Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2765616228', 'doi': 'https://doi.org/10.1016/j.celrep.2017.09.046', 'title': 'Clonal Heterogeneity Influences the Fate of New Adaptive Mutations', 'display_name': 'Clonal Heterogeneity Influences the Fate of New Adaptive Mutations', 'publication_year': 2017, 'publication_date': '2017-10-01', 'ids': {'openalex': 'https://openalex.org/W2765616228', 'doi': 'https://doi.org/10.1016/j.celrep.2017.09.046', 'mag': '2765616228', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29045840', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5656752'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.celrep.2017.09.046', 'pdf_url': 'http://www.cell.com/article/S2211124717313360/pdf', 'source': {'id': 'https://openalex.org/S169236886', 'display_name': 'Cell Reports', 'issn_l': '2211-1247', 'issn': ['2211-1247', '2639-1856'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.cell.com/article/S2211124717313360/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5046081802', 'display_name': 'Ignacio Vázquez-Garćıa', 'orcid': 'https://orcid.org/0000-0003-0427-2639'}, 'institutions': [{'id': 'https://openalex.org/I2802476451', 'display_name': 'Wellcome Sanger Institute', 'ror': 'https://ror.org/05cy4wa09', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2802476451', 'https://openalex.org/I87048295']}, {'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}], 'countries': ['GB'], 'is_corresponding': True, 'raw_author_name': 'Ignacio Vázquez-García', 'raw_affiliation_strings': ['Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge CB3 0WA, UK', 'Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK'], 'affiliations': [{'raw_affiliation_string': 'Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK', 'institution_ids': ['https://openalex.org/I2802476451']}, {'raw_affiliation_string': 'Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge CB3 0WA, UK', 'institution_ids': ['https://openalex.org/I241749']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068241183', 'display_name': 'F. Salinas', 'orcid': 'https://orcid.org/0000-0002-8391-8145'}, 'institutions': [{'id': 'https://openalex.org/I4210119200', 'display_name': 'Institut de Recherche sur le Cancer et le Vieillissement de Nice', 'ror': 'https://ror.org/01td3kv81', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I201841394', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210119200']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I201841394', 'display_name': "Université Côte d'Azur", 'ror': 'https://ror.org/019tgvf94', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I201841394']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Francisco Salinas', 'raw_affiliation_strings': ['Université Côte d’Azur, INSERM, CNRS, IRCAN, 06107 Nice, France'], 'affiliations': [{'raw_affiliation_string': 'Université Côte d’Azur, INSERM, CNRS, IRCAN, 06107 Nice, France', 'institution_ids': ['https://openalex.org/I4210119200', 'https://openalex.org/I154526488', 'https://openalex.org/I201841394', 'https://openalex.org/I1294671590']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100336756', 'display_name': 'Jing Li', 'orcid': 'https://orcid.org/0000-0001-5697-9527'}, 'institutions': [{'id': 'https://openalex.org/I4210119200', 'display_name': 'Institut de Recherche sur le Cancer et le Vieillissement de Nice', 'ror': 'https://ror.org/01td3kv81', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I201841394', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210119200']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I201841394', 'display_name': "Université Côte d'Azur", 'ror': 'https://ror.org/019tgvf94', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I201841394']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Jing Li', 'raw_affiliation_strings': ['Université Côte d’Azur, INSERM, CNRS, IRCAN, 06107 Nice, France'], 'affiliations': [{'raw_affiliation_string': 'Université Côte d’Azur, INSERM, CNRS, IRCAN, 06107 Nice, France', 'institution_ids': ['https://openalex.org/I4210119200', 'https://openalex.org/I154526488', 'https://openalex.org/I201841394', 'https://openalex.org/I1294671590']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062269665', 'display_name': 'Andrej Fischer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802476451', 'display_name': 'Wellcome Sanger Institute', 'ror': 'https://ror.org/05cy4wa09', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2802476451', 'https://openalex.org/I87048295']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Andrej Fischer', 'raw_affiliation_strings': ['Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK'], 