Publication Information

{'id': 'https://openalex.org/W2765390900', 'doi': 'https://doi.org/10.3390/ijms18112306', 'title': 'The C-C Chemokines CCL17 and CCL22 and Their Receptor CCR4 in CNS Autoimmunity', 'display_name': 'The C-C Chemokines CCL17 and CCL22 and Their Receptor CCR4 in CNS Autoimmunity', 'publication_year': 2017, 'publication_date': '2017-11-02', 'ids': {'openalex': 'https://openalex.org/W2765390900', 'doi': 'https://doi.org/10.3390/ijms18112306', 'mag': '2765390900', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29099057', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5713275'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/ijms18112306', 'pdf_url': 'https://www.mdpi.com/1422-0067/18/11/2306/pdf', 'source': {'id': 'https://openalex.org/S10623703', 'display_name': 'International Journal of Molecular Sciences', 'issn_l': '1422-0067', 'issn': ['1422-0067', '1661-6596'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.mdpi.com/1422-0067/18/11/2306/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5061441225', 'display_name': 'Stefanie Scheu', 'orcid': 'https://orcid.org/0000-0002-9707-8191'}, 'institutions': [{'id': 'https://openalex.org/I4210089242', 'display_name': 'Düsseldorf University Hospital', 'ror': 'https://ror.org/006k2kk72', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210089242']}, {'id': 'https://openalex.org/I44260953', 'display_name': 'Heinrich Heine University Düsseldorf', 'ror': 'https://ror.org/024z2rq82', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I44260953']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Stefanie Scheu', 'raw_affiliation_strings': ['Institute of Medical Microbiology and Hospital Hygiene, University of Düsseldorf, 40225 Düsseldorf, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute of Medical Microbiology and Hospital Hygiene, University of Düsseldorf, 40225 Düsseldorf, Germany', 'institution_ids': ['https://openalex.org/I4210089242', 'https://openalex.org/I44260953']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084918087', 'display_name': 'Shafaqat Ali', 'orcid': 'https://orcid.org/0000-0002-2707-9391'}, 'institutions': [{'id': 'https://openalex.org/I4210089242', 'display_name': 'Düsseldorf University Hospital', 'ror': 'https://ror.org/006k2kk72', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210089242']}, {'id': 'https://openalex.org/I44260953', 'display_name': 'Heinrich Heine University Düsseldorf', 'ror': 'https://ror.org/024z2rq82', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I44260953']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Shafaqat Ali', 'raw_affiliation_strings': ['Institute of Medical Microbiology and Hospital Hygiene, University of Düsseldorf, 40225 Düsseldorf, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute of Medical Microbiology and Hospital Hygiene, University of Düsseldorf, 40225 Düsseldorf, Germany', 'institution_ids': ['https://openalex.org/I4210089242', 'https://openalex.org/I44260953']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025465926', 'display_name': 'Christina Ruland', 'orcid': 'https://orcid.org/0000-0002-2284-5229'}, 'institutions': [{'id': 'https://openalex.org/I22465464', 'display_name': 'University of Münster', 'ror': 'https://ror.org/00pd74e08', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I22465464']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Christina Ruland', 'raw_affiliation_strings': ['Cells in Motion, Cluster of Excellence, University of Münster, 48149 Münster, Germany', 'Department of Psychiatry, University of Münster, 48149 Münster, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Psychiatry, University of Münster, 48149 Münster, Germany', 'institution_ids': ['https://openalex.org/I22465464']}, {'raw_affiliation_string': 'Cells in Motion, Cluster of Excellence, University of Münster, 48149 Münster, Germany', 'institution_ids': ['https://openalex.org/I22465464']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110364676', 'display_name': 'Volker Arolt', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I22465464', 'display_name': 'University of Münster', 'ror': 'https://ror.org/00pd74e08', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I22465464']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Volker Arolt', 