Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2758335486', 'doi': 'https://doi.org/10.1161/circimaging.117.007015', 'title': 'Targeting High Oxygen Consumption to Prevent Cardiac Dysfunction in Patients With Aortic Valve Stenosis', 'display_name': 'Targeting High Oxygen Consumption to Prevent Cardiac Dysfunction in Patients With Aortic Valve Stenosis', 'publication_year': 2017, 'publication_date': '2017-09-28', 'ids': {'openalex': 'https://openalex.org/W2758335486', 'doi': 'https://doi.org/10.1161/circimaging.117.007015', 'mag': '2758335486', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28956777'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/circimaging.117.007015', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/CIRCIMAGING.117.007015', 'source': {'id': 'https://openalex.org/S110626636', 'display_name': 'Circulation Cardiovascular Imaging', 'issn_l': '1941-9651', 'issn': ['1941-9651', '1942-0080'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'letter', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.ahajournals.org/doi/pdf/10.1161/CIRCIMAGING.117.007015', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5008468085', 'display_name': 'Jolanda van der Velden', 'orcid': 'https://orcid.org/0000-0001-5224-5788'}, 'institutions': [{'id': 'https://openalex.org/I911458345', 'display_name': 'Amsterdam UMC Location VUmc', 'ror': 'https://ror.org/00q6h8f30', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210151833', 'https://openalex.org/I911458345']}, {'id': 'https://openalex.org/I2802849423', 'display_name': 'University Medical Center', 'ror': 'https://ror.org/036pt7h44', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802849423']}, {'id': 'https://openalex.org/I4210108968', 'display_name': 'University Hospital and Clinics', 'ror': 'https://ror.org/013v7fk41', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210108968']}], 'countries': ['NL', 'US'], 'is_corresponding': True, 'raw_author_name': 'Jolanda van der Velden', 'raw_affiliation_strings': ['Amsterdam Cardiovascular Sciences, The Netherlands.', 'Department of Physiology, VU University Medical Center,', 'From the Department of Physiology, VU University Medical Center, Amsterdam Cardiovascular Sciences, The Netherlands.'], 'affiliations': [{'raw_affiliation_string': 'Amsterdam Cardiovascular Sciences, The Netherlands.', 'institution_ids': []}, {'raw_affiliation_string': 'From the Department of Physiology, VU University Medical Center, Amsterdam Cardiovascular Sciences, The Netherlands.', 'institution_ids': ['https://openalex.org/I911458345']}, {'raw_affiliation_string': 'Department of Physiology, VU University Medical Center,', 'institution_ids': ['https://openalex.org/I911458345', 'https://openalex.org/I2802849423', 'https://openalex.org/I4210108968']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5008468085'], 'corresponding_institution_ids': ['https://openalex.org/I911458345', 'https://openalex.org/I2802849423', 'https://openalex.org/I4210108968'], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 64, 'max': 71}, 'biblio': {'volume': '10', 'issue': '10', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10172', 'display_name': 'Management of Valvular Heart Disease', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10172', 'display_name': 'Management of Valvular Heart Disease', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10821', 'display_name': 'Recommendations for Cardiac Chamber Quantification by Echocardiography', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10882', 'display_name': 'Diagnosis and Management of Hypertrophic Cardiomyopathy', 'score': 0.9966, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/pressure-overload', 'display_name': 'Pressure overload', 'score': 0.6995409}, {'id': 'https://openalex.org/keywords/aortic-stenosis', 