Snapin promotes <scp>HIV</scp> ‐1 transmission from dendritic cells by dampening <scp>TLR</scp> 8 signaling

Name: Work Video:
Duration: 3 min 30 s
Elham Khatamzas; M. Hipp; Daniel Gaughan; Tica Pichulik; Alasdair Leslie; Ricardo A. Fernandes; Daniele Muraro; Sarah Booth; Kieran Zausmer; Meiyi Sun; Benedikt M. Kessler; Sarah Rowland‐Jones; Vincenzo Cerundolo; Alison Simmons
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543, 635, 637, 740, 748], 'Booth': [190, 192, 542, 544], 'Immunotherapy,': [195, 547, 796], 'College': [196, 548, 797], 'Medical': [198, 550, 799], 'Dental': [200, 552, 801], 'Sciences,': [201, 553, 802], 'Birmingham,': [204, 205, 556, 557, 805, 806], 'Kieran': [214, 216, 566, 568, 742], 'Zausmer': [215, 217, 567, 569], 'Mei-Yi': [238, 240, 590, 592, 744], 'Sun': [239, 241, 591, 593], 'Benedikt': [262, 264, 614, 616, 746], 'Kessler': [263, 265, 615, 617], 'Rowland-Jones': [284, 286, 636, 638], 'Nuffield': [287, 354, 639, 706, 822], 'Department': [288, 355, 640, 707, 809, 823], 'Clinical': [290, 642, 811], 'NDMRB,': [295, 647, 816], 'Vincenzo': [305, 307, 657, 659, 750], 'Cerundolo': [306, 308, 658, 660], 'Alison': [329, 333, 681, 685, 753], 'Simmons': [330, 334, 682, 686, 754], 'Corresponding': [331, 683], 'Author': [332, 684, 722], '[email': [335, 687, 846], 'protected]': [336, 688, 847], 'orcid.org/0000-0003-3454-0710': [337, 689], 'Translational': [351, 703], 'Gastroenterology': [352, 704, 820], 'Information': [723], 'Khatamzas1,‡,': [725], 'Hipp1,‡,': [728], 'Gaughan1,': [730], 'Pichulik1,': [732], 'Leslie2,': [734], 'Fernandes3,': [737], 'Muraro1,': [739], 'Booth4,': [741], 'Zausmer1,': [743], 'Sun1,': [745], 'Kessler2,': [747], 'Rowland-Jones5,': [749], 'Cerundolo1': [751], '*,1,6': [755], '1MRC': [756], '2KwaZulu-Natal': [769], '3Molecular': [779], '4Immunology': [794], '5Nuffield': [808], '6Translational': [819], '‡These': [831], 'authors': [832], 'contributed': [833], 'equally': [834], 'to': [835, 878, 881, 899, 909, 1037, 1053, 1056, 1092, 1108, 1139, 1161, 1213, 1218, 1337, 1417, 1487, 1516, 1546, 1575, 1595, 1606, 1635, 1657, 1665, 1693, 1713, 1722, 1766, 1772, 1775, 1787, 1839, 1904, 1961, 2058, 2114, 2236, 2243, 2274, 2287, 2342, 2367, 2399, 2453, 2467, 2495, 2540, 2552, 2578, 2665, 2673, 2836, 2849, 2870, 2904, 3015, 3126, 3146, 3148, 3203, 3205, 3672, 3732, 3815, 3828, 3832, 3878, 3903, 3923, 3936, 3949, 3966, 4078, 4111, 4113, 4156, 4297], 'work': [837], '*Corresponding': [838], 'author.': [839], 'Tel:': [840], '+44': [841], '1865': [842], '222': [843], '628;': [844], 'E-mail:': [845], 'The': [848, 2032, 2302, 2509, 2527, 2781, 2900], 'EMBO': [849], 'Journal': [850], '(2017)36:2998-3011https://doi.org/10.15252/embj.201695364': [851], 'PDFDownload': [852], 'PDF': [853], 'article': [855], 'text': [856], 'main': [858], 'figures.': [859], 'Peer': [860], 'ReviewDownload': [861], 'a': [862, 901, 932, 937, 991, 1012, 1021, 1078, 1103, 1205, 1249, 1432, 1649, 1653, 1900, 2219, 2271, 2334, 2405, 2410, 2569, 2625, 2768, 2921, 2983, 3257, 3447, 3540, 3644, 3649, 3734, 3765, 3865, 4037, 4167, 4303], 'summary': [863], 'the': [865, 923, 956, 974, 1006, 1045, 1098, 1141, 1148, 1220, 1234, 1240, 1243, 1263, 1277, 1281, 1289, 1356, 1377, 1398, 1455, 1517, 1533, 1573, 1597, 1620, 1695, 1714, 1731, 1808, 1842, 1848, 1851, 1877, 1880, 1887, 1917, 1930, 1944, 1954, 2005, 2040, 2044, 2050, 2053, 2068, 2116, 2196, 2205, 2253, 2259, 2276, 2279, 2284, 2359, 2387, 2392, 2419, 2455, 2484, 2576, 2589, 2634, 2719, 2740, 2785, 2833, 2850, 2867, 2905, 2933, 2957, 2977, 3055, 3060, 3078, 3110, 3128, 3391, 3492, 3531, 3557, 3588, 3618, 3625, 3630, 3659, 3674, 3677, 3701, 3717, 3746, 3782, 3787, 3794, 3844, 3882, 3887, 3899, 3998, 4027, 4063, 4132, 4226], 'editorial': [866, 870], 'decision': [867, 871], 'including': [869, 973], 'letters,': [872], 'reviewer': [873], 'comments': [874], 'responses': [877, 1124, 1167, 1321, 1492, 1524, 1529, 1610, 1638, 3831], 'feedback.': [879], 'ToolsAdd': [880], 'favoritesDownload': [882], 'CitationsTrack': [883], 'CitationsPermissions': [884], 'ShareFacebookTwitterLinked': [885], 'InMendeleyWechatReddit': [886], 'Figures': [887], 'Info': [889], 'Abstract': [890], 'traffics': [892], 'through': [893, 2914, 4012], '(DCs)': [896, 1052, 1131], 'en': [897], 'route': [898], 'establishing': [900], 'productive': [902], 'infection': [903, 1369, 2227, 2497, 3452, 3472, 3858], 'in': [904, 971, 1005, 1030, 1049, 1071, 1125, 1147, 1225, 1233, 1340, 