Title: Tryptophan and Amitriptyline in the Treatment of Depression
Abstract: Amitriptyline together with /.-tryptophan were compared with amitriptyline alone in a double-blind trial on 30 hospitalized patients suffering from depressive illness. Patients receiving the amino acid together with amitriptyline were found to improve more than control patients given amitriptyline only. The average scores obtained on a depression-inventory were, however, not significantly different either at 15 days or after treatment. There was no evidence that either treatment had any advantage with regard to speed of action. Side effects were more numerous in patients treated with amitriptyline plus /.-tryptophan than control patients, the difference being significant, (p <0.01). We wish to express our thanks to the Research Department of Productos Roche, S.A.,for having supplied /.-tryptophan and amitriptyline.
Publication Year: 1973
Publication Date: 1973-01-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 21
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