Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2741026493', 'doi': None, 'title': 'Effect oftheleukotriene receptor antagonists FPL55712, LY 163443, andMK-571on theelimination ofcysteinyl leukotrienes intherat', 'display_name': 'Effect oftheleukotriene receptor antagonists FPL55712, LY 163443, andMK-571on theelimination ofcysteinyl leukotrienes intherat', 'publication_year': 1991, 'publication_date': '1991-01-01', 'ids': {'openalex': 'https://openalex.org/W2741026493', 'mag': '2741026493'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://www.researchgate.net/profile/Alexander_Kapp/publication/21301100_Effect_of_the_leukotriene_receptor_antagonists_FPL_55712_LY_163443_and_MK-571_on_the_elimination_of_cysteinyl_leukotrienes_in_the_rat/links/0912f50f54f07293e3000000.pdf?disableCoverPage=true', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': [], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5062968394', 'display_name': 'Claudio Denzlinger', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'C. Denzlinger', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018686694', 'display_name': 'M. Grimberg', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'M. Grimberg', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016449107', 'display_name': 'Alexander Kapp', 'orcid': 'https://orcid.org/0000-0002-1748-6276'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'A. Kapp', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110377098', 'display_name': 'C. Haberl', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'C. Haberl', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5108534913', 'display_name': 'W. Wilmanns', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'W. Wilmanns', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 53}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11481', 'display_name': 'Sulfur Compounds in Biology', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11481', 'display_name': 'Sulfur Compounds in Biology', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12910', 'display_name': 'Eicosanoids and Hypertension Pharmacology', 'score': 0.9952, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10387', 'display_name': 'Fatty Acid Research and Health', 'score': 0.9824, 'subfield': {'id': 'https://openalex.org/subfields/2916', 'display_name': 'Nutrition and Dietetics'}, 'field': {'id': 'https://openalex.org/fields/29', 'display_name': 'Nursing'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/leukotriene-d4', 'display_name': 'Leukotriene D4', 'score': 0.9082145}, {'id': 'https://openalex.org/keywords/leukotriene-c4', 'display_name': 'Leukotriene C4', 'score': 0.75033396}, {'id': 'https://openalex.org/keywords/leukotriene-e4', 'display_name': 'Leukotriene E4', 'score': 0.66141534}, {'id': 'https://openalex.org/keywords/leukotriene-receptor', 'display_name': 'Leukotriene receptor', 'score': 0.4296481}], 'concepts': [{'id': 'https://openalex.org/C2777242621', 'wikidata': 'https://www.wikidata.org/wiki/Q647917', 'display_name': 'Leukotriene D4', 'level': 4, 'score': 0.9082145}, {'id': 'https://openalex.org/C2776452501', 'wikidata': 'https://www.wikidata.org/wiki/Q424190', 'display_name': 'Leukotriene', 'level': 3, 'score': 0.8547296}, {'id': 'https://openalex.org/C2779543280', 'wikidata': 'https://www.wikidata.org/wiki/Q2704310', 'display_name': 'Leukotriene C4', 'level': 4, 'score': 0.75033396}, {'id': 'https://openalex.org/C2778053663', 'wikidata': 'https://www.wikidata.org/wiki/Q2705859', 'display_name': 'Leukotriene E4', 'level': 4, 'score': 0.66141534}, {'id': 'https://openalex.org/C2777477808', 'wikidata': 'https://www.wikidata.org/wiki/Q407595', 'display_name': 'Metabolite', 'level': 2, 'score': 0.57022077}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5372353}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5232096}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.52114177}, {'id': 'https://openalex.org/C24998067', 'wikidata': 'https://www.wikidata.org/wiki/Q4114622', 'display_name': 'Stimulation', 'level': 2, 'score': 0.48247674}, {'id': 'https://openalex.org/C2776885963', 'wikidata': 'https://www.wikidata.org/wiki/Q245204', 'display_name': 'Antagonist', 'level': 3, 'score': 0.48136407}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.47393754}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.43820804}, {'id': 'https://openalex.org/C2780212800', 'wikidata': 'https://www.wikidata.org/wiki/Q20708039', 'display_name': 'Leukotriene receptor', 'level': 4, 'score': 0.4296481}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.38901782}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.2569846}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.24516761}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C2776042228', 'wikidata': 'https://www.wikidata.org/wiki/Q35869', 'display_name': 'Asthma', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://www.researchgate.net/profile/Alexander_Kapp/publication/21301100_Effect_of_the_leukotriene_receptor_antagonists_FPL_55712_LY_163443_and_MK-571_on_the_elimination_of_cysteinyl_leukotrienes_in_the_rat/links/0912f50f54f07293e3000000.pdf?disableCoverPage=true', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.61, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 