'display_name': 'Aortic Stenosis', 'score': 0.581103}, {'id': 'https://openalex.org/keywords/transcatheter-aortic-valve-replacement', 'display_name': 'Transcatheter Aortic-Valve Replacement', 'score': 0.567094}, {'id': 'https://openalex.org/keywords/cardiac-imaging', 'display_name': 'Cardiac Imaging', 'score': 0.557826}, {'id': 'https://openalex.org/keywords/surgical-aortic-valve-replacement', 'display_name': 'Surgical Aortic-Valve Replacement', 'score': 0.550335}, {'id': 'https://openalex.org/keywords/diastolic-function', 'display_name': 'Diastolic Function', 'score': 0.539528}], 'concepts': [{'id': 'https://openalex.org/C164705383', 'wikidata': 'https://www.wikidata.org/wiki/Q10379', 'display_name': 'Cardiology', 'level': 1, 'score': 0.77487564}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.7304474}, {'id': 'https://openalex.org/C2778271984', 'wikidata': 'https://www.wikidata.org/wiki/Q17126794', 'display_name': 'Pressure overload', 'level': 4, 'score': 0.6995409}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6919513}, {'id': 'https://openalex.org/C2778921608', 'wikidata': 'https://www.wikidata.org/wiki/Q2002035', 'display_name': 'Ventricle', 'level': 2, 'score': 0.68123883}, {'id': 'https://openalex.org/C2780007028', 'wikidata': 'https://www.wikidata.org/wiki/Q2343082', 'display_name': 'Stenosis', 'level': 2, 'score': 0.6156817}, {'id': 'https://openalex.org/C2776570981', 'wikidata': 'https://www.wikidata.org/wiki/Q4413093', 'display_name': 'Aortic valve replacement', 'level': 3, 'score': 0.52647495}, {'id': 'https://openalex.org/C2781414266', 'wikidata': 'https://www.wikidata.org/wiki/Q531019', 'display_name': 'Aortic valve stenosis', 'level': 3, 'score': 0.52312297}, {'id': 'https://openalex.org/C2908647359', 'wikidata': 'https://www.wikidata.org/wiki/Q2625603', 'display_name': 'Population', 'level': 2, 'score': 0.4294607}, {'id': 'https://openalex.org/C2777910003', 'wikidata': 'https://www.wikidata.org/wiki/Q1707292', 'display_name': 'Asymptomatic', 'level': 2, 'score': 0.42221102}, {'id': 'https://openalex.org/C2776002628', 'wikidata': 'https://www.wikidata.org/wiki/Q1628627', 'display_name': 'Left ventricular hypertrophy', 'level': 3, 'score': 0.41347206}, {'id': 'https://openalex.org/C2778198053', 'wikidata': 'https://www.wikidata.org/wiki/Q181754', 'display_name': 'Heart failure', 'level': 2, 'score': 0.3541896}, {'id': 'https://openalex.org/C84393581', 'wikidata': 'https://www.wikidata.org/wiki/Q82642', 'display_name': 'Blood pressure', 'level': 2, 'score': 0.22175121}, {'id': 'https://openalex.org/C3018791406', 'wikidata': 'https://www.wikidata.org/wiki/Q945225', 'display_name': 'Cardiac hypertrophy', 'level': 3, 'score': 0.09925315}, {'id': 'https://openalex.org/C99454951', 'wikidata': 'https://www.wikidata.org/wiki/Q932068', 'display_name': 'Environmental health', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001024', 'descriptor_name': 'Aortic Valve Stenosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008790', 'descriptor_name': 'Metoprolol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D006439', 'descriptor_name': 'Hemodynamics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010101', 'descriptor_name': 'Oxygen Consumption', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/circimaging.117.007015', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/CIRCIMAGING.117.007015', 'source': {'id': 'https://openalex.org/S110626636', 'display_name': 'Circulation Cardiovascular Imaging', 'issn_l': '1941-9651', 'issn': ['1941-9651', '1942-0080'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28956777', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/circimaging.117.007015', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/CIRCIMAGING.117.007015', 'source': {'id': 'https://openalex.org/S110626636', 