Abstract: Publisher Summary This chapter describes modified thiamine compounds. There has been a great increase in Japan in the sale of vitamin preparations containing thiamine, and also in the enrichment of staple foods, candies, and other food items with thiamine. This increase has encouraged the search for derivatives of thiamine that are odorless and more stable than its chloride-hydrochloride form. It has stimulated the successful development of modified thiamine compounds both for therapeutic and enrichment purposes. Modified thiamine compounds can be classified into two types: masked compounds which still retain thiamine activity in animals, and permanently altered compounds, which have no thiamine activity even though they are chemically convertible to thiamine to a greater or lesser extent. The masked thiamine compounds are interesting examples of successful changes of the thiamine molecule, and they may be superior to thiamine both in physical and in biochemical properties. Other vitamins than thiamine do not usually form this type of modified compound, these thiamine-active modified compounds may be divided into the disulfide and the S-acyl thiamine types.
Publication Year: 1971
Publication Date: 1971-01-01
Language: en
Type: article
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