'raw_affiliation_strings': ['Department of Psychiatry, University of Münster, 48149 Münster, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Psychiatry, University of Münster, 48149 Münster, Germany', 'institution_ids': ['https://openalex.org/I22465464']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5019232897', 'display_name': 'Judith Alferink', 'orcid': 'https://orcid.org/0000-0002-3251-6584'}, 'institutions': [{'id': 'https://openalex.org/I22465464', 'display_name': 'University of Münster', 'ror': 'https://ror.org/00pd74e08', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I22465464']}], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'Judith Alferink', 'raw_affiliation_strings': ['Cells in Motion, Cluster of Excellence, University of Münster, 48149 Münster, Germany', 'Department of Psychiatry, Alexian Brothers Hospital, 48149 Münster, Germany', 'Department of Psychiatry, University of Münster, 48149 Münster, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Psychiatry, University of Münster, 48149 Münster, Germany', 'institution_ids': ['https://openalex.org/I22465464']}, {'raw_affiliation_string': 'Cells in Motion, Cluster of Excellence, University of Münster, 48149 Münster, Germany', 'institution_ids': ['https://openalex.org/I22465464']}, {'raw_affiliation_string': 'Department of Psychiatry, Alexian Brothers Hospital, 48149 Münster, Germany', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5019232897'], 'corresponding_institution_ids': ['https://openalex.org/I22465464'], 'apc_list': {'value': 2300, 'currency': 'CHF', 'value_usd': 2490, 'provenance': 'doaj'}, 'apc_paid': {'value': 2300, 'currency': 'CHF', 'value_usd': 2490, 'provenance': 'doaj'}, 'fwci': 1.099, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 118, 'citation_normalized_percentile': {'value': 0.570727, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '18', 'issue': '11', 'first_page': '2306', 'last_page': '2306'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11532', 'display_name': 'Chemokine receptors and signaling', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11532', 'display_name': 'Chemokine receptors and signaling', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10580', 'display_name': 'Immunotherapy and Immune Responses', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11503', 'display_name': 'Cytokine Signaling Pathways and Interactions', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ccl17', 'display_name': 'CCL17', 'score': 0.8793385}, {'id': 'https://openalex.org/keywords/ccr4', 'display_name': 'CCR4', 'score': 0.80060416}, {'id': 'https://openalex.org/keywords/ccl22', 'display_name': 'CCL22', 'score': 0.5805722}, {'id': 'https://openalex.org/keywords/cc-chemokine-receptors', 'display_name': 'CC chemokine receptors', 'score': 0.50922906}], 'concepts': [{'id': 'https://openalex.org/C143172330', 'wikidata': 'https://www.wikidata.org/wiki/Q1069599', 'display_name': 'CCL17', 'level': 5, 'score': 0.8793385}, {'id': 'https://openalex.org/C2775866117', 'wikidata': 'https://www.wikidata.org/wiki/Q21102300', 'display_name': 'CCR4', 'level': 5, 'score': 0.80060416}, {'id': 'https://openalex.org/C2780130043', 'wikidata': 'https://www.wikidata.org/wiki/Q192360', 'display_name': 'Autoimmunity', 'level': 3, 'score': 0.62208}, {'id': 'https://openalex.org/C134678942', 'wikidata': 'https://www.wikidata.org/wiki/Q3776878', 'display_name': 'CCL22', 'level': 5, 'score': 0.5805722}, {'id': 'https://openalex.org/C13373296', 'wikidata': 'https://www.wikidata.org/wiki/Q421866', 'display_name': 'Chemokine', 'level': 3, 'score': 0.52578783}, {'id': 'https://openalex.org/C12823836', 'wikidata': 'https://www.wikidata.org/wiki/Q24720618', 'display_name': 'Chemokine receptor', 'level': 4, 'score': 0.5103192}, {'id': 'https://openalex.org/C128879288', 'wikidata': 'https://www.wikidata.org/wiki/Q5009764', 'display_name': 'CC chemokine receptors', 'level': 5, 'score': 0.50922906}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.47177032}, {'id': 'https://openalex.org/C94205230', 'wikidata': 'https://www.wikidata.org/wiki/Q5005868', 'display_name': 'C-C chemokine receptor type 6', 'level': 5, 'score': 0.41059655}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.29295054}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.18901637}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.09274885}], 