Publication Information

{'id': 'https://openalex.org/W2741770342', 'doi': 'https://doi.org/10.1158/1538-7445.am2017-5794', 'title': 'Abstract 5794: TrkB-mediated signaling contributes to malignant phenotypes of gallbladder cancer', 'display_name': 'Abstract 5794: TrkB-mediated signaling contributes to malignant phenotypes of gallbladder cancer', 'publication_year': 2017, 'publication_date': '2017-07-01', 'ids': {'openalex': 'https://openalex.org/W2741770342', 'doi': 'https://doi.org/10.1158/1538-7445.am2017-5794', 'mag': '2741770342'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2017-5794', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': 'https://doi.org/10.1158/1538-7445.am2017-5794', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5072862484', 'display_name': 'Makoto Kawamoto', 'orcid': 'https://orcid.org/0000-0002-5488-7933'}, 'institutions': [{'id': 'https://openalex.org/I135598925', 'display_name': 'Kyushu University', 'ror': 'https://ror.org/00p4k0j84', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I135598925']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Makoto Kawamoto', 'raw_affiliation_strings': ['Kyushu University, Fukuoka, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Kyushu University, Fukuoka, Japan.', 'institution_ids': ['https://openalex.org/I135598925']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077613670', 'display_name': 'Hideya Onishi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I135598925', 'display_name': 'Kyushu University', 'ror': 'https://ror.org/00p4k0j84', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I135598925']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hideya Onishi', 'raw_affiliation_strings': ['Kyushu University, Fukuoka, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Kyushu University, Fukuoka, Japan.', 'institution_ids': ['https://openalex.org/I135598925']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075280404', 'display_name': 'Keigo Ozono', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I135598925', 'display_name': 'Kyushu University', 'ror': 'https://ror.org/00p4k0j84', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I135598925']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Keigo Ozono', 'raw_affiliation_strings': ['Kyushu University, Fukuoka, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Kyushu University, Fukuoka, Japan.', 'institution_ids': ['https://openalex.org/I135598925']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010385392', 'display_name': 'Akio Yamasaki', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I135598925', 'display_name': 'Kyushu University', 'ror': 'https://ror.org/00p4k0j84', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I135598925']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Akio Yamasaki', 'raw_affiliation_strings': ['Kyushu University, Fukuoka, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Kyushu University, Fukuoka, Japan.', 'institution_ids': ['https://openalex.org/I135598925']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053106439', 'display_name': 'Akira Imaizumi', 'orcid': 'https://orcid.org/0000-0002-8615-1007'}, 'institutions': [{'id': 'https://openalex.org/I135598925', 'display_name': 'Kyushu University', 'ror': 'https://ror.org/00p4k0j84', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I135598925']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Akira Imaizumi', 'raw_affiliation_strings': ['Kyushu University, Fukuoka, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Kyushu University, Fukuoka, Japan.', 'institution_ids': ['https://openalex.org/I135598925']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5017008069', 'display_name': 'Masafumi Nakamura', 'orcid': 'https://orcid.org/0000-0002-6196-8643'}, 'institutions': [{'id': 'https://openalex.org/I135598925', 'display_name': 'Kyushu University', 'ror': 'https://ror.org/00p4k0j84', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I135598925']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masafumi Nakamura', 'raw_affiliation_strings': ['Kyushu University, Fukuoka, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Kyushu