Publication Information

{'id': 'https://openalex.org/W2744162400', 'doi': 'https://doi.org/10.3389/fphar.2017.00521', 'title': 'Advances in the Understanding of Protein-Protein Interactions in Drug Metabolizing Enzymes through the Use of Biophysical Techniques', 'display_name': 'Advances in the Understanding of Protein-Protein Interactions in Drug Metabolizing Enzymes through the Use of Biophysical Techniques', 'publication_year': 2017, 'publication_date': '2017-08-08', 'ids': {'openalex': 'https://openalex.org/W2744162400', 'doi': 'https://doi.org/10.3389/fphar.2017.00521', 'mag': '2744162400', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28848438', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5550701'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/fphar.2017.00521', 'pdf_url': 'https://www.frontiersin.org/articles/10.3389/fphar.2017.00521/pdf', 'source': {'id': 'https://openalex.org/S132108250', 'display_name': 'Frontiers in Pharmacology', 'issn_l': '1663-9812', 'issn': ['1663-9812'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.frontiersin.org/articles/10.3389/fphar.2017.00521/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5068700897', 'display_name': 'Jed N. Lampe', 'orcid': 'https://orcid.org/0000-0003-0794-2263'}, 'institutions': [{'id': 'https://openalex.org/I4210128618', 'display_name': 'University of Kansas Medical Center', 'ror': 'https://ror.org/036c9yv20', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210128618']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Jed N. Lampe', 'raw_affiliation_strings': ['Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, MO, United States'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, MO, United States', 'institution_ids': ['https://openalex.org/I4210128618']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5068700897'], 'corresponding_institution_ids': ['https://openalex.org/I4210128618'], 'apc_list': {'value': 2950, 'currency': 'USD', 'value_usd': 2950, 'provenance': 'doaj'}, 'apc_paid': {'value': 2950, 'currency': 'USD', 'value_usd': 2950, 'provenance': 'doaj'}, 'fwci': 0.509, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 16, 'citation_normalized_percentile': {'value': 0.99458, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '8', 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10375', 'display_name': 'Pharmacogenetics and Drug Metabolism', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10375', 'display_name': 'Pharmacogenetics and Drug Metabolism', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12827', 'display_name': 'Biochemical and Molecular Research', 'score': 0.9959, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11178', 'display_name': 'Receptor Mechanisms and Signaling', 'score': 0.9871, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/glutathione-transferase', 'display_name': 'Glutathione transferase', 'score': 0.46039504}], 'concepts': [{'id': 'https://openalex.org/C526171541', 'wikidata': 'https://www.wikidata.org/wiki/Q407693', 'display_name': 'Cytochrome P450', 'level': 3, 'score': 0.6683099}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.5263185}, {'id': 'https://openalex.org/C2780035454', 'wikidata': 'https://www.wikidata.org/wiki/Q8386', 'display_name': 'Drug', 'level': 2, 'score': 0.48960835}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.4724976}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.46260628}, {'id': 'https://openalex.org/C3019047270', 'wikidata': 'https://www.wikidata.org/wiki/Q307302', 'display_name': 'Glutathione transferase', 'level': 4, 'score': 0.46039504}, {'id': 'https://openalex.org/C14036430', 'wikidata': 'https://www.wikidata.org/wiki/Q3736076', 'display_name': 'Function (biology)', 'level': 2, 'score': 0.4465916}, {'id': 'https://openalex.org/C74187038', 'wikidata': 'https://www.wikidata.org/wiki/Q1418791', 'display_name': 'Drug discovery', 'level': 2, 'score': 0.4306671}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.42246136}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3736812}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.36100215}, {'id': 'https://openalex.org/C538909803', 'wikidata': 