Publication Information

{'id': 'https://openalex.org/W2750961797', 'doi': 'https://doi.org/10.18632/oncotarget.20721', 'title': 'Enhancing conventional chemotherapy drug cisplatin-induced anti-tumor effects on human gastric cancer cells both <i>in vitro</i> and <i>in vivo</i> by Thymoquinone targeting PTEN gene', 'display_name': 'Enhancing conventional chemotherapy drug cisplatin-induced anti-tumor effects on human gastric cancer cells both <i>in vitro</i> and <i>in vivo</i> by Thymoquinone targeting PTEN gene', 'publication_year': 2017, 'publication_date': '2017-09-08', 'ids': {'openalex': 'https://openalex.org/W2750961797', 'doi': 'https://doi.org/10.18632/oncotarget.20721', 'mag': '2750961797', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29156767', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5689657'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.20721', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=20721&path%5B%5D=66015', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=20721&path%5B%5D=66015', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101571393', 'display_name': 'Jingjing Ma', 'orcid': 'https://orcid.org/0000-0003-3944-9086'}, 'institutions': [{'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}, {'id': 'https://openalex.org/I4210140357', 'display_name': 'Renmin Hospital of Wuhan University', 'ror': 'https://ror.org/03ekhbz91', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210140357']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jingjing Ma', 'raw_affiliation_strings': ['Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China', 'Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China; Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province, China', 'Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China; Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province, China', 'institution_ids': ['https://openalex.org/I37461747', 'https://openalex.org/I4210140357']}, {'raw_affiliation_string': 'Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province, China', 'institution_ids': []}, {'raw_affiliation_string': 'Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China', 'institution_ids': ['https://openalex.org/I37461747', 'https://openalex.org/I4210140357']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101659340', 'display_name': 'Xue Hu', 'orcid': 'https://orcid.org/0000-0002-8324-972X'}, 'institutions': [{'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}, {'id': 'https://openalex.org/I4210140357', 'display_name': 'Renmin Hospital of Wuhan University', 'ror': 'https://ror.org/03ekhbz91', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210140357']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xue Hu', 'raw_affiliation_strings': ['Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China', 'Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China; Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province, China', 'Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China; Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province, China', 'institution_ids': ['https://openalex.org/I37461747', 'https://openalex.org/I4210140357']}, {'raw_affiliation_string': 'Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province, China', 'institution_ids': []}, {'raw_affiliation_string': 'Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China', 'institution_ids': ['https://openalex.org/I37461747', 'https://openalex.org/I4210140357']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100419509', 'display_name': 'Jiao Li', 'orcid': 'https://orcid.org/0000-0003-1611-9439'}, 'institutions': [{'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}, {'id': 'https://openalex.org/I4210140357', 'display_name': 'Renmin Hospital of Wuhan University', 'ror': 'https://ror.org/03ekhbz91', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210140357']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jiao Li', 'raw_affiliation_strings': ['Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China', 'Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China', 'institution_ids': ['https://openalex.org/I37461747', 'https://openalex.org/I4210140357']}, {'raw_affiliation_string': 'Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China', 'institution_ids': ['https://openalex.org/I4210140357', 'https://openalex.org/I37461747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102005875', 'display_name': 'Dandan Wu', 'orcid': 'https://orcid.org/0000-0002-8429-0898'}, 'institutions': [{'id': 