'display_name': 'Circulation Cardiovascular Imaging', 'issn_l': '1941-9651', 'issn': ['1941-9651', '1942-0080'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.72, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 17, 'referenced_works': ['https://openalex.org/W1969871474', 'https://openalex.org/W1976629814', 'https://openalex.org/W1986102534', 'https://openalex.org/W2037555627', 'https://openalex.org/W2047697804', 'https://openalex.org/W2071518542', 'https://openalex.org/W2105472710', 'https://openalex.org/W2106436142', 'https://openalex.org/W2116298701', 'https://openalex.org/W2130883549', 'https://openalex.org/W2159697997', 'https://openalex.org/W2337043813', 'https://openalex.org/W2530532819', 'https://openalex.org/W2596986305', 'https://openalex.org/W2760172151', 'https://openalex.org/W2893581659', 'https://openalex.org/W4230220778'], 'related_works': ['https://openalex.org/W4297173676', 'https://openalex.org/W3175657831', 'https://openalex.org/W3012701549', 'https://openalex.org/W2550487528', 'https://openalex.org/W2384676687', 'https://openalex.org/W2198592471', 'https://openalex.org/W2079561906', 'https://openalex.org/W2070327453', 'https://openalex.org/W2067905792', 'https://openalex.org/W1983749074'], 'abstract_inverted_index': {'HomeCirculation:': [0], 'Cardiovascular': [1, 95, 103, 648, 1696], 'ImagingVol.': [2], '10,': [3, 1701], 'No.': [4], '10Targeting': [5], 'High': [6, 34], 'Oxygen': [7, 35], 'Consumption': [8, 36], 'to': [9, 24, 37, 60, 167, 197, 215, 220, 254, 261, 280, 369, 412, 468, 483, 503, 604, 659, 695, 713, 741, 772, 790, 849, 868, 880, 891, 953, 965, 1024, 1051, 1675], 'Prevent': [10, 38], 'Cardiac': [11, 39], 'Dysfunction': [12, 40], 'in': [13, 41, 118, 165, 202, 213, 301, 355, 396, 455, 474, 490, 507, 523, 531, 550, 578, 597, 624, 638, 667, 753, 766, 847, 902, 912, 927, 932, 957, 969, 1016, 1035, 1121, 1162, 1196, 1261, 1297, 1349, 1386, 1397, 1465, 1491, 1509, 1539, 1566, 1577, 1624, 1664, 1685], 'Patients': [14, 42, 977], 'With': [15, 43], 'Aortic': [16, 44, 120, 1078, 1687], 'Valve': [17, 45, 121, 1688], 'Stenosis': [18, 46, 122, 1689], 'Free': [19], 'AccessEditorialPDF/EPUBAboutView': [20], 'PDFView': [21], 'EPUBSections': [22], 'ToolsAdd': [23], 'favoritesDownload': [25], 'citationsTrack': [26], 'citationsPermissions': [27], 'ShareShare': [28], 'onFacebookTwitterLinked': [29], 'InMendeleyReddit': [30], 'Jump': [31], 'toFree': [32], 'AccessEditorialPDF/EPUBTargeting': [33], 'Jolanda': [47, 52, 61, 1052], 'van': [48, 53, 56, 62, 1053, 1099, 1104, 1234, 1248, 1280, 1291, 1308, 1374, 1379], 'der': [49, 54, 57, 63, 1054, 1105, 1249, 1292, 1309, 1380], 'Velden,': [50, 64, 1055], 'PhD': [51], 'VeldenJolanda': [55], 'Velden': [58, 1106, 1250, 1293, 1310, 1381], 'Correspondence': [59], 'PhD,': [65, 1056], 'Department': [66, 87, 1057], 'of': [67, 88, 125, 134, 144, 153, 170, 181, 199, 210, 230, 240, 311, 322, 333, 341, 388, 405, 445, 450, 472, 567, 646, 680, 763, 777, 795, 808, 817, 824, 896, 922, 990, 1042, 1046, 1058, 1114, 1158, 1418, 1424], 'Physiology,': [68, 89, 1059], 'VU': [69, 90, 1060], 'University': [70, 91, 1061], 'Medical': [71, 92, 1062], 'Center,': [72, 93, 1063], 'Boelelaan': [73, 1064], '1118,': [74, 1065], 'Amsterdam': [75, 94, 1066], '1081': [76, 1067], 'HV,': [77, 1068], 'The': [78, 97, 308, 425, 1001, 1069], 'Netherlands.': [79, 98, 1070], 'E-mail': [80, 81, 1071], 'Address:': [82], '[email': [83], 'protected]': [84], 'From': [85], 'the': [86, 111, 130, 147, 171, 192, 200, 207, 211, 231, 241, 244, 249, 288, 328, 334, 342, 370, 406, 413, 434, 469, 528, 574, 608, 643, 681, 697, 703, 739, 774, 796, 804, 809, 834, 838, 858, 893, 897, 923, 1043, 1047, 1540, 1574], 'Sciences,': [96], 'Originally': [99, 1714], 'published27': [100], 'Sep': [101], '2017https://doi.org/10.1161/CIRCIMAGING.117.007015Circulation:': [102], 