Publication Information

{'id': 'https://openalex.org/W2763321376', 'doi': None, 'title': 'Hot water extracts from broccoli sprouts trigger induction of carcinogen-detoxification enzymes in prostate tissues.', 'display_name': 'Hot water extracts from broccoli sprouts trigger induction of carcinogen-detoxification enzymes in prostate tissues.', 'publication_year': 2004, 'publication_date': '2004-04-01', 'ids': {'openalex': 'https://openalex.org/W2763321376', 'mag': '2763321376'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://cancerres.aacrjournals.org/content/64/7_Supplement/729.4', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': [], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5041611223', 'display_name': 'Angela J. Caruso', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Angela J. Caruso', 'raw_affiliation_strings': ['Johns Hopkins University,Baltimore,MD'], 'affiliations': [{'raw_affiliation_string': 'Johns Hopkins University,Baltimore,MD', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086896931', 'display_name': 'Srinivasan Yegnasubramanian', 'orcid': 'https://orcid.org/0000-0003-0744-6606'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Srinivasan Yegnasubramanian', 'raw_affiliation_strings': ['Johns Hopkins University,Baltimore,MD'], 'affiliations': [{'raw_affiliation_string': 'Johns Hopkins University,Baltimore,MD', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101503668', 'display_name': 'Xiaohui Lin', 'orcid': 'https://orcid.org/0000-0003-1747-1485'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xiaohui Lin', 'raw_affiliation_strings': ['Johns Hopkins University,Baltimore,MD'], 'affiliations': [{'raw_affiliation_string': 'Johns Hopkins University,Baltimore,MD', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072089972', 'display_name': 'Thomas W. Kensler', 'orcid': 'https://orcid.org/0000-0002-6676-261X'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Thomas W. Kensler', 'raw_affiliation_strings': ['Johns Hopkins University,Baltimore,MD'], 'affiliations': [{'raw_affiliation_string': 'Johns Hopkins University,Baltimore,MD', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5021386247', 'display_name': 'William G. Nelson', 'orcid': 'https://orcid.org/0000-0002-4379-0730'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'William G. Nelson', 'raw_affiliation_strings': ['Johns Hopkins University,Baltimore,MD'], 'affiliations': [{'raw_affiliation_string': 'Johns Hopkins University,Baltimore,MD', 'institution_ids': ['https://openalex.org/I145311948']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.333434, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 61, 'max': 68}, 'biblio': {'volume': '64', 'issue': None, 'first_page': '729', 'last_page': '729'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11332', 'display_name': 'Genomics, phytochemicals, and oxidative stress', 'score': 0.9927, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11332', 'display_name': 'Genomics, phytochemicals, and oxidative stress', 'score': 0.9927, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/sulforaphane', 'display_name': 'Sulforaphane', 'score': 0.96898633}, {'id': 'https://openalex.org/keywords/cruciferous-vegetables', 'display_name': 'Cruciferous vegetables', 'score': 0.9538538}, {'id': 'https://openalex.org/keywords/chemoprotective', 'display_name': 'Chemoprotective', 'score': 0.870858}, {'id': 'https://openalex.org/keywords/myrosinase', 'display_name': 'Myrosinase', 'score': 0.79598105}, {'id': 'https://openalex.org/keywords/phenethyl-isothiocyanate', 'display_name': 'Phenethyl isothiocyanate', 'score': 0.5528035}, {'id': 'https://openalex.org/keywords/detoxification', 'display_name': 'Detoxification', 