'https://openalex.org/I4210140357', 'display_name': 'Renmin Hospital of Wuhan University', 'ror': 'https://ror.org/03ekhbz91', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210140357']}, {'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Dandan Wu', 'raw_affiliation_strings': ['Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China', 'Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China', 'institution_ids': ['https://openalex.org/I4210140357', 'https://openalex.org/I37461747']}, {'raw_affiliation_string': 'Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China', 'institution_ids': ['https://openalex.org/I37461747', 'https://openalex.org/I4210140357']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017457389', 'display_name': 'Qingzhi Lan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210140357', 'display_name': 'Renmin Hospital of Wuhan University', 'ror': 'https://ror.org/03ekhbz91', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210140357']}, {'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qingzhi Lan', 'raw_affiliation_strings': ['Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China', 'Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China'], 'affiliations': [{'raw_affiliation_string': 'Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China', 'institution_ids': ['https://openalex.org/I4210140357', 'https://openalex.org/I37461747']}, {'raw_affiliation_string': 'Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China', 'institution_ids': ['https://openalex.org/I37461747', 'https://openalex.org/I4210140357']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100391090', 'display_name': 'Qian Wang', 'orcid': 'https://orcid.org/0000-0002-6514-3470'}, 'institutions': [{'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}, {'id': 'https://openalex.org/I4210140357', 'display_name': 'Renmin Hospital of Wuhan University', 'ror': 'https://ror.org/03ekhbz91', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210140357']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qian Wang', 'raw_affiliation_strings': ['Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China; Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province, China', 'Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China; Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province, China', 'institution_ids': ['https://openalex.org/I37461747', 'https://openalex.org/I4210140357']}, {'raw_affiliation_string': 'Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province, China', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004319671', 'display_name': 'Shan Tian', 'orcid': 'https://orcid.org/0000-0002-0782-3427'}, 'institutions': [{'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}, {'id': 'https://openalex.org/I4210140357', 'display_name': 'Renmin Hospital of Wuhan University', 'ror': 'https://ror.org/03ekhbz91', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210140357']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Shan Tian', 'raw_affiliation_strings': ['Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China; Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province, China', 'Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province, China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province, China', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China; Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province, China', 'institution_ids': ['https://openalex.org/I37461747', 'https://openalex.org/I4210140357']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5057948360', 'display_name': 'Weiguo Dong', 'orcid': 'https://orcid.org/0000-0002-4228-6508'}, 'institutions': [{'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}, {'id': 'https://openalex.org/I4210140357', 'display_name': 'Renmin Hospital of Wuhan University', 'ror': 'https://ror.org/03ekhbz91', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210140357']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Weiguo Dong', 'raw_affiliation_strings': ['Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China', 'institution_ids': ['https://openalex.org/I37461747', 'https://openalex.org/I4210140357']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 4.918, 'has_fulltext': False, 'cited_by_count': 34, 'citation_normalized_percentile': {'value': 0.920657, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '8', 'issue': '49', 'first_page': '85926', 'last_page': '85939'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12750', 