Epigenetic regulation by DNA methylation and miRNA molecules in cancer

Name: Work Video:
Duration: 3 min 30 s
Veronika Holubeková; Andrea Mendelová; Karin Jašek; Sandra Meršaková; Pavol Žúbor; Zora Lasabová
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1959, 2050, 2091, 2116, 2217, 2247, 2256, 2284, 2300, 2312, 2388, 2411, 2443, 2452, 2463, 2468, 2509, 2516, 2544, 2569, 2578, 2598, 2617, 2723, 2778, 2787, 2835, 2882, 2905, 2912, 2925, 2939, 3014, 3038, 3078, 3110, 3122, 3133, 3169, 3176, 3218, 3248, 3294, 3305, 3316, 3477, 3513, 3621, 3656, 3684, 3707, 3752, 3773, 3827, 3850, 3876, 3926, 3990, 4015, 4055, 4068, 4088, 4099, 4108, 4327, 4358, 4370, 4386, 4426, 4446, 4492, 4503, 4514], 'cancerVeronika': [17], 'Holubekova,': [18], 'Andrea': [19, 60], 'Mendelova,': [20], 'Karin': [21, 82], 'Jasek,': [22], 'Sandra': [23, 103], 'Mersakova,': [24], 'Pavol': [25, 124], 'Zubor': [26, 125], '&': [27, 166, 908, 1488, 3240, 4025, 4438], 'Zora': [28, 167], 'LasabovaVeronika': [29], 'Holubekova*Author': [30], 'for': [31, 229, 306, 533, 794, 826, 840, 878, 901, 1143, 1784, 1903, 1912, 2059, 2143, 2225, 2263, 2272, 2319, 2355, 2418, 2625, 2648, 2844, 2861, 2886, 3197, 3229, 3327, 3542, 3573, 3853, 3903, 4244, 4414], 'correspondence:': [32], 'Tel.:': [33], '+421': [34], '43': [35], '2633': [36], '651;': [37], 'E-mail': [38], 'Address:': [39], '[email protected]': [40], 'Division': [41, 62, 84, 105, 126, 169], 'of': [42, 49, 63, 71, 85, 92, 106, 113, 127, 134, 146, 152, 170, 177, 189, 197, 241, 264, 274, 301, 349, 393, 422, 444, 451, 464, 505, 559, 595, 605, 628, 706, 737, 764, 782, 799, 808, 813, 820, 828, 854, 880, 888, 905, 946, 982, 1055, 1084, 1095, 1124, 1148, 1162, 1169, 1173, 1178, 1185, 1196, 1202, 1249, 1254, 1264, 1303, 1353, 1413, 1455, 1485, 1505, 1513, 1521, 1543, 1569, 1589, 1628, 1665, 1703, 1711, 1738, 1772, 1786, 1800, 1871, 1882, 1894, 1907, 1952, 1994, 2002, 2008, 2026, 2038, 2076, 2088, 2098, 2119, 2140, 2147, 2150, 2158, 2163, 2178, 2228, 2233, 2249, 2259, 2280, 2303, 2315, 2322, 2336, 2343, 2348, 2352, 2370, 2385, 2392, 2403, 2421, 2428, 2455, 2512, 2518, 2558, 2581, 2584, 2595, 2630, 2645, 2659, 2666, 2679, 2697, 2736, 2753, 2761, 2781, 2804, 2832, 2863, 2874, 2879, 2915, 2927, 2959, 2996, 3035, 3092, 3113, 3125, 3152, 3159, 3173, 3180, 3185, 3192, 3199, 3221, 3235, 3319, 3387, 3413, 3421, 3467, 3501, 3507, 3545, 3594, 3619, 3682, 3705, 3726, 3825, 3846, 3856, 3872, 3879, 3952, 3959, 4038, 4091, 4103, 4115, 4171, 4188, 4196, 4209, 4247, 4268, 4280, 4288, 4302, 4308, 4345, 4368, 4395, 4517], 'Oncology,': [43, 86, 107, 128, 171, 4100], 'Biomedical': [44, 66, 87, 108, 129, 172, 192, 3259, 4457], 'Center': [45, 67, 88, 109, 130, 173, 193, 3260, 4458], 'Martin,': [46, 52, 58, 68, 74, 80, 89, 95, 101, 110, 116, 122, 131, 137, 143, 155, 164, 174, 180, 186, 194, 200, 206], 'Jessenius': [47, 69, 90, 111, 132, 150, 175, 195], 'Faculty': [48, 70, 91, 112, 133, 151, 176, 196], 'Medicine': [50, 72, 93, 114, 135, 153, 178, 198, 4433], 'Comenius': [53, 75, 96, 117, 138, 156, 181, 201], 'University': [54, 76, 97, 118, 139, 157, 161, 182, 202], 'Bratislava,': [56, 78, 99, 120, 141, 159, 184, 204], 'SK-03601': [57, 79, 100, 121, 142, 163, 185, 205], 'Slovakia,': [59, 81, 102, 123], 'Mendelova': [61], 'Molecular': [64, 190, 4218, 4281, 4303, 4346, 4396], 'Medicine,': [65], 'Jasek': [83], 'Mersakova': [104], 'Slovakia': [144, 165, 187], 'Department': [145, 188], 'Obstetrics': [147], 'Gynecology,': [149], 'Martin': [160, 3261, 4459], 'Hospital,': [162], 'Lasabova': [168], 'Biology,': [191, 4076], 'SlovakiaPublished': [207], 'Online:4': [208], 'Oct': [209], '2017https://doi.org/10.2217/fon-2017-0363AboutSectionsPDF/EPUB': [210], 'ToolsAdd': [211], 'to': [212, 270, 475, 497, 645, 708, 724, 733, 788, 797, 865, 873, 884, 894, 911, 921, 933, 1105, 1119, 1135, 1224, 1289, 1342, 1381, 1578, 1620, 1645, 1735, 1780, 1873, 2193, 2292, 2440, 2490, 2531, 2705, 2749, 2884, 2901, 2964, 3009, 3025, 3140, 3154, 3213, 3733, 3932, 4140, 4240], 'favoritesDownload': [213], 'CitationsTrack': [214], 'Citations': [215], 'ShareShare': [216], 'onFacebookTwitterLinkedInReddit': [217], 'Keywords:': [218], 'circulating': [219, 2099, 2204, 2285, 2386, 2456, 2504, 2536, 2562, 2596, 2646, 2731, 2754, 2805, 2868, 2916, 3160, 3205, 3874, 3897, 3953, 3992], 'markersDNA': [220, 4435], 'methylationepigenetic': [221, 4436], 'silencingmiRNAFirst': [222], 'draft': [223], 'submitted:': [224], '27': [225], 'July': [226, 4319], '2017;': [227, 233], 'Accepted': [228], 'publication:': [230], '23': [231], 'August': [232, 4184], 'Published': [234, 4420, 4425], 'online:': [235], '4': [236, 4422], 'October': [237, 4215, 4423, 4428], '2017The': [238], 'leading': [239, 796, 3325], 'causes': [240, 1176, 3326], 'death': [242, 2181, 2184], 'across': [243, 