipitation', 'display_name': 'Chromatin immunoprecipitation', 'score': 0.6064998}, {'id': 'https://openalex.org/keywords/hek-293-cells', 'display_name': 'HEK 293 cells', 'score': 0.5641142}, {'id': 'https://openalex.org/keywords/immunolabeling', 'display_name': 'Immunolabeling', 'score': 0.5264134}, {'id': 'https://openalex.org/keywords/proximity-ligation-assay', 'display_name': 'Proximity ligation assay', 'score': 0.49493927}], 'concepts': [{'id': 'https://openalex.org/C2776879488', 'wikidata': 'https://www.wikidata.org/wiki/Q3959366', 'display_name': 'Shelterin', 'level': 5, 'score': 0.92124027}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.78295255}, {'id': 'https://openalex.org/C71829478', 'wikidata': 'https://www.wikidata.org/wiki/Q901305', 'display_name': 'Immunoprecipitation', 'level': 3, 'score': 0.6824305}, {'id': 'https://openalex.org/C25602115', 'wikidata': 'https://www.wikidata.org/wiki/Q407111', 'display_name': 'Ubiquitin', 'level': 3, 'score': 0.65298426}, {'id': 'https://openalex.org/C102658986', 'wikidata': 'https://www.wikidata.org/wiki/Q5266092', 'display_name': 'Deubiquitinating enzyme', 'level': 4, 'score': 0.61274534}, {'id': 'https://openalex.org/C134320426', 'wikidata': 'https://www.wikidata.org/wiki/Q901026', 'display_name': 'Chromatin immunoprecipitation', 'level': 5, 'score': 0.6064998}, {'id': 'https://openalex.org/C177336024', 'wikidata': 'https://www.wikidata.org/wiki/Q14872779', 'display_name': 'Telomere', 'level': 3, 'score': 0.5648009}, {'id': 'https://openalex.org/C174510640', 'wikidata': 'https://www.wikidata.org/wiki/Q489618', 'display_name': 'HEK 293 cells', 'level': 3, 'score': 0.5641142}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.52837515}, {'id': 'https://openalex.org/C2777877921', 'wikidata': 'https://www.wikidata.org/wiki/Q6005532', 'display_name': 'Immunolabeling', 'level': 3, 'score': 0.5264134}, {'id': 'https://openalex.org/C2776243700', 'wikidata': 'https://www.wikidata.org/wiki/Q7252869', 'display_name': 'Proximity ligation assay', 'level': 3, 'score': 0.49493927}, {'id': 'https://openalex.org/C83640560', 'wikidata': 'https://www.wikidata.org/wiki/Q180951', 'display_name': 'Chromatin', 'level': 3, 'score': 0.43159425}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.41170368}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.29936138}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.23695758}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.22799715}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.21447942}, {'id': 'https://openalex.org/C94966510', 'wikidata': 'https://www.wikidata.org/wiki/Q2252764', 'display_name': 'DNA-binding protein', 'level': 4, 'score': 0.17847812}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.10262412}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.08732909}, {'id': 'https://openalex.org/C101762097', 'wikidata': 'https://www.wikidata.org/wiki/Q224093', 'display_name': 'Promoter', 'level': 4, 'score': 0.0}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D016615', 'descriptor_name': 'Telomere', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D034501', 'descriptor_name': 'Telomere-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D043222', 'descriptor_name': 'Ubiquitin Thiolesterase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057809', 'descriptor_name': 'HEK293 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000089804', 'descriptor_name': 'Shelterin Complex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016615', 'descriptor_name': 'Telomere', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034501', 'descriptor_name': 'Telomere-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D035321', 'descriptor_name': 'Telomeric Repeat Binding Protein 1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D035321', 'descriptor_name': 'Telomeric Repeat Binding Protein 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D035341', 