4, 'referenced_works': ['https://openalex.org/W1502207890', 'https://openalex.org/W1976757947', 'https://openalex.org/W2099264330', 'https://openalex.org/W2465718698'], 'related_works': ['https://openalex.org/W3027268353', 'https://openalex.org/W3010590529', 'https://openalex.org/W2473338486', 'https://openalex.org/W2466364808', 'https://openalex.org/W2412199294', 'https://openalex.org/W2409051269', 'https://openalex.org/W2092923755', 'https://openalex.org/W2085556000', 'https://openalex.org/W2057758369', 'https://openalex.org/W2054842438', 'https://openalex.org/W2016604526', 'https://openalex.org/W2013527644', 'https://openalex.org/W2007323623', 'https://openalex.org/W2007008433', 'https://openalex.org/W1985618513', 'https://openalex.org/W1982568862', 'https://openalex.org/W1968792529', 'https://openalex.org/W1526872343', 'https://openalex.org/W1525534263', 'https://openalex.org/W1502207890'], 'abstract_inverted_index': {'Universitat,': [0], 'D-8000Munchen70,WestGermany': [1], '1': [2], 'Leukotriene': [3], 'elimination': [4, 107, 131, 153, 186, 218], 'viabile': [5], 'andurine': [6], 'isan': [7], 'important': [8, 190], 'mechanism': [9, 220], 'ofinactivation': [10], 'forthese': [11], 'potent': [12], 'lipid': [13], 'mediators.': [14], 'We': [15], 'investigated': [16], 'whether': [17], 'theelimination': [18], 'ofcysteinyl': [19], 'leukotrienes': [20, 39], 'isa': [21], 'targetfortheaction': [22], 'ofleukotriene': [23], 'receptor': [24, 41, 196, 213], 'antagonists.': [25, 197], '2': [26], 'Experiments': [27], 'were': [28, 43, 61], 'performed': [29], 'inmaleratsunderdeepthiopentone': [30], 'anaesthesia.': [31], 'Thebile': [32], 'ductandthe': [33], 'urinary': [34], 'bladder': [35], 'werecannulated.': [36], 'Tritium': [37], 'labelled': [38], 'andleukotriene': [40], 'antagonists': [42, 214, 228], 'given': [44], 'viacentral': [45], 'venous': [46], 'catheters.': [47], 'Elimination': [48], 'ofleukotrienes': [49], 'produced': [50, 66], 'invivowas': [51], 'studied': [52], 'following': [53], 'stimulation': [54], 'ofendogenous': [55], 'leukotriene': [56, 97, 100, 217], 'biosynthesis': [57], 'byoperative': [58], 'trauma.3H-leukotriene': [59], 'metabolites': [60, 155], 'identified': [62], 'byh.p.l.c.': [63], 'analysis.': [64], 'Leukotrienes': [65], 'invivo': [67], 'weremeasured': [68], 'bycombined': [69], 'useofh.p.l.c.': [70], 'and': [71, 202], 'RIA.': [72], '3': [73], 'Undercontrol': [74], 'conditions,': [75], '49+': [76], '12%oftheinjected': [77], '3H-leukotriene': [78], 'radioactivity': [79, 109, 200], 'was': [80, 123, 157, 192, 204], 'recovered': [81], 'inbile': [82, 175, 182], 'and1': [83], '+': [84], '0.8%inurine': [85], 'within': [86], '90min.Operative': [87], 'traumaresulted': [88], 'ininitial': [89], 'hepatobiliary': [90, 106], 'secretion': [91], 'of': [92], '887+': [93], '206pmolkg-': [94], 'h-': [95], 'oftheendogenous': [96], 'metabolite': [98], 'N-acetyl': [99], 'E4(LTE4NAc).': [101], '4': [102], 'FPL': [103], '55712strongly': [104], 'inhibited': [105, 159], 'of3H-leukotriene': [108, 154, 199], 'ina': [110], 'dosedependent': [111], 'manner': [112], 'after': [113, 147], 'i.v.': [114, 148], 'injection': [115], 'of[3H]-LTC4,': [116], '[3H]-LTD4': [117, 122, 146], 'or': [118], '[3H]-LTE4,': [119], 'respectively.': [120], 'Biliary': [121], 'reduced': [124], 'mosteffectively.': [125], 'Theleukotriene': [126], 'antagonist': [127], 'potently': [128, 169], 'prevented': [129], 'biliary': [130, 145], 'ofLTE4NAcproduced': [132], 'invivo.': [133], 'Bileflowandelimination': [134], 'frombloodintobile': [135], 'of[3H]-ouabain': [136], 'werealso': [137], 'impaired': [138], 'byFPL55712,': [139], 'buttoalesser': [140], 'extent.': [141], '5': [142], 'LY': [143], '163443reduced': [144], 'administration': [149, 166], 'of[3H]-LTD4.': [150], 'However,': [151], 'thetotal': [152, 173], 'intobile': [156], 'notsignificantly': [158, 193], 'bythedrug.': [160], '6': [161], 'MK-571reduced': [162], 'thebiliary': [163], 'concentration': [164], 'oftracerafter': [165], 'of3H-leukotrienes': [167], 'most': [168], 'withrespect': [170], 'to[3H]-LTD4.': [171], 'Incontrast,': [172], 'recoveryof3H-leukotrienes': [174], 'tended': [176], 'to': [177], 'increase.': [178], 'Thisisexplained': [179], 'byadrug-induced': [180], 'increase': [181], 'flow.': [183], '7': [184], 'Urinary': [185], 'of3H-leukotrienes,': [187], 'quantitatively': [188, 205], 'less': [189], 'intherat,': [191], 'influenced': [194], 'bytheleukotriene': [195], 'Recovery': [198], 'inliver': [201], 'kidneys': [203], 'insignificant.': [206], '8': [207], 'Fromour': [208], 'data,': [209], 'we': [210], 'conclude': [211], 'thatleukotriene': [212], 'havethepotential': [215], 'toaffect': [216], 'bya': [219], 'notnecessarily': [221], 'related': [222], 'toreceptor': [223], 'blockade.': [224], 'Inhibition': [225], 'ofelimination': [226], 'bythereceptor': [227], 'may': [229, 236], 'prolong': [230], 'thebiological': [231], 'half': [232], 'life': [233], 'ofleukotrienes.': [234], 'Thiseffect': [235], 'counteract': [237], 'theantagonistic': [238], 'properties': [239], 'ofthese': [240], 'drugs.': [241]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2741026493', 'counts_by_year': [], 'updated_date': '2024-12-07T17:24:55.146574', 'created_date': '2017-08-08'}