'https://www.wikidata.org/wiki/Q116907', 'display_name': 'Glutathione', 'level': 3, 'score': 0.30957747}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.3008459}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.2257545}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.14619195}], 'mesh': [], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/fphar.2017.00521', 'pdf_url': 'https://www.frontiersin.org/articles/10.3389/fphar.2017.00521/pdf', 'source': {'id': 'https://openalex.org/S132108250', 'display_name': 'Frontiers in Pharmacology', 'issn_l': '1663-9812', 'issn': ['1663-9812'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/2fd093963e12434ab1943525c66c9261', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5550701', 'pdf_url': 'https://europepmc.org/articles/pmc5550701?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550701', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28848438', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/fphar.2017.00521', 'pdf_url': 'https://www.frontiersin.org/articles/10.3389/fphar.2017.00521/pdf', 'source': {'id': 'https://openalex.org/S132108250', 'display_name': 'Frontiers in Pharmacology', 'issn_l': '1663-9812', 'issn': ['1663-9812'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'QH846868-K-INBRE'}, {'funder': 'https://openalex.org/F4320337354', 'funder_display_name': 'National Institute of General Medical Sciences', 'award_id': 'P20- GM103549-07'}, {'funder': 'https://openalex.org/F4320337375', 'funder_display_name': 'National Center for Research Resources', 'award_id': 'P20-RR021940-07'}], 'datasets': [], 'versions': [], 'referenced_works_count': 124, 'referenced_works': ['https://openalex.org/W1541023832', 'https://openalex.org/W1550145440', 'https://openalex.org/W1760521361', 'https://openalex.org/W1882723718', 'https://openalex.org/W1919120605', 'https://openalex.org/W1963741838', 'https://openalex.org/W1963803763', 'https://openalex.org/W1965126745', 'https://openalex.org/W1965951315', 'https://openalex.org/W1969521879', 'https://openalex.org/W1970424644', 'https://openalex.org/W1971172643', 'https://openalex.org/W1971850788', 'https://openalex.org/W1972267232', 'https://openalex.org/W1973543652', 'https://openalex.org/W1974302220', 'https://openalex.org/W1974543768', 'https://openalex.org/W1975206909', 'https://openalex.org/W1976261167', 'https://openalex.org/W1979309233', 'https://openalex.org/W1981457648', 'https://openalex.org/W1981553176', 'https://openalex.org/W1983174721', 'https://openalex.org/W1985349154', 'https://openalex.org/W1987838008', 'https://openalex.org/W1988280744', 'https://openalex.org/W1990357483', 'https://openalex.org/W1992475241', 'https://openalex.org/W1992581513', 'https://openalex.org/W1992679494', 'https://openalex.org/W1993263557', 'https://openalex.org/W1994673901', 'https://openalex.org/W2000270075', 'https://openalex.org/W2001957776', 'https://openalex.org/W2004218488', 'https://openalex.org/W2005588447', 'https://openalex.org/W2005764895', 'https://openalex.org/W2006358281', 'https://openalex.org/W2007838439', 'https://openalex.org/W2011637350', 'https://openalex.org/W2012235132', 'https://openalex.org/W2012907539', 'https://openalex.org/W2013396018', 'https://openalex.org/W2013416504', 'https://openalex.org/W2014668832', 'https://openalex.org/W2014919794', 'https://openalex.org/W2015091165', 'https://openalex.org/W2019158833', 'https://openalex.org/W2020166585', 'https://openalex.org/W2021193295', 'https://openalex.org/W2023951398', 'https://openalex.org/W2024092408', 'https://openalex.org/W2027791614', 'https://openalex.org/W2032941773', 'https://openalex.org/W2034720893', 'https://openalex.org/W2035889789', 'https://openalex.org/W2036026119', 'https://openalex.org/W2036951082', 'https://openalex.org/W2040558179', 'https://openalex.org/W2043026524', 'https://openalex.org/W2048822589', 'https://openalex.org/W2050906162', 'https://openalex.org/W2051543812', 'https://openalex.org/W2052772877', 'https://openalex.org/W2054756587', 'https://openalex.org/W2061370608', 'https://openalex.org/W2061879386', 'https://openalex.org/W2062190140', 'https://openalex.org/W2062296602', 