429], 'the': [244, 271, 289, 430, 476, 576, 651, 656, 661, 704, 735, 846, 922, 944, 960, 1091, 1106, 1109, 1117, 1158, 1192, 1200, 1326, 1410, 1431, 1440, 1464, 1492, 1503, 1511, 1539, 1552, 1587, 1609, 1626, 1632, 1666, 1701, 1712, 1761, 1770, 1810, 1977, 2094, 2144, 2151, 2164, 2221, 2257, 2268, 2278, 2298, 2301, 2313, 2320, 2326, 2353, 2361, 2390, 2396, 2401, 2453, 2510, 2570, 2579, 2585, 2662, 2741, 2788, 2802, 2840, 2906, 2913, 2955, 3058, 3069, 3123, 3142, 3149, 3170, 3186, 3215, 3257, 3267, 3271, 3299, 3306, 3317, 3543, 3877, 4016, 4130, 4137, 4207, 4245, 4269, 4309, 4364, 4366, 4415, 4455, 4465, 4469, 4497, 4504, 4515], 'world': [245], 'are': [246, 334, 404, 411, 448, 494, 518, 539, 545, 548, 553, 572, 609, 823, 1001, 1052, 1065, 1079, 1102, 1133, 1235, 1460, 1508, 1669, 1682, 1697, 1755, 1901, 1957, 2136, 2172, 2191, 2267, 2275, 2416, 2438, 2575, 2623, 2669, 2714, 3065, 3100, 3130, 3195], 'cancer,': [247, 2148, 2239, 2324, 3174], 'cardiovascular': [248], 'diseases': [249], 'chronic': [251, 1839], 'lower': [252], 'respiratory': [253], 'diseases,': [254, 256, 991, 1829, 1832], 'cerebrovascular': [255], "Alzheimer's": [257], 'disease,': [258, 1355, 2152], 'diabetes': [259], 'other': [261, 835, 892, 1033, 1193, 1470, 1584, 1615, 2692, 2724, 2893, 3279, 4477], '[1].': [262], 'All': [263], 'these': [265, 461, 869, 1592, 1680, 2667], 'conditions': [266], 'still': [267, 858], 'appear': [268, 1808, 3118], 'due': [269, 787, 2748], 'immense': [272], 'scope': [273], 'research': [275, 945], 'management': [277], 'at': [278, 418, 1887, 2852], 'basic': [279, 3447], 'molecular': [280, 1598, 2141, 2683], 'or': [281, 424, 437, 490, 701, 719, 1017, 1048, 1480, 1655, 1661, 1675, 1686, 1700, 1759, 2129, 2182, 2237, 2474, 2483, 2494, 2497, 2556, 2998, 3282, 3288, 3295, 3302, 3677, 4249, 4480, 4486, 4493, 4500], 'targeted': [282, 3126], 'clinical': [283, 1960, 2649, 3900], 'level.': [284], 'In': [285, 959, 1733, 1950, 2891, 2970], 'normal': [286, 378, 729, 814, 1014, 1242, 1260, 2020, 2179, 3015, 3039, 3146], 'eukaryotic': [287], 'organisms,': [288], 'key': [290, 3219], 'process': [291, 2189], 'embryonic': [293, 1214], 'development,': [294, 1215, 3019], 'differentiation,': [295, 1980, 2935], 'imprinting,': [296], 'chromosome': [297], 'stability': [298], 'inactivation': [300], 'large': [302], 'chromosomal': [303], 'domains': [304], '–': [305, 435, 440, 950, 953, 1099, 1113, 1115, 2224, 2472], 'example,': [307, 2060, 2226], 'X-chromosome': [308], 'is': [309, 316, 472, 531, 623, 692, 722, 745, 863, 954, 1127, 1277, 1295, 1325, 1371, 1402, 1525, 1533, 1556, 1575, 1595, 2109, 2166, 2252, 2305, 2359, 2398, 2409, 2424, 2450, 2615, 2699, 2921, 2937, 3060, 3080, 3138, 3226, 3246, 4444], 'epigenetic': [310, 314, 347, 913, 928, 1490, 1611, 1698, 3750, 3924, 4172], 'silencing.': [311], 'One': [312], 'well-studied': [313], 'modification': [315], 'that': [319, 403, 570, 601, 630, 1064, 1217, 1234, 1284, 1319, 1404, 1433, 1447, 1500, 1705, 1767, 1818, 2045, 2072, 2083, 2274, 2459, 2700, 2801, 2898, 3106], 'represents': [320], 'a': [321, 390, 394, 556, 626, 632, 641, 675, 686, 746, 762, 915, 1053, 1350, 1418, 1449, 1453, 1904, 1913, 1946, 1970, 1992, 1995, 2114, 2137, 2176, 2187, 2250, 2253, 2260, 2316, 2334, 2728, 2779, 2829, 2857, 2877, 2922, 3166, 3227, 3291, 3571, 3642, 3776, 3796, 3899, 4011, 4489], 'heritable': [322], 'state': [323], 'without': [324, 2016], 'altered': [325, 1252, 1730], 'nucleotide': [326], 'sequence;': [327], 'moreover,': [328], 'modified': [329, 1557], 'patterns': [330, 2622], 'predominantly': [335, 425], 'found': [336, 512, 563, 986, 1012, 1232, 1341, 1644, 1716, 1766, 1868, 2049, 2462], 'many': [338, 1286, 1421, 1529, 1614, 2691, 3006, 3026], 'cancers': [339, 839, 1026, 1047, 1360, 1844], '[2].': [340], 'This': [341], 'commentary': [342], 'covers': [343], 'actual': [344], 'information': [345, 2614, 3070], 'about': [346, 360, 2425, 3071, 3233], 'gene': [350, 433, 506, 515, 535, 567, 680, 699, 740, 753, 759, 1149, 1523, 1673, 1695, 2928, 2968, 2994, 3425, 3475, 3510, 3728], 'expression': [351, 376, 568, 691, 754, 760, 980, 1009, 1150, 1253, 1477, 1487, 1504, 1524, 1696, 1799, 2005, 2044, 2621, 2929, 2945, 2995, 3077, 3088, 3426, 3476], 'molecules.': [357, 1375, 3000, 3207], 'Recent': [358], 'findings': [359, 2870], 'may': [363, 373, 1392, 1634, 1724, 1778, 2207, 2460, 2702], 'also': [364, 449, 510, 1231, 1461, 1607, 1807, 1990, 2378, 2909, 3031, 3117], 'have': [365, 509, 561, 779, 857, 973, 984, 1230, 1378, 1448, 1642, 1945, 1991, 2035, 2046, 2364, 2379, 2807, 3277, 4475], 'an': [366, 1322, 1407, 1596, 1726, 2541, 2566, 2808, 2947], 'influence': [367, 498, 2948], 'on': [368, 384, 679, 774, 1394, 1474, 1528, 1758, 2000, 2019, 2277, 2744, 2949, 2954, 2993, 3005, 3145, 3539, 3645, 4203, 4229, 4411], 