Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2744400235', 'doi': 'https://doi.org/10.18632/oncotarget.19982', 'title': 'The activation of SRC family kinases and focal adhesion kinase with the loss of the amplified, mutated<i>EGFR</i>gene contributes to the resistance to afatinib, erlotinib and osimertinib in human lung cancer cells', 'display_name': 'The activation of SRC family kinases and focal adhesion kinase with the loss of the amplified, mutated<i>EGFR</i>gene contributes to the resistance to afatinib, erlotinib and osimertinib in human lung cancer cells', 'publication_year': 2017, 'publication_date': '2017-08-07', 'ids': {'openalex': 'https://openalex.org/W2744400235', 'doi': 'https://doi.org/10.18632/oncotarget.19982', 'mag': '2744400235', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29050315', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5642590'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.19982', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=19982&path%5B%5D=63767', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=19982&path%5B%5D=63767', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5085723082', 'display_name': 'Yûichi Murakami', 'orcid': 'https://orcid.org/0009-0003-2971-8841'}, 'institutions': [{'id': 'https://openalex.org/I135598925', 'display_name': 'Kyushu University', 'ror': 'https://ror.org/00p4k0j84', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I135598925']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yuichi Murakami', 'raw_affiliation_strings': ['Cancer Translational Research Center, St. Mary’s Institute of Health Sciences, Fukuoka, Japan', 'Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan'], 'affiliations': [{'raw_affiliation_string': 'Cancer Translational Research Center, St. Mary’s Institute of Health Sciences, Fukuoka, Japan', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan', 'institution_ids': ['https://openalex.org/I135598925']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111896684', 'display_name': 'Kahori Sonoda', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I135598925', 'display_name': 'Kyushu University', 'ror': 'https://ror.org/00p4k0j84', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I135598925']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kahori Sonoda', 'raw_affiliation_strings': ['Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan', 'institution_ids': ['https://openalex.org/I135598925']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036058432', 'display_name': 'Hideyuki Abe', 'orcid': 'https://orcid.org/0000-0003-0704-8413'}, 'institutions': [{'id': 'https://openalex.org/I4210096146', 'display_name': 'Kurume University Hospital', 'ror': 'https://ror.org/00vjxjf30', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210096146']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hideyuki Abe', 'raw_affiliation_strings': ['Department of Diagnostic Pathology, Kurume University Hospital, Fukuoka, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Diagnostic Pathology, Kurume University Hospital, Fukuoka, Japan', 'institution_ids': ['https://openalex.org/I4210096146']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055017893', 'display_name': 'Kosuke Watari', 'orcid': 'https://orcid.org/0000-0003-0260-2323'}, 'institutions': [{'id': 'https://openalex.org/I135598925', 'display_name': 'Kyushu University', 'ror': 'https://ror.org/00p4k0j84', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I135598925']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kosuke Watari', 'raw_affiliation_strings': ['Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan', 'institution_ids': ['https://openalex.org/I135598925']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052416001', 'display_name': 'Daiki Kusakabe', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210111488', 'display_name': 'Life Science Institute', 'ror': 'https://ror.org/01yeyd808', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I4210111488']}, {'id': 'https://openalex.org/I135598925', 'display_name': 'Kyushu University', 'ror': 'https://ror.org/00p4k0j84', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I135598925']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Daiki Kusakabe', 