'display_name': 'Nigella sativa pharmacological applications', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2707', 'display_name': 'Complementary and alternative medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12750', 'display_name': 'Nigella sativa pharmacological applications', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2707', 'display_name': 'Complementary and alternative medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12429', 'display_name': 'Chemotherapy-induced organ toxicity mitigation', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10570', 'display_name': 'Drug Transport and Resistance Mechanisms', 'score': 0.9952, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/thymoquinone', 'display_name': 'Thymoquinone', 'score': 0.94923115}], 'concepts': [{'id': 'https://openalex.org/C2779034068', 'wikidata': 'https://www.wikidata.org/wiki/Q7799650', 'display_name': 'Thymoquinone', 'level': 3, 'score': 0.94923115}, {'id': 'https://openalex.org/C2778239845', 'wikidata': 'https://www.wikidata.org/wiki/Q412415', 'display_name': 'Cisplatin', 'level': 3, 'score': 0.84827006}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.74193573}, {'id': 'https://openalex.org/C2777609662', 'wikidata': 'https://www.wikidata.org/wiki/Q416356', 'display_name': 'PTEN', 'level': 4, 'score': 0.5613416}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.55747736}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.50469863}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.50339454}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.4851471}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.44569233}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.43560094}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.3252455}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3186802}, {'id': 'https://openalex.org/C86554907', 'wikidata': 'https://www.wikidata.org/wiki/Q285613', 'display_name': 'PI3K/AKT/mTOR pathway', 'level': 3, 'score': 0.20929256}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.14158896}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.12608418}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C2778004101', 'wikidata': 'https://www.wikidata.org/wiki/Q133948', 'display_name': 'Antioxidant', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.20721', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=20721&path%5B%5D=66015', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5689657', 'pdf_url': 'https://europepmc.org/articles/pmc5689657?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689657', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29156767', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.20721', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=20721&path%5B%5D=66015', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.84, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 34, 'referenced_works': ['https://openalex.org/W1549261396', 'https://openalex.org/W1674534321', 'https://openalex.org/W1798331894', 'https://openalex.org/W1965424564', 'https://openalex.org/W1976535708', 'https://openalex.org/W1978619135', 'https://openalex.org/W1981352366', 'https://openalex.org/W1982294158', 'https://openalex.org/W1986568749', 'https://openalex.org/W1994174907', 'https://openalex.org/W2018965350', 'https://openalex.org/W2021354272', 'https://openalex.org/W2022015635', 'https://openalex.org/W2025438468', 'https://openalex.org/W2050767064', 'https://openalex.org/W2061258565', 'https://openalex.org/W2087799170', 'https://openalex.org/W2128785693', 'https://openalex.org/W2142700129', 'https://openalex.org/W2154413149', 'https://openalex.org/W2154743486', 'https://openalex.org/W2155764185', 'https://openalex.org/W2155982722', 'https://openalex.org/W2157443457', 'https://openalex.org/W2161996879', 'https://openalex.org/W2164277862', 'https://openalex.org/W2171773664', 'https://openalex.org/W2298761778', 'https://openalex.org/W2344923222', 'https://openalex.org/W2555131124', 'https://openalex.org/W2560322684', 'https://openalex.org/W2738996050', 'https://openalex.org/W4235607015', 'https://openalex.org/W48554387'], 'related_works': ['https://openalex.org/W44641635', 'https://openalex.org/W4307702869', 'https://openalex.org/W4298627165', 'https://openalex.org/W3165037977', 'https://openalex.org/W2357943637', 'https://openalex.org/W2349881481', 'https://openalex.org/W2257639774', 'https://openalex.org/W2087309076', 'https://openalex.org/W1962094870', 'https://openalex.org/W1723369229'], 