'promoter': [370, 577, 1811, 2070, 2282, 2961, 3469, 3508], 'region': [371, 1160], 'regulate': [374, 1798], 'cancer': [380, 731, 1189, 1236, 1300, 1306, 1890, 1908, 1925, 1982, 2014, 2033, 2077, 2089, 2264, 2294, 2344, 2357, 2375, 2587, 2591, 3041, 3079, 3155, 3181, 3222, 3574, 3828, 3995, 4212, 4375], 'tissue.Recent': [381], 'studies': [382, 1229, 2055, 2212, 3202], 'focused': [383], 'methylationDNA': [386], 'occurs': [388], 'as': [389, 520, 584, 682, 715, 926, 993, 1071, 1268, 1321, 1366, 1406, 1417, 1613, 1751, 1969, 1976, 2103, 2124, 2175, 2382, 2606, 2652, 2826, 2984, 3047, 3053, 3119, 3994, 4010], 'covalent': [391], 'addition': [392, 910, 1734], 'methyl': [395, 633], 'group': [396, 634], 'generally': [397], 'cytosine': [399], 'within': [400, 1653, 1760, 2681], 'CpG': [401, 407, 488], 'dinucleotides': [402], 'concentrated': [405], 'islands': [408], '(CGIs).': [409], 'CGIs': [410, 493, 508], 'GC-rich,': [412], 'CpG-rich,': [413], 'mostly': [414], 'unmethylated': [415], 'when': [416, 427, 2756], 'localized': [417], 'transcription': [419, 445, 606, 1537], 'start': [420, 446], 'sites': [421, 447, 450, 1181, 1206, 1678, 1747], 'genes': [423, 439, 538, 1256, 1507, 1630, 1641, 1714, 1740, 1821, 1861, 1884, 1896, 4107], 'methylated': [426, 458, 523, 546, 750, 1885, 2372], 'scattered': [428], 'genome': [431, 717, 1228, 1624, 1633, 2986, 3350], '(within': [432], 'bodies': [434], 'intragenic': [436, 1651], 'between': [438, 478, 748, 1013, 1257, 1591, 2446, 4174, 4261, 4365], 'intergenic).': [441], 'CpGs': [442, 480], 'outside': [443], 'transcriptional': [452, 585, 937, 3514], 'initiation': [453], 'during': [454, 666, 1212, 1535, 2498, 2930], 'development': [455, 2314, 2932, 3124, 3223], 'become': [457], 'hence': [459], 'lose': [460], 'properties.': [462], 'Silencing': [463], 'CGI': [465], 'promoters': [466, 516, 1737, 1754], 'demethylation': [470, 889], 'reactions': [471], 'differentially': [473, 522, 749], 'sensitive': [474], 'distance': [477], 'interacting': [479], '(CpG': [481], 'clustering)': [482], '[3],': [483], 'accomplished': [485], 'through': [486, 625, 806, 939, 956, 2011, 2079, 2554, 4058], 'dense': [487], 'polycomb': [491], 'recruitment.': [492], 'therefore': [495, 824, 1721], 'equipped': [496], 'local': [499], 'chromatin': [500], 'structure': [501], 'simplify': [503], 'activity.': [507], 'been': [511, 562, 919, 974, 985, 1011, 1210, 1340, 1379, 1498, 1643, 2048, 2290, 2365, 2799, 2978], 'tissue-specific': [514, 521, 534, 537, 2973, 3393, 3414], 'known': [519], 'regions': [524, 578, 751, 1652, 1674, 1681, 1719, 1776, 1783], '(T-DMRs)': [525], '[4].': [526], 'Tissue-specific': [527, 2816], 'pattern': [530, 644, 654, 2952, 3085, 3466], 'important': [532, 1311, 1577, 1727, 2542, 2567, 2938, 3652], 'regulation,': [536], 'not': [540, 1239, 1516, 2167, 2208, 2670, 3066], 'expressed': [541, 549, 1240], 'tissues': [543, 551, 732, 2015, 2021, 3042, 3389], 'which': [544, 552, 930, 1125, 1329, 1391, 1475, 2339, 2423], 'unmethylated.': [554], 'However,': [555, 1362, 1803, 2727, 3188], 'significant': [557, 850], 'portion': [558], 'T-DMRs': [560], 'positively': [564], 'correlated': [565], 'with': [566, 891, 989, 1140, 1157, 1466, 1580, 1827, 1962, 2186, 2230, 2235, 2477, 2520, 2758, 2774, 3204, 3285, 3290, 3298, 3473, 4129, 4180, 4483, 4488, 4496], 'considering': [569], 'they': [571, 2701], 'more': [573, 3027, 3230], 'enriched': [574], 'bind': [580, 2767], 'negative': [581, 590, 614, 3424], 'regulators,': [582], 'such': [583, 714, 992, 1267, 1975, 2102, 2123, 2381, 2651, 2983], 'repressors.': [586], 'For': [587, 2433], 'positive': [588, 612, 3422], 'T-DMRs,': [591], 'two': [592, 602, 780, 1121, 1889], 'distinct': [593, 603, 3419], 'sets': [594, 604], 'sequence': [597, 967, 2430], 'motifs': [598], 'exist,': [599], 'suggesting': [600, 1910], 'factors': [607, 1443, 1473, 1692, 1787, 2530, 2895], '(TFs)': [608], 'involved': [610, 697, 1462, 1509, 3013], 'mediated': [616, 624], '[5].': [620], 'Cytosine': [621], 'family': [627, 1054, 2067], 'DNMTs': [629], 'transfer': [631], 'SAM.': [635], 'DNMT3a': [636], 'DNMT3b': [638], 'can': [639, 1222, 1967, 2539, 2549, 2564, 2601], 'establish': [640], 'new': [642, 712, 1996, 3797, 4012], 'unmodified': [646], 'DNMT1': [649], 'copies': [650, 2427, 2794], 'from': [655, 1622, 2198, 2492, 2710, 2716, 2733, 2810, 2820, 3201, 3309, 3730, 3929, 4136, 4151, 4199, 4507], 'parental': [657], 'strand': [659, 665], 'onto': [660], 'newly': [662], 'synthetized': [663], 'daughter': [664], 'cell': [667, 775, 1307, 1978, 1983, 2180, 2183, 4312], 'replication': [668], 'differentiation': [670, 1397, 1442, 1605], '[6].Widespread': [671], 'has': [674, 918, 931, 1010, 1209, 1339, 1497, 1816, 2289, 2798, 2946, 2977, 3165], 'general': [676], 'inhibitory': [677], 'effect': [678, 2992, 4195], 