Publication Information

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3952], 'Giorgio': [256], 'Tarzia': [257], '(Figures': [258, 1219], '1–2).': [259], 'sponsored': [262, 1297], 'a': [266, 292, 476, 533, 736, 757, 778, 830, 849, 855, 972, 998, 1033, 1040, 1121, 1126, 1363, 1399, 1442, 1454, 1654, 1720, 1749, 1784, 1821, 1886, 1891, 2034, 2046, 2088, 2114, 2127, 2138, 2153, 2206, 2222, 2232, 2241, 2249, 2257, 2325, 2408, 2460, 2554, 2611, 2618, 2735, 2749, 2754, 2791, 2846, 2927, 2970, 2976, 3083, 3140, 3217, 3270, 3276, 3299, 3306, 3394, 3405, 3413, 3421, 3627, 3640, 3667, 3713, 3881, 3911, 3958, 4042, 4134], 'generous': [267], 'financial': [268], 'contribution': [269, 3473], 'used': [270, 3522], 'for': [271, 714, 874, 1069, 1106, 1149, 1481, 1512, 1724, 1815, 1890, 1932, 1981, 2037, 2080, 2155, 2193, 2253, 2263, 2421, 2462, 2604, 2758, 3305, 3453, 3525, 3530, 3535, 3573, 3603, 3632, 3644, 3696, 4267], 'effective': [273, 3063], 'realization': [274], 'event.': [277, 3902], 'This': [278, 530, 1415, 1472, 1517, 1832, 3181, 4249], 'included': [279, 1189], 'welcome': [281, 654], 'reception,': [282], 'Editor-in-Chief': [288], 'David': [289, 641, 677], 'Peralta': [290, 678], 'raised': [291], 'toast': [293, 664], 'along': [300], 'organizers': [304], 'journal′s': [306], 'board': [308], 'members.': [309], 'Opening': [310], 'ceremony': [311, 361], '(from': [312, 625, 665, 1308, 1336], 'left': [313, 626, 666, 1309, 1337], 'right):': [315, 628, 668, 1339], '(Co-chair),': [318, 321], 'Gabriele': [322, 596, 629, 669, 1326], 'Costantino': [323, 597], '(2016–2019': [324], 'DCF-SCI': [325, 330, 599], 'President),': [326, 331], 'Girolamo': [327, 680, 1321], 'Cirrincione': [328], '(2013–2015': [329], 'Fabrizio': [332, 405, 1552], 'Figorilli': [333], '(Pro-Rector': [334], 'Perugia),': [338], 'Leonardo': [339, 2873], 'Varasano': [340], '(President': [341], 'Municipality': [343], 'Council': [344], 'Perugia).': [346], 'celebrating': [353], 'during': [358, 612, 1412, 1965], 'Sala': [363, 570, 609], 'dei': [364, 367, 574, 610], 'Notari,': [365], 'Palazzo': [366, 573], 'Priori,': [368], 'city': [370, 3693, 3816], 'center': [371], 'During': [372], 'ceremony,': [375], 'appointed': [379], 'awards:': [382], 'Chemical': [392, 455, 593, 3664, 3765], "Society's": [393], 'Award': [394, 418], '(Rosella': [395], 'Ombrato,': [396], 'Angelini': [397], 'Research': [398], 'Center,': [399], 'S.': [400, 3579], 'Palomba,': [401], 'Rome,': [402, 424, 432], 'Carta,': [406], 'Florence,': [409], 'Italy)': [410, 474, 708], 'Best': [415], 'Doctoral': [416], 'Thesis': [417], '(Sara': [419], 'Consalvi,': [420], 'La': [422, 430], 'Sapienza,': [423, 431], 'Valeria': [427], 'Famiglini,': [428], 'Italy).': [433, 970], 'While': [434], 'Pier': [435], 'Giovanni': [436, 577, 3313], 'Baraldi': [437, 578], '(University': [438, 579, 967, 3925, 3931, 3939], 'Ferrara,': [440], 'Italy),': [441, 1256], 'recipient': [442, 582], 'Musajo': [445, 585], 'Medal': [446, 586], 'Society,': [456, 594], 'reported': [457, 902, 990, 1511, 2053, 2363, 4254], 'on': [458, 495, 721, 903, 991, 1062, 1159, 1445, 1492, 1515, 1542, 1557, 1702, 2111, 2214, 2273, 2280, 2396, 2402, 2598, 2744, 2823, 2831, 2967, 2982, 3113, 3192, 3216, 3433, 3482, 3506, 3586, 3608, 3984, 4224], 'his': [459, 838, 845, 1434], 'academic': [460], 'research': [461, 1141, 1180, 1926, 3262, 3719, 3979, 4026, 4115, 4137, 4208, 4250], 'life,': [462], 'lecture': [465, 697, 818, 961, 1114, 1273, 1296, 3913], 'Roberto': [469, 602, 1355], 'Pellicciari': [470], '(TES': [471], 'Pharma,': [472, 507], 'stimulating': [477], 'titled': [479, 847, 974, 1123], '“Engineering': [480], 'novel': [481, 499, 1561, 1986, 2258, 2463, 2895, 3370], 'drugs.': [482], 'long': [484, 856, 4135], 'journey': [485], 'into': [486, 517, 1390, 1523, 2804], 'changing': [488], 'landscape': [489], 'drug': [491, 1127, 1150, 1183, 1830, 1921, 2174, 3027, 3451, 3601, 4021], 'discovery”.': [492], 'He': [493, 1157], 'focused': [494, 720, 3983], 'exploration': [497], 'interactive': [500], 'ways': [501], 'frame': [504], 'TES': [506, 604, 1299], 'innovative': [509, 2456, 2466], 'start-up': [510], 