'https://openalex.org/W2062675935', 'https://openalex.org/W2063270966', 'https://openalex.org/W2063637565', 'https://openalex.org/W2064355980', 'https://openalex.org/W2065513881', 'https://openalex.org/W2069356838', 'https://openalex.org/W2070846071', 'https://openalex.org/W2071845335', 'https://openalex.org/W2073174207', 'https://openalex.org/W2073400020', 'https://openalex.org/W2074547466', 'https://openalex.org/W2078650317', 'https://openalex.org/W2079792093', 'https://openalex.org/W2080856125', 'https://openalex.org/W2081468521', 'https://openalex.org/W2083484066', 'https://openalex.org/W2083967315', 'https://openalex.org/W2085711038', 'https://openalex.org/W2089031969', 'https://openalex.org/W2090086884', 'https://openalex.org/W2092024874', 'https://openalex.org/W2097646133', 'https://openalex.org/W2104925243', 'https://openalex.org/W2106411950', 'https://openalex.org/W2124899877', 'https://openalex.org/W2125147320', 'https://openalex.org/W2129995310', 'https://openalex.org/W2133048181', 'https://openalex.org/W2135285532', 'https://openalex.org/W2150040818', 'https://openalex.org/W2150099264', 'https://openalex.org/W2151743041', 'https://openalex.org/W2163488599', 'https://openalex.org/W2182792128', 'https://openalex.org/W2234528424', 'https://openalex.org/W2268616733', 'https://openalex.org/W2284327081', 'https://openalex.org/W2290989669', 'https://openalex.org/W2294625644', 'https://openalex.org/W2297841053', 'https://openalex.org/W2314407623', 'https://openalex.org/W2319704017', 'https://openalex.org/W2405996587', 'https://openalex.org/W2511075802', 'https://openalex.org/W2535363557', 'https://openalex.org/W2556637776', 'https://openalex.org/W2556721777', 'https://openalex.org/W2560709451', 'https://openalex.org/W2564137162', 'https://openalex.org/W2580412156', 'https://openalex.org/W2589805304', 'https://openalex.org/W2598676964', 'https://openalex.org/W2603552761', 'https://openalex.org/W4248144747', 'https://openalex.org/W4251551338'], 'related_works': ['https://openalex.org/W3039337335', 'https://openalex.org/W2793230427', 'https://openalex.org/W2419207259', 'https://openalex.org/W2335927495', 'https://openalex.org/W2095368586', 'https://openalex.org/W2043635599', 'https://openalex.org/W1982344941', 'https://openalex.org/W163472367', 'https://openalex.org/W1484528198', 'https://openalex.org/W1006515002'], 'abstract_inverted_index': {'In': [0, 70], 'recent': [1], 'years,': [2], 'a': [3, 75], 'growing': [4], 'appreciation': [5], 'has': [6, 106], 'developed': [7], 'for': [8, 33], 'the': [9, 16, 81, 89, 107], 'importance': [10], 'of': [11, 18, 51, 80, 83, 85, 91, 101, 113], 'protein-protein': [12, 35, 92], 'interactions': [13, 36, 93], 'to': [14, 48, 88, 109], 'modulate': [15], 'function': [17], 'drug': [19, 52, 95], 'metabolizing': [20, 53], 'enzymes.': [21], 'Accompanied': [22], 'with': [23], 'this': [24, 71], 'appreciation,': [25], 'new': [26], 'methods': [27], 'and': [28, 40, 67, 78, 104], 'technologies': [29, 44, 87], 'have': [30, 45], 'been': [31, 46], 'designed': [32], 'analyzing': [34], 'both': [37], 'in': [38, 41, 94, 122], 'vitro': [39], 'vivo.': [42, 123], 'These': [43], 'applied': [47], 'several': [49], 'classes': [50], 'enzymes,': [54], 'including:': [55], 'cytochrome': [56], "P450's": [57], '(CYPs),': [58], 'monoamine': [59], 'oxidases': [60], "(MAO's),": [61], 'UDP-glucuronosyltransferases': [62], '(UGTs),': [63], 'glutathione': [64], 'S-transferases': [65], '(GSTs),': [66], 'sulfotransferases': [68], '(SULTs).': [69], 'review,': [72], 'we': [73], 'offer': [74], 'brief': [76], 'description': [77], 'assessment': [79], 'impact': [82], 'many': [84], 'these': [86, 102, 115], 'study': [90], 'disposition.': [96], 'The': [97], 'still': [98], 'expanding': [99], 'list': [100], 'techniques': [103], 'assays': [105], 'potential': [108], 'revolutionize': [110], 'our': [111], 'understanding': [112], 'how': [114], 'enzymes': [116], 'carry': [117], 'out': [118], 'their': [119], 'important': [120], 'functions': [121]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2744162400', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}], 'updated_date': '2024-12-23T14:57:31.083614', 'created_date': '2017-08-17'}