'Imaging.': [104, 1135, 1403, 1475, 1669, 1697], '2017;10:e007015This': [105], 'article': [106, 1037], 'is': [107, 185, 218, 259, 316, 336, 381, 573, 610, 798, 812, 826, 963, 1008, 1110], 'a': [108, 252, 255, 430, 456, 475, 501, 556, 617, 619, 654, 693, 951, 1126, 1191, 1352, 1471], 'commentary': [109], 'on': [110, 521, 607, 685], 'followingMetoprolol': [112], 'Reduces': [113, 1680], 'Hemodynamic': [114, 1681], 'and': [115, 160, 224, 276, 293, 359, 366, 386, 422, 437, 461, 488, 518, 729, 820, 883, 916, 941, 993, 998, 1020, 1129, 1201, 1225, 1343, 1390, 1462, 1516, 1542, 1570, 1620, 1656, 1661, 1682], 'Metabolic': [116, 930, 1614, 1683], 'Overload': [117, 1684], 'Asymptomatic': [119, 1686], 'PatientsOther': [123], 'version(s)': [124], 'this': [126, 135, 1036], 'articleYou': [127], 'are': [128, 738, 770, 1038], 'viewing': [129], 'most': [131, 967], 'recent': [132], 'version': [133], 'article.': [136], 'Previous': [137, 142, 1673], 'versions:': [138], 'September': [139], '27,': [140, 1716], '2017:': [141], 'Version': [143], 'Record': [145], 'In': [146, 466, 511, 642, 803], 'aging': [148], 'population,': [149], 'an': [150, 594, 686, 749, 889, 1111], 'increasing': [151], 'number': [152], 'people': [154], 'experience': [155], 'aortic': [156, 175, 464, 724, 1118, 1122, 1163, 1199, 1270, 1421, 1425, 1467, 1580, 1666], 'valve': [157, 176, 725, 1119, 1123, 1164, 1426, 1468, 1719], 'stenosis': [158, 1124, 1200, 1469], '(AS)': [159], 'develop': [161, 1025], 'severe': [162, 417, 462, 568, 581, 1420], 'concentric': [163, 339], 'hypertrophy': [164, 196, 340, 391, 1267], 'response': [166, 209, 214], 'pressure': [168, 217, 385, 704], 'overload': [169, 229, 1464], 'left': [172, 1265, 1345, 1653], 'ventricle.1': [173], 'Although': [174, 672, 830], 'replacement': [177, 1120], '(AVR)': [178], 'prevents': [179, 191], 'worsening': [180], 'cardiac': [182, 486, 505, 569, 801, 904, 913, 1223, 1259, 1299, 1387, 1567], 'disease,': [183], 'there': [184], 'currently': [186], 'no': [187], 'treatment': [188, 264, 576, 589, 623, 673, 717, 722, 1027], 'that': [189, 236, 247, 286, 497, 562, 743, 852, 1009], 'effectively': [190], 'transition': [193, 250], 'from': [194, 251, 857, 877, 906, 1004], 'compensatory': [195, 219, 253], 'failure': [198, 239, 622, 1511, 1518], 'ventricle': [201, 212, 232, 258, 310, 335], 'patients': [203, 267, 302, 312, 356, 508, 512, 524, 552, 579, 598, 625, 639, 668, 707, 754, 767, 907, 937, 958, 970, 1017, 1197, 1578], 'with': [204, 268, 303, 306, 313, 357, 459, 478, 509, 513, 525, 535, 553, 580, 599, 616, 626, 635, 640, 669, 674, 708, 755, 760, 768, 908, 959, 971, 974, 978, 981, 1018, 1170, 1198, 1351, 1512, 1519, 1579], 'AS.': [205, 269, 510, 601, 671, 756, 961], 'Initially,': [206], 'hypertrophic': [208, 935, 1400, 1626], 'increased': [216, 329, 399, 426, 517, 698, 975, 982], 'preserve': [221], 'wall': [222], 'stress': [223, 400, 431, 606], 'systolic': [225], 'function.': [226], 'However,': [227, 544], 'chronic': [228], 'induces': [233], 'pathological': [234, 485], 'changes': [235, 411, 911, 1385, 1508], 'ultimately': [237], 'cause': [238, 409], 'ventricle.': [242], 'Defining': [243], 'pathophysiologic': [245], 'mechanisms': [246], 'underlie': [248, 352, 1393], 'failing': [256, 1543], 'hypertrophied': [257, 309, 872, 928], 'key': [260, 1002], 'finding': [262], 'pharmacological': [263], 'options': [265], 'for': [266, 433, 718, 837, 1193], 'Imaging': [270], 'studies': [271, 495, 759, 1007], 'combining': [272], 'cardiovascular': [273, 1005], 'magnetic': [274], 'resonance': [275], '11C-acetate': [277], 'positron-emission': [278], 'tomography': [279, 1169], 'assess': [281, 773], 'myocardial': [282, 294, 479, 665, 733, 764, 1159, 1354, 1395], 'external': [283, 291], 'efficiency': [284, 666, 765, 1109, 1396], '(MEE),': [285], 'is,': [287], 'ratio': [289], 'between': [290, 1222, 