'aimed': [511], 'converting': [513], 'in-depth': [514], 'biological': [515, 2947, 3009, 3100, 3995], 'innovations': [516], 'candidate': [518, 3086, 3642], 'therapeutic': [519, 1656, 1888, 2261, 2419], 'targets': [520, 1645], 'area': [523], 'aging,': [527], 'oncology.': [529, 761], 'activity': [531, 1011, 2239, 2442, 2702, 3248, 3280, 3292, 4027, 4209, 4251], 'natural': [534, 1028, 3610], 'evolution': [535], 'after': [536], 'years,': [539, 4262], 'which': [541, 866, 1025, 1578, 1601, 2288, 2308, 2690, 2719, 2787, 3055, 3245, 3302, 3734], 'collaboration': [543, 1170], 'big': [545], 'Pharma': [546, 1131], 'Biotech': [548], 'companies': [549], 'provides': [550], 'necessary': [552], 'interdisciplinary': [553], 'environment': [554], '(Figure': [555, 3677], '3).': [556], 'Highlights': [557, 1230], 'NMMC': [561, 1225, 1234], '&': [562, 1226, 1235], 'NPCF10': [563], 'ceremony.': [565], 'a)': [566, 1237], 'registration': [568], 'della': [571], 'Vaccara,': [572], 'Priori.': [575], 'b)': [576], 'Ferrara),': [581], 'Division,': [591], '(2016–2018': [598], 'President).': [600], 'c)': [601], 'Pellicciari,': [603], 'Pharma–Perugia,': [605], 'lecture.': [607, 1261, 1284], 'd)': [608, 1246], 'Notari': [611], 'conference.': [614], 'e)': [615, 1262], 'Cake': [616], 'celebrate': [618], 'Anniversary.': [622], 'f)': [623, 1276], 'Cake-cutting': [624], 'Costantino,': [630, 670, 1327], 'Cecchetti,': [632, 1329], 'Marco': [633, 1996], 'Mor,': [634], 'Filippo': [635, 671], 'Minutolo,': [636, 672], 'Antonello': [637, 673], 'Mai,': [638, 674], 'Goeliz,': [640, 676], 'Peralta,': [642], 'Gianluca': [643, 1353], 'Sbardella,': [644, 1354], 'Maria': [645, 1344], 'Laura': [646], 'Bolognesi,': [647], 'Natalini.': [649], 'g)': [650, 1285], 'Participants': [651, 1221], 'enjoying': [652], 'buffet': [655], 'cloister': [657], 'San': [659], 'Lorenzo': [660], 'Cathedral.': [661], 'h)': [662, 1288], 'Ceremony': [663], 'Cirrrincione.': [681], 'Three': [682, 2710], 'plenary': [683, 696, 817, 960, 1113, 1260, 1272, 1283, 3912], 'lectures': [684], 'featured': [685, 2279, 2395, 2743], 'topic': [687], 'national': [690, 3674, 4093], 'meeting′s': [691, 1217], 'daily': [692], 'session.': [693, 1287], 'The': [694, 815, 921, 958, 1088, 1185, 1624, 1959, 1992, 2098, 2169, 2659, 3286, 3426, 3501, 3679, 3702, 3759, 3839, 3903, 4172], 'first': [695, 1550, 1713, 1993, 4017], 'given': [698, 820], 'Alessia': [700, 1247], 'Montagnoli': [701], '(Nerviano': [702], 'Medical': [703, 1250], 'Sciences': [704, 1251], 'S.r.l.,': [705], 'Nerviano': [706, 1249, 1254], '(MI),': [707], 'title': [711], '“PARP': [712], 'inhibitors': [713, 764, 793, 1491, 1495, 1527, 2880, 3031, 3350], 'treatment': [716, 876, 911, 3455], 'human': [718, 881, 1489, 1499, 1525, 1618, 2836, 2968, 3179, 3628], 'cancer”': [719], 'family': [723, 1501], 'poly(ADP-ribose)': [725], 'polymerases': [726], '(PARPs)': [727], 'humans,': [729], 'consisting': [730], '17': [732], 'enzymes': [733], 'that': [734, 1590, 1677, 1741, 1765, 1928, 2147, 2235, 2336, 2407, 2427, 2517, 2539, 2842, 2974, 2992, 3170, 3202, 3230, 3274, 3288, 3318, 3542], 'share': [735], 'catalytic': [737], 'PARP': [738, 792, 4156], 'domain.': [739], 'PARP-1,': [740], 'most': [742, 1404, 3706], 'well-studied,': [743], 'established': [746], 'role': [747, 1035, 1094, 1747, 2013, 2862, 2978], 'signaling': [750, 2025], 'repair': [752, 774], 'DNA': [754, 773], 'prominent': [758], 'target': [759, 766, 1814, 2036, 3559], 'Accordingly,': [762], 'PARP-1': [763], 'selectively': [765], 'tumors': [767, 1801], 'defects': [769], 'HR': [772], 'pathway': [775, 1873, 4153], '(which': [776], 'include': [777, 4058], 'high': [779, 3290], 'percentage': [780], 'breast,': [782], 'ovarian,': [783], 'pancreatic,': [784], 'prostate': [786], 'cancers),': [787], 'while': [788, 3443], 'sparing': [789], 'normal': [790], 'tissues.': [791], 'are': [794, 871, 1026, 1496, 1683, 2414, 2431, 2843, 3382, 3430], 'different': [796, 810, 1410, 1721, 1798, 2373, 2925, 3490, 3551], 'stages': [797], 'clinical': [799], 'investigation': [800], 'single': [802], 'agents,': [803, 4123], 'combination': [808], 'agents': [811, 2262, 2293, 2426, 4040], 