'expression,': [681], 'we': [683], 'confirmed': [684, 2800], 'recent': [687, 2971], 'study': [688, 1815, 1858, 2729], '[7].': [689], 'Gene': [690], 'regulated': [693, 1824, 1862, 1876, 1897], 'recruiting': [695], 'proteins': [696, 1571, 1582, 2479, 2482], 'repression': [700, 1168], 'inhibiting': [703], 'binding': [705, 1205, 1785], 'TFs': [707, 1704], '[6].': [710], 'Using': [711], 'techniques': [713, 2605], 'whole': [716, 1623, 2985], 'sequencing': [718, 2612, 2987, 3500, 3958], 'microarray,': [720, 2989], 'it': [721, 1438, 1496, 1532, 1555, 1911, 3137], 'possible': [723], 'quantify': [725], 'clarify': [734], 'role': [736, 1312, 1728, 2543, 2568], 'cancer.': [743, 1005, 2120, 3114, 3685, 3708, 3857, 3880], 'There': [744], 'correlation': [747], 'changes': [755, 1501, 3116], '[8].': [756], 'Changes': [757], 'function': [763, 1603, 2696, 3059, 3704], 'demethylating': [765, 821], 'agents': [766, 778, 822, 890], 'like': [767, 1833, 2480], 'azacitidine,': [768], 'decitabine': [769], 'zebularine': [771], 'were': [772, 1715, 1822, 1927, 2507, 2638, 2824, 2850], 'studied': [773], 'cultures.': [776], 'The': [777, 1273, 1916, 2160, 2287, 2502, 2593, 3157, 3275, 3592, 3613, 3639, 3680, 4473], 'mechanisms': [781, 1594], 'antitumor': [783], 'activity,': [784], 'especially': [785, 3175], 'cytotoxicity': [786], 'incorporation': [789], 'into': [790, 1081, 2013, 2395, 2719], '(and': [792], 'RNA': [793, 923, 1068, 1165, 1559, 1564, 1573, 3957], 'azacitidine)': [795], 'induction': [798], 'damage': [801], 'response': [802, 882], 'hypomethylation': [805], 'inhibition': [807], 'methyltransferase,': [810], 'enabling': [811], 'restoration': [812], 'growth': [815, 1308, 4307], 'differentiation.': [817], 'Low': [818], 'doses': [819], 'used': [825, 2624, 3132], 'treatment': [827, 853, 881, 896, 3544], 'leukemias,': [829, 1021], 'myelodysplastic': [830], 'syndromes': [831], '(MDS)': [832], 'hematologic': [836, 1414, 3546], 'solid': [838, 1359, 1422, 1456, 1843], '10': [841], 'years': [842, 1495], 'after': [843, 2195, 2707], 'approval': [844], 'US': [847], 'FDA.': [848], 'Despite': [849], 'improvement': [851, 2258], 'cancers,': [855, 1041, 1043], 'patients': [856, 902, 2229, 2234, 2519], 'overall': [859, 1637, 1869], 'poor': [860], 'prognosis.': [861], 'It': [862, 1764, 2797], 'necessary': [864, 2417, 3139], 'better': [866], 'understand': [867], 'how': [868], 'inhibitors': [870], 'act': [871, 1968, 2703, 2773], 'identify': [874], 'validate': [876], 'biomarkers': [877, 2090, 2577, 2668, 2680, 2865, 3121, 3164, 3925], 'prediction': [879, 2154], 'find': [885], 'effective': [886, 3150], 'combination': [887, 2678], 'drugs': [893, 1956, 3153], 'improve': [895], 'success': [897], 'its': [899, 1489, 2966, 2991, 3347, 3446, 3471, 3646], 'durability': [900], '[9].Brief': [903], 'summary': [904], 'biogenesis': [907], 'functionIn': [909], 'previous': [912, 1857], 'modifications,': [914], 'great': [916, 1947, 2138, 3167], 'importance': [917, 1451], 'attributed': [920], 'interference': [924], 'phenomena': [925, 929], 'another': [927, 1390], 'proven': [932], 'be': [934, 1136, 1382, 1428, 1646, 1874, 2209, 2461, 2550, 2602, 2675, 2910, 3108, 3211], 'implicated': [935], 'silencing': [938, 1699, 2920, 3769, 4287], 'small': [940, 947, 1056, 2469, 3956], 'duplex': [941], 'RNA.': [942], 'Currently,': [943], 'noncoding': [948, 1057], 'microRNAs': [951, 3683, 3706, 3826], '(miRNAs)': [952], 'successful': [955], 'modern': [957], 'technologies.': [958], 'miRbase': [961], 'database': [962], 'version': [963], '21,': [964, 4046, 4118, 4284], 'nearly': [965], '2000': [966], 'precursors': [968, 1083], '2588': [970], 'mature': [971, 1122, 1773], 'miRNAs': [972, 983, 1088, 1132, 1233, 1266, 1668, 1708, 1872, 1922, 2458, 2466, 2476, 2488, 2563, 2597, 2647, 2698, 2732, 2755, 2772, 2806, 2842, 3046, 3064, 3993], 'identified': [975, 1859, 2036, 2056, 2639, 2979], 'humans': [977], '[10].': [978], 'Aberrant': [979, 3701], 'profiles': [981, 2918], 'directly': [987, 1797], 'associated': [988, 2185, 3238, 4179], 'human': [990, 1354, 1518, 2027, 2051, 3388, 3753, 3774, 4210], 'autoimmune': [994], 'cardiac': [996], 'disorders,': [997], 'schizophrenia,': [999], 'highly': [1002], 'dysregulated': [1003, 1921], 'A': [1006, 1399, 1813, 1856, 3536], 'different': [1007, 1924, 2586, 2682, 3904], 'benign': [1016], 'malignant': [1018], 'tissue': [1019, 1395, 2833, 2934, 3018, 3094, 3147], 'including': [1020, 1356, 1830, 1880, 2685], 'lymphomas;': [1022], 'lung,': [1023], 'breast,': [1024, 1850], 'colorectal': [1025, 4211], '(CRCs),': [1027], 'papillary': [1028], 'thyroid': [1029], 'carcinomas,': [1030, 1037], 'glioblastomas': [1031], 'brain': [1034, 4017], 'tumors,': [1035, 1039], 'hepatocellular': [1036], 'pancreatic': [1038, 2356], 'cervical': [1040, 1853, 3479, 4374], 