'score': 0.42736173}], 'concepts': [{'id': 'https://openalex.org/C2780841255', 'wikidata': 'https://www.wikidata.org/wiki/Q424489', 'display_name': 'Sulforaphane', 'level': 2, 'score': 0.96898633}, {'id': 'https://openalex.org/C2779487296', 'wikidata': 'https://www.wikidata.org/wiki/Q5189799', 'display_name': 'Cruciferous vegetables', 'level': 3, 'score': 0.9538538}, {'id': 'https://openalex.org/C2911092814', 'wikidata': 'https://www.wikidata.org/wiki/Q5090611', 'display_name': 'Chemoprotective', 'level': 3, 'score': 0.870858}, {'id': 'https://openalex.org/C113850282', 'wikidata': 'https://www.wikidata.org/wiki/Q416212', 'display_name': 'Myrosinase', 'level': 4, 'score': 0.79598105}, {'id': 'https://openalex.org/C114246631', 'wikidata': 'https://www.wikidata.org/wiki/Q187661', 'display_name': 'Carcinogen', 'level': 2, 'score': 0.7295173}, {'id': 'https://openalex.org/C2778164613', 'wikidata': 'https://www.wikidata.org/wiki/Q416883', 'display_name': 'Glucosinolate', 'level': 3, 'score': 0.67966616}, {'id': 'https://openalex.org/C2776572452', 'wikidata': 'https://www.wikidata.org/wiki/Q416049', 'display_name': 'Isothiocyanate', 'level': 2, 'score': 0.62156355}, {'id': 'https://openalex.org/C2780740852', 'wikidata': 'https://www.wikidata.org/wiki/Q7181339', 'display_name': 'Phenethyl isothiocyanate', 'level': 3, 'score': 0.5528035}, {'id': 'https://openalex.org/C538909803', 'wikidata': 'https://www.wikidata.org/wiki/Q116907', 'display_name': 'Glutathione', 'level': 3, 'score': 0.5325614}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.50496346}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.46798277}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.44124198}, {'id': 'https://openalex.org/C2780497538', 'wikidata': 'https://www.wikidata.org/wiki/Q1192006', 'display_name': 'Detoxification (alternative medicine)', 'level': 3, 'score': 0.42736173}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.36977702}, {'id': 'https://openalex.org/C31903555', 'wikidata': 'https://www.wikidata.org/wiki/Q1637030', 'display_name': 'Food science', 'level': 1, 'score': 0.35362697}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.21238098}, {'id': 'https://openalex.org/C2776747608', 'wikidata': 'https://www.wikidata.org/wiki/Q58677', 'display_name': 'Brassica', 'level': 2, 'score': 0.12882924}, {'id': 'https://openalex.org/C59822182', 'wikidata': 'https://www.wikidata.org/wiki/Q441', 'display_name': 'Botany', 'level': 1, 'score': 0.12719285}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.10616529}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://cancerres.aacrjournals.org/content/64/7_Supplement/729.4', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2951576573', 'https://openalex.org/W2883447345', 'https://openalex.org/W2552835330', 'https://openalex.org/W2467212113', 'https://openalex.org/W2327239100', 'https://openalex.org/W2159636247', 'https://openalex.org/W2140142690', 'https://openalex.org/W2121314041', 'https://openalex.org/W2090034740', 'https://openalex.org/W2087315272', 'https://openalex.org/W2073756585', 'https://openalex.org/W2054667879', 'https://openalex.org/W2054396682', 'https://openalex.org/W2011914667', 'https://openalex.org/W2005391598', 'https://openalex.org/W1977544302', 'https://openalex.org/W1968951777', 'https://openalex.org/W1930944948', 'https://openalex.org/W1544761163', 'https://openalex.org/W139158669'], 'abstract_inverted_index': {'3149': [0], 'Intake': [2], 'of': [3, 28, 39, 53, 79, 93, 154, 213, 227], 'vegetables,': [4, 7, 18, 44, 229], 'particularly': [5], 'cruciferous': [6, 17, 43, 228], 'reduces': [8], 'prostate': [9, 83, 110, 137], 'cancer': [10, 22, 111], 'risks.1': [11], 'Sulforaphane,': [12], 'an': [13, 211], 