1355, 1397, 1469, 1530, 1539, 1589, 1627, 1685, 1699, 1737, 1760, 1850, 1879, 1916, 2011, 2020, 2071, 2119, 2142, 2153, 2162, 2195, 2204, 2252, 2306, 2382, 2391, 2396, 2425, 2433, 2462, 2601, 2604, 2646, 2653, 2701, 2739, 2830, 2930, 3047, 3059, 3133, 3216, 3263, 3289, 3298, 3319, 3362, 3473, 3509, 3517, 3556, 3581, 3596, 3604, 3629, 3638, 3695, 3716, 3786, 3805, 3811, 3834, 3849, 3881, 3891, 3908, 3993, 4014, 4026, 4062, 4080, 4285, 4310], 'T': [905, 969, 999, 1057, 1110, 1196, 1419, 1680, 2401, 2469, 2507, 2580, 2703, 3211, 3219, 3816], 'lymphocytes': [906, 1197], 'but': [907, 1483], 'fails': [908, 1486], 'induce': [910], 'an': [911, 1085, 1348, 1689, 2941], 'innate': [912, 1025, 1046, 1165, 1390, 2371, 3830], 'immune': [913, 1026, 1047, 1166, 1251, 1257, 4010], 'response.': [914], 'Within': [915, 1276], 'DC': [916, 1764, 1912, 2280, 2394, 3217], 'endosomes,': [917, 989, 1409], 'somehow': [919, 1485], 'evades': [920, 1042, 1155, 1406], 'detection': [921, 1043, 1156, 1224, 1267, 1312, 1407, 1781, 2372, 3880], 'pattern-recognition': [924, 1440], 'receptor': [925, 928, 1446], '(PRR)': [926], 'Toll-like': [927, 1445], '8': [929, 1447], '(TLR8).': [930], 'Using': [931, 2409], 'phosphoproteomic': [933, 1060, 1650, 1955], 'approach,': [934], 'we': [935, 1019, 1647, 2213, 2282, 3623, 3761, 3884, 4020, 4312], 'identified': [936, 957, 2038, 2214, 2814, 2863, 2913, 3841], 'robust': [938, 1489], 'diverse': [940, 2349], 'cascade': [942], 'triggered': [943, 990], 'upon': [946, 1663, 2181, 2225, 2240, 3856, 3910], 'entry': [947, 1091, 1664, 1903, 2242, 2341, 2565], 'into': [948, 1394, 2566], 'human': [949, 2261, 4038], 'DCs.': [950, 1093, 1126, 1531, 2229, 3639, 4016, 4161], 'secondary': [952, 1062, 1654, 2406, 2635], 'siRNA': [953, 1063, 1095, 1655, 2407, 2446, 2622], 'screen': [954, 1064, 1096, 1656, 2623, 2637, 2741, 2757], 'factors': [959, 1335, 2793, 2806], 'revealed': [960, 3977], 'several': [961], 'new': [962, 1022, 4291], 'mediators': [963], 'trans-infection': [966, 996, 1194, 1422, 1641, 1676, 2383, 2398, 2464, 2512, 2534, 2551, 2574, 2594, 2629, 2796, 2825, 2841, 2964, 2988, 3083, 3098, 3130, 3576, 3582, 3814], 'CD4+': [968, 998, 1109, 1418, 1679, 2400, 2468, 2506, 2521, 2579, 2677, 2702, 3210, 3218], 'DCs,': [972, 1031, 1159, 1470, 3812, 3860, 4311], 'dynein': [975, 1099, 2978, 3518, 3525, 3558, 3589, 3795, 3823], 'motor': [976, 1100, 2979, 3495], 'protein': [977, 1845, 2021, 2054, 2309, 2907, 2980, 3662, 3681], 'Snapin.': [978, 4032], 'Inhibition': [979], 'enhanced': [982, 3829, 3931, 3950, 3999], 'localization': [983, 1115, 2829, 3631, 3675, 4025, 4095], 'with': [986, 1116, 1373, 1865, 2348, 2358, 2431, 2481, 2504, 2648, 2675, 2686, 2713, 2917, 3008, 3102, 3139, 3163, 3183, 3189, 3209, 3226, 3241, 3267, 3302, 3327, 3343, 3399, 3441, 3446, 3453, 3465, 3468, 3539, 3643, 3764, 3917, 4046, 4057, 4096, 4102, 4131, 4166, 4185, 4192, 4234], 'TLR8+': [987], 'early': [988, 1118, 1266, 3683, 3702, 3788, 3973], 'pro-inflammatory': [992, 1123, 1527], 'response,': [993], 'inhibited': [995, 1002], 'cells.': [1000, 1111, 1681, 2508, 2704, 3212, 3294, 3324, 3368], 'absence': [1007, 1920, 4030, 4064], 'is': [1011, 1033, 1077, 1211, 1414, 1428, 1473, 1580, 2362, 2638, 2822, 2940, 3045, 3052, 3094, 3480, 3609, 3791, 3876, 4295], 'general': [1013], 'regulator': [1014, 3867], 'endosomal': [1016, 1587, 2906, 3032, 3483, 3489, 3605, 3684, 3688, 3704, 3719, 3850], 'maturation.': [1017], 'Thus,': [1018, 2212, 2563, 3802], 'identify': [1020, 1670], 'mechanism': [1023], 'sensing': [1027, 1391], 'which': [1032, 1247, 1287, 1536, 1818, 2886, 2897, 3818, 3847], 'exploited': [1034], 'promote': [1038], 'transmission.': [1039, 1082, 2584], 'Synopsis': [1040], 'system': [1048, 2722, 3062, 4135], 'facilitate': [1054, 2376], 'spreading': [1055], 'lymphocytes.': [1058], 'identifies': [1065, 1097], 'pathways': [1067, 2083, 2305, 2605], 'induced': [1068, 1088, 1660, 1701], 'DCs': [1072, 1226, 1341, 1371, 1395, 1540, 1590, 1628, 1668, 1686, 1700, 1707, 1905, 1958, 2072, 2128, 2143, 2164, 2244, 2343, 2374, 2466, 2478, 2567, 2643, 2710, 2831, 3006, 3099, 3136, 3161, 3187, 3224, 3239, 3260, 3295, 3325, 3445, 3474, 3536, 3597, 3642, 3763, 3835, 3909, 3916, 3959, 4081, 4100, 4286], 'shows': [1074, 1758, 3157, 3175, 3283, 3313, 3356, 4200], 'that': [1075, 1136, 1210, 1260, 1350, 1431, 1514, 1583, 1634, 2200, 2221, 2331, 2344, 2355, 2572, 2597, 2967, 3781, 4007, 4072], 'mediator': [1079, 1104], 'Phosphoproteomics': [1083], 