Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2767166610', 'doi': 'https://doi.org/10.18632/oncotarget.21949', 'title': 'Tomentodione M sensitizes multidrug resistant cancer cells by decreasing P-glycoprotein via inhibition of p38 MAPK signaling', 'display_name': 'Tomentodione M sensitizes multidrug resistant cancer cells by decreasing P-glycoprotein via inhibition of p38 MAPK signaling', 'publication_year': 2017, 'publication_date': '2017-10-19', 'ids': {'openalex': 'https://openalex.org/W2767166610', 'doi': 'https://doi.org/10.18632/oncotarget.21949', 'mag': '2767166610', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29254218', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5731928'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.21949', 'pdf_url': 'https://www.oncotarget.com/article/21949/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.oncotarget.com/article/21949/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5010982976', 'display_name': 'Xu-Wei Zhou', 'orcid': 'https://orcid.org/0009-0006-1304-3802'}, 'institutions': [{'id': 'https://openalex.org/I161716053', 'display_name': 'China Pharmaceutical University', 'ror': 'https://ror.org/01sfm2718', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I161716053']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xu-Wei Zhou', 'raw_affiliation_strings': ['Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China'], 'affiliations': [{'raw_affiliation_string': 'Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China', 'institution_ids': ['https://openalex.org/I161716053']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010017519', 'display_name': 'Yuan‐Zheng Xia', 'orcid': 'https://orcid.org/0000-0002-8526-5184'}, 'institutions': [{'id': 'https://openalex.org/I161716053', 'display_name': 'China Pharmaceutical University', 'ror': 'https://ror.org/01sfm2718', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I161716053']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yuan-Zheng Xia', 'raw_affiliation_strings': ['Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China'], 'affiliations': [{'raw_affiliation_string': 'Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China', 'institution_ids': ['https://openalex.org/I161716053']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052290693', 'display_name': 'Yalong Zhang', 'orcid': 'https://orcid.org/0000-0002-9995-7659'}, 'institutions': [{'id': 'https://openalex.org/I161716053', 'display_name': 'China Pharmaceutical University', 'ror': 'https://ror.org/01sfm2718', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I161716053']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ya-Long Zhang', 'raw_affiliation_strings': ['Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China'], 'affiliations': [{'raw_affiliation_string': 'Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China', 'institution_ids': ['https://openalex.org/I161716053']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079519225', 'display_name': 'Jian‐Guang Luo', 'orcid': 'https://orcid.org/0000-0003-1251-8539'}, 'institutions': [{'id': 'https://openalex.org/I161716053', 'display_name': 'China Pharmaceutical University', 'ror': 'https://ror.org/01sfm2718', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I161716053']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jian-Guang Luo', 'raw_affiliation_strings': ['Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China'], 'affiliations': [{'raw_affiliation_string': 'Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China', 'institution_ids': ['https://openalex.org/I161716053']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067001113', 'display_name': 'Chao Han', 'orcid': 'https://orcid.org/0000-0001-8580-4697'}, 'institutions': [{'id': 'https://openalex.org/I161716053', 'display_name': 'China Pharmaceutical University', 'ror': 'https://ror.org/01sfm2718', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I161716053']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Chao Han', 'raw_affiliation_strings': ['Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China'], 'affiliations': [{'raw_affiliation_string': 'Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China', 'institution_ids': ['https://openalex.org/I161716053']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100396824', 'display_name': 'Hao Zhang', 'orcid': 