'affiliations': [{'raw_affiliation_string': 'Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK', 'institution_ids': ['https://openalex.org/I2802476451']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045241718', 'display_name': 'Benjamin Barré', 'orcid': 'https://orcid.org/0000-0002-3649-612X'}, 'institutions': [{'id': 'https://openalex.org/I4210119200', 'display_name': 'Institut de Recherche sur le Cancer et le Vieillissement de Nice', 'ror': 'https://ror.org/01td3kv81', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I201841394', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210119200']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I201841394', 'display_name': "Université Côte d'Azur", 'ror': 'https://ror.org/019tgvf94', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I201841394']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Benjamin Barré', 'raw_affiliation_strings': ['Université Côte d’Azur, INSERM, CNRS, IRCAN, 06107 Nice, France'], 'affiliations': [{'raw_affiliation_string': 'Université Côte d’Azur, INSERM, CNRS, IRCAN, 06107 Nice, France', 'institution_ids': ['https://openalex.org/I4210119200', 'https://openalex.org/I154526488', 'https://openalex.org/I201841394', 'https://openalex.org/I1294671590']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084279149', 'display_name': 'Johan Hallin', 'orcid': 'https://orcid.org/0000-0003-0586-9576'}, 'institutions': [{'id': 'https://openalex.org/I4210119200', 'display_name': 'Institut de Recherche sur le Cancer et le Vieillissement de Nice', 'ror': 'https://ror.org/01td3kv81', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I201841394', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210119200']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I201841394', 'display_name': "Université Côte d'Azur", 'ror': 'https://ror.org/019tgvf94', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I201841394']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Johan Hallin', 'raw_affiliation_strings': ['Université Côte d’Azur, INSERM, CNRS, IRCAN, 06107 Nice, France'], 'affiliations': [{'raw_affiliation_string': 'Université Côte d’Azur, INSERM, CNRS, IRCAN, 06107 Nice, France', 'institution_ids': ['https://openalex.org/I4210119200', 'https://openalex.org/I154526488', 'https://openalex.org/I201841394', 'https://openalex.org/I1294671590']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050753246', 'display_name': 'Anders Bergström', 'orcid': 'https://orcid.org/0000-0002-4096-9268'}, 'institutions': [{'id': 'https://openalex.org/I4210119200', 'display_name': 'Institut de Recherche sur le Cancer et le Vieillissement de Nice', 'ror': 'https://ror.org/01td3kv81', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I201841394', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210119200']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I201841394', 'display_name': "Université Côte d'Azur", 'ror': 'https://ror.org/019tgvf94', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I201841394']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}, {'id': 'https://openalex.org/I2802476451', 'display_name': 'Wellcome Sanger Institute', 'ror': 'https://ror.org/05cy4wa09', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2802476451', 'https://openalex.org/I87048295']}], 'countries': ['FR', 'GB'], 'is_corresponding': False, 'raw_author_name': 'Anders Bergström', 'raw_affiliation_strings': ['Université Côte d’Azur, INSERM, CNRS, IRCAN, 06107 Nice, France', 'Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK'], 'affiliations': [{'raw_affiliation_string': 'Université Côte d’Azur, INSERM, CNRS, IRCAN, 06107 Nice, France', 'institution_ids': ['https://openalex.org/I4210119200', 'https://openalex.org/I154526488', 'https://openalex.org/I201841394', 'https://openalex.org/I1294671590']}, {'raw_affiliation_string': 'Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK', 'institution_ids': ['https://openalex.org/I2802476451']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082147440', 'display_name': 'Elisa Alonso‐Perez', 'orcid': 'https://orcid.org/0000-0003-3568-5727'}, 'institutions': [{'id': 'https://openalex.org/I881427289', 'display_name': 'University of Gothenburg', 'ror': 'https://ror.org/01tm6cn81', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I881427289']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Elisa Alonso-Perez', 'raw_affiliation_strings': ['Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden', 'institution_ids': ['https://openalex.org/I881427289']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063706428', 'display_name': 'Jonas Warringer', 'orcid': 'https://orcid.org/0000-0001-6144-2740'}, 'institutions': [{'id': 'https://openalex.org/I54108979', 'display_name': 