'map': [1084], 'signalosome': [1087, 1901, 2220, 2395], 'on': [1089, 1902, 2170, 2258, 2418, 2588, 2751, 2962, 2986, 2997, 3533, 4307], 'viral': [1090, 1190, 1228, 1315, 1477, 1558, 3968], 'Secondary': [1094, 2621], 'as': [1102, 1444, 1471, 1501, 1730, 2028, 2056, 2138, 2422, 2607, 2630, 2732, 3000, 3256, 3262, 3297, 3384, 3776, 3852, 3864, 3934, 3970, 4219], 'reduces': [1113], 'TLR8-expressing': [1117], 'endosomes.': [1119, 4089], 'dampens': [1121], 'HIV-1-mediated': [1122], 'Introduction': [1127], 'Myeloid': [1128], 'are': [1132, 1137, 1541, 1642, 1863, 2087, 2222, 2245, 2599, 2772, 3222, 3280, 3372, 3382, 4207, 4217, 4265], 'important': [1133, 3053], 'antigen-presenting': [1134], 'thought': [1138], 'be': [1140, 2237, 2871, 3714, 3733, 3820], 'first': [1142, 2272, 2912, 3436], 'encountered': [1144], 'mucosa': [1149], 'during': [1150, 1227, 1392, 1421, 1747], '(Borrow,': [1152], '2011).': [1153, 1309], 'myeloid': [1158], 'leading': [1160], 'defective': [1162, 3591], 'cell': [1163, 2369, 3049, 3220, 4040], 'intrinsic': [1164, 2370], '(Granelli-Piperno': [1168, 1493], 'et': [1169, 1173, 1177, 1181, 1185, 1269, 1273, 1299, 1303, 1307, 1323, 1327, 1331, 1359, 1381, 1462, 1480, 1494, 1511, 1553, 1612, 1616, 1815, 1830, 1868, 1872, 2109, 3041, 3064, 3068, 3504, 3565], 'al,': [1170, 1174, 1178, 1182, 1186, 1270, 1274, 1300, 1304, 1308, 1324, 1328, 1332, 1360, 1382, 1463, 1481, 1495, 1512, 1554, 1613, 1617, 1816, 1831, 1869, 1873, 2110, 3042, 3065, 3069, 3505, 3566], '2004;': [1171], 'Krathwohl': [1172], '2006;': [1175], 'Sabado': [1176], '2010;': [1179, 1424, 1614], 'Manel': [1180], '2011;': [1183, 1301, 1305], 'Frleta': [1184], '2012)': [1187], 'facilitating': [1189], 'spread': [1191], 'promoting': [1193, 2582, 4083], '(Menager': [1198], 'Littman,': [1200], '2016).': [1201], 'This': [1202, 1310, 3962], 'helps': [1203], 'establish': [1204], 'latent': [1206], 'reservoir': [1207], 'resistant': [1212], 'anti-retroviral': [1214], 'drugs,': [1215], 'hampering': [1216], 'efforts': [1217], 'cure': [1219], 'disease.': [1221], 'escapes': [1223], 'uptake,': [1229, 1239], 'intracellular': [1230, 2690, 2698, 3870, 4085], 'trafficking': [1231, 1571, 3033, 3807, 3871, 4086], 'cytosol': [1235], '(Luban,': [1236], '2012).': [1237, 1618], 'During': [1238], 'virus': [1241, 1264, 2577], 'binds': [1242], 'C-type': [1244], 'lectin': [1245], 'DC-SIGN,': [1246], 'triggers': [1248, 2333, 2568], 'tolerogenic': [1250], 'response': [1252, 1697, 2571], 'involving': [1253], 'downregulation': [1254], 'specific': [1256, 2716, 3635, 4296], 'molecules': [1259, 1673], 'may': [1261, 3819], 'help': [1262], 'evade': [1265, 2368, 3879], '(Hodges': [1268], '2007;': [1271], 'Shan': [1272], '2007).': [1275, 1895], 'cytosol,': [1278], 'encounters': [1280], 'deoxyribose': [1282], 'nucleoside': [1283], 'triphosphate': [1284], 'hydrolase': [1285], 'SAMHD1,': [1286], 'limits': [1288], 'efficiency': [1290, 2706], 'HIV': [1292, 1353, 1378], 'reverse': [1293], 'transcription': [1294, 1478], 'inhibits': [1296, 4009, 4074], 'replication': [1297], '(Goldstone': [1298], 'Hrecka': [1302], 'Laguette': [1306], 'prevents': [1311], 'reverse-transcribed': [1314, 1352], 'DNA': [1316, 1354], 'activation': [1318, 1518, 3905], 'interferon': [1320, 1523, 1637], '(Gao': [1322], '2013;': [1325], 'Bridgeman': [1326], '2015;': [1329], 'Gentili': [1330], '2015).': [1333], 'Other': [1334], 'contributing': [1336], 'escape': [1339], 'have': [1342, 3514, 3840], 'been': [1343, 3515, 3602], 'described': [1344, 3132], 'include': [1346], 'TREX1,': [1347], 'exonuclease': [1349], 'degrades': [1351], 'cytoplasm': [1357], '(Yan': [1358], '2010),': [1361, 1482, 1817], 'APOBEC3G/3F': [1363], '(A3G/3F)': [1364], 'whose': [1365], 'knockdown': [1366, 2528, 2968, 2992, 3074, 3293, 3323, 3656, 3930, 3947, 3984, 3995, 4160], 'enhances': [1367], 'associated': [1372, 2045, 2347], 'G-to-A': [1374], 'hypermutation': [1375], 'genome': [1379], '(Pion': [1380], '2006).': [1383], 'These': [1384, 2328, 2880, 4069], 'observations': [1385], 'explain': [1386], 'how': [1387, 1404, 1411, 1630], 'avoids': [1389], 'uptake': [1393], 'cytosol.': [1399], 'But': [1400], 'it': [1401, 1405, 1472, 1484, 4301], 'remains': [1402], 'unknown': [1403], 'within': [1408, 1437, 1563, 2338, 2874, 3634, 3682, 3700, 3743], 'internalized': [1412], 'effectively': [1415], 'transferred': [1416], '(McDonald,': [1423], 'Rinaldo,': [1425], '2013).': [1426], 'It': [1427, 3044], 'well': [1429], 'established': [1430], 