'raw_affiliation_strings': ['Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan; Physical Chemistry for Life Science Laboratory, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan', 'Physical Chemistry for Life Science Laboratory, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan'], 'affiliations': [{'raw_affiliation_string': 'Physical Chemistry for Life Science Laboratory, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan', 'institution_ids': ['https://openalex.org/I4210111488', 'https://openalex.org/I135598925']}, {'raw_affiliation_string': 'Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan; Physical Chemistry for Life Science Laboratory, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan', 'institution_ids': ['https://openalex.org/I135598925']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045245886', 'display_name': 'Koichi Azuma', 'orcid': 'https://orcid.org/0000-0001-5040-5856'}, 'institutions': [{'id': 'https://openalex.org/I105296287', 'display_name': 'Kurume University', 'ror': 'https://ror.org/057xtrt18', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I105296287']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Koichi Azuma', 'raw_affiliation_strings': ['Division of Respirology, Neurology and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Fukuoka, Japan'], 'affiliations': [{'raw_affiliation_string': 'Division of Respirology, Neurology and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Fukuoka, Japan', 'institution_ids': ['https://openalex.org/I105296287']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067368086', 'display_name': 'Akihiko Kawahara', 'orcid': 'https://orcid.org/0000-0002-4081-2519'}, 'institutions': [{'id': 'https://openalex.org/I4210096146', 'display_name': 'Kurume University Hospital', 'ror': 'https://ror.org/00vjxjf30', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210096146']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Akihiko Kawahara', 'raw_affiliation_strings': ['Department of Diagnostic Pathology, Kurume University Hospital, Fukuoka, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Diagnostic Pathology, Kurume University Hospital, Fukuoka, Japan', 'institution_ids': ['https://openalex.org/I4210096146']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024527863', 'display_name': 'Jun Akiba', 'orcid': 'https://orcid.org/0000-0003-2657-8604'}, 'institutions': [{'id': 'https://openalex.org/I4210096146', 'display_name': 'Kurume University Hospital', 'ror': 'https://ror.org/00vjxjf30', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210096146']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Jun Akiba', 'raw_affiliation_strings': ['Department of Diagnostic Pathology, Kurume University Hospital, Fukuoka, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Diagnostic Pathology, Kurume University Hospital, Fukuoka, Japan', 'institution_ids': ['https://openalex.org/I4210096146']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023388437', 'display_name': 'Chitose Oneyama', 'orcid': 'https://orcid.org/0000-0002-5719-9431'}, 'institutions': [{'id': 'https://openalex.org/I4210133851', 'display_name': 'Aichi Cancer Center', 'ror': 'https://ror.org/03kfmm080', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210133851']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Chitose Oneyama', 'raw_affiliation_strings': ['Division of Microbiology and Oncology, Aichi Cancer Center Research Institute, Nagoya, Japan'], 'affiliations': [{'raw_affiliation_string': 'Division of Microbiology and Oncology, Aichi Cancer Center Research Institute, Nagoya, Japan', 'institution_ids': ['https://openalex.org/I4210133851']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073675187', 'display_name': 'Jonathan A. Pachter', 'orcid': 'https://orcid.org/0000-0002-0263-474X'}, 'institutions': [{'id': 'https://openalex.org/I4210154584', 'display_name': 'Verastem (United States)', 'ror': 'https://ror.org/0562yk913', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210154584']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jonathan A. Pachter', 'raw_affiliation_strings': ['Verastem Inc., Cambridge, MA, USA'], 'affiliations': [{'raw_affiliation_string': 'Verastem Inc., Cambridge, MA, USA', 