University, Fukuoka, Japan.', 'institution_ids': ['https://openalex.org/I135598925']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 63}, 'biblio': {'volume': '77', 'issue': '13_Supplement', 'first_page': '5794', 'last_page': '5794'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10515', 'display_name': 'Cancer-related molecular mechanisms research', 'score': 0.9865, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10515', 'display_name': 'Cancer-related molecular mechanisms research', 'score': 0.9865, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11072', 'display_name': 'Peroxisome Proliferator-Activated Receptors', 'score': 0.9757, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11765', 'display_name': 'Circular RNAs in diseases', 'score': 0.9619, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C97124661', 'wikidata': 'https://www.wikidata.org/wiki/Q14897782', 'display_name': 'Tropomyosin receptor kinase B', 'level': 4, 'score': 0.9564784}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.65516925}, {'id': 'https://openalex.org/C555283112', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Carcinogenesis', 'level': 3, 'score': 0.56740767}, {'id': 'https://openalex.org/C171034665', 'wikidata': 'https://www.wikidata.org/wiki/Q14897694', 'display_name': 'Tropomyosin receptor kinase A', 'level': 4, 'score': 0.50185275}, {'id': 'https://openalex.org/C2778790584', 'wikidata': 'https://www.wikidata.org/wiki/Q123045', 'display_name': 'Brain-derived neurotrophic factor', 'level': 4, 'score': 0.4964431}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.42766935}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.42458394}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.37339932}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.35325497}, {'id': 'https://openalex.org/C160539049', 'wikidata': 'https://www.wikidata.org/wiki/Q3064187', 'display_name': 'Neurotrophic factors', 'level': 3, 'score': 0.34118068}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3150803}, {'id': 'https://openalex.org/C92020748', 'wikidata': 'https://www.wikidata.org/wiki/Q420457', 'display_name': 'Neurotrophin', 'level': 3, 'score': 0.30320528}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.21980947}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2017-5794', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2017-5794', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/2', 'score': 0.41, 'display_name': 'Zero hunger'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4366989961', 'https://openalex.org/W2935462606', 'https://openalex.org/W2734680246', 'https://openalex.org/W2586095933', 'https://openalex.org/W2095302115', 'https://openalex.org/W2090228900', 'https://openalex.org/W2087696642', 'https://openalex.org/W2082304714', 'https://openalex.org/W2041041031', 'https://openalex.org/W1997405480'], 'abstract_inverted_index': {'Abstract': [0], 'Background:': [1], 'Brain': [2], 'derived': [3], 'neurotrophic': [4], 'factor': [5, 220], '(BDNF)/': [6], 'Tropomyosin-related': [7], 'kinase': [8], 'B': [9], '(TrkB)': [10], 'signaling': [11, 29, 51, 94, 112, 321, 352], 'has': [12], 'been': [13], 'shown': [14], 'to': [15, 30, 44, 114, 323, 354], 'be': [16], 'associated': [17], 'with': [18, 60, 218, 232, 243], 'aggressive': [19], 'phenotype': [20], 'in': [21, 52, 70, 145, 177, 206, 213, 230, 236, 241, 311, 335], 'some': [22], 'cancers.': [23], 'However,': [24], 'the': [25, 46, 81, 115, 141, 159, 165, 214, 237, 324, 364], 'contribution': [26], 'of': [27, 35, 49, 143, 147, 167, 187, 326, 357, 363], 'BDNF/TrkB': [28, 50, 93, 111], 'gallbladder': [31, 358], 'cancer': [32, 359], '(GBC),': [33], 'one': [34], 'refractory': [36], 'malignancies,': [37], 'still': [38], 'remains': [39], 'unclear.': [40], 'This': [41], 'study': [42], 'aims': [43], 'analyze': [45], 'biological': [47, 116], 'significance': [48], 'GBC.': [53, 178, 336], 'Methods:': [54], '1)': [55, 199], 'Clinical': [56, 200], 'experiment:': [57, 92, 182], '69': [58], 'patients': [59, 231], 'primary': [61], 'GBC': [62, 130, 190, 209], 'who': [63], 'underwent': [64], 