'https://orcid.org/0000-0001-9366-7151'}, 'institutions': [{'id': 'https://openalex.org/I161716053', 'display_name': 'China Pharmaceutical University', 'ror': 'https://ror.org/01sfm2718', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I161716053']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hao Zhang', 'raw_affiliation_strings': ['Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China'], 'affiliations': [{'raw_affiliation_string': 'Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China', 'institution_ids': ['https://openalex.org/I161716053']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100460214', 'display_name': 'Chao Zhang', 'orcid': 'https://orcid.org/0000-0002-8163-9716'}, 'institutions': [{'id': 'https://openalex.org/I161716053', 'display_name': 'China Pharmaceutical University', 'ror': 'https://ror.org/01sfm2718', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I161716053']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Chao Zhang', 'raw_affiliation_strings': ['Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China'], 'affiliations': [{'raw_affiliation_string': 'Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China', 'institution_ids': ['https://openalex.org/I161716053']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070019426', 'display_name': 'Lei Yang', 'orcid': 'https://orcid.org/0000-0001-5107-2416'}, 'institutions': [{'id': 'https://openalex.org/I161716053', 'display_name': 'China Pharmaceutical University', 'ror': 'https://ror.org/01sfm2718', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I161716053']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lei Yang', 'raw_affiliation_strings': ['Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China'], 'affiliations': [{'raw_affiliation_string': 'Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China', 'institution_ids': ['https://openalex.org/I161716053', 'https://openalex.org/I161716053']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101537258', 'display_name': 'Ling‐Yi Kong', 'orcid': 'https://orcid.org/0000-0002-4791-8615'}, 'institutions': [{'id': 'https://openalex.org/I161716053', 'display_name': 'China Pharmaceutical University', 'ror': 'https://ror.org/01sfm2718', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I161716053']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ling-Yi Kong', 'raw_affiliation_strings': ['Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China'], 'affiliations': [{'raw_affiliation_string': 'Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China', 'institution_ids': ['https://openalex.org/I161716053']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.613, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 27, 'citation_normalized_percentile': {'value': 0.79181, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '8', 'issue': '60', 'first_page': '101965', 'last_page': '101983'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10570', 'display_name': 'Mechanisms of Multidrug Resistance in Cancer', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10570', 'display_name': 'Mechanisms of Multidrug Resistance in Cancer', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12347', 'display_name': 'Phytochemical, Pharmacological, and Toxicological Properties of Ginger', 'score': 0.994, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11332', 'display_name': 'Role of Nrf2 Signaling in Oxidative Stress Response', 'score': 0.9852, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/p-glycoprotein', 'display_name': 'P-glycoprotein', 'score': 0.6696427}, {'id': 'https://openalex.org/keywords/k562-cells', 'display_name': 'K562 cells', 'score': 0.55633646}, {'id': 'https://openalex.org/keywords/multidrug-resistance', 'display_name': 'Multidrug Resistance', 'score': 0.531413}, {'id': 'https://openalex.org/keywords/rhodamine-123', 'display_name': 'Rhodamine 123', 'score': 0.45197177}], 'concepts': [{'id': 'https://openalex.org/C2778707650', 'wikidata': 'https://www.wikidata.org/wiki/Q412902', 'display_name': 'P-glycoprotein', 'level': 4, 'score': 0.6696427}, {'id': 'https://openalex.org/C51551487', 'wikidata': 'https://www.wikidata.org/wiki/Q2043632', 'display_name': 'p38 mitogen-activated protein kinases', 'level': 4, 'score': 0.63230675}, {'id': 'https://openalex.org/C133936738', 'wikidata': 'https://www.wikidata.org/wiki/Q643839', 'display_name': 'Multiple drug