'institution_ids': ['https://openalex.org/I4210154584']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015524135', 'display_name': 'Kazuko Sakai', 'orcid': 'https://orcid.org/0000-0003-1822-2720'}, 'institutions': [{'id': 'https://openalex.org/I916559398', 'display_name': 'Kindai University', 'ror': 'https://ror.org/05kt9ap64', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I916559398']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kazuko Sakai', 'raw_affiliation_strings': ['Department of Genome Biology, Kinki University Faculty of Medicine, Osaka, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Genome Biology, Kinki University Faculty of Medicine, Osaka, Japan', 'institution_ids': ['https://openalex.org/I916559398']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004282323', 'display_name': 'Kazuto Nishio', 'orcid': 'https://orcid.org/0000-0002-8275-0846'}, 'institutions': [{'id': 'https://openalex.org/I916559398', 'display_name': 'Kindai University', 'ror': 'https://ror.org/05kt9ap64', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I916559398']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kazuto Nishio', 'raw_affiliation_strings': ['Department of Genome Biology, Kinki University Faculty of Medicine, Osaka, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Genome Biology, Kinki University Faculty of Medicine, Osaka, Japan', 'institution_ids': ['https://openalex.org/I916559398']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112640224', 'display_name': 'Michihiko Kuwano', 'orcid': None}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Michihiko Kuwano', 'raw_affiliation_strings': ['Cancer Translational Research Center, St. Mary’s Institute of Health Sciences, Fukuoka, Japan'], 'affiliations': [{'raw_affiliation_string': 'Cancer Translational Research Center, St. Mary’s Institute of Health Sciences, Fukuoka, Japan', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101665606', 'display_name': 'Mayumi Ono', 'orcid': 'https://orcid.org/0000-0001-7649-0323'}, 'institutions': [{'id': 'https://openalex.org/I135598925', 'display_name': 'Kyushu University', 'ror': 'https://ror.org/00p4k0j84', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I135598925']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Mayumi Ono', 'raw_affiliation_strings': ['Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan', 'institution_ids': ['https://openalex.org/I135598925']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 7, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.431, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 26, 'citation_normalized_percentile': {'value': 0.841005, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '8', 'issue': '41', 'first_page': '70736', 'last_page': '70751'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10417', 'display_name': 'Lung Cancer Treatments and Mutations', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10417', 'display_name': 'Lung Cancer Treatments and Mutations', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10755', 'display_name': 'HER2/EGFR in Cancer Research', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11157', 'display_name': 'Chronic Lymphocytic Leukemia Research', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/afatinib', 'display_name': 'Afatinib', 'score': 0.91563904}, {'id': 'https://openalex.org/keywords/osimertinib', 'display_name': 'Osimertinib', 'score': 0.5593197}], 'concepts': [{'id': 'https://openalex.org/C2780586478', 'wikidata': 'https://www.wikidata.org/wiki/Q4688818', 'display_name': 'Afatinib', 'level': 5, 'score': 0.91563904}, {'id': 'https://openalex.org/C2778087573', 'wikidata': 'https://www.wikidata.org/wiki/Q418369', 'display_name': 'Erlotinib', 'level': 4, 'score': 0.6450144}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6192898}, {'id': 'https://openalex.org/C2776256026', 'wikidata': 'https://www.wikidata.org/wiki/Q47912', 'display_name': 'Lung cancer', 'level': 2, 'score': 0.6150994}, {'id': 'https://openalex.org/C2777626846', 'wikidata': 'https://www.wikidata.org/wiki/Q21506464', 'display_name': 'Osimertinib', 'level': 5, 'score': 0.5593197}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.52353907}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.4894756}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.48590794}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.4518957}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.44827956}, {'id': 