'mesh': [{'descriptor_ui': 'D020274', 'descriptor_name': 'Autoimmune Diseases of the Nervous System', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D015551', 'descriptor_name': 'Autoimmunity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D054414', 'descriptor_name': 'Chemokine CCL17', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D054422', 'descriptor_name': 'Chemokine CCL22', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D054398', 'descriptor_name': 'Receptors, CCR4', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020274', 'descriptor_name': 'Autoimmune Diseases of the Nervous System', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D020274', 'descriptor_name': 'Autoimmune Diseases of the Nervous System', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D020274', 'descriptor_name': 'Autoimmune Diseases of the Nervous System', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015551', 'descriptor_name': 'Autoimmunity', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D002490', 'descriptor_name': 'Central Nervous System', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002490', 'descriptor_name': 'Central Nervous System', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D002490', 'descriptor_name': 'Central Nervous System', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D002490', 'descriptor_name': 'Central Nervous System', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054414', 'descriptor_name': 'Chemokine CCL17', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D054414', 'descriptor_name': 'Chemokine CCL17', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054422', 'descriptor_name': 'Chemokine CCL22', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D054422', 'descriptor_name': 'Chemokine CCL22', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003713', 'descriptor_name': 'Dendritic Cells', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D003713', 'descriptor_name': 'Dendritic Cells', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D003713', 'descriptor_name': 'Dendritic Cells', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D003713', 'descriptor_name': 'Dendritic Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004681', 'descriptor_name': 'Encephalomyelitis, Autoimmune, Experimental', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D004681', 'descriptor_name': 'Encephalomyelitis, Autoimmune, Experimental', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D004681', 'descriptor_name': 'Encephalomyelitis, Autoimmune, Experimental', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D004681', 'descriptor_name': 'Encephalomyelitis, Autoimmune, Experimental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058990', 'descriptor_name': 'Molecular Targeted Therapy', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D058990', 'descriptor_name': 'Molecular Targeted Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009103', 'descriptor_name': 'Multiple Sclerosis', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D009103', 'descriptor_name': 'Multiple Sclerosis', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D009103', 'descriptor_name': 'Multiple Sclerosis', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009103', 'descriptor_name': 'Multiple Sclerosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054398', 'descriptor_name': 'Receptors, CCR4', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D054398', 'descriptor_name': 'Receptors, CCR4', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 6, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/ijms18112306', 'pdf_url': 'https://www.mdpi.com/1422-0067/18/11/2306/pdf', 'source': {'id': 'https://openalex.org/S10623703', 'display_name': 'International Journal of Molecular Sciences', 'issn_l': '1422-0067', 'issn': ['1422-0067', '1661-6596'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/2fe1a59cf793482e8c2ec3d08ba70af8', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5713275', 'pdf_url': 'https://europepmc.org/articles/pmc5713275?