'curative': [65], 'surgical': [66], 'resection': [67], 'were': [68, 192], 'enrolled': [69], 'this': [71], 'study.': [72], 'We': [73, 156], 'investigated': [74], 'TrkB': [75, 84, 162, 188, 202, 211, 234, 245, 262, 283, 290, 303], 'expression': [76, 85, 163, 203, 212, 235, 246], 'by': [77, 104, 120, 255, 271], 'immunohistochemistry': [78], 'and': [79, 86, 101, 123, 152, 164, 173, 184, 222, 261, 274, 296, 308, 313, 333], 'analyzed': [80], 'correlation': [82], 'between': [83, 161], 'clinicopathological': [87], 'findings.': [88], '2)': [89, 248], 'In': [90, 180, 249, 300], 'vitro': [91, 250], 'was': [95, 102, 118, 204, 228, 253], 'inhibited': [96], 'using': [97, 127, 194], 'k252a': [98], 'or': [99, 284], 'siRNA,': [100], 'activated': [103], 'recombinant': [105], 'human': [106], 'BDNF': [107, 285], '(rhBDNF).': [108], 'Then,': [109], 'whether': [110], 'contributes': [113, 322, 353], 'function': [117], 'estimated': [119], 'proliferation': [121], 'assay': [122], 'Matrigel': [124], 'invasion': [125, 144], 'assay,': [126], 'TrkB-expressing': [128], '5': [129], 'cell': [131], 'lines': [132], '(NOZ,': [133], 'TGBC2TKB,': [134], 'GBd15,': [135], 'TYGBK-1,': [136], 'TYGBK-8).': [137], 'Furthermore,': [138], 'we': [139], 'determined': [140], 'mechanisms': [142], 'terms': [146], 'epithelial': [148], 'mesenchymal': [149], 'transition': [150], '(EMT)': [151], 'matrix': [153], 'metalloproteinases': [154], '(MMPs).': [155], 'also': [157], 'examined': [158], 'relationship': [160], 'level': [166], 'vascular': [168], 'endothelial': [169], 'growth': [170, 186, 310], 'factors': [171], '(VEGFs)': [172], 'hypoxia-inducible': [174], 'factor-1α': [175], '(HIF-1α)': [176], '3)': [179, 299], 'vivo': [181, 301], 'Tumorigenesis': [183], 'tumor': [185, 309], 'siRNA-transfected': [189], 'cells': [191], 'analyzed,': [193], 'xenograft': [195], 'mice': [196], 'model.': [197], 'Results:': [198], 'results;': [201, 251, 302], 'detected': [205], '63': [207], '(91.3%)': [208], 'specimens.': [210], 'invasive': [215, 238], 'front': [216, 239], 'correlated': [217], 'T': [219], '(p=0.0391)': [221], 'clinical': [223], 'staging': [224], '(p=0.0391).': [225], 'Overall': [226], 'survival': [227], 'lower': [229], 'high': [233], 'than': [240], 'those': [242], 'low': [244], '(p=0.0363).': [247], 'Proliferation': [252], 'unaffected': [254], 'rhBDNF': [256, 267], 'treatment;': [257], 'however,': [258], 'K252a': [259, 278], 'treatment': [260, 268, 279], 'siRNA': [263, 286, 291, 304], 'transfection': [264, 287, 292, 305], 'decreased': [265, 293, 306], 'proliferation.': [266], 'increased': [269], 'invasiveness': [270], 'inducing': [272], 'EMT': [273], 'activating': [275], 'MMP-2/MMP-9,': [276], 'whereas': [277], 'abrogated': [280], 'these': [281], 'effects.': [282], 'suppressed': [288], 'invasiveness.': [289], 'HIF-1α,': [294], 'VEGF-A,': [295], 'VEGF-C/-D': [297], 'expressions.': [298], 'tumorigenicity': [307], 'NOZ': [312], 'TYGBK-1.': [314], 'Conclusion:': [315], 'These': [316], 'findings': [317], 'demonstrate': [318], 'that': [319], 'TrkB-mediated': [320, 351], 'induction': [325], 'malignant': [327, 355], 'phenotypes': [328, 356], '(proliferation,': [329], 'invasiveness,': [330], 'angiogenesis,': [331], 'lymphangiogenesis,': [332], 'tumorigenesis)': [334], 'Citation': [337], 'Format:': [338], 'Makoto': [339], 'Kawamoto,': [340], 'Hideya': [341], 'Onishi,': [342], 'Keigo': [343], 'Ozono,': [344], 'Akio': [345], 'Yamasaki,': [346], 'Akira': [347], 'Imaizumi,': [348], 'Masafumi': [349], 'Nakamura.': [350], '[abstract].': [360], 'In:': [361], 'Proceedings': [362], 'American': [365], 'Association': [366], 'for': [367], 'Cancer': [368, 381], 'Research': [369], 'Annual': [370], 'Meeting': [371], '2017;': [372], '2017': [373], 'Apr': [374], '1-5;': [375], 'Washington,': [376], 'DC.': [377], 'Philadelphia': [378], '(PA):': [379], 'AACR;': [380], 'Res': [382], '2017;77(13': [383], 'Suppl):Abstract': [384], 'nr': [385], '5794.': [386], 'doi:10.1158/1538-7445.AM2017-5794': [387]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2741770342', 'counts_by_year': [], 'updated_date': '2024-12-12T23:29:04.974430', 'created_date': '2017-08-08'}