'prostate': [1042, 2238], 'kidney': [1044], 'bladder': [1046, 2236], 'pituitary': [1049], 'adenomas': [1050], '[11].MiRNAs': [1051], 'RNAs,': [1058], '21–25': [1059], 'nucleotides': [1060], '(nt)': [1061], 'length': [1063], 'transcribed': [1066, 1756], 'polymerase': [1069], 'II': [1070], 'long': [1072], 'primary': [1073, 2052, 2222], 'transcripts': [1074], '(pri-miRNAs)': [1075], 'nucleus.': [1077], 'Pri-miRNAs': [1078], 'processed': [1080], 'stem-loop': [1082], 'approximately': [1085], '70': [1086], 'nt': [1087], '(pre-miRNAs)': [1089], 'microprocessor': [1092], 'complex': [1093], 'consisting': [1094], 'RNase': [1096], 'III': [1097, 1111], 'enzyme': [1098], 'DROSHA.': [1100], 'Pre-miRNAs': [1101], 'then': [1103], 'exported': [1104], 'cytoplasm': [1107], 'where': [1108, 2325], 'RNAse': [1110], 'endonuclease': [1112], 'Dicer': [1114, 1549], 'cleaves': [1116], 'pre-miRNAs': [1118], 'produce': [1120], 'miRNAs,': [1123], 'one': [1126, 1385, 3022], 'usually': [1128], 'degraded': [1129], '[11].': [1130], 'Mature': [1131], 'thought': [1134], 'extremely': [1137, 2750], 'stable': [1138], 'little': [1141], 'evidence': [1142], 'active': [1144], 'degradation.': [1145], 'MiRNA-mediated': [1146], 'acts': [1151, 1320, 1405], 'primarily': [1152], 'imperfect': [1154], 'base': [1155], 'pairing': [1156], '3′-untranslated': [1159], '(3′UTR)': [1161], 'target': [1163, 1180, 1285, 1706, 2745, 4357], 'messenger': [1164], '(mRNA)': [1166], 'protein': [1170, 1616], 'production.': [1171], 'Shortening': [1172], 'mRNA': [1174, 2106, 2776, 2997], '3′UTR': [1175], 'loss': [1177], 'post-transcriptional': [1183], 'upregulation': [1184], 'critical': [1186], 'oncogenes': [1187, 1287, 1367, 3048], 'cells.': [1190, 3156], 'On': [1191, 2839], 'hand,': [1194], 'lengthening': [1195], '3′UTRs': [1197], 'increasing': [1199], 'number': [1201], 'potential': [1203, 2075, 2864, 2888, 3168, 3616, 3964, 4355], 'mRNAs': [1208], 'observed': [1211, 3109], 'mouse': [1213], 'indicating': [1216], 'alterations': [1218], 'lead': [1223], 'pathological': [1225, 2188], 'processes': [1226, 1974, 3012], '[12].Whole': [1227], 'specific': [1237, 1265, 1364, 1667, 1707, 1902, 2843, 3045], 'tissue.': [1243], 'MiRNA': [1244, 1458, 1640, 1753, 3029], 'profiling': [1245, 3030, 3386, 3951], 'allows': [1246, 1262], 'accurate': [1247], 'classification': [1248, 1365], 'malignancies': [1250, 1415, 1446], 'tumor': [1258, 1269, 1369, 1831, 2205, 2223, 3017, 3050, 3093, 3678], 'cells': [1261, 2034, 2078, 2206, 2524, 2553, 2712, 2721, 2812, 4156], 'sorting': [1263], 'suppressors': [1270, 1370], 'oncogenes.': [1272], 'well-known': [1274], 'tumor-suppressor': [1275, 1419, 1971], 'miR-34': [1278, 1294, 1953], 'cluster': [1279, 2041], '(miR-34a,': [1280], 'miR-34b': [1281, 1929], 'miR-34c)': [1283], 'related': [1288, 3008], 'proliferation,': [1290, 1344], 'apoptosis': [1291], 'invasion.': [1293], 'silenced': [1296], 'hypermethylation': [1298, 2023, 2071], 'reintroduction': [1302], 'miR-34a': [1304, 1988, 3620], 'inhibits': [1305, 4031, 4306], 'shows': [1310], 'tumorigenesis': [1314, 2499], '[13].': [1315], 'An': [1316, 4133, 4353], 'opposite': [1317, 1425], 'example': [1318, 1401], 'oncogene': [1324], 'miR-17–92': [1327], 'cluster,': [1328, 1954], 'comprises': [1330], 'miR-17,': [1331], 'miR-18a,': [1332], 'miR-19a,': [1333], 'miR-20a,': [1334], 'miR-19b': [1335], 'miR-92a,': [1337], 'promote': [1343], 'angiogenesis,': [1345], 'invasion': [1346], 'metastasis': [1348, 1985, 2028], 'wide': [1351, 2830], 'array': [1352], 'hematopoietic': [1357, 1441], '[14].': [1361], 'this': [1363, 2003, 3320, 4518], 'inconsistent': [1372], 'some': [1374, 2170], 'Specific': [1376], 'reported': [1380, 1919, 2213], 'oncogenic': [1383, 1479], 'context': [1386], 'tumor-suppressive': [1388, 1481, 3614], 'depend': [1393], 'and/or': [1396], 'specificity.': [1398], 'good': [1400, 4036], 'miR-125b': [1403, 1434], 'oncomiR': [1408], 'vast': [1411], 'majority': [1412, 1454, 2803], 'tumors.': [1423, 1457, 2053], 'These': [1424, 2573], 'roles': [1426, 3506, 3655], 'could': [1427, 1806, 2899], 'explained': [1429], 'fact': [1432], 'targets': [1435, 2777], 'multiple': [1436, 2080, 3502], 'mRNAs,': [1437], 'suppresses': [1439], 'hematological': [1445], 'weak': [1450], 'interactions': [1465, 4173], 'cancer-immune': [1467], 'system': [1468], 'tumor-modifying': [1471], 'extrinsic': [1472], 'their': [1476, 2770, 2775], 'pathways': [1482, 2082, 3220], 'depends': [1483], '[15].Regulation': [1484], 'silencingOver': [1491], 'last': [1493, 2095], 'few': [1494], 'shown': [1499, 1817], 'pathogenesis': [1512], 'most': [1514, 1917, 2940], 'if': [1515], 'all': [1517, 2880, 2887, 3193], 'cancers.': [1519, 3547, 3905], 'Regulation': [1520, 3824], 'taking': [1526, 2113], 'place': [1527, 2115], 'levels.': [1530], 'First,': [1531], 