Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2757819788', 'doi': 'https://doi.org/10.1038/nrm.2017.86', 'title': 'Mechanistic insights into precursor messenger RNA splicing by the spliceosome', 'display_name': 'Mechanistic insights into precursor messenger RNA splicing by the spliceosome', 'publication_year': 2017, 'publication_date': '2017-09-27', 'ids': {'openalex': 'https://openalex.org/W2757819788', 'doi': 'https://doi.org/10.1038/nrm.2017.86', 'mag': '2757819788', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28951565'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/nrm.2017.86', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S196724125', 'display_name': 'Nature Reviews Molecular Cell Biology', 'issn_l': '1471-0072', 'issn': ['1471-0072', '1471-0080'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100610126', 'display_name': 'Yigong Shi', 'orcid': 'https://orcid.org/0000-0003-2030-168X'}, 'institutions': [{'id': 'https://openalex.org/I99065089', 'display_name': 'Tsinghua University', 'ror': 'https://ror.org/03cve4549', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I99065089']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Yigong Shi', 'raw_affiliation_strings': ['Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, 100084, Beijing, China'], 'affiliations': [{'raw_affiliation_string': 'Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, 100084, Beijing, China', 'institution_ids': ['https://openalex.org/I99065089']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5100610126'], 'corresponding_institution_ids': ['https://openalex.org/I99065089'], 'apc_list': None, 'apc_paid': None, 'fwci': 4.725, 'has_fulltext': False, 'cited_by_count': 339, 'citation_normalized_percentile': {'value': 0.999735, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '18', 'issue': '11', 'first_page': '655', 'last_page': '670'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10604', 'display_name': 'Regulation of RNA Processing and Function', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10604', 'display_name': 'Regulation of RNA Processing and Function', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10521', 'display_name': 'Ribosome Structure and Translation Mechanisms', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11482', 'display_name': 'RNA Methylation and Modification in Gene Expression', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/spliceosome', 'display_name': 'Spliceosome', 'score': 0.98079705}, {'id': 'https://openalex.org/keywords/minor-spliceosome', 'display_name': 'Minor spliceosome', 'score': 0.7631316}, {'id': 'https://openalex.org/keywords/polypyrimidine-tract', 'display_name': 'Polypyrimidine tract', 'score': 0.64032555}, {'id': 'https://openalex.org/keywords/rna-structure', 'display_name': 'RNA Structure', 'score': 0.580857}, {'id': 'https://openalex.org/keywords/trna-fragments', 'display_name': 'tRNA fragments', 'score': 0.556364}, {'id': 'https://openalex.org/keywords/rna-phase-transitions', 'display_name': 'RNA Phase Transitions', 'score': 0.53627}, {'id': 'https://openalex.org/keywords/rna-methylation', 'display_name': 'RNA methylation', 'score': 0.536002}, {'id': 'https://openalex.org/keywords/mrna-modification', 'display_name': 'mRNA modification', 'score': 0.520649}, {'id': 'https://openalex.org/keywords/splicing-factor', 'display_name': 'Splicing factor', 'score': 0.48601443}, {'id': 'https://openalex.org/keywords/precursor-mrna', 'display_name': 'Precursor mRNA', 'score': 0.48586294}, {'id': 'https://openalex.org/keywords/exonic-splicing-enhancer', 'display_name': 'Exonic splicing enhancer', 'score': 0.4323571}], 'concepts': [{'id': 'https://openalex.org/C40000846', 'wikidata': 'https://www.wikidata.org/wiki/Q915868', 'display_name': 'Spliceosome', 'level': 5, 'score': 0.98079705}, {'id': 'https://openalex.org/C54458228', 'wikidata': 'https://www.wikidata.org/wiki/Q237218', 'display_name': 'RNA splicing', 'level': 4, 'score': 0.9244496}, {'id': 'https://openalex.org/C60542250', 'wikidata': 'https://www.wikidata.org/wiki/Q21105762', 'display_name': 'Minor spliceosome', 'level': 5, 'score': 0.7631316}, {'id': 'https://openalex.org/C72994624', 'wikidata': 'https://www.wikidata.org/wiki/Q7226900', 'display_name': 'Polypyrimidine tract', 'level': 5, 'score': 0.64032555}, {'id': 'https://openalex.org/C94671646', 'wikidata': 'https://www.wikidata.org/wiki/Q207551', 'display_name': 'Intron', 'level': 3, 'score': 0.5558134}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5301393}, {'id': 'https://openalex.org/C73758832', 'wikidata': 'https://www.wikidata.org/wiki/Q7578564', 'display_name': 'Splicing factor', 'level': 5, 'score': 0.48601443}, {'id': 'https://openalex.org/C102063271', 'wikidata': 'https://www.wikidata.org/wiki/Q7243183', 'display_name': 'Precursor mRNA', 'level': 5, 'score': 0.48586294}, {'id': 