resistance', 'level': 3, 'score': 0.6211765}, {'id': 'https://openalex.org/C2781190966', 'wikidata': 'https://www.wikidata.org/wiki/Q420436', 'display_name': 'Docetaxel', 'level': 3, 'score': 0.5943328}, {'id': 'https://openalex.org/C171122931', 'wikidata': 'https://www.wikidata.org/wiki/Q6324626', 'display_name': 'K562 cells', 'level': 3, 'score': 0.55633646}, {'id': 'https://openalex.org/C2781303535', 'wikidata': 'https://www.wikidata.org/wiki/Q18936', 'display_name': 'Doxorubicin', 'level': 3, 'score': 0.53186077}, {'id': 'https://openalex.org/C109316439', 'wikidata': 'https://www.wikidata.org/wiki/Q246181', 'display_name': 'Cytotoxicity', 'level': 3, 'score': 0.5106736}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.4985993}, {'id': 'https://openalex.org/C57074206', 'wikidata': 'https://www.wikidata.org/wiki/Q14197552', 'display_name': 'MAPK/ERK pathway', 'level': 3, 'score': 0.49677998}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.4905607}, {'id': 'https://openalex.org/C2778589691', 'wikidata': 'https://www.wikidata.org/wiki/Q3429577', 'display_name': 'Rhodamine 123', 'level': 4, 'score': 0.45197177}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.44509327}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.40298143}, {'id': 'https://openalex.org/C114851261', 'wikidata': 'https://www.wikidata.org/wiki/Q12147416', 'display_name': 'Drug resistance', 'level': 2, 'score': 0.38451508}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.36930177}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.3095253}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.281213}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.27665102}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.20391273}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.15108883}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.14417121}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.12301713}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.21949', 'pdf_url': 'https://www.oncotarget.com/article/21949/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5731928', 'pdf_url': 'https://europepmc.org/articles/pmc5731928?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731928', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29254218', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.21949', 'pdf_url': 'https://www.oncotarget.com/article/21949/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 74, 'referenced_works': ['https://openalex.org/W147439079', 'https://openalex.org/W1481486686', 'https://openalex.org/W1497498736', 'https://openalex.org/W1604468403', 'https://openalex.org/W1750541550', 'https://openalex.org/W1839646025', 'https://openalex.org/W1922145593', 'https://openalex.org/W1964375358', 'https://openalex.org/W1967945605', 'https://openalex.org/W1972372496', 'https://openalex.org/W1980504987', 'https://openalex.org/W1986777667', 'https://openalex.org/W1987194369', 'https://openalex.org/W1989556137', 'https://openalex.org/W1994583599', 'https://openalex.org/W1998691988', 'https://openalex.org/W1999594247', 'https://openalex.org/W2000605006', 'https://openalex.org/W2008790922', 'https://openalex.org/W2023569030', 'https://openalex.org/W2027263866', 'https://openalex.org/W2033413353', 'https://openalex.org/W2036459730', 'https://openalex.org/W2038672661', 'https://openalex.org/W2049905327', 'https://openalex.org/W2055904567', 'https://openalex.org/W2056318761', 'https://openalex.org/W2056772956', 'https://openalex.org/W2067815150', 'https://openalex.org/W2068041606', 'https://openalex.org/W2070966969', 'https://openalex.org/W2080881172', 'https://openalex.org/W2082926700', 'https://openalex.org/W2086525709', 'https://openalex.org/W2101884133', 'https://openalex.org/W2110790042', 'https://openalex.org/W2112929496', 'https://openalex.org/W2118386164', 'https://openalex.org/W2118897660', 'https://openalex.org/W2119913968', 'https://openalex.org/W2122002008', 'https://openalex.org/W2128050375', 'https://openalex.org/W2131026799', 'https://openalex.org/W2132188648', 'https://openalex.org/W2140744545', 'https://openalex.org/W2149848093', 'https://openalex.org/W2154770510', 'https://openalex.org/W2154962843', 'https://openalex.org/W2155738087', 'https://openalex.org/W2156088967', 'https://openalex.org/W2166078316', 'https://openalex.org/W2227630971', 'https://openalex.org/W2257878018', 'https://openalex.org/W2259308424', 