'https://openalex.org/C2779438470', 'wikidata': 'https://www.wikidata.org/wiki/Q424401', 'display_name': 'Epidermal growth factor receptor', 'level': 3, 'score': 0.43965667}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.18072364}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.1101259}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.19982', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=19982&path%5B%5D=63767', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5642590', 'pdf_url': 'https://europepmc.org/articles/pmc5642590?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642590', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29050315', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.19982', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=19982&path%5B%5D=63767', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 50, 'referenced_works': ['https://openalex.org/W1546552389', 'https://openalex.org/W1619850371', 'https://openalex.org/W1908940658', 'https://openalex.org/W1938449115', 'https://openalex.org/W1983774108', 'https://openalex.org/W1990938833', 'https://openalex.org/W1998971866', 'https://openalex.org/W2003984225', 'https://openalex.org/W2011474098', 'https://openalex.org/W2028113472', 'https://openalex.org/W2032397471', 'https://openalex.org/W2038385234', 'https://openalex.org/W2043696829', 'https://openalex.org/W2044423100', 'https://openalex.org/W2050211354', 'https://openalex.org/W2056881829', 'https://openalex.org/W2063391304', 'https://openalex.org/W2065293650', 'https://openalex.org/W2068135384', 'https://openalex.org/W2071437006', 'https://openalex.org/W2071539936', 'https://openalex.org/W2076178766', 'https://openalex.org/W2088540000', 'https://openalex.org/W2100189272', 'https://openalex.org/W2102498455', 'https://openalex.org/W2108688207', 'https://openalex.org/W2126709309', 'https://openalex.org/W2129656399', 'https://openalex.org/W2131088620', 'https://openalex.org/W2132157071', 'https://openalex.org/W2132540363', 'https://openalex.org/W2133555426', 'https://openalex.org/W2133662417', 'https://openalex.org/W2135117965', 'https://openalex.org/W2139236349', 'https://openalex.org/W2141552280', 'https://openalex.org/W2143913849', 'https://openalex.org/W2145742598', 'https://openalex.org/W2147545245', 'https://openalex.org/W2149560669', 'https://openalex.org/W2152905269', 'https://openalex.org/W2154149901', 'https://openalex.org/W2161821474', 'https://openalex.org/W2170532460', 'https://openalex.org/W2236524872', 'https://openalex.org/W2292347930', 'https://openalex.org/W2299551224', 'https://openalex.org/W2328222367', 'https://openalex.org/W299686445', 'https://openalex.org/W4255226419'], 'related_works': ['https://openalex.org/W4388081083', 'https://openalex.org/W4382399958', 'https://openalex.org/W3206729878', 'https://openalex.org/W3186445616', 'https://openalex.org/W3137959397', 'https://openalex.org/W3136482224', 'https://openalex.org/W2981698511', 'https://openalex.org/W2965410028', 'https://openalex.org/W2953884587', 'https://openalex.org/W2896513927'], 'abstract_inverted_index': {'//': [0], 'Yuichi': [1], 'Murakami': [2], '1,': [3, 9, 22], '2,': [4], '*': [5, 10, 162], ',': [6, 11, 15, 19, 24, 28, 32, 36, 40, 45, 49, 53], 'Kahori': [7], 'Sonoda': [8], 'Hideyuki': [12], 'Abe': [13], '3': [14, 31, 35, 88], 'Kosuke': [16], 'Watari': [17], '1': [18, 60, 61], 'Daiki': [20], 'Kusakabe': [21], '4': [23, 98], 'Koichi': [25], 'Azuma': [26], '5': [27, 113], 'Akihiko': [29], 'Kawahara': [30], 'Jun': [33], 'Akiba': [34], 'Chitose': [37], 'Oneyama': [38], '6': [39, 131], 'Jonathan': [41], 'A.': [42], 'Pachter': [43], '7': [44, 144], 'Kazuko': [46], 'Sakai': [47], '8': [48, 52, 150], 'Kazuto': [50], 'Nishio': [51], 'Michihiko': [54], 'Kuwano': [55], '2': [56, 75], 'and': [57, 118, 135, 204, 234, 271, 273, 295, 330, 358, 378, 383, 406], 'Mayumi': [58, 173], 'Ono': [59], 'Department': [62, 89, 120, 151], 'of': [63, 68, 83, 90, 106, 115, 121, 127, 133, 152, 158, 207, 221, 260, 285, 298, 310, 347, 355, 373, 385, 391, 400, 412], 'Pharmaceutical': [64, 69, 107], 'Oncology,': [65, 136], 'Graduate': [66], 'School': [67, 126], 