'Norwegian University of Life Sciences', 'ror': 'https://ror.org/04a1mvv97', 'country_code': 'NO', 'type': 'education', 'lineage': ['https://openalex.org/I54108979']}, {'id': 'https://openalex.org/I881427289', 'display_name': 'University of Gothenburg', 'ror': 'https://ror.org/01tm6cn81', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I881427289']}], 'countries': ['NO', 'SE'], 'is_corresponding': False, 'raw_author_name': 'Jonas Warringer', 'raw_affiliation_strings': ['Centre for Integrative Genetics (CIGENE), Department of Animal and Aquacultural Sciences, Norwegian University of Life Sciences, Ås, Norway', 'Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Centre for Integrative Genetics (CIGENE), Department of Animal and Aquacultural Sciences, Norwegian University of Life Sciences, Ås, Norway', 'institution_ids': ['https://openalex.org/I54108979']}, {'raw_affiliation_string': 'Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden', 'institution_ids': ['https://openalex.org/I881427289']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061483267', 'display_name': 'Ville Mustonen', 'orcid': 'https://orcid.org/0000-0002-7270-1792'}, 'institutions': [{'id': 'https://openalex.org/I2802476451', 'display_name': 'Wellcome Sanger Institute', 'ror': 'https://ror.org/05cy4wa09', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2802476451', 'https://openalex.org/I87048295']}], 'countries': ['GB'], 'is_corresponding': True, 'raw_author_name': 'Ville Mustonen', 'raw_affiliation_strings': ['Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK'], 'affiliations': [{'raw_affiliation_string': 'Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK', 'institution_ids': ['https://openalex.org/I2802476451']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5029927126', 'display_name': 'Gianni Liti', 'orcid': 'https://orcid.org/0000-0002-2318-0775'}, 'institutions': [{'id': 'https://openalex.org/I4210119200', 'display_name': 'Institut de Recherche sur le Cancer et le Vieillissement de Nice', 'ror': 'https://ror.org/01td3kv81', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I201841394', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210119200']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I201841394', 'display_name': "Université Côte d'Azur", 'ror': 'https://ror.org/019tgvf94', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I201841394']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': True, 'raw_author_name': 'Gianni Liti', 'raw_affiliation_strings': ['Université Côte d’Azur, INSERM, CNRS, IRCAN, 06107 Nice, France'], 'affiliations': [{'raw_affiliation_string': 'Université Côte d’Azur, INSERM, CNRS, IRCAN, 06107 Nice, France', 'institution_ids': ['https://openalex.org/I4210119200', 'https://openalex.org/I154526488', 'https://openalex.org/I201841394', 'https://openalex.org/I1294671590']}]}], 'institution_assertions': [], 'countries_distinct_count': 4, 'institutions_distinct_count': 8, 'corresponding_author_ids': ['https://openalex.org/A5046081802', 'https://openalex.org/A5061483267', 'https://openalex.org/A5029927126'], 'corresponding_institution_ids': ['https://openalex.org/I2802476451', 'https://openalex.org/I241749', 'https://openalex.org/I2802476451', 'https://openalex.org/I4210119200', 'https://openalex.org/I154526488', 'https://openalex.org/I201841394', 'https://openalex.org/I1294671590'], 'apc_list': {'value': 5200, 'currency': 'USD', 'value_usd': 5200, 'provenance': 'doaj'}, 'apc_paid': {'value': 5200, 'currency': 'USD', 'value_usd': 5200, 'provenance': 'doaj'}, 'fwci': 3.884, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 47, 'citation_normalized_percentile': {'value': 0.999952, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '21', 'issue': '3', 'first_page': '732', 'last_page': '744'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11764', 'display_name': 'Evolutionary Dynamics of Genetic Adaptation and Mutation', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11764', 'display_name': 'Evolutionary Dynamics of Genetic Adaptation and Mutation', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11016', 'display_name': 'Therapeutic Antibodies: Development, Engineering, and Applications', 'score': 0.9715, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10497', 'display_name': 'Genomic Expression and Function in Yeast Organism', 'score': 0.9501, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/genetic-dynamics', 'display_name': 'Genetic Dynamics', 'score': 0.49648}, {'id': 'https://openalex.org/keywords/neutral-mutation', 'display_name': 'Neutral mutation', 'score': 0.42939737}, {'id': 'https://openalex.org/keywords/genetic-fitness', 'display_name': 'Genetic Fitness', 'score': 