'radiotherapy.': [814], 'second': [816, 1334, 1695, 2099], 'Johan': [822, 1263], 'Neyts': [823], '(Catholic': [824], 'Leuven,': [827, 1270], 'Belgium)': [828], 'video': [831], 'conference,': [832], 'due': [833, 2436], 'commitments': [836], 'preventing': [837], 'personal': [839], 'participation': [840, 3743], 'meeting.': [843, 1414], 'Through': [844], 'talk,': [846], '“Antivirals,': [848], 'lot': [850], 'achieved,': [853, 2312], 'yet': [854], 'way': [857, 2286], 'go?”,': [859], 'he': [860, 901, 989, 4263], 'described': [861, 1139, 2189, 3038], 'present': [863, 1684, 3386], 'situation': [864], 'small': [867, 2233, 3307, 3990, 4063], 'molecule': [868, 2234], 'antiviral': [869], 'drugs': [870, 2464], 'already': [872, 3907], 'available': [873], 'infections': [878], 'herpesviruses,': [880], 'immunodeficiency': [882], 'virus': [883, 887, 892, 952], '(HIV),': [884], 'hepatitis': [885, 890, 950], 'B': [886], '(HBV),': [888], 'C': [891], '(HCV),': [893], 'influenza': [898], 'viruses.': [899], 'Then,': [900, 3261], 'progress': [905], 'HIV,': [907], 'HBV,': [908], 'HCV': [910], 'emphasizing': [912], 'combined': [914, 3476], 'efforts': [915, 926, 1142, 1626, 3263, 4138], 'virologists': [917], 'chemists.': [920], 'discussion': [922], 'covered': [924], 'developing': [928], 'potent': [929, 2430, 2556], 'antivirals': [930], 'against': [931, 2092, 2480, 2943, 3249, 3281, 3362, 3412], 'i)': [932, 1301], 'flaviviruses': [933], '(including': [934], 'dengue': [936], 'Zika': [939], 'virus),': [940], 'ii)': [941], 'Chikungunya,': [942], 'iii)': [943], 'rhino-': [944], 'enteroviruses,': [946], 'iv)': [947], 'noroviruses,': [948], 'v)': [949], 'E': [951], ',': [953], 'vi)': [955], 'rabies': [956], 'virus.': [957], 'third': [959], 'Antonio': [965, 1277], 'Moschetta': [966], 'Bari,': [969], 'With': [971, 1120, 2350, 2890], '“Role': [975], 'FXR-FGF19': [977], 'gut': [980], 'liver': [981], 'axis:': [982], 'relevance': [983, 1105], 'disease': [986, 1108, 1822, 1855, 2887], 'cancer”,': [988], 'nuclear': [993, 4197], 'Farnesoid': [994], 'X': [995], 'Receptor': [996], '(FXR),': [997], 'transcription': [999], 'factor': [1000, 1931], 'critically': [1001], 'involved': [1002, 2995], 'homeostasis': [1005, 1103], 'gut-liver': [1008], 'axis.': [1009], 'FXR': [1010, 1029, 1031, 1084, 1096, 4194], 'mediated': [1013], 'hormonal': [1015], 'dietary': [1017], 'signals': [1018], 'driven': [1020], 'bile': [1022, 4181, 4243], 'acids': [1023, 4182, 4244], '(BAs),': [1024], 'ligands.': [1030], 'plays': [1032, 1744, 2975], 'pivotal': [1034], 'pathogenesis': [1038], 'wide': [1041, 1750, 2409], 'range': [1042, 1751], 'diseases': [1044, 1458, 1485, 1544, 3014], 'liver,': [1047], 'biliary': [1048], 'tract,': [1049], 'intestine,': [1051], 'hepatic': [1053], 'colorectal': [1055], 'cancer.': [1056, 1110, 2044, 3346], 'Taking': [1057], 'advantage': [1058], 'knowledge': [1061], 'structure–activity': [1064, 2498, 3090], 'relationship': [1065, 3091], '(SAR)': [1066], 'BAs': [1068], 'FXR,': [1070], 'semisynthetic': [1071], 'synthetic': [1073, 3634, 4161], 'molecules': [1074, 1987, 2201, 3552, 3991, 4064], 'have': [1075, 1739, 1794, 2051, 2177, 2187, 2530, 2537, 3036, 3906, 4139, 4163], 'generated': [1077], 'obtain': [1079, 1977], 'selective': [1081, 1828, 2048, 3075], 'powerful': [1083], 'activators': [1085], 'BAs.': [1087], 'presentation': [1089], 'tissue-specific': [1093], 'regulation': [1099], 'whole': [1101], 'body': [1102], 'inflammatory': [1107], 'closing': [1112, 1295], 'concluded': [1115], 'three': [1117, 1190, 3190, 3193], 'days′': [1118], 'presentations.': [1119], '“Crossing': [1124], 'over:': [1125], 'discovery': [1128, 1151, 1559, 1594, 1922, 4031, 4061], 'perspective': [1129], 'Academia’,': [1133], 'Magid': [1134, 1289], 'Abou-Gharbia': [1135], '(Temple': [1136], 'University,': [1137], 'USA)': [1138], 'establish': [1144], 'implement': [1146], 'modern': [1147, 3710], 'paradigms': [1148], 'promote': [1154, 2628], 'biomedical': [1155], 'research.': [1156, 1184], 'detailed': [1158, 3585], 'great': [1161, 1609, 2883, 2987], 'challenges': [1162], 'pharmaceutical': [1164], 'facing': [1167], 'academy': [1172], 