Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2761575442', 'doi': 'https://doi.org/10.18632/oncotarget.21652', 'title': 'Structural basis of the therapeutic anti-PD-L1 antibody atezolizumab', 'display_name': 'Structural basis of the therapeutic anti-PD-L1 antibody atezolizumab', 'publication_year': 2017, 'publication_date': '2017-10-06', 'ids': {'openalex': 'https://openalex.org/W2761575442', 'doi': 'https://doi.org/10.18632/oncotarget.21652', 'mag': '2761575442', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29163822', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5685743'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.21652', 'pdf_url': 'https://www.oncotarget.com/article/21652/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.oncotarget.com/article/21652/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100412199', 'display_name': 'Fei Zhang', 'orcid': 'https://orcid.org/0000-0003-1135-1650'}, 'institutions': [{'id': 'https://openalex.org/I4210107879', 'display_name': 'Tongren Hospital', 'ror': 'https://ror.org/01r8rcr36', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210107879']}, {'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Fei Zhang', 'raw_affiliation_strings': ['Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Key Laboratory of Cell Differentiation and Apoptosis of The Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Key Laboratory of Cell Differentiation and Apoptosis of The Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China', 'institution_ids': ['https://openalex.org/I4210107879', 'https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070298378', 'display_name': 'Xiaoqiang Qi', 'orcid': 'https://orcid.org/0000-0002-5631-4362'}, 'institutions': [{'id': 'https://openalex.org/I83519826', 'display_name': 'Nanjing Medical University', 'ror': 'https://ror.org/059gcgy73', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I83519826']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaoqiang Qi', 'raw_affiliation_strings': ['Faculty of Basic Medicine, Nanjing Medical University, Nanjing, China'], 'affiliations': [{'raw_affiliation_string': 'Faculty of Basic Medicine, Nanjing Medical University, Nanjing, China', 'institution_ids': ['https://openalex.org/I83519826']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100355060', 'display_name': 'Xiaoxiao Wang', 'orcid': 'https://orcid.org/0000-0002-3996-7900'}, 'institutions': [{'id': 'https://openalex.org/I76569877', 'display_name': 'Southeast University', 'ror': 'https://ror.org/04ct4d772', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I76569877']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaoxiao Wang', 'raw_affiliation_strings': ['The Therapeutic Antibody Research Center of SEU-Alphamab, Southeast University, Nanjing, China'], 'affiliations': [{'raw_affiliation_string': 'The Therapeutic Antibody Research Center of SEU-Alphamab, Southeast University, Nanjing, China', 'institution_ids': ['https://openalex.org/I76569877']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064454673', 'display_name': 'Diyang Wei', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I76569877', 'display_name': 'Southeast University', 'ror': 'https://ror.org/04ct4d772', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I76569877']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Diyang Wei', 'raw_affiliation_strings': ['The Therapeutic Antibody Research Center of SEU-Alphamab, Southeast University, Nanjing, China'], 'affiliations': [{'raw_affiliation_string': 'The Therapeutic Antibody Research Center of SEU-Alphamab, Southeast University, Nanjing, China', 'institution_ids': ['https://openalex.org/I76569877']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053674466', 'display_name': 'Jiawei Wu', 'orcid': 'https://orcid.org/0000-0003-0273-1686'}, 'institutions': [{'id': 'https://openalex.org/I4210107879', 'display_name': 'Tongren Hospital', 'ror': 'https://ror.org/01r8rcr36', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210107879']}, {'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jiawei Wu', 'raw_affiliation_strings': ['Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Key Laboratory of Cell Differentiation and Apoptosis of The Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Key Laboratory of Cell Differentiation and Apoptosis of The Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China', 'institution_ids': ['https://openalex.org/I4210107879', 'https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057335398', 'display_name': 'Lingling Feng', 'orcid': 'https://orcid.org/0000-0003-1260-4656'}, 'institutions': [{'id': 'https://openalex.org/I4210107879', 'display_name': 'Tongren Hospital', 'ror': 