'proportion': [1433], 'virions': [1435], 'reside': [1436], 'endosomes': [1438, 1574, 3810], 'where': [1439, 1734], 'receptors': [1441], '(PRRs)': [1442], 'such': [1443, 1500, 2606], '(TLR8)': [1448], 'should': [1449], 'recognize': [1450], 'single-stranded': [1451, 1502], 'RNA': [1452, 1503, 2448], 'derived': [1453, 1942], 'long': [1457], 'terminal': [1458], 'repeat': [1459], '(LTR)': [1460], '(Heil': [1461], '2004).': [1464, 1496, 2954], 'can': [1466, 4316], 'detect': [1467], 'required': [1474, 1623, 1674, 2823, 3095, 3529, 3610], 'inducing': [1476], '(Gringhuis': [1479], 'generate': [1488], 'anti-viral': [1490], 'cytokine': [1491, 1528], 'recognizes': [1498], 'ligands': [1499], 'imidazoquinolines': [1505], 'triggering': [1506], 'distinct': [1507], 'cascades': [1509], '(Colak': [1510], '2014)': [1513], 'lead': [1515], 'interferon-regulatory': [1520], 'factor': [1521, 2319], '(IRF)-dependent': [1522], 'NF-κB-dependent': [1526], 'However,': [1532, 1619], 'mechanisms': [1534], 'signals': [1538], 'poorly': [1542], 'understood': [1543], 'appear': [1545], 'differ': [1547], 'between': [1548, 1741, 2023, 2124, 2553, 3285, 3315, 3358, 3980], 'mice': [1549], 'humans': [1551], '(Ohto': [1552], '2014).': [1555], 'Recognition': [1556], 'nucleic': [1559], 'acids': [1560], 'TLRs': [1562, 1588], 'endolysosomal': [1564], 'compartments': [1565], 'often': [1566], 'requires': [1567, 1591], 'TLR': [1568], 'cleavage': [1569], 'lysosome-related': [1576, 2854], 'organelles.': [1577], 'And': [1578], 'there': [1579, 3730], 'mounting': [1581], 'evidence': [1582], 'effective': [1584], 'correct': [1592], 'spatial': [1593], 'compartmentalization': [1594], 'enable': [1596], 'juxtaposition': [1598], 'key': [1600, 3866], 'components': [1601, 1622, 2865, 3842], 'their': [1603], 'machinery': [1605, 2361, 2909], 'initiate': [1607], 'appropriate': [1608], 'transcriptional': [1609], '(Sasai': [1611], 'Mantegazza': [1615], 'molecular': [1621, 2074, 2296, 2798], 'might': [1632], 'manipulate': [1633], 'avoid': [1636], 'while': [1639], 'enhancing': [1640], 'unclear.': [1643], 'In': [1644, 2186, 3071, 3477, 3725, 3944], 'work,': [1646], 'used': [1648, 2113, 3255, 3671, 4034], 'approach': [1651, 1692, 1797, 1956, 2266], 'characterize': [1658, 1694], 'immature': [1666, 3501, 3915], 'monocyte-derived': [1667, 1706], 'those': [1671], 'autologous': [1678, 2505, 2676], 'Results': [1682, 3381, 4216], 'We': [1687, 2384, 2585, 2955, 3435, 3460, 3520, 3640, 3896, 4033], 'took': [1688], 'unbiased': [1690], 'proteomic': [1691], '(signalosome)': [1698], 'entry.': [1704], 'Immature': [1705, 2477], 'were': [1708, 1739, 1770, 1884, 1959, 1977, 1991, 2136, 2151, 2159, 2202, 2308, 2443, 2479, 2644, 2660, 2684, 2711, 2807, 2844, 2881, 2898, 3100, 3137, 3537, 4129, 4164], 'mock': [1709, 1742, 1964], 'infected': [1710, 1965, 2055, 3538, 3641, 3762], 'or': [1711, 1963, 2250, 2746, 2804, 3010, 3105, 3123, 3196, 3228, 3243, 3291, 3321, 3331, 3334, 3365, 3457, 3686, 3751, 3769, 3919, 4049, 4104, 4123, 4158, 4173, 4299], 'exposed': [1712, 1745, 1960, 2664, 3014], 'BaL': [1716, 2668], 'strain': [1717], '10': [1719, 1924, 1967, 2875, 3151, 3456, 3469], 'min': [1720, 1925, 2876, 3470], 'prior': [1721, 1786, 2494, 2672, 3125, 3145, 3202, 3922, 4110], 'lysis': [1723, 3924], 'phosphoenrichment.': [1725], 'Ten': [1726], 'minutes': [1727, 2339], 'was': [1728, 1805, 2112, 2451, 2513, 2887, 2911, 3087, 3254, 3394, 3408, 3528, 3583, 3670, 3963, 4059, 4138, 4229, 4243], 'chosen': [1729], 'time': [1732, 1748], 'point': [1733], 'greatest': [1735], 'changes': [1736, 1759, 2019, 2118], 'phosphorylation': [1738, 1762, 2120, 2179, 2194], 'observed': [1740, 3584], 'courses': [1749], 'exposure': [1752, 1765, 3147, 3204, 3912, 4112, 4155], '(data': [1753], 'not': [1754, 3755, 3964], 'shown).': [1755], 'Figure': [1756, 1896, 2096, 2619, 3091, 4090, 4274], '1A': [1757, 2097], 'tyrosine': [1761], 'following': [1763, 3585, 3727, 4153], 'HIV-1.': [1767], 'Phosphoenriched': [1768], 'eluates': [1769], 'subjected': [1771, 2283], 'off-gel': [1773], 'fractionation': [1774, 1995], 'reduce': [1776, 2837], 'sample': [1777], 'complexity': [1778], 'enhance': [1780], 'low': [1783], 'abundance': [1784, 2022, 2051], 'proteins': [1785, 2037, 2123, 2135, 2158, 2174, 2189, 2217, 2234, 2249, 2286, 2346, 2380, 2390, 2420, 2731, 2834], 'LC/MS/MS': [1788], 'analysis': [1789, 2000, 2003, 2065, 2289, 2293, 2416, 2518, 2790, 2860, 3004, 3389, 3407, 4137, 4224, 4242], '(Appendix': [1790, 