'isothiocyanate': [14], 'present': [15], 'in': [16, 42, 72, 82, 181, 184, 190, 204, 218, 238, 252], 'may': [19, 232], 'protect': [20], 'against': [21], 'development': [23], 'by': [24, 118], 'inducing': [25], 'the': [26, 54, 57, 77, 185, 188, 196, 205, 219, 244, 247, 257], 'expression': [27, 78, 153, 166, 208], 'carcinogen-detoxification': [29, 123], 'enzymes,': [30], 'such': [31, 242, 255], 'as': [32, 243, 249, 251, 256], 'glutathione': [33], 'S-': [34], 'transferases': [35], '(GSTs).2,3': [36], 'Upon': [37], 'consumption': [38, 226], 'glucosinolate': [40], 'compounds': [41], 'isothiocyanates': [45, 71], 'can': [46, 75], 'be': [47], 'released': [48], 'during': [49], 'chewing': [50], 'via': [51, 162], 'exposure': [52], 'glucosinolates': [55], 'to': [56, 65, 101, 108, 114, 164], 'plant': [58], 'enzyme': [59, 124], 'myrosinase': [60], '(thioglucoside': [61], 'glucohydrolase).': [62], 'In': [63], 'order': [64], 'test': [66], 'whether': [67], 'sulforaphane': [68, 87, 174], 'and': [69, 88, 127, 136, 175, 187, 246], 'other': [70, 157], 'broccoli': [73, 94, 176, 197], 'sprouts': [74, 95], 'elevate': [76], 'chemoprotective': [80, 158, 216], 'enzymes': [81, 159, 217], 'tissues,': [84], 'both': [85, 173, 237], 'purified': [86], 'a': [89, 149, 191], 'hot': [90], 'water': [91], 'extract': [92], '(broccoli': [96], 'sprout': [97, 177, 198], 'tea)': [98], 'were': [99, 130, 170], 'administered': [100], 'adult': [102], 'male': [103], 'Fisher': [104], '344': [105], 'rats,': [106], 'prone': [107], 'develop': [109], 'when': [112], 'exposed': [113], 'heterocyclic': [115], 'amine': [116], 'carcinogens,4': [117], 'gastric': [119], 'gavage.': [120], 'To': [121], 'monitor': [122], 'expression,': [125], 'RNA-': [126], 'protein-containing': [128], 'extracts': [129], 'prepared': [131], 'from': [132], 'liver,': [133], 'intestine,': [134, 189, 248], 'spleen': [135], 'tissues': [138], 'recovered': [139], '48': [140], 'hours': [141], 'after': [142], 'treatment.': [143], 'GST': [144, 182, 202], 'activity': [145, 183, 203], 'was': [146, 160], 'assessed': [147], 'using': [148], 'CDNB': [150], 'assay.5': [151], 'The': [152, 168], 'mRNAs': [155], 'encoding': [156, 215], 'evaluated': [161], 'hybridization': [163], 'Affymetrix': [165], 'arrays.': [167], 'results': [169], 'that': [171, 225], 'while': [172], 'tea': [178, 199], 'triggered': [179], 'increases': [180], 'liver': [186, 245], 'dose': [192], 'dependent': [193], 'manor,': [194], 'only': [195], 'caused': [200], 'increased': [201], 'prostate.': [206, 258], 'mRNA': [207], 'profiling': [209], 'confirmed': [210], 'induction': [212], 'transcripts': [214], 'different': [220], 'tissues.': [221], 'These': [222], 'findings': [223], 'suggest': [224], 'containing': [230], 'glucosinolates,': [231], 'effectively': [233], 'augment': [234], 'carcinogen': [235], 'defenses': [236], 'major': [239], 'metabolic': [240], 'organs,': [241, 254], 'well': [250], 'cancer-prone': [253], 'References:': [259], '1Cohen': [260], 'JH': [261], 'et': [262, 272, 282, 291, 299], 'al.': [263, 273, 283, 292, 300], 'J.': [264, 301], 'Natl.': [265, 275], 'Cancer': [266, 293], 'Inst.': [267], '92:61-68': [268], '(2000).': [269], '2Fahey': [270], 'JW': [271], 'Proc.': [274], 'Acad.': [276], 'Sci.,': [277], '94:10367-10372': [278], '(1997).': [279, 296], '3Talalay': [280], 'P': [281], 'Adv': [284], 'Enzyme': [285], 'Regul.,': [286], '43:121-134': [287], '(2003).': [288], 'Shirai': [289], 'T': [290], 'Res.': [294], '57:195-198': [295], '5Habig': [297], 'WH': [298], 'Biol.': [302], 'Chem.': [303], '249:7130-7139': [304], '(1974).': [305]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2763321376', 'counts_by_year': [], 'updated_date': '2024-12-07T16:01:50.270177', 'created_date': '2017-10-20'}