'https://ror.org/01r8rcr36', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210107879']}, {'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lingling Feng', 'raw_affiliation_strings': ['Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Key Laboratory of Cell Differentiation and Apoptosis of The Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Key Laboratory of Cell Differentiation and Apoptosis of The Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China', 'institution_ids': ['https://openalex.org/I4210107879', 'https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084533462', 'display_name': 'Haiyan Cai', 'orcid': 'https://orcid.org/0000-0002-0280-4331'}, 'institutions': [{'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}, {'id': 'https://openalex.org/I4210107879', 'display_name': 'Tongren Hospital', 'ror': 'https://ror.org/01r8rcr36', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210107879']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Haiyan Cai', 'raw_affiliation_strings': ['Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Key Laboratory of Cell Differentiation and Apoptosis of The Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Key Laboratory of Cell Differentiation and Apoptosis of The Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China', 'institution_ids': ['https://openalex.org/I183067930', 'https://openalex.org/I4210107879']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100664052', 'display_name': 'Yugang Wang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210107879', 'display_name': 'Tongren Hospital', 'ror': 'https://ror.org/01r8rcr36', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210107879']}, {'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yugang Wang', 'raw_affiliation_strings': ['Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Key Laboratory of Cell Differentiation and Apoptosis of The Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Key Laboratory of Cell Differentiation and Apoptosis of The Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China', 'institution_ids': ['https://openalex.org/I4210107879', 'https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110216415', 'display_name': 'Naiyan Zeng', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210107879', 'display_name': 'Tongren Hospital', 'ror': 'https://ror.org/01r8rcr36', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210107879']}, {'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Naiyan Zeng', 'raw_affiliation_strings': ['Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Key Laboratory of Cell Differentiation and Apoptosis of The Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Key Laboratory of Cell Differentiation and Apoptosis of The Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China', 'institution_ids': ['https://openalex.org/I4210107879', 'https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080326933', 'display_name': 'Ting Xu', 'orcid': 'https://orcid.org/0000-0002-7851-3389'}, 'institutions': [{'id': 'https://openalex.org/I76569877', 'display_name': 'Southeast University', 'ror': 'https://ror.org/04ct4d772', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I76569877']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ting Xu', 'raw_affiliation_strings': ['The Therapeutic Antibody Research Center of SEU-Alphamab, Southeast University, Nanjing, China'], 'affiliations': [{'raw_affiliation_string': 'The Therapeutic Antibody Research Center of SEU-Alphamab, Southeast University, Nanjing, China', 'institution_ids': ['https://openalex.org/I76569877']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084605677', 'display_name': 'Aiwu Zhou', 'orcid': 'https://orcid.org/0000-0002-2555-5091'}, 'institutions': [{'id': 'https://openalex.org/I4210107879', 'display_name': 'Tongren Hospital', 'ror': 'https://ror.org/01r8rcr36', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210107879']}, {'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Aiwu Zhou', 'raw_affiliation_strings': ['Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Key Laboratory of Cell Differentiation and Apoptosis of The Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Key Laboratory of Cell Differentiation and Apoptosis of The Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China', 'institution_ids': ['https://openalex.org/I4210107879', 'https://openalex.org/I183067930']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5102010518', 'display_name': 'Ying Zheng', 'orcid': 'https://orcid.org/0000-0003-3014-1587'}, 'institutions': [{'id': 'https://openalex.org/I4210107879', 'display_name': 'Tongren Hospital', 'ror': 