0.4162879}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.8543678}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.67437935}, {'id': 'https://openalex.org/C141231307', 'wikidata': 'https://www.wikidata.org/wiki/Q7020', 'display_name': 'Genome', 'level': 3, 'score': 0.46789396}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.45356297}, {'id': 'https://openalex.org/C139807058', 'wikidata': 'https://www.wikidata.org/wiki/Q352374', 'display_name': 'Adaptation (eye)', 'level': 2, 'score': 0.45209652}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.44683248}, {'id': 'https://openalex.org/C178169997', 'wikidata': 'https://www.wikidata.org/wiki/Q2892636', 'display_name': 'Genome instability', 'level': 4, 'score': 0.43209335}, {'id': 'https://openalex.org/C149129301', 'wikidata': 'https://www.wikidata.org/wiki/Q3883802', 'display_name': 'Neutral mutation', 'level': 3, 'score': 0.42939737}, {'id': 'https://openalex.org/C127716648', 'wikidata': 'https://www.wikidata.org/wiki/Q104053', 'display_name': 'Phenotype', 'level': 3, 'score': 0.422584}, {'id': 'https://openalex.org/C2910387474', 'wikidata': 'https://www.wikidata.org/wiki/Q331710', 'display_name': 'Genetic Fitness', 'level': 3, 'score': 0.4162879}, {'id': 'https://openalex.org/C98638677', 'wikidata': 'https://www.wikidata.org/wiki/Q2067051', 'display_name': 'Mutation rate', 'level': 3, 'score': 0.41406542}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.32077974}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.18317187}, {'id': 'https://openalex.org/C143425029', 'wikidata': 'https://www.wikidata.org/wiki/Q5205747', 'display_name': 'DNA damage', 'level': 3, 'score': 0.07599664}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D012441', 'descriptor_name': 'Saccharomyces cerevisiae', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D002999', 'descriptor_name': 'Clone Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005787', 'descriptor_name': 'Gene Frequency', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005787', 'descriptor_name': 'Gene Frequency', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056084', 'descriptor_name': 'Genetic Fitness', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016681', 'descriptor_name': 'Genome, Fungal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042822', 'descriptor_name': 'Genomic Instability', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019656', 'descriptor_name': 'Loss of Heterozygosity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012441', 'descriptor_name': 'Saccharomyces cerevisiae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012641', 'descriptor_name': 'Selection, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 7, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.celrep.2017.09.046', 'pdf_url': 'http://www.cell.com/article/S2211124717313360/pdf', 'source': {'id': 'https://openalex.org/S169236886', 'display_name': 'Cell Reports', 'issn_l': '2211-1247', 'issn': ['2211-1247', '2639-1856'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/67d5e7b804914c569c22c3a74d3e33d1', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5656752', 'pdf_url': 'https://europepmc.org/articles/pmc5656752?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/11250/2490057', 'pdf_url': 'https://nmbu.brage.unit.no/nmbu-xmlui/bitstream/11250/2490057/2/CRIStin-post_1530700_VazquezEtAl_OpenAccess.pdf', 'source': {'id': 'https://openalex.org/S4306401716', 'display_name': 'Duo Research Archive (University of Oslo)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I184942183', 'host_organization_name': 'University of Oslo', 'host_organization_lineage': ['https://openalex.org/I184942183'], 'host_organization_lineage_names': ['University of Oslo'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656752', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/039859', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29045840', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.celrep.2017.09.046', 'pdf_url': 'http://www.cell.com/article/S2211124717313360/pdf', 'source': {'id': 'https://openalex.org/S169236886', 'display_name': 'Cell Reports', 'issn_l': '2211-1247', 'issn': ['2211-1247', '2639-1856'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320307794', 'funder_display_name': 'DuPont', 'award_id': None}, {'funder': 'https://openalex.org/F4320307874', 'funder_display_name': 'Wellcome', 'award_id': 'WT098051'}, {'funder': 'https://openalex.org/F4320307874', 'funder_display_name': 'Wellcome', 'award_id': 'WT097678'}, {'funder': 'https://openalex.org/F4320320879', 'funder_display_name': 'Deutsche Forschungsgemeinschaft', 'award_id': 'FI 1882/1-1'}, {'funder': 'https://openalex.org/F4320320883', 