1652], 'work': [292], 'oxygen': [295, 379, 793, 845, 866, 1391], 'consumption': [296, 867], '(MVO2),': [297], 'revealed': [298, 910], 'reduced': [299, 627, 723, 1394, 1520], 'MEE': [300, 516, 532, 549], 'AS': [304, 315, 358, 491, 554, 710, 769, 909, 973, 980, 1019], 'compared': [305], 'controls.2': [307], 'symptomatic': [314, 514, 933, 1625], 'characterized': [317], 'by': [318, 383, 611, 702, 784, 799, 814, 988, 1269], 'high': [319, 323, 498, 781, 792, 955], 'MVO2,2,3': [320], 'indicative': [321], 'metabolic': [324, 699, 917, 925, 946, 1463, 1507, 1571, 1575], 'demand.': [325], 'To': [326], 'match': [327], 'MVO2,': [330, 730], 'adequate': [331], 'perfusion': [332, 365], 'crucial.': [337], 'Ongoing': [338], 'heart,': [343, 436, 806, 839], 'however,': [344], 'impairs': [345], 'coronary': [346, 376, 394, 1189, 1203, 1226], 'blood': [347], 'flow': [348], 'reserve,4': [349], 'which': [350, 559, 886], 'may': [351, 360, 428, 440, 560, 676, 691, 887, 948, 985], 'angina': [353, 1194], 'pectoris': [354, 1195], 'worsen': [361], 'disease': [362, 751, 1031, 1165], 'outcome.': [363], 'Coronary': [364], 'energy': [367, 810, 939, 1506, 1618], 'supply': [368], 'heart': [371, 407, 414, 609, 621, 797, 1492, 1510, 1517], 'muscle': [372, 1224], 'occurs': [373], 'during': [374, 398, 443, 540, 999, 1662], 'diastole;': [375], 'inflow': [377], '(ie,': [378], 'delivery)': [380], 'determined': [382], 'diastolic': [384, 994], 'duration': [387], 'diastole.5': [389], 'Concentric': [390], 'will': [392, 408], 'limit': [393], 'flow,': [395], 'particular,': [397], '(eg,': [401], 'exercise).': [402], 'Ischemic': [403], 'damage': [404, 564], 'irreversible': [410, 563], 'muscle,': [415], 'including': [416], 'mitochondrial': [418, 815, 854], 'damage,': [419], 'collagen': [420], 'formation,': [421], 'microvascular': [423], 'rarefaction.': [424], 'MVO2': [427, 499, 519, 956, 1012], 'represent': [429, 692, 833, 888, 950], 'factor': [432], 'pressure-overloaded': [435], 'detrimental': [438, 448], 'effects': [439, 471], 'be': [441, 585, 591, 677, 966, 986], 'exacerbated': [442], 'episodes': [444], 'exercise.': [446], 'A': [447, 900], 'effect': [449, 684, 776], 'exercise': [451, 473, 481, 537, 542, 943, 1338, 1622, 1663], 'has': [452, 632], 'been': [453, 633], 'shown': [454], 'mouse': [457, 476], 'model': [458, 477], 'mild': [460], 'transverse': [463], 'constriction.6': [465], 'contrast': [467], 'beneficial': [470], 'infarction,7': [480], 'tended': [482], 'aggravate': [484], 'remodeling': [487, 1015], 'dysfunction': [489, 506, 1348], 'mice.6,8': [492], 'These': [493], 'previous': [494], 'indicate': [496], 'represents': [500], 'target': [502, 954], 'prevent': [504], 'AS,': [515, 582], 'decreased': [520], 'AVR': [522, 545, 572], 'AS.2,9': [526], 'Moreover,': [527], 'AVR-induced': [529], 'increase': [530], 'was': [533], 'associated': [534, 634], 'improved': [536, 942], 'capacity': [538, 1623], 'assessed': [539], 'cardiopulmonary': [541], 'testing.2': [543], 'did': [546], 'not': [547, 1039, 1257], 'correct': [548], 'several': [551], 'within': [555], '4-month': [557], 'follow-up,2': [558], 'suggest': [561], 'occurred': [565], 'because': [566, 679], 'remodeling.': [570], 'As': [571], 'final': [575], 'option': [577], 'it': [583, 690], 'would': [584, 864], 'preferable': [586], 'if': [587], 'medical': [588], 'could': [590, 663], 'initiated': [592], 'at': [593, 748, 780, 996, 1029, 1659], 'earlier': [595], 'stage': [596, 752], 'asymptomatic': [600, 670, 709, 960, 972, 979, 1419, 1665], 'One': [602], 'way': [603, 789], 'reduce': [605, 696, 865], 'blocking': [612], 'adrenergic': [613], 'receptor': [614], 'stimulation': [615], 'β-blocker,': [618], 'standard': [620], 'ejection': [628, 1514, 1521], 'fraction.': [629], 'β-blocker': [630], 'use': [631], 'better': [636], 'prognosis': [637], 'AS.10': [641], 'current': [644], 