'https://openalex.org/C194583182', 'wikidata': 'https://www.wikidata.org/wiki/Q21114084', 'display_name': 'Alternative splicing', 'level': 4, 'score': 0.44710618}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.445862}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.43776482}, {'id': 'https://openalex.org/C42576000', 'wikidata': 'https://www.wikidata.org/wiki/Q5420618', 'display_name': 'Exonic splicing enhancer', 'level': 5, 'score': 0.4323571}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.43052703}, {'id': 'https://openalex.org/C105580179', 'wikidata': 'https://www.wikidata.org/wiki/Q188928', 'display_name': 'Messenger RNA', 'level': 3, 'score': 0.4163273}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.38438326}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.2575783}], 'mesh': [{'descriptor_ui': 'D012322', 'descriptor_name': 'RNA Precursors', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D012326', 'descriptor_name': 'RNA Splicing', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D016337', 'descriptor_name': 'RNA, Catalytic', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D017381', 'descriptor_name': 'Spliceosomes', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018360', 'descriptor_name': 'Crystallography, X-Ray', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008854', 'descriptor_name': 'Microscopy, Electron', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012322', 'descriptor_name': 'RNA Precursors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012322', 'descriptor_name': 'RNA Precursors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012322', 'descriptor_name': 'RNA Precursors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012326', 'descriptor_name': 'RNA Splicing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016337', 'descriptor_name': 'RNA, Catalytic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016337', 'descriptor_name': 'RNA, Catalytic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016337', 'descriptor_name': 'RNA, Catalytic', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017381', 'descriptor_name': 'Spliceosomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017381', 'descriptor_name': 'Spliceosomes', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017381', 'descriptor_name': 'Spliceosomes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/nrm.2017.86', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S196724125', 'display_name': 'Nature Reviews Molecular Cell Biology', 'issn_l': '1471-0072', 'issn': ['1471-0072', '1471-0080'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28951565', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Zero hunger', 'id': 'https://metadata.un.org/sdg/2', 'score': 0.49}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 168, 'referenced_works': ['https://openalex.org/W133794913', 'https://openalex.org/W1530522395', 'https://openalex.org/W1553769217', 'https://openalex.org/W155939263', 'https://openalex.org/W1574133493', 'https://openalex.org/W1594437264', 'https://openalex.org/W1597533137', 'https://openalex.org/W1642715359', 'https://openalex.org/W1660995962', 'https://openalex.org/W177901988', 'https://openalex.org/W1784525375', 'https://openalex.org/W1812124372', 'https://openalex.org/W1812165257', 'https://openalex.org/W1874585174', 'https://openalex.org/W1876329184', 'https://openalex.org/W1893343372', 'https://openalex.org/W1918332224', 'https://openalex.org/W1924714349', 'https://openalex.org/W1965137486', 'https://openalex.org/W1968223204', 'https://openalex.org/W1968322556', 'https://openalex.org/W1968843636', 'https://openalex.org/W1971314065', 'https://openalex.org/W1973976973', 'https://openalex.org/W1974108684', 'https://openalex.org/W1975642325', 'https://openalex.org/W1976708319', 'https://openalex.org/W1977304564', 'https://openalex.org/W1979211031', 'https://openalex.org/W1979455742', 'https://openalex.org/W1979491817', 'https://openalex.org/W1979564291', 'https://openalex.org/W1979765627', 'https://openalex.org/W1979907792', 'https://openalex.org/W1980424685', 'https://openalex.org/W1982610079', 'https://openalex.org/W1983568945', 'https://openalex.org/W1984116290', 'https://openalex.org/W1985475442', 'https://openalex.org/W1988455121', 'https://openalex.org/W1994261379', 'https://openalex.org/W1994898384', 'https://openalex.org/W1995478437', 'https://openalex.org/W1996948250', 'https://openalex.org/W2000713154', 'https://openalex.org/W2002337973', 'https://openalex.org/W2004005433', 'https://openalex.org/W2004055568', 'https://openalex.org/W2005302570', 'https://openalex.org/W2006628267', 'https://openalex.org/W2008139645', 'https://openalex.org/W2008422577', 'https://openalex.org/W2009103135', 'https://openalex.org/W2011223230', 'https://openalex.org/W2012565885', 'https://openalex.org/W2015670742', 