2147, 2166, 2183, 2209, 2267, 2560, 3023, 3757, 3986, 4003], 'Fig': [1791, 1798, 3024, 3134, 3570, 3758, 3987, 4004], 'S1': [1792], 'schematic': [1794], 'experimental': [1796], '1B).': [1799], 'Raw': [1800], 'data': [1801, 1852, 1881, 2086, 4070, 4264], 'obtained': [1802], 'LC-MS/MS': [1804, 1999], 'processed': [1806], 'using': [1807, 1908, 2290, 2516, 2718, 3396, 3410, 4121, 4140, 4231, 4245], 'Central': [1809, 2006], 'Proteomics': [1810, 2007], 'Facilities': [1811, 2008], 'Pipeline': [1812, 2009], '(CPFP)': [1813], '(Trudgian': [1814, 2108], 'searches': [1819], 'three': [1820, 2775, 2847, 2864, 3375, 4210], 'different': [1821, 2779, 3379, 3735, 4214], 'databases:': [1822], 'Mascot': [1823], '(Matrix': [1824], 'Science,': [1825], 'London,': [1826], 'UK),': [1827], 'OMSSA': [1828], '(Geer': [1829], '2004),': [1832, 1838], 'TANDEM': [1834], '(Craig': [1835], 'Beavis,': [1837], 'increase': [1840, 1876], 'both': [1841, 2154, 3658], 'number': [1843, 2811], 'identifications': [1846, 1858], 'confidence': [1849, 1878], 'obtained.': [1853], 'On': [1854], 'platform,': [1856], 'peptide': [1857], 'each': [1860], 'search': [1861], 'engine': [1862], 'validated': [1864], 'PeptideProphet': [1866], '(Nesvizhskii': [1867], '2003;': [1870], 'Keller': [1871], '2005).': [1874], 'To': [1875, 4017, 4287], 'obtained,': [1882], 'results': [1883, 3837], 'set': [1885], 'at': [1886, 3150, 3657], '1%': [1888], 'false': [1889], 'discovery': [1890], 'rate': [1891], '(Elias': [1892], 'Gygi,': [1894], '1.': [1897], 'induces': [1899], 'A.': [1906], 'Immunoblot': [1907], 'anti-phosphotyrosine': [1909], 'antibody': [1910], 'whole-cell': [1913], 'lysates': [1914, 1990], '(WCL)': [1915], 'presence': [1918, 2206, 4028], '(lanes': [1926, 1935, 1947], '1': [1927, 2884, 4187], '2),': [1929], 'same': [1931, 1945], 'WCL': [1932, 1946], 'diluted': [1933], '1:10': [1934], '3': [1936], '4),': [1938], 'phosphoenriched': [1940, 1989], 'fractions': [1941], '5': [1948, 2640], '6).': [1950], 'B.': [1951], 'Schematic': [1952], 'used.': [1957], 'min,': [1968], 'lysed': [1969, 4117], 'enriched': [1971], 'phosphoproteins.': [1973], 'Nine': [1974], 'biological': [1975], 'replicates': [1976], 'collected,': [1978], 'pooled,': [1979], 'quantified': [1981], 'Bradford': [1983], 'dye': [1984], 'assay.': [1985], 'Equalized': [1986], 'amounts': [1987], 'separated': [1992], 'OFFGEL': [1994], 'prepared': [1997], 'before': [2001], 'bioinformatics': [2002, 2413], 'based': [2010, 2257, 2417], 'Oxford.': [2012], 'C.': [2013], 'Plot': [2014], 'showing': [2015, 2073, 2742], 'distribution': [2016], 'fold': [2018, 2047, 2117], 'mock-infected': [2026, 2059, 2127, 2163], 'samples': [2027], 'determined': [2029], 'SINQ.': [2031], 'x-axis': [2033], '(blue': [2034], 'rhombi)': [2035], 'represents': [2036, 2767, 4260], 'y-axis': [2041], '(black': [2042], 'bars)': [2043], 'log2': [2046], 'change': [2048, 3756], 'opposed': [2057], 'fractions.': [2060], 'D,': [2061], 'E.': [2062], 'Ingenuity': [2063, 2788], 'pathway': [2064, 2288, 2292, 2789], '(IPA)': [2066, 2294], 'phosphoproteome': [2070], 'cellular': [2076, 2298, 2350], 'function': [2077, 2277, 2299, 2458, 4292], '(D)': [2078, 3264, 3299], 'top': [2080, 2303], 'five': [2081], 'canonical': [2082, 2304], '(E).': [2084], 'available': [2088, 4266], 'online': [2089, 4267], 'figure.': [2092, 4270], 'Data': [2094, 3369, 3371, 4204, 4206, 4272], '[embj201695364-sup-0002-SDataFig1.pdf]': [2098], 'Download': [2099, 2101, 2817, 2819, 3431, 3433, 4277, 4279], 'figure': [2100, 2818, 3432, 4278], 'PowerPoint': [2102, 2820, 3434, 4280], 'Normalized': [2103], 'spectral': [2104], 'index': [2105], 'quantitation': [2106], '(SINQ)': [2107], '2011)': [2111], 'determine': [2115], 'levels': [2121, 2180, 2559, 2838, 3214, 3663, 3710, 3933, 4151], '(Fig': [2129, 2300, 2322, 2471, 2489, 2523, 2617, 2989, 3475, 3598, 3664, 3706, 3723, 3800, 3940, 3960, 4067], '1C).': [2130], 'total': [2132, 2231], '124': [2134], 'detected': [2137, 2421, 3215, 3461, 3715, 4152], 'being': [2139, 3853], 'exclusively': [2140, 2160], 'phosphorylated': [2141, 2161, 2224, 2239, 2424, 2873, 3855], 'treatment': [2146], 'Table': [2148, 2167, 2184, 2210, 2268, 2326, 2561], 'S1),': [2149], '134': [2150], 'present': [2152], 'conditions,': [2155], '48': [2157, 2492, 2657, 2725], 'alone': [2165], 'S2).': [2168, 3025], 'Based': [2169], 'SINQ': [2171], 'analysis,': [2172], '68': [2173], 'had': [2175, 2861, 2982, 2993, 3077], '>': [2176, 2191], '1.25-fold': [2177], 