'https://ror.org/01r8rcr36', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210107879']}, {'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ying Zheng', 'raw_affiliation_strings': ['Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Key Laboratory of Cell Differentiation and Apoptosis of The Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Key Laboratory of Cell Differentiation and Apoptosis of The Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China', 'institution_ids': ['https://openalex.org/I4210107879', 'https://openalex.org/I183067930']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.634, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 70, 'citation_normalized_percentile': {'value': 0.999955, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '8', 'issue': '52', 'first_page': '90215', 'last_page': '90224'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10158', 'display_name': 'Cancer Immunotherapy and Biomarkers', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10158', 'display_name': 'Cancer Immunotherapy and Biomarkers', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11491', 'display_name': 'CAR-T cell therapy research', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10031', 'display_name': 'T-cell and B-cell Immunology', 'score': 0.9962, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/atezolizumab', 'display_name': 'Atezolizumab', 'score': 0.96107984}], 'concepts': [{'id': 'https://openalex.org/C2775949291', 'wikidata': 'https://www.wikidata.org/wiki/Q20707748', 'display_name': 'Atezolizumab', 'level': 5, 'score': 0.96107984}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.5832511}, {'id': 'https://openalex.org/C2777701055', 'wikidata': 'https://www.wikidata.org/wiki/Q1427096', 'display_name': 'Immunotherapy', 'level': 3, 'score': 0.40053916}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.26820335}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.24072579}, {'id': 'https://openalex.org/C2780030458', 'wikidata': 'https://www.wikidata.org/wiki/Q7041828', 'display_name': 'Nivolumab', 'level': 4, 'score': 0.17143568}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.21652', 'pdf_url': 'https://www.oncotarget.com/article/21652/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5685743', 'pdf_url': 'https://europepmc.org/articles/pmc5685743?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685743', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29163822', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.21652', 'pdf_url': 'https://www.oncotarget.com/article/21652/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.77, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 36, 'referenced_works': ['https://openalex.org/W1491394604', 'https://openalex.org/W1568317937', 'https://openalex.org/W1749548564', 'https://openalex.org/W1913780655', 'https://openalex.org/W1969888643', 'https://openalex.org/W1971208896', 'https://openalex.org/W1982488143', 'https://openalex.org/W1994286350', 'https://openalex.org/W2001641653', 'https://openalex.org/W2013013791', 'https://openalex.org/W2016983859', 'https://openalex.org/W2029086221', 'https://openalex.org/W2035503835', 'https://openalex.org/W2058527555', 'https://openalex.org/W2063264144', 'https://openalex.org/W2066671159', 'https://openalex.org/W2092565093', 'https://openalex.org/W2100228832', 'https://openalex.org/W2114622716', 'https://openalex.org/W2121498145', 'https://openalex.org/W2124427232', 'https://openalex.org/W2130473166', 'https://openalex.org/W2140066663', 'https://openalex.org/W2144081223', 'https://openalex.org/W2149748445', 'https://openalex.org/W2180229411', 'https://openalex.org/W2338150527', 'https://openalex.org/W2516527638', 'https://openalex.org/W2542082502', 'https://openalex.org/W2560367415', 'https://openalex.org/W2572174216', 'https://openalex.org/W2586232813', 'https://openalex.org/W2592103537', 'https://openalex.org/W2613452439', 'https://openalex.org/W2616581328', 'https://openalex.org/W2625296602'], 'related_works': ['https://openalex.org/W3108674512', 'https://openalex.org/W3032375762', 'https://openalex.org/W3031052312', 'https://openalex.org/W2899084033', 'https://openalex.org/W2748952813', 'https://openalex.org/W2604872355', 'https://openalex.org/W2080531066', 'https://openalex.org/W2048182022', 'https://openalex.org/W1995515455', 'https://openalex.org/W1506200166'], 'abstract_inverted_index': {'//': [0], 'Fei': [1], 'Zhang': [2], '1,': [3], '*': [4, 9, 14, 107], ',': [5, 10, 15, 19, 23, 27, 31, 35, 39, 43, 280], 'Xiaoqiang': [6], 'Qi': [7], '2,': [8], 'Xiaoxiao': [11], 'Wang': [12, 33], '3,': [13], 'Diyang': [16], 'Wei': [17], '3': [18, 42, 95], 'Jiawei': [20], 'Wu': [21], '1': [22, 26, 30, 34, 38, 46, 50, 51], 'Lingling': [24], 'Feng': [25], 'Haiyan': [28], 'Cai': [29], 