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://dx.doi.org/10.3390/ijms18112306', 'pdf_url': 'https://www.mdpi.com/1422-0067/18/11/2306/pdf?version=1509611405', 'source': {'id': 'https://openalex.org/S4306400947', 'display_name': 'MDPI (MDPI AG)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210097602', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute (Switzerland)', 'host_organization_lineage': ['https://openalex.org/I4210097602'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute (Switzerland)'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713275', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29099057', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/ijms18112306', 'pdf_url': 'https://www.mdpi.com/1422-0067/18/11/2306/pdf', 'source': {'id': 'https://openalex.org/S10623703', 'display_name': 'International Journal of Molecular Sciences', 'issn_l': '1422-0067', 'issn': ['1422-0067', '1661-6596'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.65, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 119, 'referenced_works': ['https://openalex.org/W1524773295', 'https://openalex.org/W1531876501', 'https://openalex.org/W1583355211', 'https://openalex.org/W1589261928', 'https://openalex.org/W1601258731', 'https://openalex.org/W1729103553', 'https://openalex.org/W1828576284', 'https://openalex.org/W1913122697', 'https://openalex.org/W1925299062', 'https://openalex.org/W1970448164', 'https://openalex.org/W1971207794', 'https://openalex.org/W1971270464', 'https://openalex.org/W1974071913', 'https://openalex.org/W1974171294', 'https://openalex.org/W1981862998', 'https://openalex.org/W1983662281', 'https://openalex.org/W1986991315', 'https://openalex.org/W1997295702', 'https://openalex.org/W2000983371', 'https://openalex.org/W2001487688', 'https://openalex.org/W2001849162', 'https://openalex.org/W2001867160', 'https://openalex.org/W2004844427', 'https://openalex.org/W2006741811', 'https://openalex.org/W2008823687', 'https://openalex.org/W2009569010', 'https://openalex.org/W2013090420', 'https://openalex.org/W2013152655', 'https://openalex.org/W2014125703', 'https://openalex.org/W2016317210', 'https://openalex.org/W2020548323', 'https://openalex.org/W2021836043', 'https://openalex.org/W2025262171', 'https://openalex.org/W2025878623', 'https://openalex.org/W2033227144', 'https://openalex.org/W2038570679', 'https://openalex.org/W2038610464', 'https://openalex.org/W2040334938', 'https://openalex.org/W2041852804', 'https://openalex.org/W2042412331', 'https://openalex.org/W2044983494', 'https://openalex.org/W2048143404', 'https://openalex.org/W2052834898', 'https://openalex.org/W2054586855', 'https://openalex.org/W2055421535', 'https://openalex.org/W2059410321', 'https://openalex.org/W2060525968', 'https://openalex.org/W2060594102', 'https://openalex.org/W2063303147', 'https://openalex.org/W2065955484', 'https://openalex.org/W2066031247', 'https://openalex.org/W2067003511', 'https://openalex.org/W2067438849', 'https://openalex.org/W2068526296', 'https://openalex.org/W2074847389', 'https://openalex.org/W2076078066', 'https://openalex.org/W2077009876', 'https://openalex.org/W2078725156', 'https://openalex.org/W2078865976', 'https://openalex.org/W2078873071', 'https://openalex.org/W2079136206', 'https://openalex.org/W2079198405', 'https://openalex.org/W2082651651', 'https://openalex.org/W2084372525', 'https://openalex.org/W2086196933', 'https://openalex.org/W2086411755', 'https://openalex.org/W2097276049', 'https://openalex.org/W2097640935', 'https://openalex.org/W2103011392', 'https://openalex.org/W2107580687', 'https://openalex.org/W2108230289', 'https://openalex.org/W2110890034', 'https://openalex.org/W2111856386', 'https://openalex.org/W2114056456', 'https://openalex.org/W2123093300', 'https://openalex.org/W2125610020', 'https://openalex.org/W2128627731', 'https://openalex.org/W2129741568', 'https://openalex.org/W2130397839', 'https://openalex.org/W2133247340', 'https://openalex.org/W2134486617', 'https://openalex.org/W2139152451', 'https://openalex.org/W2142827416', 'https://openalex.org/W2146107139', 'https://openalex.org/W2147137293', 'https://openalex.org/W2150678612', 'https://openalex.org/W2153960708', 'https://openalex.org/W2155371505', 'https://openalex.org/W2156768991', 'https://openalex.org/W2160933319', 'https://openalex.org/W2161234218', 'https://openalex.org/W2163112215', 'https://openalex.org/W2166447284', 'https://openalex.org/W2168989328', 'https://openalex.org/W2170737790', 'https://openalex.org/W2177327503', 