Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2752584372', 'doi': 'https://doi.org/10.1056/nejmoa1704064', 'title': 'Tezepelumab in Adults with Uncontrolled Asthma', 'display_name': 'Tezepelumab in Adults with Uncontrolled Asthma', 'publication_year': 2017, 'publication_date': '2017-09-07', 'ids': {'openalex': 'https://openalex.org/W2752584372', 'doi': 'https://doi.org/10.1056/nejmoa1704064', 'mag': '2752584372', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28877011'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1056/nejmoa1704064', 'pdf_url': 'https://www.nejm.org/doi/pdf/10.1056/NEJMoa1704064?articleTools=true', 'source': {'id': 'https://openalex.org/S62468778', 'display_name': 'New England Journal of Medicine', 'issn_l': '0028-4793', 'issn': ['0028-4793', '1533-4406'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320239', 'host_organization_name': 'Massachusetts Medical Society', 'host_organization_lineage': ['https://openalex.org/P4310320239'], 'host_organization_lineage_names': ['Massachusetts Medical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.nejm.org/doi/pdf/10.1056/NEJMoa1704064?articleTools=true', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5021417774', 'display_name': 'Jonathan Corren', 'orcid': 'https://orcid.org/0000-0001-5951-3239'}, 'institutions': [{'id': 'https://openalex.org/I161318765', 'display_name': 'University of California, Los Angeles', 'ror': 'https://ror.org/046rm7j60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I161318765']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jonathan Corren', 'raw_affiliation_strings': ['David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles'], 'affiliations': [{'raw_affiliation_string': 'David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles', 'institution_ids': ['https://openalex.org/I161318765']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112737083', 'display_name': 'Jane R. Parnes', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1320553840', 'display_name': 'Amgen (United States)', 'ror': 'https://ror.org/03g03ge92', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1320553840']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jane R. Parnes', 'raw_affiliation_strings': ['Amgen, Thousand Oaks'], 'affiliations': [{'raw_affiliation_string': 'Amgen, Thousand Oaks', 'institution_ids': ['https://openalex.org/I1320553840']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027715453', 'display_name': 'Wang Liang-wei', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Liangwei Wang', 'raw_affiliation_strings': ['MedImmune, Gaithersburg, MD'], 'affiliations': [{'raw_affiliation_string': 'MedImmune, Gaithersburg, MD', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110901924', 'display_name': 'May Mo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1320553840', 'display_name': 'Amgen (United States)', 'ror': 'https://ror.org/03g03ge92', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1320553840']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'May Mo', 'raw_affiliation_strings': ['Amgen, Thousand Oaks'], 'affiliations': [{'raw_affiliation_string': 'Amgen, Thousand Oaks', 'institution_ids': ['https://openalex.org/I1320553840']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065748911', 'display_name': 'Stephanie L. Roseti', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Stephanie L. Roseti', 'raw_affiliation_strings': ['MedImmune, Gaithersburg, MD'], 'affiliations': [{'raw_affiliation_string': 'MedImmune, Gaithersburg, MD', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030343988', 'display_name': 'Janet M. Griffiths', 'orcid': 'https://orcid.org/0000-0001-8958-7140'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Janet M. Griffiths', 'raw_affiliation_strings': ['MedImmune, Gaithersburg, MD'], 'affiliations': [{'raw_affiliation_string': 'MedImmune, Gaithersburg, MD', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5044664487', 'display_name': 'René van der Merwe', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210129479', 'display_name': 'PredictImmune', 'ror': 'https://ror.org/02nkjx490', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210129479']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'René van der Merwe', 'raw_affiliation_strings': ['MedImmune, Cambridge, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'MedImmune, Cambridge, United Kingdom', 'institution_ids': ['https://openalex.org/I4210129479']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 59.979, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 789, 'citation_normalized_percentile': {'value': 0.999953, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '377', 'issue': '10', 'first_page': '936', 'last_page': '946'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10051', 'display_name': 'Asthma and respiratory diseases', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10051', 'display_name': 'Asthma and respiratory diseases', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10837', 'display_name': 'Dermatology and Skin Diseases', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/2708', 'display_name': 'Dermatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10877', 'display_name': 'Allergic Rhinitis and Sensitization', 'score': 0.9936, 'subfield': {'id': 'https://openalex.org/subfields/2723', 'display_name': 'Immunology and Allergy'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/thymic-stromal-lymphopoietin', 'display_name': 'Thymic stromal lymphopoietin', 'score': 0.9841518}], 'concepts': [{'id': 'https://openalex.org/C2778070265', 'wikidata': 'https://www.wikidata.org/wiki/Q18048067', 'display_name': 'Thymic stromal lymphopoietin', 'level': 3, 'score': 0.9841518}, {'id': 'https://openalex.org/C2776042228', 'wikidata': 'https://www.wikidata.org/wiki/Q35869', 'display_name': 'Asthma', 'level': 2, 'score': 0.7695472}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.68602467}, {'id': 'https://openalex.org/C2778690821', 'wikidata': 'https://www.wikidata.org/wiki/Q212354', 'display_name': 'Cytokine', 'level': 2, 'score': 0.5967492}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.5798226}, {'id': 'https://openalex.org/C542903549', 'wikidata': 'https://www.wikidata.org/wiki/Q422248', 'display_name': 'Monoclonal antibody', 'level': 3, 'score': 