'Sciences,': [70, 85, 108], 'Kyushu': [71, 109], 'University,': [72, 110], 'Fukuoka,': [73, 86, 96, 111, 129], 'Japan': [74, 87, 97, 112, 130, 143, 161], 'Cancer': [76, 138], 'Translational': [77], 'Research': [78, 140], 'Center,': [79], 'St.': [80], "Mary's": [81], 'Institute': [82], 'Health': [84], 'Diagnostic': [91], 'Pathology,': [92], 'Kurume': [93, 124], 'University': [94, 125, 156], 'Hospital,': [95], 'Physical': [99], 'Chemistry': [100], 'for': [101], 'Life': [102], 'Science': [103], 'Laboratory,': [104], 'Faculty': [105, 157], 'Division': [114, 132], 'Respirology,': [116], 'Neurology': [117], 'Rheumatology,': [119], 'Internal': [122], 'Medicine,': [123, 128, 159], 'Microbiology': [134], 'Aichi': [137], 'Center': [139], 'Institute,': [141], 'Nagoya,': [142], 'Verastem': [145], 'Inc.,': [146], 'Cambridge,': [147], 'MA,': [148], 'USA': [149], 'Genome': [153], 'Biology,': [154], 'Kinki': [155], 'Osaka,': [160], 'These': [163, 262, 278, 367], 'authors': [164], 'have': [165], 'contributed': [166], 'equally': [167], 'to': [168, 237, 267, 336, 416], 'this': [169], 'work': [170], 'Correspondence': [171], 'to:': [172], 'Ono,': [174], 'email:': [175], '[email protected]': [176], 'Keywords:': [177], 'afatinib': [178], 'resistance,': [179], 'SRC': [180, 323, 374], 'family': [181, 288, 375, 394], 'kinase,': [182, 185], 'focal': [183], 'adhesion': [184], 'non-small': [186, 224], 'cell': [187, 225, 247, 328], 'lung': [188, 226, 245, 413], 'cancer': [189, 246, 414], 'Received:': [190], 'February': [191], '28,': [192], '2017': [193, 197, 201], 'Accepted:': [194], 'July': [195], '18,': [196], 'Published:': [198], 'August': [199], '07,': [200], 'ABSTRACT': [202], 'Second-': [203], 'third-generation': [205, 275], 'inhibitors': [206], 'epidermal': [208], 'growth': [209], 'factor': [210], 'receptor': [211], '(EGFR)': [212], 'tyrosine': [213, 257], 'kinase': [214, 258], 'activity': [215, 259], '(EGFR-TKIs)': [216], 'are': [217], 'improving': [218], 'the': [219, 243, 256, 291, 315, 345, 381, 389, 410], 'treatment': [220], 'patients': [222], 'with': [223, 303, 314, 321, 341, 353], 'cancer.': [227], 'Here': [228], 'we': [229], 'established': [230], 'two': [231], 'sublines': [232, 264, 280, 335], '(BR1-8': [233], 'BR2-3)': [235], 'resistant': [236, 266, 279], 'a': [238, 252, 274, 322, 337], 'second-generation': [239, 417], 'inhibitor,': [240], 'afatinib,': [241], 'from': [242], 'human': [244], 'line': [248], 'HCC827': [249, 306, 342, 356], 'that': [250, 254, 354, 370, 403], 'harbors': [251], 'mutation': [253], 'activates': [255], 'EGFR.': [261], 'afatinib-resistant': [263, 386], 'were': [265], 'first-generation': [268], 'EGFR-TKIs,': [269], 'gefitinib': [270], 'erlotinib,': [272], 'EGFR-TKI,': [276], 'osimertinib.': [277], 'showed': [281], 'markedly': [282], 'reduced': [283], 'levels': [284], 'multiple': [286, 392], 'EGFR': [287, 299, 311, 393], 'proteins,': [289], 'including': [290], 'activated': [292], 'mutant': [293], 'EGFR,': [294], 'complete': [296], 'loss': [297], 'amplification': [300, 309], 'as': [301], 'compared': [302, 340, 352], 'their': [304], 'parental': [305], 'cells': [307, 349, 357, 387, 415], 'harboring': [308], 'gene.': [312], 'Treatment': [313], 'multikinase': [316], 'inhibitor': [317], 'dasatinib': [318, 362], 'or': [319, 363], 'transfection': [320], 'small': [324], 'interfering': [325], 'RNA': [326], 'inhibited': [327, 360], 'survival': [329, 382], 'AKT': [331], 'phosphorylation': [332], 'in': [333], 'drug-resistant': [334, 348], 'greater': [338, 351], 'extent': [339], 'cells.': [343], 'Further,': [344], 'migration': [346, 384], 'was': [350, 359, 396], 'by': [361], 'an': [364], 'FAK': [365, 379, 407], 'inhibitor.': [366], 'findings': [368], 'indicate': [369], 'compensatory': [371], 'activation': [372], 'kinases': [376], '(SFKs)': [377], 'supports': [380], 'when': [388], 'expression': [390], 'proteins': [395], 'mostly': [397], 'abrogated.': [398], 'Combinations': [399], 'potent': [401], 'drugs': [402], 'target': [404], 'SFKs': [405], 'may': [408], 'overcome': [409], 'resistance': [411], 'TKIs.': [418]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2744400235', 'counts_by_year': [{'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 9}], 'updated_date': '2024-12-11T20:35:33.834333', 'created_date': '2017-08-17'}