'https://openalex.org/W2179531916', 'https://openalex.org/W2200436278', 'https://openalex.org/W2301355704', 'https://openalex.org/W2306881841', 'https://openalex.org/W2325912006', 'https://openalex.org/W2397739328', 'https://openalex.org/W2410605652', 'https://openalex.org/W2414019220', 'https://openalex.org/W2414589197', 'https://openalex.org/W2539358755', 'https://openalex.org/W2562977489', 'https://openalex.org/W2579921919', 'https://openalex.org/W2610923556', 'https://openalex.org/W2640341220', 'https://openalex.org/W2734750805', 'https://openalex.org/W2740885263', 'https://openalex.org/W2760172662', 'https://openalex.org/W2953144376', 'https://openalex.org/W4211254511', 'https://openalex.org/W4313331406', 'https://openalex.org/W4313347685', 'https://openalex.org/W607832765', 'https://openalex.org/W72465079'], 'related_works': ['https://openalex.org/W3152136054', 'https://openalex.org/W3147472132', 'https://openalex.org/W2309837982', 'https://openalex.org/W2160129587', 'https://openalex.org/W2074045776', 'https://openalex.org/W2072195899', 'https://openalex.org/W2050428704', 'https://openalex.org/W2034816404', 'https://openalex.org/W1987569008', 'https://openalex.org/W1857019503'], 'abstract_inverted_index': {'Multiple': [0], 'sclerosis': [1], '(MS)': [2], 'is': [3], 'a': [4, 52, 183], 'chronic': [5], 'inflammatory': [6, 127], 'demyelinating': [7], 'disease': [8, 54], 'of': [9, 47, 65, 76, 134, 137, 150, 163, 177, 189], 'the': [10, 45, 135, 174], 'central': [11], 'nervous': [12], 'system': [13], '(CNS).': [14], 'It': [15], 'affects': [16], 'more': [17], 'than': [18], 'two': [19], 'million': [20], 'people': [21], 'worldwide,': [22], 'mainly': [23], 'young': [24], 'adults,': [25], 'and': [26, 34, 73, 84, 93, 106, 109, 126, 139, 166, 182], 'may': [27], 'lead': [28], 'to': [29, 40, 119], 'progressive': [30], 'neurological': [31], 'disability.': [32], 'Chemokines': [33], 'their': [35, 110], 'receptors': [36], 'have': [37, 116, 159], 'been': [38, 117], 'shown': [39, 118], 'play': [41, 120], 'critical': [42], 'roles': [43, 162], 'in': [44, 124, 142, 156, 168], 'pathogenesis': [46], 'experimental': [48, 154], 'autoimmune': [49], 'encephalomyelitis': [50], '(EAE),': [51], 'murine': [53], 'model': [55], 'induced': [56], 'by': [57, 96], 'active': [58], 'immunization': [59], 'with': [60, 153], 'myelin': [61], 'proteins': [62], 'or': [63], 'transfer': [64], 'encephalitogenic': [66], 'CD4⁺': [67], 'T': [68], 'cells': [69, 98], 'that': [70, 158], 'recapitulates': [71], 'clinical': [72, 148], 'neuropathological': [74], 'features': [75], 'MS.': [77, 190], 'Chemokine': [78], 'ligand-receptor': [79], 'interactions': [80], 'orchestrate': [81], 'leukocyte': [82], 'trafficking': [83], 'influence': [85], 'multiple': [86], 'pathophysiological': [87], 'cellular': [88], 'processes,': [89], 'including': [90], 'antigen': [91], 'presentation': [92], 'cytokine': [94], 'production': [95], 'dendritic': [97], '(DCs).': [99], 'The': [100], 'C-C': [101, 111], 'class': [102], 'chemokines': [103], '17': [104], '(CCL17)': [105], '22': [107], '(CCL22)': [108], 'chemokine': [112], 'receptor': [113], '4': [114], '(CCR4)': [115], 'an': [121, 132], 'important': [122], 'role': [123], 'homeostasis': [125], 'responses.': [128], 'Here,': [129], 'we': [130, 172], 'provide': [131], 'overview': [133], 'involvement': [136], 'CCR4': [138, 180], 'its': [140], 'ligands': [141], 'CNS': [143], 'autoimmunity.': [144], 'We': [145], 'review': [146], 'key': [147], 'studies': [149, 155], 'MS': [151], 'together': [152], 'animals': [157], 'demonstrated': [160], 'functional': [161], 'CCR4,': [164], 'CCL17,': [165], 'CCL22': [167], 'EAE': [169], 'pathogenesis.': [170], 'Finally,': [171], 'discuss': [173], 'therapeutic': [175], 'potential': [176], 'newly': [178], 'developed': [179], 'antagonists': [181], 'humanized': [184], 'anti-CCR4': [185], 'antibody': [186], 'for': [187], 'treatment': [188]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2765390900', 'counts_by_year': [{'year': 2024, 'cited_by_count': 22}, {'year': 2023, 'cited_by_count': 17}, {'year': 2022, 'cited_by_count': 17}, {'year': 2021, 'cited_by_count': 29}, {'year': 2020, 'cited_by_count': 18}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 5}], 'updated_date': '2024-12-27T22:16:31.083918', 'created_date': '2017-11-10'}