'Yugang': [32], 'Naiyan': [36], 'Zeng': [37], 'Ting': [40, 122], 'Xu': [41], 'Aiwu': [44, 118], 'Zhou': [45], 'and': [47, 68, 230, 243, 269, 321, 325, 357, 365], 'Ying': [48, 126], 'Zheng': [49], 'Hongqiao': [52], 'International': [53], 'Institute': [54], 'of': [55, 60, 65, 70, 74, 81, 87, 101, 187, 204, 220, 265, 300, 307, 345, 353, 368], 'Medicine,': [56, 62, 82, 89], 'Shanghai': [57, 76], 'Tongren': [58], 'Hospital/Faculty': [59], 'Basic': [61, 88], 'Key': [63], 'Laboratory': [64], 'Cell': [66], 'Differentiation': [67], 'Apoptosis': [69], 'The': [71, 96, 211, 238, 309], 'Chinese': [72], 'Ministry': [73], 'Education,': [75], 'Jiao': [77], 'Tong': [78], 'University': [79], 'School': [80], 'Shanghai,': [83], 'China': [84, 94, 106], '2': [85, 279], 'Faculty': [86], 'Nanjing': [90], 'Medical': [91], 'University,': [92, 104], 'Nanjing,': [93, 105], 'Therapeutic': [97], 'Antibody': [98], 'Research': [99], 'Center': [100], 'SEU-Alphamab,': [102], 'Southeast': [103], 'These': [108], 'authors': [109], 'have': [110, 157, 199], 'contributed': [111], 'equally': [112], 'to': [113, 304], 'this': [114], 'work': [115], 'Correspondence': [116], 'to:': [117], 'Zhou,': [119], 'email:': [120, 124, 128], '[email protected]': [121], 'Xu,': [123], '[email protected]': [125], 'Zheng,': [127], '[email protected]': [129], 'Keywords:': [130], 'atezolizumab,': [131], 'PD-L1,': [132], 'crystal': [133, 202], 'structure,': [134], 'immunotherapy,': [135], 'hot-spot': [136, 296], 'residue': [137], 'Received:': [138], 'July': [139], '14,': [140], '2017': [141, 145, 149], 'Accepted:': [142], 'August': [143], '29,': [144], 'Published:': [146], 'October': [147], '06,': [148], 'ABSTRACT': [150], 'Monoclonal': [151], 'antibodies': [152], 'targeting': [153, 372], 'PD-1/PD-L1': [154, 191, 328], 'signaling': [155], 'pathway': [156], 'achieved': [158], 'unprecedented': [159], 'success': [160], 'in': [161, 189, 355], 'cancer': [162, 181], 'treatment': [163], 'over': [164], 'the': [165, 171, 184, 201, 217, 227, 235, 253, 263, 266, 270, 283, 287, 305, 335, 342, 350], 'last': [166], 'few': [167], 'years.': [168], 'Atezolizumab': [169], 'is': [170, 193, 274, 282], 'first': [172], 'PD-L1': [173, 221, 301, 316, 337, 373], 'monoclonal': [174, 362], 'antibody': [175, 363], 'approved': [176], 'by': [177], 'US': [178], 'FDA': [179], 'for': [180, 334, 360], 'therapy;': [182], 'however': [183], 'molecular': [185, 351], 'basis': [186, 359], 'atezolizumab': [188, 215, 314, 354], 'blocking': [190], 'interaction': [192, 329], 'not': [194], 'fully': [195], 'understood.': [196], 'Here': [197], 'we': [198], 'solved': [200, 347], 'structure': [203, 212, 310, 344], 'PD-L1/atezolizumab': [205, 346], 'complex': [206, 343], 'at': [207], '2.9': [208], 'angstrom': [209], 'resolution.': [210], 'shows': [213, 312], 'that': [214, 294, 313], 'binds': [216, 315], 'front': [218], 'beta-sheet': [219], 'through': [222, 330], 'three': [223], 'CDR': [224, 232, 254], 'loops': [225, 255], 'from': [226, 234, 252], 'heavy': [228, 320], 'chain': [229, 323], 'one': [231], 'loop': [233], 'light': [236, 322], 'chain.': [237], 'binding': [239, 267, 306], 'involves': [240], 'extensive': [241], 'hydrogen-bonding': [242], 'hydrophobic': [244], 'interactions.': [245], 'Notably': [246], 'there': [247], 'are': [248], 'multiple': [249], 'aromatic': [250], 'residues': [251, 297], 'forming': [256], 'Pi-Pi': [257], 'stacking': [258], 'or': [259], 'cation-Pi': [260], 'interactions': [261], 'within': [262], 'center': [264], 'interface': [268], 'buried': [271], 'surface': [272, 338], 'area': [273], 'more': [275], 'than': [276], '2000': [277], 'Å': [278], 'which': [281], 'largest': [284], 'amongst': [285], 'all': [286], 'known': [288], 'PD-L1/antibody': [289], 'structures.': [290], 'Mutagenesis': [291], 'study': [292], 'revealed': [293, 349], 'two': [295], '(E58,': [298], 'R113)': [299], 'contribute': [302], 'significantly': [303], 'atezolizumab.': [308], 'also': [311], 'with': [317, 332], 'a': [318], 'distinct': [319], 'orientation': [324], 'it': [326], 'blocks': [327], 'competing': [331], 'PD-1': [333], 'same': [336], 'area.': [339], 'Taken': [340], 'together,': [341], 'here': [348], 'mechanism': [352], 'immunotherapy': [356], 'provides': [358], 'future': [361], 'optimization': [364], 'rational': [366], 'design': [367], 'small': [369], 'chemical': [370], 'compounds': [371], 'surface.': [374]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2761575442', 'counts_by_year': [{'year': 2024, 'cited_by_count': 10}, {'year': 2023, 'cited_by_count': 12}, {'year': 2022, 'cited_by_count': 13}, {'year': 2021, 'cited_by_count': 15}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 2}], 'updated_date': '2024-12-24T09:28:06.813892', 'created_date': '2017-10-20'}