'fostering': [1174], 'next': [1177], 'generation': [1178, 3527], 'cutting-edge': [1182], 'scientific': [1186, 1406, 3715], 'program': [1187, 3716], 'days': [1191], 'keynote': [1193], '(10),': [1194], 'oral': [1195], '(42),': [1196], 'flash': [1198], '(12)': [1199], 'eminent': [1206], 'many': [1209, 4090, 4261], 'alongside': [1211], '168': [1212], 'posters': [1213], 'exhibited': [1214], 'throughout': [1215], 'duration': [1218], '4-5).': [1220], 'NPCF10,': [1227], 'NPCF10.': [1236], 'venue,': [1239], 'Hotel': [1240, 1244], 'Giò.': [1241, 1245], 'b–c)': [1242], 'Auditorium': [1243], 'Montagnoli,': [1248], 'S.r.l.': [1252], '-': [1253], '(Milan,': [1255], 'Neyts,': [1264], 'Catholic': [1265], 'Leuven': [1268], '(KU': [1269], 'Belgium),': [1271], '(via': [1274], 'Skype).': [1275], 'Moschetta,': [1278], 'Bari': [1281], '(Italy),': [1282], 'Poster': [1286], 'Abou-Gharbia,': [1290], 'Temple': [1291], '(Philadelphia,': [1293], 'USA),': [1294], 'Pharma.': [1300], 'Organizing': [1302], 'Scientific': [1304], 'Committees;': [1305], 'front': [1306, 2282, 2399], 'row': [1307, 1335], 'right': [1311], '):': [1312], 'Emidio': [1313], 'Camaioni,': [1314], 'Oriana': [1315], 'Tabarrini,': [1316], 'Natalini,': [1318], 'Daniele': [1319], 'Donati,': [1320], 'Cirrincione,': [1322], 'Ersilia': [1323], 'De': [1324], 'Lorenzi,': [1325], 'Federico': [1330], 'Corelli,': [1331], 'Maurizio': [1332], 'Recanatini;': [1333], 'Giuseppe': [1340], 'Manfroni,': [1341], 'Serena': [1342], 'Massari,': [1343], 'Letizia': [1345], 'Barreca,': [1346], 'Antimo': [1347], 'Gioiello,': [1348], 'Roccaldo': [1349], 'Sardella,': [1350], 'Andrea': [1351, 2107], 'Carotti,': [1352], 'Di': [1356], 'Santo,': [1357], 'Tiziano': [1358], 'Bandiera,': [1359], 'Stefano': [1360, 2275, 2511], 'Sabatini.': [1361], 'As': [1362, 1783, 3880], 'reminder': [1364], 'excellent': [1367], 'content': [1369], 'part': [1372, 3656], 'ChemMedChem′s': [1374], 'Anniversary,': [1376], 'Issue': [1379, 1393, 1417], 'formed.': [1381], 'Among': [1382, 2266, 2304], 'various': [1384, 1788], 'contributions,': [1385], '18': [1386], 'articles': [1387], 'made': [1388], 'it': [1389], 'aim': [1396, 2352, 2648, 2892, 3235], 'offering': [1398], 'representative': [1400], 'overview': [1401, 1444, 1836], 'recent': [1405, 1925, 2302, 2535, 4056], 'advances': [1407], 'presented': [1408, 4089], 'forms': [1411], 'includes': [1418], 'Review': [1420, 1435], 'article,': [1421, 1436, 1863], 'Minireviews,': [1423], 'Concept': [1425, 1862], 'paper,': [1426], 'Communications,': [1428], 'twelve': [1430], 'Full': [1431, 2268], 'Papers.': [1432], 'Emanuele': [1437], 'Amata': [1438], '(DOI:': [1439, 1554, 1699, 1866, 2001, 2109, 2277, 2393, 2513, 2595, 2741, 2875, 2962, 3132, 3211, 3315, 3467, 3581], '10.1002/cmdc.201700259)': [1440], 'gives': [1441], 'general': [1443], 'Human': [1446], 'African': [1447], 'Trypanosomiasis': [1448], '(HAT),': [1449], 'Chagas': [1450], 'disease,': [1451], 'leishmaniasis,': [1453], 'group': [1455, 2854], 'known': [1459, 1488, 2405], 'neglected': [1461, 1482], 'tropical': [1462, 1483], 'induced': [1464, 2027, 2673], 'infection': [1466], 'protozoan': [1468, 1484], 'parasites': [1469], 'named': [1470], 'trypanosomatids.': [1471, 1493, 1516, 1547], 'review': [1473, 1833], 'summarizes': [1474], 'finding': [1476], 'new': [1478, 1535, 1596, 2084, 2379, 2503, 2651, 2750, 2762, 3103, 3238, 3271, 3395, 3447, 4225, 4231], 'hit': [1479, 3085, 3259, 3409], 'compounds': [1480, 1514, 1606, 1630, 1687, 1917, 1971, 2381, 2697, 2711, 2841, 3172, 3371, 3448], 'repurposing': [1487], 'kinase': [1490, 1500, 1526, 3324, 3364], 'Kinase': [1494], 'grouped': [1497], 'discussed': [1503], 'according': [1504], 'screening': [1507, 1691, 2076, 2175, 3571], '(target-based': [1508], 'phenotypic)': [1510], 'these': [1513, 1629, 1787, 2444, 3162, 3171, 3243], 'collection': [1518], 'aims': [1519], 'insight': [1522], 'repurposed': [1524], 'their': [1529, 1637, 2057, 2438, 2701, 3360], 'importance': [1530, 2884], 'development': [1533, 1984, 2255, 2345, 3388, 4014, 4216], 'chemical': [1536, 2085, 2223, 2357, 3159, 3460], 'entities': [1537], 'potential': [1539, 1848, 2942], 