The influence of KGF on CTGF and Bcl-2 gene in duodenal tissue induced by radiation

原雅艺; Yuan Yayi; 任越; Yue Ren; 张睿凤; Ruifeng Zhang; 刘红岩; Liu Hongyan; 董娟聪; Dong Juancong; 张忠新; Zhongxin Zhang; 左雅慧; Zuo Yahui
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'https://openalex.org/W2328486206', 'https://openalex.org/W2281282558', 'https://openalex.org/W2133003824', 'https://openalex.org/W2029792161'], 'abstract_inverted_index': {'Objective\r\nTo': [0], 'observe': [1], 'the': [2, 29, 38, 63, 114, 128, 143, 172, 177, 180, 190, 203, 214, 217, 236, 257, 260, 279, 311, 314, 318], 'effects': [3], 'of': [4, 32, 80, 87, 105, 202, 226, 263, 273, 286, 313, 317], 'keratinocyte': [5], 'growth': [6, 12, 327, 329], 'factor': [7, 13], '(KGF)': [8], 'on': [9], 'connective': [10], 'tissue': [11, 130, 326], '(CTGF)': [14], 'and': [15, 26, 50, 69, 83, 96, 146, 168, 184, 200, 205, 222, 241, 271, 305], 'B-cell': [16], 'lymphoma': [17], '2': [18, 93], '(Bcl-2)': [19], 'gene': [20, 148, 243, 261], 'expressions': [21, 150, 244], 'in': [22, 34, 151, 209, 231, 278], 'radiation-induced': [23, 35], 'duodenal': [24, 129, 152], 'tissue,': [25], 'to': [27, 113, 141], 'investigate': [28], 'molecular': [30], 'mechanism': [31], 'KGF': [33, 101, 115, 293], 'intestinal': [36, 182], 'injuries.\r\n\r\n\r\nMethods\r\nUsing': [37], 'stochastic': [39], 'indicator': [40], 'method,': [41], 'Kunming': [42], 'mice': [43, 119], 'were': [44, 120, 133, 157, 162, 187, 207], 'randomly': [45], 'divided': [46], 'into': [47], 'control,': [48], 'radiation,': [49], 'treatment': [51, 70, 116, 215, 280], 'groups,': [52], 'each': [53], 'with': [54, 76, 90, 102, 235, 256], '10': [55], 'mice.': [56], 'The': [57, 66, 154, 159], 'control': [58, 178, 237], 'group': [59, 68, 71, 281], 'did': [60], 'not': [61], 'undergo': [62], 'radiation': [64, 67, 191, 258, 300], 'process.': [65], 'underwent': [72], 'abdominal': [73], 'cavity': [74], 'irradiation': [75, 248], 'a': [77, 103, 223], 'dose': [78, 86, 104], 'rate': [79], '0.678': [81], 'Gy/min': [82], 'an': [84], 'absorbed': [85], '8': [88], 'Gy': [89], 'γ-ray.': [91], 'For': [92, 189, 213], 'd': [94, 98, 123], 'before': [95], '3': [97], 'after': [99, 124, 126, 247], 'irradiation,': [100, 125], '6': [106], 'mg/kg': [107], 'was': [108, 139, 174, 195, 220, 265, 275, 290, 296, 308], 'administered': [109], 'via': [110], 'intraperitoneal': [111], 'injection': [112], 'group.': [117], 'All': [118], 'executed': [121], '15': [122], 'which': [127], 'pathological': [131], 'slices': [132], 'captured.': [134], 'Quantitative': [135], 'polymerase': [136], 'chain': [137], 'reaction': [138], 'used': [140], 'detect': [142], 'KGF,': [144, 239], 'CTGF,': [145, 240], 'Bcl-2': [147, 242, 274, 320], 'relative': [149], 'tissue.': [153], 'measurement': [155], 'data': [156], '±s.': [158], 'two': [160], 'groups': [161], 'compared': [163], 'using': [164], 'independent': [165], 'samples': [166], 't-test,': [167], 'P<0.05': [169], 'indicated': [170], 'that': [171, 272], 'difference': [173], 'statistically': [175], 'significant.\r\n\r\n\r\nResults\r\nFor': [176], 'group,': [179, 192, 216, 238, 259], 'duodenum': [181], 'villus': [183], 'crypt': [185, 204, 227], 'structure': [186, 219], 'complete.': [188], 'villi': [193, 206], 'atrophy': [194], 'shorter': [196], 'or': [197], 'fell': [198], 'off,': [199], 'parts': [201], 'observed': [208], 'few': [210], 'apoptotic': [211, 232], 'cells.': [212, 233], 'organizational': [218], 'complete,': [221], 'small': [224], 'amount': [225], 'can': [228], 'be': [229], 'seen': [230], 'Compared': [234, 255], 'significantly': [245, 266, 276], 'increased': [246], '(t=-125.55,': [249], '-6.55,': [250], '-6.69,': [251], 'all': [252], 'P<0.05)': [253, 269, 283], '.': [254], 'expression': [262, 315], 'CTGF': [264, 303], 'down-regulated': [267], '(t=4.89,': [268], ',': [270], 'up-regulated': [277], '(t=-20.96,': [282], '.\r\n\r\n\r\nConclusions\r\nThe': [284], 'model': [285], 'acute': [287], 'radioactive': [288], 'duodenitis': [289], 'successfully': [291], 'established.': [292], 'repair': [294], 'damage': [295], 'caused': [297, 309], 'by': [298, 310], 'ionizing': [299], 'through': [301], 'down-regulating': [302], 'gene,': [304], 'reduce': [306], 'apoptosis': [307], 'regulation': [312], 'levels': [316], 'apoptosis-related': [319], 'gene.\r\n\r\n\r\nKey': [321], 'words:': [322], '\r\nRadiation,': [323], 'ionizing;\xa0Gene,': [324], 'bcl-2;\xa0Connective': [325], 'factor;\xa0Keratinocyte': [328], 'factor;\xa0Radiation': [330], 'enteritis': [331]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2743499939', 'counts_by_year': [], 'updated_date': '2024-12-07T17:08:17.977247', 'created_date': '2017-08-17'}
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