Title: Bypassing Troubles: Relation of Exhaustion, Viral Burden, and Inflammation to Depressive Symptoms After Cardiac Surgery
Abstract:CORE 2. EPIDEMIOLOGY AND PREVENTION OF CV DISEASE: PHYSIOLOGY, PHARMACOLOGY AND LIFESTYLE SESSION TITLE: FATIGUE AND CARDIAC PATIENTS: SICK AND TIRED Abstract 14769: Bypassing Troubles: Relation of Ex...CORE 2. EPIDEMIOLOGY AND PREVENTION OF CV DISEASE: PHYSIOLOGY, PHARMACOLOGY AND LIFESTYLE SESSION TITLE: FATIGUE AND CARDIAC PATIENTS: SICK AND TIRED Abstract 14769: Bypassing Troubles: Relation of Exhaustion, Viral Burden, and Inflammation to Depressive Symptoms After Cardiac Surgery Pamela S Miiier, Lorraine S Evangelista, Joyce Newman Giger, Otonlel Martinez-Maza, Teresita Corvera-Tindel and Lynn V Doering Published: November 22, 2011 Artlcle Info & Metrics eLetters ,,. Jump to Abstract Background: Inflammation is a mechanism by which depressive symptoms and vital exhaustion (VE) may confer increased risk of adverse cardiac outcomes. Objective: To elucidate the relationship of post- bypass {CABG) depressive symptoms to VE, immune-mediated inflammation and pathogen burden (PB), defined as cumulative seropositive exposure to infectious pathogens. Methods: In a secondary analysis of 42 patients {age 67.5 ± 12.6 years, 90.5% male, 66.7% Caucasian, nonsmokers, and without malignancy, autoimmune disease or infection), depressive symptoms (Patient Health Questionnaire-9 [PHQ-9]), VE (Maastricht Interview), CBC and lipids were assessed before and 4-8 weeks aft.er CABG. Immune markers (interleukin [IL]-6, IL-10, soluble intercellular adhesion molecule-1) and serum lgG antibodies (Herpes Simplex Virus-1 and -2, Cytomegalovirus, Epstein Barr Virus) were measured by ELISA. PB was defined as low {0-1 exposures), moderate {2-3 exposures) and high (4 exposures). Analyses included Mann- Whitney U test and logistic regression.Read More
Publication Year: 2011
Publication Date: 2011-11-22
Language: en
Type: article
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