'higher': [2178], 'HIV-1-infection': [2182], 'S3).': [2185], 'comparison,': [2187], '66': [2188], 'displayed': [2190], '0.75-fold': [2192], 'less': [2193], 'HIV-1-infected': [2197, 4015], 'fractions,': [2198], 'indicating': [2199], 'they': [2201, 2843], 'dephosphorylated': [2203], 'S4).': [2211, 3759], '306': [2215, 2285], 'candidate': [2216], 'differentially': [2223, 2238, 2423, 2872, 3854], '167': [2233], 'found': [2235, 2596, 2835, 2966], 'known': [2246], 'interacting': [2248], 'involved': [2251, 2381, 2600], 'life': [2255], 'cycle': [2256], 'interaction': [2262, 2357], 'database': [2263], 'validating': [2264], 'our': [2265, 2426, 3072], 'S5).': [2269, 3988], 'As': [2270], 'step': [2273], 'identifying': [2275], 'signalosome,': [2281], 'ingenuity': [2291], '1D).': [2301], 'IPA': [2307, 2587], 'ubiquitination,': [2310, 2436], 'amyloid': [2311], 'processing,': [2312], 'antigen': [2313], 'presentation,': [2314], 'glycolysis/gluconeogenesis,': [2315], 'insulin-like': [2317], 'growth': [2318], '(IGF)-1': [2320], '1E': [2323], 'Appendix': [2325, 3569], 'S6).': [2327], 'findings': [2329], 'reveal': [2330], 'complex': [2335, 2856, 2869, 2902, 2943, 3112], 'event': [2337], 'involves': [2345], 'processes.': [2351], 'Altogether,': [2352], 'indicates': [2354, 2784, 2810], 'active': [2356], 'host': [2360, 2792], 'employed': [2363], 'likely': [2366], 'trans-infection.': [2377, 2753, 2764, 3535, 3873], 'Discovery': [2378], 'next': [2385, 3885], 'investigated': [2386, 3089], 'role': [2388, 3626, 3888], 'conducting': [2404], 'screen.': [2408], 'combination': [2411], 'literature': [2415], 'primary': [2427], 'screen,': [2428], '125': [2429], 'genes': [2430, 2461, 2531, 2545, 2591, 2761, 2813, 2931], 'roles': [2432], 'either': [2434, 3549], 'trafficking,': [2435, 2602], 'signaling,': [2437, 2609], 'autophagy,': [2438], 'neural': [2440], 'synapse': [2441], 'formation': [2442], 'selected': [2444, 2708], 'targeting.': [2447], 'interference': [2449], '(RNAi)': [2450], 'performed': [2452, 2586, 3395, 3409, 4139, 4230, 4244], 'study': [2454], 'loss': [2456], 'these': [2460], '2A': [2472], 'Materials': [2474], 'Methods).': [2476], 'transfected': [2480, 2645, 3007, 3101, 3138, 3188, 3225, 3240, 3261, 3296, 3326, 3367, 4101], 'siRNAs': [2482, 2650, 2717, 2738, 3012, 3104, 3106, 3230, 3245, 3921, 4106], 'targeting': [2483, 3107], 'respective': [2485], 'gene': [2486], 'interest': [2488], '2B)': [2490], 'h': [2493, 2500, 2671, 2726, 3022, 3144, 3201, 3233, 3248, 3340, 4109, 4188], '2': [2499, 2670, 2803, 3021], 'subsequent': [2502], 'co-culture': [2503, 2674, 3208], 'level': [2510], 'then': [2514, 2661], 'assessed': [2515, 3001], 'FACS': [2517, 2735, 3003], 'p24-positive': [2520], '2C': [2524], 'D).': [2526], 'four': [2530, 2970], 'reduced': [2532, 2549, 3709], 'than': [2537], '50%': [2538], 'compared': [2539, 3935], 'controls.': [2541], 'further': [2543], '51': [2544], 'when': [2546, 2842], 'knocked': [2547, 2845], 'down': [2548], '50': [2554], '75%': [2556], 'control': [2558, 3651, 3937], 'S7).': [2562], 'regulates': [2573], 'cells,': [2581, 3817, 4036], 'disease': [2583], '55': [2590], 'affecting': [2592, 2762, 2794, 2932], '26': [2598], 'specifically': [2603, 2972, 3699, 3862], 'integrin': [2608], 'endocytosis,': [2610], 'focal': [2612], 'adhesion': [2613], 'kinase': [2614], '(FAK)': [2615], '2E).': [2618], '2.': [2620, 3135], 'utilizing': [2624], 'FACS-based': [2626, 3129], 'assay': [2627, 3131], 'readout': [2631], 'Workflow': [2632], 'RNAi': [2636, 2756], 'shown.': [2639, 3223, 3238, 3281], '×': [2641], '104': [2642], 'triplicates': [2647], 'SMARTpool': [2649], 'incubated': [2652], '96-well': [2654], 'plates': [2655], 'h.': [2658], 'Cells': [2659], 'washed': [2662], 'NL4-3': [2667], 'PHA': [2678], 'blasts.': [2679], 'Three': [2680], 'days': [2681], 'later': [2682, 2727], 'stained': [2685, 3162, 3266, 3301, 3342, 4191], 'surface': [2687], 'markers': [2688], 'p24': [2691, 2699, 3213], 'analyzed': [2693, 3437, 3573, 4021, 4177], 'flow': [2695], 'cytometry': [2696], 'gag': [2700, 3680], 'Knockdown': [2705, 3691], 'genes.': [2709], 'electroporated': [2712], 'non-silencing': [2714], 'Neon': [2720], 'transfection': [2721], 'harvested': [2724], 'immunoblot': [2729, 3250, 4119], 'indicated.': [2733], 'Representative': [2734, 3277], 'plots': [2736], 'reduction': [2743, 3580], '(siRNA': [2744, 2749], '1)': [2745, 2857], 'no': [2747, 2994, 3978], 'effect': [2748, 2958, 2985, 2996, 3532, 4306], '10)': [2750], 