'descriptor_name': 'Telomeric Repeat Binding Protein 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D035341', 'descriptor_name': 'Telomeric Repeat Binding Protein 2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D043222', 'descriptor_name': 'Ubiquitin Thiolesterase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 6, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/s13072-017-0160-2', 'pdf_url': 'https://epigeneticsandchromatin.biomedcentral.com/track/pdf/10.1186/s13072-017-0160-2', 'source': {'id': 'https://openalex.org/S155115555', 'display_name': 'Epigenetics & Chromatin', 'issn_l': '1756-8935', 'issn': ['1756-8935'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/51f8e7968c3647f89f206db1ab91b6d2', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5681776', 'pdf_url': 'https://europepmc.org/articles/pmc5681776?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/1993/32708', 'pdf_url': 'https://mspace.lib.umanitoba.ca/xmlui/bitstream/1993/32708/1/13072_2017_Article_160.pdf', 'source': {'id': 'https://openalex.org/S4306400554', 'display_name': 'Mspace (University of Manitoba)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I46247651', 'host_organization_name': 'University of Manitoba', 'host_organization_lineage': ['https://openalex.org/I46247651'], 'host_organization_lineage_names': ['University of Manitoba'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681776', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29126443', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/s13072-017-0160-2', 'pdf_url': 'https://epigeneticsandchromatin.biomedcentral.com/track/pdf/10.1186/s13072-017-0160-2', 'source': {'id': 'https://openalex.org/S155115555', 'display_name': 'Epigenetics & Chromatin', 'issn_l': '1756-8935', 'issn': ['1756-8935'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.41}], 'grants': [{'funder': 'https://openalex.org/F4320311169', 'funder_display_name': 'Cancer Research Society', 'award_id': None}, {'funder': 'https://openalex.org/F4320319928', 'funder_display_name': 'Canadian Cancer Society', 'award_id': None}, {'funder': 'https://openalex.org/F4320334506', 'funder_display_name': 'Canadian Institutes of Health Research', 'award_id': None}, {'funder': 'https://openalex.org/F4320334593', 'funder_display_name': 'Natural Sciences and Engineering Research Council of Canada', 'award_id': None}], 'datasets': [], 'versions': [], 'referenced_works_count': 74, 'referenced_works': ['https://openalex.org/W1203778187', 'https://openalex.org/W1488008687', 'https://openalex.org/W1530945514', 'https://openalex.org/W1590774449', 'https://openalex.org/W1596880630', 'https://openalex.org/W1624649331', 'https://openalex.org/W1853562702', 'https://openalex.org/W1964268598', 'https://openalex.org/W1967072140', 'https://openalex.org/W1967573239', 'https://openalex.org/W1974732946', 'https://openalex.org/W1987502035', 'https://openalex.org/W1995313045', 'https://openalex.org/W2002039834', 'https://openalex.org/W2004293444', 'https://openalex.org/W2006498791', 'https://openalex.org/W2007927465', 'https://openalex.org/W2014483347', 'https://openalex.org/W2014677321', 'https://openalex.org/W2018393684', 'https://openalex.org/W2020083160', 'https://openalex.org/W2021341670', 'https://openalex.org/W2023466241', 'https://openalex.org/W2027657574', 'https://openalex.org/W2030503662', 'https://openalex.org/W2036468298', 'https://openalex.org/W2037398372', 'https://openalex.org/W2041964828', 'https://openalex.org/W2043051494', 'https://openalex.org/W2044616456', 'https://openalex.org/W2045315430', 'https://openalex.org/W2046830583', 'https://openalex.org/W2056352736', 'https://openalex.org/W2057527139', 'https://openalex.org/W2070062778', 'https://openalex.org/W2080096650', 'https://openalex.org/W2083703501', 'https://openalex.org/W2084538148', 'https://openalex.org/W2096600031', 'https://openalex.org/W2097812689', 'https://openalex.org/W2101362932', 