'issue': [645], 'Circulation:': [647, 1695], 'Imaging,': [649], 'Hansson': [650, 735, 785, 1435], 'et': [651, 736, 786, 1693], 'al11': [652, 737], 'performed': [653], 'randomized,': [655], 'double-blind,': [656], 'placebo-controlled': [657], 'trial': [658], 'study': [660, 901], 'whether': [661], 'metoprolol': [662, 714], 'improve': [664, 1258], 'β-blockers': [675], 'harmful': [678], 'negative': [682], 'inotropic': [683], 'already': [687], 'overloaded': [688, 898], 'ventricle,': [689], 'therapy': [694, 778, 931, 947, 952], 'demand': [700, 794, 811], 'caused': [701], 'overload.': [705], 'Forty': [706], 'were': [711], 'randomized': [712, 1472], 'or': [715, 1045, 1263], 'placebo': [716], '22': [719], 'weeks.11': [720], 'Metoprolol': [721, 1459], 'gradients,': [726], 'global': [727], 'afterload,': [728], 'thereby': [731], 'improving': [732], 'efficiency.': [734], 'first': [740], 'illustrate': [742], 'β-blockade': [744], 'exerts': [745], 'hemodynamic': [746, 983, 1461], 'benefit': [747, 1423], 'early': [750, 1030], 'Future': [757], 'prospective': [758], 'repeated': [761], 'measurement': [762], 'warranted': [771], 'long-term': [775], 'targeted': [779], 'MVO2.See': [782], 'Article': [783, 1705], 'alAn': [787], 'alternative': [788], 'tackle': [791], 'targeting': [800], 'metabolism.12–14': [802], 'healthy': [805], '95%': [807], 'met': [813], 'oxidation': [816, 1490], 'fatty': [818, 831, 860, 878, 1488], 'acids': [819, 832, 861, 879], 'carbohydrates,': [821], 'whereas': [822], '5%': [823], 'ATP': [825, 843], 'produced': [827], 'via': [828], 'glycolysis.': [829], 'predominant': [835], 'fuel': [836], 'they': [840], 'provide': [841], 'less': [842], 'per': [844], 'molecule': [846], 'comparison': [848], 'carbohydrates.13,14': [850], 'Agents': [851], 'shift': [853, 874, 1576], 'oxygenation': [855], 'away': [856], 'preferred': [859], 'toward': [862], 'carbohydrates': [863], 'produce': [869], 'ATP.': [870], 'Interestingly,': [871], 'hearts': [873], 'their': [875], 'metabolism': [876, 1161, 1538], 'glucose': [881], 'utilization': [882, 1392], 'glycolytic': [884], 'metabolism,': [885], 'attempt': [890], 'optimize': [892], 'energetic': [894], 'status': [895], 'heart.': [899], 'human': [903, 1398], 'tissue': [905], 'substrate': [914, 1537, 1568], 'transporters': [915, 1569], 'proteins': [918, 1572], 'as': [919], 'underlying': [920], 'causes': [921], 'modified': [924], 'flux': [926], 'myocardium.15': [929], '(advanced)': [934], 'cardiomyopathy': [936], 'corrected': [938], 'deficiency': [940, 1619], 'capacity.16': [944], 'Thus,': [945], 'also': [949], 'Treatment': [962], 'expected': [964], 'effective': [968], 'MVO2.': [976], 'burden': [984], 'identified': [987], 'analysis': [989], 'atrial': [991, 1654], 'dimensions': [992], 'function': [995, 1260, 1342], 'rest': [997, 1660], 'exercise.17': [1000], 'message': [1003], 'imaging': [1006], 'chronically': [1010], 'elevated': [1011], 'triggers': [1013], 'maladaptive': [1014], 'warrants': [1021], 'further': [1022], 'investigation': [1023], 'preventive': [1026], 'strategies': [1028], 'stage.DisclosuresNone.FootnotesThe': [1032], 'opinions': [1033], 'expressed': [1034], 'necessarily': [1040], 'those': [1041], 'editors': [1044], 'American': [1048, 1709], 'Heart': [1049, 1132, 1173, 1710, 1726], 'Association.Correspondence': [1050], 'j.