Title: Recent progress of national banking project on homozygous <scp>HLA</scp> ‐typed induced pluripotent stem cells in <scp>S</scp> outh <scp>K</scp> orea
Abstract: Journal of Tissue Engineering and Regenerative MedicineVolume 12, Issue 3 p. e1531-e1536 SHORT COMMUNICATION Recent progress of national banking project on homozygous HLA-typed induced pluripotent stem cells in South Korea Yeri Alice Rim, Yeri Alice Rim orcid.org/0000-0001-9541-3075 CiSTEM Laboratory, Catholic iPSC Research Center, College of Medicine, The Catholic University of Korea, Seoul, 137-701 Republic of Korea Department of Internal Medicine, Seoul St. Mary's Hospital, Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaSearch for more papers by this authorNarae Park, Narae Park CiSTEM Laboratory, Catholic iPSC Research Center, College of Medicine, The Catholic University of Korea, Seoul, 137-701 Republic of Korea Department of Internal Medicine, Seoul St. Mary's Hospital, Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaSearch for more papers by this authorYoojun Nam, Yoojun Nam CiSTEM Laboratory, Catholic iPSC Research Center, College of Medicine, The Catholic University of Korea, Seoul, 137-701 Republic of Korea Department of Internal Medicine, Seoul St. Mary's Hospital, Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaSearch for more papers by this authorDong-Sik Ham, Dong-Sik Ham Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaSearch for more papers by this authorJi-Won Kim, Ji-Won Kim Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaSearch for more papers by this authorHye-Yeong Ha, Hye-Yeong Ha Division of Intractable Diseases, Center for Biomedical Sciences, Korea National Institute of Health, Cheongju, Republic of KoreaSearch for more papers by this authorJi-Won Jung, Ji-Won Jung Division of Intractable Diseases, Center for Biomedical Sciences, Korea National Institute of Health, Cheongju, Republic of KoreaSearch for more papers by this authorSeung Min Jung, Seung Min Jung Division of Rheumatology, Department of Internal Medicine, College of Medicine, Yonsei University, Seoul, Republic of KoreaSearch for more papers by this authorIn Cheol Baek, In Cheol Baek Catholic Hematopoietic Stem Cell Bank, Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaSearch for more papers by this authorSu-Yeon Kim, Su-Yeon Kim Catholic Hematopoietic Stem Cell Bank, Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaSearch for more papers by this authorTai-Gyu Kim, Tai-Gyu Kim Catholic Hematopoietic Stem Cell Bank, Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaSearch for more papers by this authorJihwan Song, Jihwan Song Department of Biomedical Science and CHA Stem Cell Institute, College of Life Science, CHA University, Seongnam, Republic of KoreaSearch for more papers by this authorJennifer Lee, Jennifer Lee CiSTEM Laboratory, Catholic iPSC Research Center, College of Medicine, The Catholic University of Korea, Seoul, 137-701 Republic of Korea Department of Internal Medicine, Seoul St. Mary's Hospital, Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaSearch for more papers by this authorSung-Hwan Park, Sung-Hwan Park Department of Internal Medicine, Seoul St. Mary's Hospital, Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaSearch for more papers by this authorNak-Gyun Chung, Nak-Gyun Chung Department of Pediatrics, Seoul St. Mary's Hospital, Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaSearch for more papers by this authorKun-Ho Yoon, Kun-Ho Yoon Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaSearch for more papers by this authorJi Hyeon Ju, Corresponding Author Ji Hyeon Ju [email protected] orcid.org/0000-0002-1381-5466 CiSTEM Laboratory, Catholic iPSC Research Center, College of Medicine, The Catholic University of Korea, Seoul, 137-701 Republic of Korea Department of Internal Medicine, Seoul St. Mary's Hospital, Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea Correspondence Ji Hyeon Ju, Division of Rheumatology, Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea. Email: [email protected] for more papers by this author Yeri Alice Rim, Yeri Alice Rim orcid.org/0000-0001-9541-3075 CiSTEM Laboratory, Catholic iPSC Research Center, College of Medicine, The Catholic University of Korea, Seoul, 137-701 Republic of Korea Department of Internal Medicine, Seoul St. Mary's Hospital, Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaSearch for more papers by this authorNarae Park, Narae Park CiSTEM Laboratory, Catholic iPSC Research Center, College of Medicine, The Catholic University of Korea, Seoul, 137-701 Republic of Korea Department of Internal Medicine, Seoul