'https://openalex.org/W2102075074', 'https://openalex.org/W2109034263', 'https://openalex.org/W2110862168', 'https://openalex.org/W2110926898', 'https://openalex.org/W2113902100', 'https://openalex.org/W2120511656', 'https://openalex.org/W2123460634', 'https://openalex.org/W2124985265', 'https://openalex.org/W2135192254', 'https://openalex.org/W2138300856', 'https://openalex.org/W2138576404', 'https://openalex.org/W2144477691', 'https://openalex.org/W2144860816', 'https://openalex.org/W2145280442', 'https://openalex.org/W2145636817', 'https://openalex.org/W2146573750', 'https://openalex.org/W2156854438', 'https://openalex.org/W2157009395', 'https://openalex.org/W2158172903', 'https://openalex.org/W2158217645', 'https://openalex.org/W2171808845', 'https://openalex.org/W2218766790', 'https://openalex.org/W2224259865', 'https://openalex.org/W2226320632', 'https://openalex.org/W2258294381', 'https://openalex.org/W2298666323', 'https://openalex.org/W2342847104', 'https://openalex.org/W2407242198', 'https://openalex.org/W2409076492', 'https://openalex.org/W2415856576', 'https://openalex.org/W2520313731', 'https://openalex.org/W2520694393', 'https://openalex.org/W4285719527'], 'related_works': ['https://openalex.org/W4389045517', 'https://openalex.org/W3157604801', 'https://openalex.org/W2899211828', 'https://openalex.org/W2767935554', 'https://openalex.org/W2611649496', 'https://openalex.org/W2286105938', 'https://openalex.org/W2056210416', 'https://openalex.org/W2017746919', 'https://openalex.org/W2001588157', 'https://openalex.org/W1971257391'], 'abstract_inverted_index': {'Ubiquitin': [0], 'C-terminal': [1], 'hydrolase': [2], 'isozyme': [3], 'L1': [4], '(UCHL1)': [5], 'is': [6, 26, 51], 'primarily': [7], 'expressed': [8], 'in': [9, 31, 56, 73, 154], 'neuronal': [10, 80], 'cells': [11, 14, 65, 77], 'and': [12, 15, 34, 43, 72, 84, 95, 102, 116, 124, 129, 135, 157], 'neuroendocrine': [13], 'has': [16], 'been': [17], 'associated': [18, 52], 'with': [19, 53, 78], 'various': [20], 'diseases,': [21], 'including': [22, 62], 'many': [23], 'cancers.': [24], 'It': [25], 'a': [27, 68, 79, 136, 149], 'multifunctional': [28], 'protein': [29], 'involved': [30], 'deubiquitination,': [32], 'ubiquitination': [33], 'ubiquitin': [35], 'homeostasis,': [36], 'but': [37], 'its': [38], 'specific': [39], 'roles': [40], 'are': [41], 'disputed': [42], 'still': [44], 'generally': [45], 'undetermined.Herein,': [46], 'we': [47], 'demonstrate': [48], 'that': [49, 87], 'UCHL1': [50, 88, 115, 128, 153], 'genomic': [54], 'DNA': [55], 'certain': [57], 'prostate': [58], 'cancer': [59], 'cell': [60], 'lines,': [61], 'DU': [63], '145': [64], 'derived': [66], 'from': [67], 'brain': [69], 'metastatic': [70], 'site,': [71], 'HEK293T': [74], 'embryonic': [75], 'kidney': [76], 'lineage.': [81], 'Chromatin': [82], 'immunoprecipitation': [83, 123], 'sequencing': [85], 'revealed': [86], 'localizes': [89], 'to': [90, 144], 'TTAGGG': [91], 'repeats': [92], 'at': [93], 'telomeres': [94, 156], 'interstitial': [96, 158], 'telomeric': [97, 159], 'sequences,': [98], 'as': [99, 133], 'do': [100], 'TRF1': [101], 'TRF2,': [103], 'components': [104], 'of': [105, 138, 152], 'the': [106, 117, 139, 145], 'shelterin': [107, 118, 140], 'complex.': [108], 'A': [109], 'weak': [110], 'or': [111], 'transient': [112], 'interaction': [113], 'between': [114], 'complex': [119], 'was': [120], 'confirmed': [121], 'by': [122], 'proximity': [125], 'ligation': [126], 'assays.': [127], 'RAP1,': [130], 'also': [131], 'known': [132], 'TERF2IP': [134], 'component': [137], 'complex,': [141], 'were': [142], 'bound': [143], 'nuclear': [146], 'scaffold.We': [147], 'demonstrated': [148], 'novel': [150], 'feature': [151], 'binding': [155], 'sites.': [160]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2767935554', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}], 'updated_date': '2024-12-17T15:13:29.306766', 'created_date': '2017-11-17'}