0.57494557}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.49540627}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.47503975}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.2772159}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.22885507}], 'mesh': [{'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D001249', 'descriptor_name': 'Asthma', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000280', 'descriptor_name': 'Administration, Inhalation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000318', 'descriptor_name': 'Adrenergic beta-Agonists', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D000318', 'descriptor_name': 'Adrenergic beta-Agonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018927', 'descriptor_name': 'Anti-Asthmatic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D018927', 'descriptor_name': 'Anti-Asthmatic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061067', 'descriptor_name': 'Antibodies, Monoclonal, Humanized', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001249', 'descriptor_name': 'Asthma', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D001249', 'descriptor_name': 'Asthma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004311', 'descriptor_name': 'Double-Blind Method', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004359', 'descriptor_name': 'Drug Therapy, Combination', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004804', 'descriptor_name': 'Eosinophils', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005938', 'descriptor_name': 'Glucocorticoids', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D005938', 'descriptor_name': 'Glucocorticoids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007279', 'descriptor_name': 'Injections, Subcutaneous', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057194', 'descriptor_name': 'Intention to Treat Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1056/nejmoa1704064', 'pdf_url': 'https://www.nejm.org/doi/pdf/10.1056/NEJMoa1704064?articleTools=true', 'source': {'id': 'https://openalex.org/S62468778', 'display_name': 'New England Journal of Medicine', 'issn_l': '0028-4793', 'issn': ['0028-4793', '1533-4406'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320239', 'host_organization_name': 'Massachusetts Medical Society', 'host_organization_lineage': ['https://openalex.org/P4310320239'], 'host_organization_lineage_names': ['Massachusetts Medical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28877011', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1056/nejmoa1704064', 'pdf_url': 'https://www.nejm.org/doi/pdf/10.1056/NEJMoa1704064?articleTools=true', 'source': {'id': 'https://openalex.org/S62468778', 'display_name': 'New England Journal of Medicine', 'issn_l': '0028-4793', 'issn': ['0028-4793', '1533-4406'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320239', 'host_organization_name': 'Massachusetts Medical Society', 'host_organization_lineage': ['https://openalex.org/P4310320239'], 'host_organization_lineage_names': ['Massachusetts Medical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.83, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 39, 'referenced_works': ['https://openalex.org/W146790210', 'https://openalex.org/W1506450640', 'https://openalex.org/W1596818240', 'https://openalex.org/W1963919173', 'https://openalex.org/W1965484089', 'https://openalex.org/W1975438745', 'https://openalex.org/W2001220620', 'https://openalex.org/W2011777173', 'https://openalex.org/W2011998167', 'https://openalex.org/W2021701428', 'https://openalex.org/W2024585538', 'https://openalex.org/W2025502983', 'https://openalex.org/W2039930386', 'https://openalex.org/W2043551932', 'https://openalex.org/W2048520233', 'https://openalex.org/W2054606150', 'https://openalex.org/W2055172715', 'https://openalex.org/W2061435251', 'https://openalex.org/W2061775758', 'https://openalex.org/W2064087919', 'https://openalex.org/W2075699130', 'https://openalex.org/W2098276532', 'https://openalex.org/W2109755061', 'https://openalex.org/W2111609315', 'https://openalex.org/W2126612550', 'https://openalex.org/W2127482775', 'https://openalex.org/W2138355864', 'https://openalex.org/W2138794826', 'https://openalex.org/W2140299259', 'https://openalex.org/W2141343329', 'https://openalex.org/W2151041131', 'https://openalex.org/W2153034426', 'https://openalex.org/W2162803006', 'https://openalex.org/W2170948066', 'https://openalex.org/W2511120040', 'https://openalex.org/W2513258422', 'https://openalex.org/W2550120573', 'https://openalex.org/W2789682581', 'https://openalex.org/W4211006694'], 'related_works': ['https://openalex.org/W4226213106', 'https://openalex.org/W3034553424', 'https://openalex.org/W3032501255', 'https://openalex.org/W3031839855', 'https://openalex.org/W3031731171', 'https://openalex.org/W2133202447', 'https://openalex.org/W2116056303', 'https://openalex.org/W2082794354', 'https://openalex.org/W2077196450', 'https://openalex.org/W2024867031'], 'abstract_inverted_index': {'In': [0], 'some': [1], 'patients': [2, 40], 'with': [3, 8, 47], 'moderate-to-severe': [4], 'asthma,': [5], 'particularly': [6], 'those': [7], 'noneosinophilic': [9], 'inflammation,': [10], 'the': [11, 18, 32], 'disease': [12], 'remains': [13], 'uncontrolled.': [14], 'This': [15], 'trial': [16], 'evaluated': [17], 'efficacy': [19], 'and': [20, 50], 'safety': [21], 'of': [22, 53], 'tezepelumab': [23], '(AMG': [24], '157/MEDI9929),': [25], 'a': [26], 'human': [27], 'monoclonal': [28], 'antibody': [29], 'specific': [30], 'for': [31], 'epithelial-cell–derived': [33], 'cytokine': [34], 'thymic': [35], 'stromal': [36], 'lymphopoietin': [37], '(TSLP),': [38], 'in': [39], 'whose': [41], 'asthma': [42], 'remained': [43], 'uncontrolled': [44], 'despite': [45], 'treatment': [46], 'long-acting': [48], 'beta-agonists': [49], 'medium-to-high': [51], 'doses': [52], 'inhaled': [54], 'glucocorticoids.': [55]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2752584372', 'counts_by_year': [{'year': 2024, 'cited_by_count': 86}, {'year': 2023, 'cited_by_count': 115}, {'year': 2022, 'cited_by_count': 119}, {'year': 2021, 'cited_by_count': 116}, {'year': 2020, 'cited_by_count': 124}, {'year': 2019, 'cited_by_count': 119}, {'year': 2018, 'cited_by_count': 96}, {'year': 2017, 'cited_by_count': 13}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2025-01-13T02:41:48.984608', 'created_date': '2017-09-15'}