'https://openalex.org/W2015677193', 'https://openalex.org/W2016156986', 'https://openalex.org/W2021054898', 'https://openalex.org/W2021585897', 'https://openalex.org/W2021783076', 'https://openalex.org/W2022346667', 'https://openalex.org/W2028265213', 'https://openalex.org/W2029751805', 'https://openalex.org/W2032508482', 'https://openalex.org/W2034793790', 'https://openalex.org/W2035133245', 'https://openalex.org/W2035956243', 'https://openalex.org/W2036764180', 'https://openalex.org/W2039749338', 'https://openalex.org/W2041421251', 'https://openalex.org/W2042477053', 'https://openalex.org/W2042811802', 'https://openalex.org/W2043472165', 'https://openalex.org/W2043583718', 'https://openalex.org/W2048630205', 'https://openalex.org/W2050858058', 'https://openalex.org/W2051539253', 'https://openalex.org/W2051694176', 'https://openalex.org/W2052745709', 'https://openalex.org/W2055138542', 'https://openalex.org/W2055688390', 'https://openalex.org/W2057990302', 'https://openalex.org/W2061420032', 'https://openalex.org/W2063206231', 'https://openalex.org/W2063749542', 'https://openalex.org/W2065262709', 'https://openalex.org/W2067838228', 'https://openalex.org/W2073105366', 'https://openalex.org/W2073548475', 'https://openalex.org/W2073601378', 'https://openalex.org/W2073766088', 'https://openalex.org/W2074030375', 'https://openalex.org/W2075362101', 'https://openalex.org/W2076992915', 'https://openalex.org/W2083520043', 'https://openalex.org/W2086913724', 'https://openalex.org/W2088259533', 'https://openalex.org/W2088264444', 'https://openalex.org/W2089775351', 'https://openalex.org/W2090041541', 'https://openalex.org/W2090643890', 'https://openalex.org/W2091377102', 'https://openalex.org/W2092801170', 'https://openalex.org/W2096352855', 'https://openalex.org/W2097001400', 'https://openalex.org/W2098906256', 'https://openalex.org/W2099583309', 'https://openalex.org/W2100065623', 'https://openalex.org/W2100179968', 'https://openalex.org/W2101204654', 'https://openalex.org/W2101536272', 'https://openalex.org/W2106967677', 'https://openalex.org/W2109618665', 'https://openalex.org/W2110090133', 'https://openalex.org/W2111064166', 'https://openalex.org/W2112412611', 'https://openalex.org/W2112590565', 'https://openalex.org/W2113018057', 'https://openalex.org/W2113656515', 'https://openalex.org/W2115101918', 'https://openalex.org/W2116382753', 'https://openalex.org/W2119513326', 'https://openalex.org/W2122071753', 'https://openalex.org/W2122427014', 'https://openalex.org/W2123289678', 'https://openalex.org/W2125959590', 'https://openalex.org/W2127843422', 'https://openalex.org/W2130577330', 'https://openalex.org/W2132505931', 'https://openalex.org/W2134006604', 'https://openalex.org/W2135972242', 'https://openalex.org/W2139033823', 'https://openalex.org/W2139239967', 'https://openalex.org/W2139966953', 'https://openalex.org/W2141518039', 'https://openalex.org/W2143069067', 'https://openalex.org/W2143350291', 'https://openalex.org/W2144846867', 'https://openalex.org/W2146008294', 'https://openalex.org/W2156318993', 'https://openalex.org/W2157070284', 'https://openalex.org/W2158991904', 'https://openalex.org/W2161666622', 'https://openalex.org/W2162106282', 'https://openalex.org/W2162338462', 'https://openalex.org/W2163686989', 'https://openalex.org/W2163793704', 'https://openalex.org/W2169345229', 'https://openalex.org/W2193225046', 'https://openalex.org/W2225521622', 'https://openalex.org/W2259134357', 'https://openalex.org/W2276393280', 'https://openalex.org/W2287289125', 'https://openalex.org/W2413340136', 'https://openalex.org/W2487288428', 'https://openalex.org/W2489507000', 'https://openalex.org/W2505052752', 'https://openalex.org/W2518229206', 'https://openalex.org/W2529778903', 'https://openalex.org/W2560980003', 'https://openalex.org/W2576357496', 'https://openalex.org/W257763096', 'https://openalex.org/W2577714543', 'https://openalex.org/W2579762306', 'https://openalex.org/W280710876', 'https://openalex.org/W4237655687', 'https://openalex.org/W89844765'], 'related_works': ['https://openalex.org/W4389433811', 'https://openalex.org/W3191209598', 'https://openalex.org/W3110942791', 'https://openalex.org/W2378923910', 'https://openalex.org/W2165535624', 'https://openalex.org/W2156762274', 'https://openalex.org/W2153284218', 'https://openalex.org/W2134366891', 'https://openalex.org/W2120914446', 'https://openalex.org/W2112662863'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2757819788', 'counts_by_year': [{'year': 2024, 'cited_by_count': 31}, {'year': 2023, 'cited_by_count': 46}, {'year': 2022, 'cited_by_count': 57}, {'year': 2021, 'cited_by_count': 54}, {'year': 2020, 'cited_by_count': 58}, {'year': 2019, 'cited_by_count': 47}, {'year': 2018, 'cited_by_count': 41}, {'year': 2017, 'cited_by_count': 2}], 'updated_date': '2024-09-18T19:07:46.620378', 'created_date': '2017-10-06'}