'Dot-plot': [2754], 'identification': [2759], 'Each': [2765], 'dot': [2766], 'single': [2769], 'gene.': [2770], 'Values': [2771], 'mean': [2773, 3385, 4220], 'independent': [2776, 3376, 4211], 'experiments': [2777, 3377, 3779, 4212], 'donors.': [2780, 3380, 4215], 'horizontal': [2782], 'line': [2783], 'population': [2786], 'mean.': [2787], 'classifying': [2791], 'function.': [2799], 'Only': [2800], 'categories': [2801], 'containing': [2802, 2944], 'charted.': [2808], 'Number': [2809], 'per': [2815], 'category.': [2816], 'influences': [2827, 4093], 'Of': [2832], 'down,': [2846], 'belonged': [2848], 'BLOC-1': [2851, 2901, 2939, 2960, 3845], '(biogenesis': [2852], 'organelles': [2855, 2937], 'complex.': [2858], 'Phosphoproteomic': [2859], 'also': [2862], 'BLOC1': [2868, 2882, 3111], 'infection.': [2879], 'subunit': [2883], '(BLOC1S1),': [2885], 'dephosphorylated,': [2888], 'cappuccino': [2890], 'homolog': [2891, 2895], '(CNO)': [2892], 'pallidin': [2894], '(PLDN),': [2896, 3122], 'phosphorylated.': [2899], 'belongs': [2903], 'sorting': [2908], 'its': [2915], 'association': [2916], 'Hermansky–Pudlak': [2918], 'syndrome': [2919], '(HPS),': [2920], 'group': [2922], 'heterogeneous': [2924], 'autosomal-recessive': [2925], 'disorders': [2926], 'caused': [2927], 'mutations': [2929, 3555], 'biogenesis': [2934], 'lysosomal-related': [2936], '(LROs).': [2938], 'octameric': [2942], 'two': [2945, 3551], 'stable': [2946], 'sub-complexes,': [2947], 'pallidin-Cappuccino-BLOS1': [2948], 'dysbindin-Snapin-BLOS2': [2950], '(Starcevic': [2951], "Dell'Angelica,": [2953], 'examined': [2956, 3886, 3898], 'subunits': [2961, 3108], 'members,': [2971], 'muted,': [2973], 'dysbindin,': [2974], 'BLOS3,': [2975], 'significant': [2984, 2995, 3579], '3A).': [2990], 'internalization': [2999], 'Ctrl': [3009, 3103, 3227, 3242, 3290, 3320, 3918, 3981, 4048, 4103, 4157, 4172], 'ATTO': [3016], '488': [3017], 'labeled': [3018], 'coordinates': [3027], 'retrograde': [3028, 3493], 'transport': [3029, 3037, 3490, 3494], 'late': [3031, 3488, 3687, 3718], 'directing': [3035], 'vesicle': [3036, 3484, 3606, 3613, 3620, 3636], 'fusion': [3039], '(Cai': [3040, 3503, 3564], '2010).': [3043, 3506], 'expressed': [3046, 3974], 'most': [3048, 3079], 'types': [3050], 'release': [3056, 3614, 3951, 4000], 'neurotransmitters': [3058], 'nervous': [3061], '(Ilardi': [3063], '1999;': [3066], 'Buxton': [3067], '2003).': [3070], 'assay,': [3073], 'dramatic': [3080], 'effect,': [3081], 'reducing': [3082], '50%,': [3085], 'therefore': [3088, 3521, 3897], 'further.': [3090], '3.': [3092], '(Blos1,': [3113], 'Blos2,': [3114], 'Blos3,': [3115], 'Cappacino': [3116], '(CNO),': [3117], 'Dysbindin': [3118], '(DTNBP1),': [3119], 'Muted,': [3120], 'Palladin': [3121], 'Snapin)': [3124], 'undertaking': [3127], 'Flag-tagged': [3140, 3191, 3328], '24': [3143, 3200, 3232, 3247, 3339, 4108], '30': [3153, 3458], 'min.': [3154, 3459], 'Left': [3155], 'panel': [3156, 3174, 4199], 'confocal': [3158, 3278, 4179], 'images': [3159, 3279, 3393, 4128, 4228], 'anti-p24': [3164, 3268, 3303, 3346, 4193], '(green),': [3165, 3269, 3304, 3347], 'anti-Flag': [3166, 3344, 4196], '(red),': [3167, 3271, 3306, 3349], 'Topra': [3169, 3273, 3308, 3351], 'nuclear': [3170, 3274, 3309, 3352], 'stain': [3171, 3275, 3310, 3353], '(blue).': [3172, 3276, 3311, 3354], 'Right': [3173, 4198], 'plot': [3176], 'correlation': [3178], 'coefficient': [3179], 'co-localized': [3182], 'over': [3185, 4115], 'time.': [3186], 'Ctrl,': [3190], 'wild-type': [3192, 3329, 3545], '(WT),': [3193], 'mutant': [3194, 3332, 3772], '(L99K),': [3195], '(V92K)': [3197, 3335], 'co-cultures': [3221], 'qPCR': [3235, 3971], '(Actin': [3253], 'loading': [3258], 'control).': [3259], 'anti-EEA1': [3270, 3348], 'Graph': [3282, 3312, 3355], 'co-localization': [3284, 3314, 3357, 3462, 4182], 'EEA-1': [3288, 3361], 'anti-Rab7': [3305], 'Rab7': [3318, 3741, 3752], '(WT)': [3330, 3546], '(L99K)': [3333], 'lentivectors': [3337], '(pink),': [3345], 'WT,': [3363], 'V92K,': [3364], 'L99K': [3366, 3563, 3595], 'information:': [3370, 4205], 'representative': [3373, 4208], 'presented': [3383, 4218], '±': [3386, 4221], 'SEM.': [3387, 4222], 'Co-localization': [3388, 4054, 4223], 'acquired': [3392, 4130, 4227], 'Fiji': [3397, 4232], 'software': [3398, 4233], 'calculation': [3400, 4235], "Pearson's": [3402, 4237], "Li's": [3404, 4239], 'coefficient.': [3405, 4240], 'Statistical': [3406, 4241], 'unpaired': [3411, 4246], "Student's": [3412, 