'controlled': [1534], 'nucleus': [1540], 'processing': [1542, 1791], 'DROSHA': [1547], 'enzymes': [1550], 'cytoplasm.': [1553], 'Second,': [1554], 'editing,': [1560], 'uridylation,': [1561], 'adenylation': [1562], 'lastly,': [1567], 'loading': [1568], 'Argonaute': [1570], 'disintegration': [1574], 'equally': [1576], 'cooperation': [1579, 1590], 'RNA-binding': [1581, 2478], 'miRNAs.': [1585], 'Synchronously,': [1586], 'result': [1588], 'regulatory': [1593, 3216], 'advanced': [1597], 'reply': [1599], 'appropriate': [1601], 'cellular': [1602, 2081, 2941, 3011], '[16].MiRNAs': [1606], 'undergo': [1608], 'same': [1610], 'coding': [1617, 1775], 'genes.': [1618, 2373], 'According': [1619], 'data': [1621, 3002, 3232], 'sequencing,': [1625], 'position': [1627], 'contribute': [1635, 2900], 'expression.': [1639, 1732, 2969], 'located': [1647, 1670, 2722], 'intergenic': [1649], 'introns': [1654], 'exons': [1656], 'either': [1659], 'sense': [1660], 'antisense': [1662], 'orientation.': [1663], 'Some': [1664, 2309, 3128], 'tumor-associated': [1672], 'fragile': [1677], 'frequently': [1683, 1741, 1918], 'deleted,': [1684], 'amplified': [1685], 'mutated': [1687], 'loci.': [1690], 'Other': [1691, 1892, 2054], 'influencing': [1693], 'dysregulation': [1702], '[17].': [1709], 'Most': [1710], 'CpG-rich': [1718], 'play': [1725, 2540, 2565], 'CGIs,': [1736], 'contain': [1742], 'TATA': [1743], 'boxes,': [1744], 'TFIIB': [1745], 'recognition': [1746], 'histone': [1749, 1795], 'modifications': [1750, 1796], 'well.': [1752], 'independently': [1757], 'host': [1762], 'gene.': [1763], 'was': [1765, 2331, 3314, 4512], 'nucleosomes': [1768], 'occupy': [1769], 'body': [1771, 2092, 2218, 2599, 2717, 3511], 'serve': [1779], 'mark': [1781], 'participating': [1788], 'pre-miRNA': [1790], '[16].DNA': [1792], 'hypermethylation/hypomethylation': [1793], 'promoters.': [1802], 'beyond': [1809], 'region.': [1812], 'comprehensive': [1814, 3231, 3643], '63': [1819], 'epigenetically': [1823, 1875, 1920], 'connection': [1826], '21': [1828], 'melanoma,': [1834], 'leukemias': [1835], '(acute': [1836], 'myeloid': [1837], 'leukemia,': [1838], 'lymphocytic': [1840], 'leukemia)': [1841], '(lung,': [1845], 'gastric,': [1846], 'colorectal,': [1847], 'prostate,': [1848], 'bladder,': [1849], 'ovarian': [1851, 4182], 'cancer)': [1854], '[18].': [1855], 'via': [1863, 2068, 3955], 'authors': [1867, 2642, 3276, 4474], '6.9%': [1870], 'methylation,': [1879, 3346], '45.5%': [1881], 'least': [1888], 'types.': [1891], '54.4%': [1893], 'certain': [1905], 'type': [1906], 'cancer-specific': [1914, 2214], 'biomarker.': [1915], 'types': [1926], 'miR-34a,': [1928], 'miR-34c': [1931], 'following': [1932, 1964], 'miR-124–123,': [1933], 'miR-124–121,': [1934], 'miR-203,': [1935], 'miR-124–122,': [1936], 'miR-127,': [1937], 'miR-9–1,': [1938], 'miR-9–3,': [1939], 'miR-137,': [1940], 'miR-148a': [1941], 'miR-199a': [1943], 'therapeutic': [1948, 1963, 1997, 3617, 4013], 'potential.': [1949], 'case': [1951], 'miR-34-based': [1955], 'tested': [1958], 'trials': [1961], '[19].': [1965], 'MiR-34a': [1966], 'regulating': [1973], 'cycle': [1979], 'apoptosis,': [1981], 'viability,': [1984], 'chemoresistance.': [1987], 'might': [1989, 2674, 3107], 'benefit': [1993], 'concept': [1998], 'based': [1999, 2276], 'replacement': [2001], 'delivery': [2007, 3151], 'mimics': [2010], 'nanotechnology': [2012], 'side': [2017, 3143], 'effects': [2018, 3144], '[20].MiRNA': [2022], 'profile': [2024, 2976, 3089], 'characteristic': [2025], 'lymph': [2030], 'node': [2031], 'metastatic': [2032, 2074, 3097], 'reactivation': [2037], 'miR-148a,': [2039], 'miR-34b/c': [2040], 'miR-9': [2043], 'already': [2047, 3131], 'downregulation': [2057, 3732], 'of,': [2058], 'mir-203,': [2061], 'miR-212,': [2062], 'miR-124,': [2063], 'miR-135b': [2064], 'miR-200': [2066], 'aberrant': [2069, 3076], 'increased': [2073], 'facilitated': [2084], 'epithelial-mesenchymal': [2085], 'transition': [2086], '[21].Detection': [2087], 'fluidsIn': [2093], 'years,': [2096, 2972], 'detection': [2097, 2146, 2157, 2279, 2321, 2358, 2420, 2454, 2627, 3855], 'nucleic': [2100], 'acids,': [2101], 'cell-free': [2104, 2457, 2686, 3873, 3895], 'DNA,': [2105], 'getting': [2110], 'ahead': [2111], 'noninvasive': [2117], 'diagnostics': [2118], 'Body': [2121], 'fluids': [2122, 2219, 2600, 2718, 3852], 'venous': [2125], 'peripheral': [2126], 'blood,': [2127], 'saliva': [2128], 'buccal': [2130], 'epithelium,bronchial': [2131], 'aspirates,': [2132], 'urine': [2133, 2232], 'stools': [2135], 'source': [2139, 2831], 'markers': [2142, 3105, 3129], 'early': [2145, 2156, 2404, 2582, 2653, 3111, 3171, 3854, 3930], 'monitoring': [2149, 2658, 3179], 'prognosis': [2153, 2629, 2655, 3184, 4037], 'recurrence.': [2159], 'precise': [2161], 'mechanism': [2162, 3234], 