'https://openalex.org/W2285846084', 'https://openalex.org/W2298123086', 'https://openalex.org/W2329552021', 'https://openalex.org/W2343643984', 'https://openalex.org/W2404609997', 'https://openalex.org/W2411881982', 'https://openalex.org/W2471110501', 'https://openalex.org/W2472377024', 'https://openalex.org/W2482262519', 'https://openalex.org/W2485375858', 'https://openalex.org/W2491724962', 'https://openalex.org/W2563112419', 'https://openalex.org/W2580384849', 'https://openalex.org/W2582990169', 'https://openalex.org/W2583909258', 'https://openalex.org/W2587496999', 'https://openalex.org/W2592746333', 'https://openalex.org/W2949407848', 'https://openalex.org/W329750643', 'https://openalex.org/W4317929586'], 'related_works': ['https://openalex.org/W75879566', 'https://openalex.org/W3014652664', 'https://openalex.org/W2094809302', 'https://openalex.org/W2065723669', 'https://openalex.org/W2048313550', 'https://openalex.org/W2044769069', 'https://openalex.org/W2040835855', 'https://openalex.org/W2014785414', 'https://openalex.org/W1977369444', 'https://openalex.org/W1976335447'], 'abstract_inverted_index': {'//': [0], 'Xu-Wei': [1], 'Zhou': [2], '1,': [3, 8], '*': [4, 9, 60], ',': [5, 10, 14, 18, 22, 26, 30], 'Yuan-Zheng': [6], 'Xia': [7], 'Ya-Long': [11], 'Zhang': [12, 24, 28], '1': [13, 17, 21, 25, 29, 33, 37, 38], 'Jian-Guang': [15], 'Luo': [16], 'Chao': [19, 27], 'Han': [20], 'Hao': [23], 'Lei': [31, 71], 'Yang': [32], 'and': [34, 47, 135, 139, 145, 152, 158, 161, 168, 189, 215], 'Ling-Yi': [35, 75], 'Kong': [36], 'Jiangsu': [39], 'Key': [40, 49], 'Laboratory': [41, 50], 'of': [42, 51, 129, 166, 185], 'Bioactive': [43], 'Natural': [44, 52], 'Product': [45], 'Research': [46], 'State': [48], 'Medicines,': [53], 'China': [54, 59], 'Pharmaceutical': [55], 'University,': [56], 'Nanjing': [57], '210009,': [58], 'These': [61, 224], 'authors': [62], 'have': [63], 'contributed': [64], 'equally': [65], 'to': [66], 'this': [67, 101], 'work': [68], 'Correspondence': [69], 'to:': [70], 'Yang,': [72], 'email:': [73, 77], '[email protected]': [74], 'Kong,': [76], '[email protected]': [78], 'Keywords:': [79], 'tomentodione': [80, 109], 'M;': [81], 'meroterpenoid;': [82], 'multidrug': [83], 'resistance;': [84], 'P-glycoprotein;': [85], 'p38': [86, 193, 198, 212, 239], 'Received:': [87], 'July': [88], '02,': [89], '2017': [90, 94, 98], 'Accepted:': [91], 'October': [92, 96], '03,': [93], 'Published:': [95], '19,': [97], 'ABSTRACT': [99], 'In': [100], 'study,': [102], 'we': [103], 'investigated': [104], 'the': [105, 127, 197], 'mechanism': [106], 'by': [107, 175, 180, 191, 207, 234], 'which': [108], 'M': [110], '(TTM),': [111], 'a': [112, 143], 'novel': [113], 'natural': [114], 'syncarpic': [115], 'acid-conjugated': [116], 'monoterpene,': [117], 'reversed': [118, 202], 'multi-drug': [119], 'resistance': [120], '(MDR)': [121], 'in': [122, 137, 142, 155, 171, 204, 231], 'cancer': [123, 173, 205, 232], 'cells.': [124], 'TTM': [125, 148, 182, 228], 'increased': [126], 'cytotoxicity': [128], 'chemotherapeutic': [130], 'drugs': [131], 'such': [132], 'as': [133], 'docetaxel': [134], 'doxorubicin': [136, 167], 'MCF-7/MDR': [138, 157], 'K562/MDR': [140, 159], 'cells': [141, 174, 206, 217, 233], 'dose-': [144], 'time-dependent': [146], 'manner.': [147], 'reduced': [149], 'colony': [150], 'formation': [151], 'enhanced': [153, 163], 'apoptosis': [154], 'docetaxel-treated': [156], 'cells,': [160], 'it': [162], 'intracellular': [164], 'accumulation': [165], 'rhodamine': [169], '123': [170], 'MDR': [172, 203, 230], 'reducing': [176], 'drug': [177], 'efflux': [178], 'mediated': [179], 'P-gp.': [181], 'decreased': [183], 'expression': [184, 221, 237], 'both': [186], 'P-gp': [187, 209, 220, 236], 'mRNA': [188], 'protein': [190], 'inhibiting': [192], 'MAPK': [194, 199, 240], 'signaling.': [195], 'Similarly,': [196], 'inhibitor': [200], 'SB203580': [201], 'decreasing': [208, 235], 'expression.': [210], 'Conversely,': [211], 'MAPK-overexpressing': [213], 'MCF-7': [214], 'K562': [216], 'showed': [218], 'higher': [219], 'than': [222], 'controls.': [223], 'observations': [225], 'indicate': [226], 'that': [227], 'reverses': [229], 'via': [238], 'inhibition.': [241]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2767166610', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 1}], 'updated_date': '2024-09-12T22:11:33.050823', 'created_date': '2017-11-10'}