'beneficial': [1540], 'effects': [1541, 2165, 2197], 'caused': [1545], 'Minireview,': [1551, 1696], 'Micheli': [1553], '10.1002/cmdc.201700148)': [1555], 'reports': [1556, 1701, 2597, 3317], 'templates': [1562], 'so-called': [1565], '“amino”': [1566], 'region': [1567], 'dopamine': [1569, 1613, 1648], 'D3': [1570], 'receptor': [1571, 1615, 2009, 2574, 3509, 3617, 4150, 4198, 4204], 'antagonists.': [1572], 'Moving': [1573], 'early': [1576, 1818, 3563], 'scaffolds,': [1577, 1675], 'modified': [1580], 'amine': [1583], 'portion,': [1584], 'Minireview': [1586], 'discusses': [1587], 'variations': [1589, 1790], 'led': [1591, 2065, 2811, 3267], 'systems': [1597], 'published': [1598, 4082], '2016,': [1600], 'allowed': [1602, 3183], 'identification': [1604, 1914, 2082, 2230], 'endowed': [1607, 2844, 3399, 3992], 'selectivity': [1610, 1640, 3187], 'over': [1611], 'D2': [1614, 1649], 'ether-à-go-go-related': [1619], 'gene': [1620], '(hERG)': [1621], 'ion': [1622], 'channel.': [1623], 'main': [1625, 3815], 'characterizing': [1628], 'not': [1633, 1939, 3352, 3366], 'only': [1634, 2178], 'determining': [1636], 'potency': [1638, 2360, 2723, 3361], 'relative': [1641], 'closely': [1643], 'associated': [1644, 3297], '(e.g.,': [1646, 3380], 'receptor),': [1650], 'but': [1651, 1944, 2375, 2621, 2779, 3041, 3489], 'ensure': [1653], 'large': [1655], 'window': [1657], 'versus': [1658], 'liability': [1659], 'points': [1660, 2515], 'such': [1661, 2317, 2693, 2797], 'hERG.': [1663], 'Furthermore,': [1664], 'much': [1665], 'focus': [1666, 2272], 'overall': [1671], 'developability': [1672], 'ensuring': [1676], 'appropriate': [1678], 'physicochemical': [1679], 'pharmacokinetic': [1681], 'parameters': [1682], 'progressing': [1688], 'through': [1689, 2921, 4041, 4166, 4245], 'cascade.': [1692], 'Nunzio': [1697], 'Denora': [1698], '10.1002/cmdc.201700322)': [1700], '18-kDa': [1704, 1879], 'mitochondrial': [1705, 1711, 1771, 1829], 'translocator': [1706, 1880], 'protein': [1707, 1743, 1881, 2136, 3488], '(TSPO),': [1708], 'interesting': [1710, 2474], 'biomarker': [1712], 'discovered': [1714], 'late': [1717], '70s': [1718], 'binding': [1722, 1904, 1941, 2668, 2680, 3555], 'site': [1723, 2335, 2681, 2688], 'diazepam,': [1725], 'enhancer': [1727], 'gamma': [1729], 'aminobutyrric': [1730], 'acid': [1731, 3221], '(GABA)': [1732], 'activity,': [1733], 'kidneys.': [1735], 'Decades': [1736], 'study': [1738, 2637, 3182, 3502], 'shown': [1740, 2551], 'important': [1746, 2023, 3707], 'cellular': [1753, 1763, 2134, 4053], 'functions,': [1754, 1789], 'cholesterol': [1756], 'transport,': [1757], 'corticosteroids': [1758], 'sex': [1760], 'steroids': [1761, 1876], 'synthesis,': [1762, 3098, 4125], 'respiration': [1764], 'takes': [1766], 'mitochondria,': [1769], 'permeability': [1772], 'transition': [1773], 'pore': [1774], '(MPTP)': [1775], 'opening,': [1776], 'programmed': [1778], 'cell': [1779, 2061, 2096, 2208, 3053, 3253, 3344], 'death,': [1780], 'proliferation.': [1782], 'result': [1785], 'TSPO': [1792, 1807, 1845, 1935], 'expression': [1793], 'related': [1796, 3106], 'endocrine': [1803, 3337], 'neurological': [1805], 'disorders.': [1806], 'therefore': [1809], 'become': [1810, 2295], 'appealing': [1812, 3304], 'subcellular': [1813], 'diagnosis': [1819, 1851], 'involving': [1823], 'overexpression': [1825, 2313], 'delivery.': [1831], 'affords': [1834], 'very': [1839], 'few': [1840, 2047], 'examples': [1841], 'nanosystems': [1843], 'targeting': [1844, 1870], 'applications': [1849], 'therapy': [1853], 'states': [1856], 'overexpressing': [1857], 'protein.': [1859], 'Sabrina': [1864], 'Taliani': [1865], '10.1002/cmdc.201700220)': [1867], 'describes': [1868, 3134], 'biosynthetic': [1872], 'neuroactive': [1875], 'specific': [1878, 2089, 2983, 3994], '(TSPO)': [1882], 'ligands': [1883, 2652, 2672, 3491, 3567, 3611], 'may': [1884, 2149, 2339], 'be': [1885, 2311, 2553, 2715, 2734, 3082, 3356, 3639, 3682, 3727], 'viable': [1887], 'approach': [1889, 4044], 'variety': [1892, 2410], 'neurodegenerative': [1894, 2117], 'neuropsychiatric': [1896], 'diseases.': [1897, 2265], 'However,': [1898], 'lack': [1900, 3048], 