'release': [2165], 'completely': [2168], 'known,': [2169], 'particles': [2171], 'presumably': [2173], 'released': [2174, 2197, 2489, 2709], 'consequence': [2177], 'spread': [2192], 'circulation': [2194, 2491, 2907], 'being': [2196, 2708], 'apoptotic': [2199, 2493], 'necrotic': [2201, 2495], 'cells,': [2202, 2496], 'although': [2203], 'present': [2210, 2825, 2851], '[22].Several': [2211], 'around': [2220], 'stool': [2227], 'CRC,': [2231], 'among': [2240], 'others.': [2241], '[22].': [2242], 'Cancer-specific': [2243], 'detectable': [2246], 'plasma': [2248, 2511, 2759], 'patient': [2251], 'feasible': [2254], 'approach': [2255], 'blood-based': [2261], 'test': [2262, 2288, 2318, 2354, 2369], 'diagnostics.': [2265], 'They': [2266], 'first': [2269, 2503], 'blood': [2270, 2317, 2397, 2734, 2814], 'tests': [2271, 2377], 'CRC': [2273], 'SEPT9': [2281], 'DNA.': [2286], 'applied': [2291], 'lung': [2293, 3927], '(LC)': [2295], 'detection;': [2296], 'however,': [2297, 3020], 'problem': [2299], 'identification': [2302], 'LC': [2304, 2626], 'correct': [2306], 'control': [2307, 2885, 2965], 'group.': [2308], 'difficulties': [2310], 'arise': [2311], 'breast': [2323], 'highest': [2327], 'sensitivity': [2328], 'specificity': [2330, 2663], 'obtained': [2332], 'using': [2333, 3991], 'panel': [2335], 'eight': [2337], 'genes,': [2338], 'accurately': [2340], 'classified': [2341, 3044], '91.7%': [2342], 'samples': [2345, 2735], '90%': [2347], 'cancer-negative': [2349], 'samples.': [2350], 'Development': [2351], 'problematic,': [2360], 'best': [2362], 'results': [2363, 3200], 'given': [2366], 'microarray': [2368], '56': [2371], 'Blood': [2374], 'screening': [2376], 'challenges,': [2380], 'low': [2383, 2751, 2854], 'concentration': [2384, 2752, 2760], 'plasma,': [2389], 'amount': [2391], 'shedding': [2394], 'influenced': [2399], 'size': [2402], 'stage': [2405], 'tumors': [2406], 'fragmented': [2410], '180–360': [2412], 'bp.': [2413], 'High-sensitive': [2414], 'methods': [2415], 'optimal': [2419], '1–2': [2426], 'per': [2431, 2795], 'assay.': [2432], 'sample': [2434, 2444], 'collection,': [2435], 'standardized': [2436], 'protocols': [2437], 'required': [2439], 'minimalize': [2441], 'discrepancy': [2442], 'handling': [2445], 'laboratories': [2447], '[23].Similar': [2448], 'situation': [2449], 'seen': [2451], 'three': [2464], 'forms;': [2465], 'enclosed': [2467], 'membranous': [2470], 'vesicles': [2471, 2527, 2538, 2548], 'microvesicles': [2473], 'exosomes;': [2475], 'agronaute': [2481], 'high': [2484], 'density': [2485], 'lipoproteins;': [2486], 'inflammation.': [2501], 'discovered': [2508, 3062], 'pregnant': [2513], 'woman': [2514], 'serum': [2517], 'B-cell': [2521], 'lymphoma.': [2522], 'Cancer': [2523, 3579, 3686, 3935, 4057, 4230, 4248, 4329], 'deliver': [2525], 'lipid': [2526, 2537], 'comprising': [2528], 'angiogenic': [2529], 'induce': [2532], 'angiogenesis': [2533], 'thus': [2535], 'intercellular': [2545], 'communication.': [2546], 'Lipid': [2547], 'gathered': [2551], 'endocytosis': [2555], 'fusion': [2557], 'membranes': [2559], 'consequently,': [2561], 'disease': [2571, 3177], 'progression.': [2572], 'promising': [2576], 'field': [2580], 'diagnosis': [2583, 3172, 3575, 3878, 3931], 'types,': [2588], 'progression': [2589, 4033, 4159, 4293], 'therapy.': [2592, 3577, 3933], 'levels': [2594, 2790, 2904], 'determined': [2603], 'qRT-PCR,': [2607], 'microarrays': [2609], 'deep': [2611], '(detailed': [2613], 'reviewed': [2616], '[24]).': [2618], 'Circulating': [2619, 3923], 'patients.': [2631], 'Several': [2632], 'upregulated': [2633], 'downregulated': [2635], 'therefore,': [2641], 'developed': [2643], 'panels': [2644], 'purpose,': [2650], 'detection,': [2654], 'therapy': [2657, 3134, 3182, 3541], 'LC.': [2660], 'Unfortunately,': [2661], 'accuracy': [2665], 'adequate.': [2671], 'Overall': [2672], 'performance': [2673], 'improved': [2676], 'classes': [2684], 'DNA/RNA,': [2687], '[25].': [2693], 'Another': [2694], 'described': [2695], 'similar': [2704], 'hormones': [2706, 2766], 'donor': [2711], 'delivered': [2715], 'receptor': [2720], 'areas': [2725], '[20].': [2726], 'analyzing': [2730], 'healthy': [2737], 'people': [2738], 'argues': [2739], 'against': [2740, 3799, 4331], 'hormone-like': [2742], 'impact': [2743], 'tissue,': [2746], 'mainly': [2747], 'compared': [2757], 'steroid': [2762], 'hormones.': [2763], 'Further,': [2764], 'common': [2765, 3731], 'receptors': 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'1603–1614': [3664], 'Scholar15': [3669], 'Svoronos': [3670], 'AA,': [3671], 'Engelman': [3672], 'DM,': [3673], 'OncomiR': [3676], 'suppressor?': [3679], 'duplicity': [3681], 'Res.': [3687, 3998], '76(13),': [3688], '3666–3670': [3689], 'Scholar16': [3694], 'Kasinski': [3697], 'AL,': [3698], 