4247], 't-test.': [3413, 4248], '*P': [3414], '<': [3415, 3418, 3421, 3424, 4250, 4253, 4256], '0.05,': [3416], '**P': [3417, 4249], '0.01,': [3419, 4251], '***P': [3420, 4252], '0.001,': [3422, 4254], '****P': [3423, 4255], '0.0001.': [3425, 4257], 'Scale': [3426, 4258], 'bars': [3427], 'represent': [3428], '6': [3429, 4261], 'μm.': [3430, 4262], 'whether': [3438, 3523, 4289, 4300, 4314], 'localizes': [3440], 'infecting': [3444], 'FLAG-Snapin': [3448], 'lentivirus': [3449, 4169], 'followed': [3450, 4170], 'Snapin-FLAG': [3466, 3766], 'already': [3467], '3B).': [3476], 'neurons,': [3478], 'essential': [3481], 'maturation': [3485, 3607], 'linking': [3487], 'dynein.': [3496], 'knockout': [3498], 'neurons': [3499], 'accumulate': [3500], 'lysosomes': [3502], 'Two': [3507], 'residues': [3508], 'Snapin,': [3510], 'V92': [3511], 'L99,': [3513], 'implicated': [3516, 3603], 'binding.': [3519, 3824], 'explored': [3522, 3624], 'binding': [3526, 3559, 3590, 3771, 3796], 'region': [3527, 3560, 3797], 'lentiviral': [3541, 3552, 3773, 4052], 'expression': [3542, 3774], 'vector': [3543, 3775], 'encoding': [3544, 3554], 'Snapin-FLAG,': [3547], 'vectors': [3553], 'V92K': [3561, 3593], '2010)': [3567], 'S3,': [3571], 'capacity.': [3577], 'overexpression': [3586], 'mutants': [3592], '3C).': [3599], 'has': [3601], 'synaptic': [3612], 'maintenance': [3616], 'recycling': [3619], 'pool.': [3621], 'Therefore,': [3622], 'subtypes': [3637], 'DsRed': [3645, 3650], 'shRNA': [3647, 3653, 4051, 4175], '(Ctrl)': [3652], 'verified': [3655], 'mRNA': [3660], '3D': [3665], 'E).': [3667], 'Confocal': [3668, 3778], 'microscopy': [3669, 4180], 'examine': [3673], 'p18': [3679], '(EEA-1)': [3685], '(Rab7)': [3689], 'compartments.': [3690], 'resulted': [3694], 'accumulation': [3696], 'EEA-1-positive': [3703, 3789], 'compartment': [3705, 3722, 3790], '3F).': [3707], 'Conversely': [3708], 'could': [3713], '(Rab7': [3720], 'positive)': [3721], '3G).': [3724], 'addition': [3726], 'knockdown,': [3729], 'appeared': [3731], 'morphological': [3736], 'appearance': [3737], 'EEA1': [3739, 3750], 'vesicles': [3742], 'DCs;': [3744], 'however,': [3745], 'overall': [3747], 'intensity': [3748], 'staining': [3753], 'did': [3754], 'Further,': [3760], 'wild-type,': [3767], 'V92K-': [3768], 'L99K-dynein': [3770], 'before.': [3777], 'showed': [3780], 'retention': [3783], 'mediated': [3792, 3821], 'via': [3793], '3H).': [3801], 'functions': [3804, 3848], 'early-to-late': [3809, 4088], 'depletion': [3826, 3990], 'leads': [3827], 'Our': [3836], 'thus': [3838], 'far': [3839], 'complex,': [3846], 'sorting,': [3851], 'Given': [3874], 'able': [3877], 'endosome,': [3883], 'HIV-1-sensing': [3892], 'signaling.': [3895], 'ability': [3900], 'influence': [3904], 'Stat1': [3907, 4076], 'transfecting': [3914], 'immunoblotting': [3926], 'phospho-Stat1.': [3928], 'phospho-Stat1': [3932], 'siRNA-transfected': [3938], '4A': [3941, 4275], 'B).': [3943], 'addition,': [3945], 'led': [3948], 'CXCL10,': [3953, 4147], 'CXCL9,': [3954], 'TNFα': [3956, 4002, 4150], 'HIV-1-exposed': [3958], '4C).': [3961], 'due': [3965], 'increased': [3967, 4061], 'replication,': [3969], 'transcripts': [3976], 'difference': [3979], 'Furthermore': [3989], 'impaired': [3997], 'S6)': [4005], 'suggesting': [4006], 'investigate': [4018], 'how,': [4019], 'MUTZ-3': [4035], 'line,': [4041], 'expressing': [4042], 'TLR8-V5': [4043], 'transduced': [4045, 4165], 'dsRed': [4047], 'vectors.': [4053], 'significantly': [4060], '4D).': [4068], 'suggest': [4071], 'TLR8-mediated': [4075], '4.': [4091], 'time,': [4116], 'undertaken': [4120], 'anti-pStat1': [4122], 'anti-actin': [4124], 'antibody.': [4125], 'For': [4126], 'quantification,': [4127], 'ChemiDoc': [4133], 'MP': [4134], 'Image': [4141], 'Lab': [4142], '4.0': [4143], 'software.': [4144], 'ELISAs': [4145], 'CXCL9': [4148], 'MUTZ3': [4162], 'TLR8-FLAG': [4168, 4186], 'post-infection': [4189], '(cells': [4190], '(green)': [4194], '(red).': [4197], 'degree': [4201], 'co-localization.': [4203], 'bar': [4259], '[embj201695364-sup-0003-SDataFig4.pdf]': [4276], 'downregulates': [4282], 'explore': [4288], 'exerts': [4302], 'generic': [4305], 'tested': [4313], 'regulate': [4317], 'i': [4320]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2755378115', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 1}], 'updated_date': '2025-01-06T17:29:21.271608', 'created_date': '2017-09-25'}
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