'correlation': [1902], 'between': [1903, 2576, 3116], 'affinity': [1905], 'vitro': [1908, 1968], 'steroidogenic': [1909, 1934], 'efficacy': [1910, 1937], 'limited': [1912], 'lead': [1916, 2737], 'traditional': [1919], 'affinity-based': [1920], 'strategies.': [1923], 'Their': [1924], 'indicates': [1927], 'robust': [1933], 'ligand': [1936, 3630], 'per': [1942], 'se,': [1943], 'rather': [1945], 'time': [1947, 1957], 'compound': [1949, 2757, 2810, 2951, 3295, 3419], 'spends': [1950], 'target,': [1953], 'namely': [1954], 'residence': [1956], '(RT).': [1958], 'assessment': [1960], 'kinetic': [1963], 'parameter': [1964], 'characterization': [1969, 4173], 'appears': [1972], 'mandatory': [1973], 'order': [1975], 'structure–efficacy': [1978], 'relationships': [1979, 2499, 2851], 'suitable': [1980, 2755], 'future': [1983], 'promising': [1989, 2035, 2736], 'pharmacological': [1990, 3311], 'properties.': [1991], 'Communication': [1994, 2100], 'Radi': [1997], 'Francesca': [1999], 'Aiello': [2000], '10.1002/cmdc.201700145)': [2002], 'deals': [2003, 3439], 'G': [2006], 'protein-coupled': [2007], 'estrogen': [2008, 2018], '(GPER)': [2010], 'mediating,': [2015], 'together': [2016, 3793], 'receptors': [2019, 2769], 'ERa': [2020], 'ERb,': [2022], 'pathophysiological': [2024], 'pathways': [2026, 4179], 'estrogens,': [2029], 'being': [2031], 'regarded': [2032], 'ER-negative': [2038], '(ER–)': [2039], 'triple-negative': [2041], '(TN)': [2042], 'breast': [2043, 2094], 'Only': [2045], 'GPER': [2049], 'modulators': [2050, 3152], 'date,': [2055], 'use': [2058, 3477, 3536], 'cancer': [2060, 2095], 'lines': [2062], 'often': [2064], 'contradictory': [2067], 'results.': [2068, 2185, 2592], 'Here': [2069, 2211, 3384], 'report': [2071, 2213, 2401, 2966, 3215], 'application': [2073], 'virtual': [2075, 3538, 3570], 'cell-based': [2078], 'studies': [2079, 2536], 'scaffolds': [2086], 'antiproliferative': [2090, 3247, 3291], 'effect': [2091], 'GPER-expressing': [2093], 'lines.': [2097], 'contributed': [2102], 'Emiliano': [2104], 'Biasini': [2105], 'Altieri': [2108], '10.1002/cmdc.201700302)': [2110], 'prion': [2112, 2135, 2264], 'class': [2115, 2259], 'disorders': [2118], 'characterized': [2119, 4187], 'accumulation': [2122], 'brain': [2125], 'self-replicating,': [2128], 'misfolded': [2129], 'isoform': [2130], '(PrPSc)': [2131], '(PrPC),': [2137], 'cell-surface': [2139], 'glycoprotein': [2140], 'uncertain': [2142], 'function.': [2143], 'Emerging': [2144], 'evidence': [2145, 2858, 2990], 'suggests': [2146], 'PrPC': [2148], 'passively': [2150], 'serve': [2151], 'substrate': [2154], 'replication': [2157], 'PrPSc,': [2159], 'actively': [2161], 'transduce': [2162], 'toxic': [2164], 'neuronal': [2167], 'cells.': [2168, 3285], 'vast': [2170], 'majority': [2171], 'previous': [2173], 'campaigns': [2176], 'targeted': [2179], 'PrPSc': [2180], 'replication,': [2181], 'largely': [2183], 'unsuccessful': [2184], 'They': [2186, 2471, 3094, 3540], 'previously': [2188, 2362, 3223, 3406], 'experimental': [2191], 'paradigm': [2192], 'detecting': [2194], 'cytotoxic': [2196, 2238], 'mutant': [2199, 2244], 'PrP': [2200], 'cultured': [2203], 'cells,': [2204], 'called': [2205], 'drug-based': [2207], 'assay': [2209, 2219], '(DBCA).': [2210], 'employment': [2216], 'screen': [2221], 'library': [2224], 'diverse': [2226, 2913], 'compounds,': [2227, 3244], 'counteracts': [2236], 'disease-associated': [2242], 'point': [2243, 2252], 'PrP,': [2246], 'becoming': [2248], 'possible': [2250], 'starting': [2251, 3403], 'Papers,': [2269], 'antibacterials.': [2274], 'Sabatini': [2276], '10.1002/cmdc.201700286),': [2278], 'cover,': [2283, 2400, 2747], 'delineates': [2284], 'bacterial': [2289, 2423], 'resistance': [2290, 2309], 'antimicrobial': [2292], 'increasingly': [2297], 'serious': [2298], 'health': [2299], 'problem': [2300], 'years.': [2303], 'strategies': [2306], 'can': [2310, 2780, 3560], 'efflux': [2315, 3194], 'pumps': [2316, 3195], 'NorA': [2319, 2365], 'Staphylococcus': [2321, 2482], 'aureus': [2322], 'leads': [2323], 'sublethal': [2326], 'concentration': [2327], 'antibacterial': [2330, 2386, 2467, 2478, 4019], 'agent': [2331], 