'Curr.': [3709], '24(16),': [3711], 'R762–R776': [3712], 'Scholar17': [3717], 'Valinezhad': [3718], 'Orang': [3719], 'Safaralizadeh': [3721], 'R,': [3722], 'Kazemzadeh-Bavili': [3723], 'Mechanisms': [3725], 'mRNA-specific': [3734], 'upregulation.': [3735], '2014,': [3739], '970607': [3740], 'Scholar18': [3744], 'Piletič': [3745], 'Kunej': [3747, 3766], 'T.': [3748, 3767], 'MicroRNA': [3749, 3768, 4242], 'signatures': [3751], 'Arch.': [3755], 'Toxicol.': [3756], '90,': [3757], '2405–2419': [3758], 'Scholar19': [3763], 'Strmsek': [3764], 'Z,': [3765, 3943], 'cancer:': [3775], 'literature': [3777], 'analysis.': [3778], 'ncRNA': [3779], '1(1),': [3780], '44–52': [3781], 'Scholar20': [3784], 'Misso': [3785], 'G,': [3786], 'Di': [3787], 'Martino': [3788], 'MT,': [3789], 'De': [3790], 'Rosa': [3791], 'Mir-34:': [3795], 'weapon': [3798], 'cancer?': [3800], 'Mol.': [3801, 3860, 3882], 'Nucleic': [3803], 'Acids': [3804], '3,': [3805], 'e194': [3806], 'Scholar21': [3811], 'Bouyssou': [3812], 'JM,': [3813], 'Manier': [3814], 'Huynh': [3816], 'D,': [3817], 'Issa': [3818], 'Roccaro': [3820], 'AM,': [3821], 'Ghobrial': [3822], 'IM.': [3823], 'metastasis.': [3829], 'Biochim.': [3830], 'Biophys.': [3831], 'Acta': [3832], '1845(2),': [3833], '255–265': [3834], '(2014).Medline,': [3835], 'Scholar22': [3838], 'Yokoi': [3839], 'Yamashita': [3841], 'Watanabe': [3843], 'Analysis': [3845], 'status': [3849], 'bodily': [3851], '18(4),': [3862], 'pii:E735': [3863], '(2017).Crossref,': [3864, 3938], 'Scholar23': [3866], 'Warton': [3867], 'Samimi': [3869], 'Front.': [3881], 'Biosci.': [3883], '2,': [3884], '13': [3885], 'Scholar24': [3889], 'Chakraborty': [3890], 'Das': [3892], 'S.': [3893], 'Profiling': [3894], 'miRNA:': [3898], 'tool': [3902], 'Tumour': [3906], '37(5),': [3908], '5705–5714': [3909], 'Scholar25': [3914], 'Tomasetti': [3915], 'Amati': [3917], 'Neuzil': [3919], 'Santarelli': [3921], 'L.': [3922], 'malignancies:': [3928], 'Lung': [3934], '107,': [3936], '65–72': [3937], 'Scholar26': [3941], 'Williams': [3942], 'Ben-Dov': [3944], 'IZ,': [3945], 'Elias': [3946], 'R': [3947], 'Comprehensive': [3950], 'microRNA': [3954, 4106, 4175], 'cDNA': [3960], 'libraries': [3961], 'biomarker': [3963], 'limitations.': [3966], 'Proc.': [3967], 'Acad.': [3969], 'USA': [3971], '110(11),': [3972], '4255–4260': [3973], 'Scholar27': [3978], 'Tiberio': [3979], 'P,': [3980], 'Callari': [3981], 'Angeloni': [3983], 'Daidone': [3985], 'MG,': [3986], 'Appierto': [3987], 'V.': [3988], 'Challenges': [3989], 'biomarkers.': [3996], 'Biomed.': [3997], '2015,': [4000], '731479': [4001], 'ScholarFiguresReferencesRelatedDetailsCited': [4005], 'ByMesenchymal': [4006], 'stem': [4007, 4155], 'cell-derived': 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'syndrome5': [4183], '2020': [4185, 4216, 4253, 4276, 4298], 'Journal': [4187, 4279, 4301, 4344, 4394], 'Human': [4189], 'Genetics,': [4190], '66,': [4192], '2Inhibitory': [4194], 'bound': [4197], 'polyphenol': [4198], 'foxtail': [4200], 'millet': [4201], 'bran': [4202], 'miR-149': [4204], 'increases': [4206], 'chemosensitivity': [4208], 'HCT-8/Fu': [4213], 'cells3': [4214], 'Cellular': [4220], 'Biochemistry,': [4221], '476,': [4223], '2Flavonoids': [4225], 'HIF-1:': [4227], 'Implications': [4228], 'Metabolism3': [4231], 'January': [4232, 4377], '1Strategies': [4239], 'Modulate': [4241], 'Functions': [4243], 'Treatment': [4246], 'Organ': [4250], 'Injury17': [4251], 'Pharmacological': [4255], 'Reviews,': [4256], '72,': [4258], '3Differences': [4260], 'Well-Differentiated': [4262], 'Neuroendocrine': [4263, 4388], 'Tumors': [4264], 'Ductal': [4266], 'Adenocarcinomas': [4267], 'Pancreas': [4270], 'Assessed': [4271], 'Multi-Omics': [4273], 'Profiling23': [4274], 'International': [4278, 4300, 4343, 4393], 'Sciences,': [4282, 4347, 4397], '12Methylation‑associated': [4286], 'miR‑638': [4289], 'promotes': [4290], 'endometrial': [4291], 'carcinoma': [4292], 'MEF2C16': [4296], 'MedicineMethylation‑regulated': [4304], 'ZNF545': [4305], 'p53‑mutant': [4310], 'KYSE150': [4311], 'line': [4313], 'inducing': [4315], 'p21': [4316], 'Bax5': [4318], '2019': [4320, 4341, 4378], 'Experimental': [4322], 'Therapeutic': [4324], 'MedicineNovel': [4325], 'Approaches': [4326], 'Ovarian': [4328], 'Heterogeneity,': [4332], 'Late': [4333], 'Diagnosis,': [4334], 'Drug': [4335], 'Resistance,': [4336], 'Transcoelomic': [4338], 'Metastases29': [4339], '11Epigenetic': [4351], 'changes:': [4352], 'emerging': [4354], 'pharmacological': [4356], 'allergic': [4359], 'rhinitisInternational': [4360], 'Immunopharmacology,': [4361], '71Correlation': [4363], 'miRNA‑1': [4369], 'c‑Met‑induced': [4371], 'progression25': [4376], 'Oncology': [4380], 'LettersHDAC-Linked': [4381], '"Proliferative"': [4382], 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