'abstract_inverted_index': {'//': [0], 'Jingjing': [1], 'Ma': [2], '1,': [3, 9, 15, 20, 25, 30, 35], '2,': [4, 10], '3': [5, 11, 16, 21, 26, 68], ',': [6, 12, 17, 22, 27, 32, 262, 304], 'Xue': [7], 'Hu': [8], 'Jiao': [13], 'Li': [14], 'Dandan': [18], 'Wu': [19], 'Qingzhi': [23], 'Lan': [24], 'Qian': [28], 'Wang': [29], '2': [31, 36, 54], 'Shan': [33], 'Tian': [34], 'and': [37, 232, 247, 251, 269, 301, 314, 339], 'Weiguo': [38, 82], 'Dong': [39], '1': [40, 41], 'Department': [42], 'of': [43, 47, 57, 73, 143, 157, 187, 220, 267], 'Gastroenterology,': [44], 'Renmin': [45, 71], 'Hospital': [46, 72], 'Wuhan': [48, 74], 'University,': [49, 75], 'Wuhan,': [50, 64, 76], 'Hubei': [51, 58, 65, 77], 'Province,': [52, 66, 78], 'China': [53, 67, 79], 'Key': [55], 'Laboratory': [56], 'Province': [59], 'for': [60, 335], 'Digestive': [61], 'System': [62], 'Disease,': [63], 'Central': [69], 'Laboratory,': [70], 'Correspondence': [80], 'to:': [81], 'Dong,': [83], 'email:': [84], '[email protected]': [85], 'Keywords:': [86], 'thymoquinone,': [87], 'cisplatin,': [88], 'gastric': [89, 96, 163, 296], 'cancer,': [90], 'PTEN,': [91, 221], 'drug': [92], 'sensitivity': [93], 'Abbreviations:': [94], 'GC:': [95], 'cancer;': [97], 'TQ:': [98], 'Thymoquinone;': [99], 'P-gp:': [100], 'P-glycoprotein;': [101], 'NC:': [102], 'negative': [103], 'control': [104], 'Received:': [105], 'May': [106], '18,': [107], '2017': [108, 112, 116], 'Accepted:': [109], 'August': [110], '09,': [111], 'Published:': [113], 'September': [114], '08,': [115], 'ABSTRACT': [117], 'Combination': [118], 'chemotherapy': [119], 'regimen': [120], 'with': [121, 160, 170, 189], 'several': [122], 'anti-tumor': [123, 155, 275, 293], 'drugs': [124], 'is': [125], 'a': [126, 192, 203, 214, 252, 265, 272, 282, 325, 329], 'strategy': [127], 'to': [128, 136, 236], 'improve': [129], 'outcome.': [130], 'Thymoquinone': [131], '(TQ)': [132], 'has': [133], 'been': [134], 'reported': [135], 'exert': [137], 'biological': [138], 'activity': [139], 'on': [140, 162, 181, 295], 'various': [141], 'types': [142], 'human': [144], 'cancers': [145], 'without': [146], 'obvious': [147, 223], 'toxicity.': [148], 'However,': [149], 'only': [150], 'few': [151], 'studies': [152], 'showed': [153, 168, 263], 'the': [154, 175, 218, 311], 'effects': [156, 177, 294], 'TQ': [158, 172, 190, 209, 231, 268, 289, 321], 'combination': [159, 266, 337], 'cisplatin': [161, 180, 188, 212, 233, 270], 'cancer': [164, 297, 330], '(GC).': [165], 'Here,': [166], 'we': [167], 'pretreatment': [169, 210], '5μM': [171], 'significantly': [173, 193, 290], 'increased': [174], 'apoptotic': [176], 'induced': [178], 'by': [179, 317], 'GC': [182], 'cell': [183], 'lines.': [184], 'Combined': [185], 'treatment': [186], 'represented': [191], 'superior': [194], 'tumor': [195, 205, 284], 'suppression': [196], 'effect': [197], 'than': [198, 277], 'either': [199, 278], 'agent': [200, 276, 279, 334], 'alone': [201, 280], 'in': [202, 217, 225, 239, 254, 260, 281, 299, 302], 'xenograft': [204, 283], 'mouse': [206, 285], 'model.': [207, 286], 'Interestingly,': [208], 'following': [211], 'caused': [213], 'significant': [215], 'increase': [216, 238], 'levels': [219], 'an': [222, 237], 'decrease': [224, 253], 'p-AKT,': [226], 'CyclinD1,': [227], 'P-glycoprotein': [228, 316], '(P-gp),': [229], 'meanwhile,': [230], 'also': [234], 'led': [235], 'Bax,': [240], 'Cyt': [241], 'C,': [242], 'AIF,': [243], 'cleaved': [244, 248], 'caspase': [245, 249], '9,': [246], '3,': [250], 'Bcl-2,': [255], 'procaspase-9,': [256], 'procaspase-3.': [257], 'Moreover,': [258], 'results': [259], 'vitro': [261, 300], 'that': [264], 'represents': [271], 'more': [273], 'effective': [274], 'In': [287], 'conclusion,': [288], 'augments': [291], 'cisplatin-induced': [292], 'both': [298], 'vivo': [303], 'through': [305], 'inhibiting': [306], 'PI3K/AKT': [307], 'signaling': [308], 'pathway,': [309, 313], 'activating': [310], 'mitochondrial': [312], 'down-regulating': [315], 'up-regulating': [318], 'PTEN': [319], 'gene.': [320], 'might': [322], 'be': [323], 'as': [324, 328], 'promising': [326], 'candidate': [327], 'chemopreventive': [331], 'or': [332], 'chemotherapeutic': [333], 'antineoplastic': [336], 'therapy': [338], 'merits': [340], 'further': [341], 'clinical': [342], 'investigation.': [343]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2750961797', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 9}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 1}], 'updated_date': '2024-12-12T19:39:11.128407', 'created_date': '2017-09-15'}