'active': [2334, 2937, 3073, 3566], 'turn': [2338], 'predispose': [2340], 'organism': [2342], 'high-level': [2347, 3718], 'target-based': [2348], 'resistance.': [2349], 'improve': [2354, 3561], 'stability': [2358, 3160], '3-phenyl-1,4-benzothiazine': [2364], 'inhibitors,': [2366, 3034, 3358], 'replaced': [2368], 'benzothiazine': [2370], 'core': [2371], 'nuclei,': [2374], 'none': [2376, 2449], 'synthesized': [2380], 'showed': [2382, 3169, 3246, 3275, 3623], 'any': [2383], 'appreciable': [2384], 'intrinsic': [2385], 'activity.': [2387, 2510, 4069], 'Valentina': [2388], 'Straniero': [2389], 'Ermanno': [2391], 'Valoti': [2392], '10.1002/cmdc.201700201),': [2394], 'inside': [2398], 'acquisition': [2406], 'drug-resistant': [2412], 'microorganisms': [2413], 'continuously': [2415], 'emerging,': [2416], 'restricting': [2417], 'options': [2420], 'common': [2422], 'infections.': [2424], 'Antimicrobial': [2425], 'originally': [2429, 2935, 3353], 'no': [2433, 2776], 'longer': [2434], 'helpful,': [2435], 'weak': [2439], 'null': [2441], 'toward': [2443, 2703, 3092, 3164], 'antibiotic-resistant': [2445], 'bacteria.': [2446], 'addition,': [2448], 'recently': [2452, 2472, 2550], 'approved': [2453, 3348], 'antibiotics': [2454], 'affect': [2455], 'targets,': [2457], 'resulting': [2458], 'need': [2461, 3059], 'mechanisms': [2468, 2572], 'action.': [2470], 'developed': [2473, 4165], 'derivatives': [2475, 3146, 3163], 'displaying': [2476], 'good': [2477, 3084], 'activities': [2479, 3996], 'methicillin-resistant': [2481], 'aureus,': [2483], 'vancomycin-resistant': [2487], 'Enterococcus': [2488], 'faecalis': [2489], 'Mycobacterium': [2491], 'tuberculosis,': [2492], 'here,': [2494], 'discuss': [2496], 'differently': [2501], 'substituted,': [2502], 'heterocycles.': [2504], 'Four': [2505, 2954], 'papers': [2506, 2955, 3429, 4081], 'deal': [2507, 2956, 2988], 'neuroprotective': [2509, 4122], 'Moro': [2512], '10.1002/cmdc.201700200)': [2514], 'out': [2516, 2582, 3505], 'physiological': [2519], 'roles': [2520, 3010], 'inosine,': [2522, 2579], 'converted': [2524], 'adenosine': [2526, 2528, 2559, 2563, 2577], 'deaminase,': [2529], 'received': [2531], 'scanty': [2532], 'attention.': [2533], 'Nevertheless,': [2534], 'demonstrated': [2538], 'inosine': [2540], 'neuroprotective,': [2542], 'cardioprotective,': [2543], 'immunomodulatory,': [2544], 'antidepressive': [2546], 'effects.': [2547], 'Inosine': [2548], 'less': [2555], 'agonist': [2557], 'A2A': [2562], 'receptor.': [2564, 3575], 'To': [2565, 2939], 'better': [2566], 'depict': [2567], 'differences': [2569], 'recognition': [2575], 'carried': [2581, 3504], 'supervised': [2583], 'molecular': [2584, 3434, 3479, 4051], 'dynamics': [2585, 3480], '(SuMD)': [2586], 'simulations,': [2587], 'reporting': [2589], 'obtained': [2591], 'Gabriella': [2593], 'Ortore': [2594], '10.1002/cmdc.201700051)': [2596], 'Transthyretin': [2599], '(TTR),': [2600], 'primary': [2602], 'carrier': [2603, 2613], 'thyroxine': [2605], '(T4)': [2606], 'cerebrospinal': [2608], 'fluid': [2609], 'secondary': [2612], 'blood.': [2615], 'TTR': [2616, 2643, 2656, 2679, 2705], 'stable': [2619, 3174], 'homotetramer,': [2620], 'certain': [2622], 'factors,': [2623], 'genetic': [2624], 'environmental,': [2626], 'could': [2627, 3023], 'degradation': [2630], 'form': [2632], 'amyloid': [2633], 'fibrils.': [2634], 'docking': [2636, 3126, 3533], 'using': [2638, 3550, 3596], 'crystal': [2639, 3483], 'structures': [2640, 3484], 'wild-type': [2642], 'planned': [2645], 'designing': [2650], 'able': [2653, 3372], 'inhibit': [2655, 3374], 'fibril': [2657, 2706], 'formation.': [2658], 'computational': [2660, 3597], 'protocol': [2661], 'thought': [2663], 'overcome': [2665], 'multiple': [2667, 3336, 3547], 'modes': [2669], 'peculiarity': [2676], 'pseudosymmetry': [2685], 'pockets,': [2689], 'generally': [2691], 'weaken': [2692], 'structure-based': [2694], 'studies.': [2695], 'Five': [2696], 'selected,': [2699], 'inhibiting': [2704], 'formation': [2707], 'assessed.': [2709], 'observed': [2713], 'actives,': [2716], 'had': [2720], 'same': [2722, 3487], 'positive': [2726, 2794, 2865, 3624], 'control,': [2727], 