[email': [1072], 'protected]nlReferences1.': [1073], 'Carabello': [1074], 'BA,': [1075], 'Paulus': [1076], 'WJ.': [1077], 'stenosis.Lancet.': [1079], '2009;': [1080], '373:956–966.': [1081], 'doi:': [1082, 1138, 1210, 1231, 1359, 1432, 1478, 1497, 1527, 1548, 1585, 1630], '10.1016/S0140-6736(09)60211-7.CrossrefMedlineGoogle': [1083], 'Scholar2.': [1084], 'Güçlü': [1085, 1362], 'A,': [1086, 1363, 1607], 'Knaapen': [1087, 1364], 'P,': [1088, 1152, 1245, 1365, 1591], 'Harms': [1089, 1366, 1439], 'HJ,': [1090, 1367, 1440], 'Vonk': [1091], 'AB,': [1092], 'Stooker': [1093], 'W,': [1094, 1593], 'Groepenhoff': [1095], 'H,': [1096, 1609, 1611], 'Lammertsma': [1097, 1372], 'AA,': [1098, 1373], 'Rossum': [1100, 1375], 'AC,': [1101, 1376], 'Germans': [1102, 1377], 'T,': [1103, 1378], 'J.': [1107, 1174, 1294, 1382], 'Myocardial': [1108, 1536], 'important': [1112], 'determinant': [1113], 'functional': [1115], 'improvement': [1116], 'after': [1117], 'patients:': [1125, 1470], 'combined': [1127], 'PET': [1128], 'CMR': [1130], 'study.Eur': [1131], 'J': [1133, 1206, 1523], 'Cardiovasc': [1134, 1402, 1474, 1668], '2015;': [1136], '16:882–889.': [1137], '10.1093/ehjci/jev009.CrossrefMedlineGoogle': [1139], 'Scholar3.': [1140], 'Hicks': [1141], 'RJ,': [1142], 'Savas': [1143], 'V,': [1144, 1148, 1313, 1482], 'Currie': [1145], 'PJ,': [1146], 'Kalff': [1147], 'Starling': [1149], 'M,': [1150, 1154, 1239, 1288, 1371], 'Bergin': [1151], 'Kirsch': [1153], 'Schwaiger': [1155], 'M.': [1156, 1613], 'Assessment': [1157], 'oxidative': [1160], 'using': [1166], 'positron': [1167], 'emission': [1168], 'C-11': [1171], 'acetate.Am': [1172], '1992;': [1175], '123:653–664.CrossrefMedlineGoogle': [1176], 'Scholar4.': [1177], 'Marcus': [1178], 'ML,': [1179], 'Doty': [1180], 'DB,': [1181], 'Hiratzka': [1182], 'LF,': [1183], 'Wright': [1184], 'CB,': [1185], 'Eastham': [1186], 'CL.': [1187], 'Decreased': [1188], 'reserve:': [1190], 'mechanism': [1192], 'normal': [1202, 1541], 'arteries.N': [1204], 'Engl': [1205], 'Med.': [1207], '1982;': [1208], '307:1362–1366.': [1209], '10.1056/NEJM198211253072202.CrossrefMedlineGoogle': [1211], 'Scholar5.': [1212], 'Westerhof': [1213], 'N,': [1214, 1410], 'Boer': [1215, 1238, 1287], 'C,': [1216], 'Lamberts': [1217], 'RR,': [1218], 'Sipkema': [1219], 'P.': [1220, 1414], 'Cross-talk': [1221], 'vasculature.Physiol': [1227], 'Rev.': [1228, 1545], '2006;': [1229, 1430], '86:1263–1308.': [1230], '10.1152/physrev.00029.2005.CrossrefMedlineGoogle': [1232], 'Scholar6.': [1233], 'Deel': [1235, 1281], 'ED,': [1236, 1282], 'de': [1237, 1283, 1286, 1305, 1326], 'Kuster': [1240], 'DW,': [1241], 'Boontje': [1242, 1318], 'NM,': [1243, 1319], 'Holemans': [1244], 'Sipido': [1246, 1331], 'KR,': [1247, 1332], 'J,': [1251, 1311, 1438, 1448, 1605], 'Duncker': [1252, 1278, 1335], 'DJ.': [1253, 1336], 'Exercise': [1254, 1295], 'training': [1255, 1296, 1339], 'does': [1256], 'compensated': [1262], 'decompensated': [1264], 'ventricular': [1266, 1346], 'induced': [1268], 'stenosis.J': [1271], 'Mol': [1272], 'Cell': [1273], 'Cardiol.': [1274, 1524], '2011;': [1275, 1495, 1583], '50:1017–1025.CrossrefMedlineGoogle': [1276], 'Scholar7.': [1277], 'DJ,': [1279], 'Waard': [1284, 1306], 'MC,': [1285, 1307], 'Merkus': [1289], 'D,': [1290, 1562], 'adverse': [1298], 'remodeling.Pflugers': [1300], 'Arch.': [1301], '2014;': [1302], '466:1079–1091.MedlineGoogle': [1303], 'Scholar8.': [1304], 'Bito': [1312], 'Ozdemir': [1314], 'S,': [1315], 'Biesmans': [1316], 'L,': [1317, 1648], 'Dekkers': [1320], 'DH,': [1321], 'Schoonderwoerd': [1322], 'K,': [1323, 1450, 1589, 1603, 1642], 'Schuurbiers': [1324], 'HC,': [1325], 'Crom': [1327], 'R,': [1328, 1444, 1638, 1640], 'Stienen': [1329], 'GJ,': [1330], 'Lamers': [1333], 'JM,': [1334], 'Early': [1337], 'normalizes': [1340], 'myofilament': [1341], 'attenuates': [1344], 'pump': [1347], 'mice': [1350], 'large': [1353], 'infarction.Circ': [1355], 'Res.': [1356, 1494], '2007;': [1357], '100:1079–1088.': [1358], '10.1161/01.RES.0000262655.16373.37.LinkGoogle': [1360], 'Scholar9.': [1361], 'Parbhudayal': [1368], 'RY,': [1369], 'Michels': [1370], 'Disease': [1383, 1727], 'stage-dependent': [1384], 'contractile': [1388], 'performance': [1389], 'inherited': [1399], 'cardiomyopathy.Circ': [1401], '2017;': [1404, 1476, 1525], '10:e005604.LinkGoogle': [1405], 'Scholar10.': [1406], 'Pai': [1407], 