Title: Tumor microenvironments of NSCLC are more heterogeneous than you would think—supported by image analysis-based assessment of PD-L1 and tumor-associated immune cell densities
Abstract:In the recent years, blockade of immune checkpoints to reinstitute host antitumor immunity has been extensively investigated in a variety of tumors (1). In the field of lung cancer, monoclonal antibod...In the recent years, blockade of immune checkpoints to reinstitute host antitumor immunity has been extensively investigated in a variety of tumors (1). In the field of lung cancer, monoclonal antibodies targeting the programmed death 1 (PD-1) (also known as CD279) receptor and its ligand, programmed death-ligand 1 (PD-L1) (also known as B7-H1) have been most studied. High profile clinical trials have shown impressive anti-tumor activity of PD-1/PD-L1 blockade and significant improvements in overall survival (OS) of non-small cell lung cancer (NSCLC) patients in the first-line and/or second or more line settings (2-6), leading to approval of nivolumab, pembrolizumab and/or atezolizumab for treatment of NSCLC in the US, Europe and some other countries (7). Clinical trials with two other agents, durvalumab and avelumab, have also shown promising results (7).Read More
Publication Year: 2017
Publication Date: 2017-08-22
Language: en
Type: article
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