'funder_display_name': 'Agence Nationale de la Recherche', 'award_id': '11-LABX-0028-01'}, {'funder': 'https://openalex.org/F4320322361', 'funder_display_name': 'Fondation ARC pour la Recherche sur le Cancer', 'award_id': 'PDF20140601375'}, {'funder': 'https://openalex.org/F4320322363', 'funder_display_name': 'Ligue Contre le Cancer', 'award_id': 'GB-MA-CD-11287'}], 'datasets': [], 'versions': [], 'referenced_works_count': 45, 'referenced_works': ['https://openalex.org/W1583066216', 'https://openalex.org/W1973175445', 'https://openalex.org/W1985561503', 'https://openalex.org/W1997478924', 'https://openalex.org/W2009720434', 'https://openalex.org/W2012977051', 'https://openalex.org/W2016168002', 'https://openalex.org/W2017521996', 'https://openalex.org/W2018288777', 'https://openalex.org/W2026412193', 'https://openalex.org/W2030332043', 'https://openalex.org/W2049833715', 'https://openalex.org/W2063013559', 'https://openalex.org/W2067829962', 'https://openalex.org/W2072201802', 'https://openalex.org/W2088580309', 'https://openalex.org/W2108543631', 'https://openalex.org/W2109601111', 'https://openalex.org/W2109948920', 'https://openalex.org/W2111187843', 'https://openalex.org/W2112233687', 'https://openalex.org/W2116701298', 'https://openalex.org/W2117737648', 'https://openalex.org/W2118055782', 'https://openalex.org/W2122881747', 'https://openalex.org/W2128099419', 'https://openalex.org/W2128726449', 'https://openalex.org/W2131229434', 'https://openalex.org/W2145004732', 'https://openalex.org/W2148323109', 'https://openalex.org/W2150575159', 'https://openalex.org/W2152177323', 'https://openalex.org/W2164696589', 'https://openalex.org/W2164832298', 'https://openalex.org/W2165017975', 'https://openalex.org/W2170343590', 'https://openalex.org/W2171197491', 'https://openalex.org/W2171679524', 'https://openalex.org/W2172105663', 'https://openalex.org/W2176937892', 'https://openalex.org/W2227467442', 'https://openalex.org/W2417483443', 'https://openalex.org/W2518349977', 'https://openalex.org/W2949073718', 'https://openalex.org/W4295837538'], 'related_works': ['https://openalex.org/W4297910419', 'https://openalex.org/W2949191837', 'https://openalex.org/W2778167829', 'https://openalex.org/W2595075053', 'https://openalex.org/W2309460529', 'https://openalex.org/W2097774084', 'https://openalex.org/W2075457237', 'https://openalex.org/W2075380571', 'https://openalex.org/W2025340064', 'https://openalex.org/W1990671617'], 'abstract_inverted_index': {'The': [0, 82], 'joint': [1], 'contribution': [2], 'of': [3, 33, 39, 51, 104, 116, 122, 139], 'pre-existing': [4, 96, 105, 126, 140], 'and': [5, 64, 79, 94, 106, 127, 135], 'de': [6, 73, 90, 107, 128], 'novo': [7, 74, 91, 108, 129], 'genetic': [8, 123], 'variation': [9], 'to': [10, 18, 133], 'clonal': [11, 69], 'adaptation': [12], 'is': [13], 'poorly': [14], 'understood': [15], 'but': [16, 76], 'essential': [17], 'designing': [19], 'successful': [20], 'antimicrobial': [21], 'or': [22], 'cancer': [23], 'therapies.': [24], 'To': [25], 'address': [26], 'this,': [27], 'we': [28, 99], 'evolve': [29], 'genetically': [30, 78], 'diverse': [31], 'populations': [32, 53, 67], 'budding': [34], 'yeast,': [35], 'S.': [36], 'cerevisiae,': [37], 'consisting': [38], 'diploid': [40], 'cells': [41], 'with': [42, 57], 'unique': [43], 'haplotype': [44], 'combinations.': [45], 'We': [46], 'study': [47], 'the': [48, 101, 136], 'asexual': [49], 'evolution': [50], 'these': [52], 'under': [54], 'selective': [55, 144], 'inhibition': [56], 'chemotherapeutic': [58], 'drugs': [59], 'by': [60, 72, 110], 'time-resolved': [61], 'whole-genome': [62], 'sequencing': [63], 'phenotyping.': [65], 'All': [66], 'undergo': [68], 'expansions': [70], 'driven': [71], 'mutations': [75, 92, 109, 118, 130], 'remain': [77], 'phenotypically': [80], 'diverse.': [81], 'clones': [83], 'exhibit': [84], 'widespread': [85], 'genomic': [86], 'instability,': [87], 'rendering': [88], 'recessive': [89], 'homozygous': [93], 'refining': [95], 'variation.': [97], 'Finally,': [98], 'decompose': [100], 'fitness': [102, 138], 'contributions': [103], 'creating': [111], 'a': [112, 143], 'large': [113], 'recombinant': [114], 'library': [115], 'adaptive': [117, 148], 'in': [119], 'an': [120], 'ensemble': [121], 'backgrounds.': [124], 'Both': [125], 'substantially': [131], 'contribute': [132], 'fitness,': [134], 'relative': [137], 'variants': [141], 'sets': [142], 'threshold': [145], 'for': [146], 'new': [147], 'mutations.': [149]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2765616228', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 11}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 1}], 'updated_date': '2024-09-19T18:51:05.136633', 'created_date': '2017-11-10'}