'other': [2730], 'compound.': [2738, 3410], 'Clelia': [2739], 'Dallanoce': [2740], '10.1002/cmdc.201700162),': [2742], 'proposes': [2748, 3446], 'azaspiro-isoxazole': [2751], 'derivative': [2752, 3067, 3273], 'model': [2756], 'design': [2760, 3986, 4144, 4190], 'silent': [2763], 'agonists': [2764, 2772], 'α7': [2766, 2783, 2837], 'nicotinic': [2767], 'acetylcholine': [2768], '(nAChRs).': [2770], 'Silent': [2771], 'evoke': [2773], 'little': [2774], 'channel': [2777], 'activation': [2778, 3320], 'induce': [2781], 'desensitized': [2784], 'Ds': [2785], 'state,': [2786], 'sensitive': [2789], 'type': [2792, 3615], 'II': [2793], 'allosteric': [2795], 'modulator,': [2796], 'PNU-120596.': [2799], 'Introduction': [2800], 'meta': [2802], 'substituents': [2803], 'benzyloxy': [2806], 'moiety': [2807], 'sets': [2814], 'tertiary': [2816], 'amines': [2817], 'quaternary': [2819, 2869], 'ammonium': [2820], 'salts': [2821], 'based': [2822, 3432, 3607], 'spirocyclic': [2825], 'quinuclidinyl-D2-isoxazoline': [2826], 'scaffold.': [2827], 'Electrophysiological': [2828], 'assays': [2829], 'performed': [2830], 'Xenopus': [2832], 'laevis': [2833], 'oocytes': [2834], 'expressing': [2835], 'nAChRs': [2838], 'highlighted': [2839], 'significant': [2847], 'silent-agonism': [2848], 'profile.': [2849, 3207], 'Structure–activity': [2850], 'analogues': [2856], 'provided': [2857], 'crucial': [2861, 2977, 3495], 'charge': [2866], 'quinuclidine': [2870], 'nitrogen': [2871], 'atom.': [2872], 'Pisani': [2874], '10.1002/cmdc.201700282)': [2876], 'considers': [2877], 'acetylcholinesterase': [2878], '(AChE)': [2879], 'still': [2881], "Alzheimer's": [2886], '(AD)': [2888], 'treatment.': [2889], 'discovering': [2894], 'AChE': [2896, 2930], 'dual': [2897], 'binders': [2898], 'improved': [2900], 'drug-likeness,': [2901], 'homo-': [2902], 'heterodimers': [2904], 'containing': [2905, 3485], '2H-chromen-2-one': [2906], 'building': [2907], 'blocks': [2908], 'developed.': [2910], 'By': [2911, 3595], 'exploring': [2912], 'linkages': [2914], 'neutral': [2916], 'protonatable': [2918], 'amino': [2919], 'moieties': [2920], 'aliphatic': [2922], 'spacers': [2923], 'length,': [2926], 'nanomolar': [2928], 'bivalent': [2929], 'inhibitor': [2931, 3077, 3398], 'identified': [2933, 3070, 3407], 'weakly': [2936], 'fragments.': [2938], 'assess': [2940], 'AD,': [2944], 'disease-related': [2946], 'properties': [2948], 'investigated.': [2953], 'cancer-related': [2958], 'topics.': [2959], 'Roberta': [2960], 'Costi': [2961], '10.1002/cmdc.201700040)': [2963], 'co-workers': [2965], 'p300,': [2969], 'polyhedric': [2971], 'transcriptional': [2972], 'coactivator': [2973], 'acetylating': [2980], 'histones': [2981], 'lysine': [2984], 'residues.': [2985], 'shows': [2991], 'p300': [2993, 3030, 3076, 3117], 'several': [2997, 3329], 'leukemia,': [3000], 'tumors,': [3001], 'viral': [3003], 'infection.': [3004], 'Its': [3005], 'involvement': [3006, 4168], 'pleiotropic': [3008], 'connections': [3012], 'rationale': [3017], 'determine': [3019], 'modulation': [3022], 'amenable': [3026], 'target.': [3028], 'Several': [3029], '(histone': [3032], 'acetyltransferase': [3033], 'HATis)': [3035], 'so': [3039], 'far,': [3040], 'suffer': [3044], 'low': [3046, 3052], 'potency,': [3047], 'specificity,': [3050], 'permeability,': [3054], 'find': [3061], 'inhibitors.': [3064, 4159], 'cinnamoyl': [3066, 3109], 'proven': [3080], 'investigate': [3088], 'p300.': [3093], 'describe': [3095], 'design,': [3097], 'evaluation': [3101, 3138, 3392, 4237], 'HATis': [3104], 'structurally': [3105], 'derivative,': [3110], 'investigating': [3112], 'interactions': [3115, 3497, 3519], 'best-emerged': [3120], 'hits': [3121], 'means': [3123], 'induced-fit': [3125], 'molecular-dynamics': [3128], 'simulations.': [3129], 'Elisabetta': [3130], 'Teodori': [3131], '10.1002/cmdc.201700239)': [3133], 'synthesis': [3136, 3988, 4146, 4192], 'series': [3141, 3191], 'amide': [3143], 'ester': [3145], 'P-glycoprotein': [3150], '(P-gp)': [3151], 'elacridar': [3153], 'tariquidar.': [3155], 'Investigation': [3156], 'spontaneous': 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