St. Mary's Hospital, Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaSearch for more papers by this authorYoojun Nam, Yoojun Nam CiSTEM Laboratory, Catholic iPSC Research Center, College of Medicine, The Catholic University of Korea, Seoul, 137-701 Republic of Korea Department of Internal Medicine, Seoul St. Mary's Hospital, Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaSearch for more papers by this authorDong-Sik Ham, Dong-Sik Ham Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaSearch for more papers by this authorJi-Won Kim, Ji-Won Kim Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaSearch for more papers by this authorHye-Yeong Ha, Hye-Yeong Ha Division of Intractable Diseases, Center for Biomedical Sciences, Korea National Institute of Health, Cheongju, Republic of KoreaSearch for more papers by this authorJi-Won Jung, Ji-Won Jung Division of Intractable Diseases, Center for Biomedical Sciences, Korea National Institute of Health, Cheongju, Republic of KoreaSearch for more papers by this authorSeung Min Jung, Seung Min Jung Division of Rheumatology, Department of Internal Medicine, College of Medicine, Yonsei University, Seoul, Republic of KoreaSearch for more papers by this authorIn Cheol Baek, In Cheol Baek Catholic Hematopoietic Stem Cell Bank, Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaSearch for more papers by this authorSu-Yeon Kim, Su-Yeon Kim Catholic Hematopoietic Stem Cell Bank, Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaSearch for more papers by this authorTai-Gyu Kim, Tai-Gyu Kim Catholic Hematopoietic Stem Cell Bank, Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaSearch for more papers by this authorJihwan Song, Jihwan Song Department of Biomedical Science and CHA Stem Cell Institute, College of Life Science, CHA University, Seongnam, Republic of KoreaSearch for more papers by this authorJennifer Lee, Jennifer Lee CiSTEM Laboratory, Catholic iPSC Research Center, College of Medicine, The Catholic University of Korea, Seoul, 137-701 Republic of Korea Department of Internal Medicine, Seoul St. Mary's Hospital, Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaSearch for more papers by this authorSung-Hwan Park, Sung-Hwan Park Department of Internal Medicine, Seoul St. Mary's Hospital, Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaSearch for more papers by this authorNak-Gyun Chung, Nak-Gyun Chung Department of Pediatrics, Seoul St. Mary's Hospital, Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaSearch for more papers by this authorKun-Ho Yoon, Kun-Ho Yoon Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaSearch for more papers by this authorJi Hyeon Ju, Corresponding Author Ji Hyeon Ju [email protected] orcid.org/0000-0002-1381-5466 CiSTEM Laboratory, Catholic iPSC Research Center, College of Medicine, The Catholic University of Korea, Seoul, 137-701 Republic of Korea Department of Internal Medicine, Seoul St. Mary's Hospital, Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea Correspondence Ji Hyeon Ju, Division of Rheumatology, Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea. Email: [email protected] for more papers by this author First published: 23 September 2017 https://doi.org/10.1002/term.2578Citations: 21Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Induced pluripotent stem cells (iPSCs) can be generated by introducing several factors into mature somatic cells. Banking of iPSCs can lead to wider application for treatment and research. In an economical view, it is important to store cells that can cover a high percentage of the population. Therefore, the use of homozygous human leukocyte antigen-iPSCs (HLA-iPSCs) is thought as a potential candidate for effective iPSC banking system for further clinical use. We screened the database stored in the Catholic Hematopoietic Stem Cell Bank of Korea and sorted the most frequent homozygous HLA types of the South Korean population. Blood cells with the selected homozygous HLA types were obtained and transferred to the GMP facility in the Catholic Institute of Cell Therapy. Cells were reprogrammed to iPSCs inside the facility and went through several quality controls. As a result, a total of 13 homozygous GMP-grade iPSC lines were obtained in the facility. The generated iPSCs showed high pluripotency and normal karyotype after reprogramming. Five HLA-homozygous iPSCs had the type that was included in the top five most frequent HLA types. Homozygous HLA-iPSCs can open a new opportunity for further application of iPSCs in clinical research and therapy. Citing Literature Volume12, Issue3March 2018Pages e1531-e1536 RelatedInformation