'RG,': [1408], 'Kapoor': [1409], 'Bansal': [1411], 'RC,': [1412], 'Varadarajan': [1413], 'Malignant': [1415], 'natural': [1416], 'history': [1417], 'stenosis:': [1422], 'replacement.Ann': [1427], 'Thorac': [1428], 'Surg.': [1429], '82:2116–2122.': [1431], '10.1016/j.athoracsur.2006.07.043.CrossrefMedlineGoogle': [1433], 'Scholar11.': [1434], 'NHS,': [1436], 'Sörensen': [1437], 'Kim': [1441], 'WY,': [1442], 'Nielsen': [1443], 'Tolbod': [1445], 'LP,': [1446], 'Frokiaer': [1447], 'Bouchelouche': [1449], 'Dodt': [1451], 'KK,': [1452], 'Sihm': [1453], 'I,': [1454, 1599], 'Poulsen': [1455], 'SH,': [1456], 'Wiggers': [1457], 'H.': [1458], 'reduces': [1460], 'aymptomatic': [1466], 'trial.Circ': [1473], '10:e006557.': [1477], '10.1161/CIRCIMAGING.117.006557.LinkGoogle': [1479], 'Scholar12.': [1480], 'Lionetti': [1481], 'Stanley': [1483, 1530], 'WC,': [1484, 1531], 'Recchia': [1485, 1532], 'FA.': [1486], 'Modulating': [1487], 'acid': [1489], 'failure.Cardiovasc': [1493], '90:202–209.': [1496], '10.1093/cvr/cvr038.CrossrefMedlineGoogle': [1498], 'Scholar13.': [1499], 'De': [1500], 'Jong': [1501], 'KA,': [1502], 'Lopaschuk': [1503, 1534], 'GD.': [1504, 1535], 'Complex': [1505], 'preserved': [1513], 'fraction': [1515], 'fraction.Can': [1522], '33:860–871.': [1526], '10.1016/j.cjca.2017.03.009.CrossrefMedlineGoogle': [1528], 'Scholar14.': [1529], 'FA,': [1533], 'heart.Physiol': [1544], '2005;': [1546], '85:1093–1129.': [1547], '10.1152/physrev.00006.2004.CrossrefMedlineGoogle': [1549], 'Scholar15.': [1550], 'Heather': [1551], 'LC,': [1552], 'Howell': [1553], 'NJ,': [1554], 'Emmanuel': [1555], 'Y,': [1556], 'Cole': [1557], 'MA,': [1558], 'Frenneaux': [1559, 1612], 'MP,': [1560], 'Pagano': [1561], 'Clarke': [1563], 'K.': [1564], 'Changes': [1565], 'mirror': [1573], 'stenosis.PLoS': [1581], 'One.': [1582], '6:e26326.': [1584], '10.1371/journal.pone.0026326.CrossrefMedlineGoogle': [1586], 'Scholar16.': [1587], 'Abozguia': [1588], 'Elliott': [1590], 'McKenna': [1592], 'Phan': [1594], 'TT,': [1595], 'Nallur-Shivu': [1596], 'G,': [1597], 'Ahmed': [1598], 'Maher': [1600], 'AR,': [1601], 'Kaur': [1602], 'Taylor': [1604], 'Henning': [1606], 'Ashrafian': [1608], 'Watkins': [1610], 'modulator': [1615], 'perhexiline': [1616], 'corrects': [1617], 'improves': [1621], 'cardiomyopathy.Circulation.': [1627], '2010;': [1628], '122:1562–1569.': [1629], '10.1161/CIRCULATIONAHA.109.934059.LinkGoogle': [1631], 'Scholar17.': [1632], 'Christensen': [1633], 'NL,': [1634], 'Dahl': [1635], 'JS,': [1636], 'Carter-Storch': [1637], 'Bakkestrøm': [1639], 'Jensen': [1641], 'Steffensen': [1643], 'FH,': [1644], 'Søndergaard': [1645], 'EV,': [1646], 'Videbæk': [1647], 'Møller': [1649], 'JE.': [1650], 'Association': [1651], 'dilatation': [1655], 'invasive': [1657], 'hemodynamics': [1658], 'stenosis.Circ': [1667], '2016;': [1670], '9:e005156.LinkGoogle': [1671], 'Scholar': [1672], 'Back': [1674], 'top': [1676], 'Next': [1677], 'FiguresReferencesRelatedDetailsRelated': [1678], 'articlesMetoprolol': [1679], 'PatientsNils': [1690], 'Henrik': [1691], 'Hansson,': [1692], 'al.': [1694], '2017;10': [1698], 'October': [1699], '2017Vol': [1700], 'Issue': [1702], '10': [1703], 'Advertisement': [1704, 1723], 'InformationMetrics': [1706], '©': [1707], '2017': [1708, 1717], 'Association,': [1711], 'Inc.https://doi.org/10.1161/CIRCIMAGING.117.007015PMID:': [1712], '28956777': [1713], 'publishedSeptember': [1715], 'Keywordsaortic': [1718], 'stenosismyocardiumdiastoleEditorialsoxygen': [1720], 'consumptionhypertrophyPDF': [1721], 'download': [1722], 'SubjectsClinical': [1724], 'StudiesHypertrophyRemodelingTreatmentValvular': [1725]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2758335486', 'counts_by_year': [{'year': 2019, 'cited_by_count': 1}], 'updated_date': '2024-09-19T01:34:29.432128', 'created_date': '2017-10-06'}