Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2741012772', 'doi': 'https://doi.org/10.1210/er.2017-00189', 'title': 'Genetic Causes of Functional Adrenocortical Adenomas', 'display_name': 'Genetic Causes of Functional Adrenocortical Adenomas', 'publication_year': 2017, 'publication_date': '2017-08-02', 'ids': {'openalex': 'https://openalex.org/W2741012772', 'doi': 'https://doi.org/10.1210/er.2017-00189', 'mag': '2741012772', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28973103'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1210/er.2017-00189', 'pdf_url': 'https://academic.oup.com/edrv/article-pdf/38/6/516/22189082/er.2017-00189.pdf', 'source': {'id': 'https://openalex.org/S13493133', 'display_name': 'Endocrine Reviews', 'issn_l': '0163-769X', 'issn': ['0163-769X', '1945-7189'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/edrv/article-pdf/38/6/516/22189082/er.2017-00189.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5018749828', 'display_name': 'Maria‐Christina Zennaro', 'orcid': 'https://orcid.org/0000-0001-5449-9191'}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I110736937', 'display_name': 'Délégation Paris 5', 'ror': 'https://ror.org/02e0y6e06', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I110736937', 'https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I4210091437', 'display_name': 'Sorbonne Paris Cité', 'ror': 'https://ror.org/001z21q04', 'country_code': 'FR', 'type': 'other', 'lineage': ['https://openalex.org/I4210091437']}, {'id': 'https://openalex.org/I204730241', 'display_name': 'Université Paris Cité', 'ror': 'https://ror.org/05f82e368', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I204730241']}, {'id': 'https://openalex.org/I4210109141', 'display_name': 'Hôpital Européen', 'ror': 'https://ror.org/01tfhsg94', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210109141']}, {'id': 'https://openalex.org/I4210097159', 'display_name': 'Assistance Publique – Hôpitaux de Paris', 'ror': 'https://ror.org/00pg5jh14', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159']}, {'id': 'https://openalex.org/I4210102325', 'display_name': 'Hôpital Européen Georges-Pompidou', 'ror': 'https://ror.org/016vx5156', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159', 'https://openalex.org/I4210102325', 'https://openalex.org/I4210120235']}, {'id': 'https://openalex.org/I4210131199', 'display_name': 'Paris Cardiovascular Research Center', 'ror': 'https://ror.org/03gvnh520', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I154526488', 'https://openalex.org/I204730241', 'https://openalex.org/I4210131199']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Maria-Christina Zennaro', 'raw_affiliation_strings': ['Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Génétique, France', 'French National Institute of Health and Medical Research (INSERM), Unité Mixte de Recherche Scientifique (UMRS)_970, Paris Cardiovascular Research Center, France', 'Université Paris Descartes, Sorbonne Paris Cité, France'], 'affiliations': [{'raw_affiliation_string': 'French National Institute of Health and Medical Research (INSERM), Unité Mixte de Recherche Scientifique (UMRS)_970, Paris Cardiovascular Research Center, France', 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I4210131199']}, {'raw_affiliation_string': 'Université Paris Descartes, Sorbonne Paris Cité, France', 'institution_ids': ['https://openalex.org/I110736937', 'https://openalex.org/I4210091437', 'https://openalex.org/I204730241']}, {'raw_affiliation_string': 'Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Génétique, France', 'institution_ids': ['https://openalex.org/I4210109141', 'https://openalex.org/I4210097159', 'https://openalex.org/I4210102325']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017494730', 'display_name': 'Sheerazed Boulkroun', 'orcid': 'https://orcid.org/0000-0002-8796-7534'}, 'institutions': [{'id': 'https://openalex.org/I4210131199', 'display_name': 'Paris Cardiovascular Research Center', 'ror': 'https://ror.org/03gvnh520', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I154526488', 'https://openalex.org/I204730241', 'https://openalex.org/I4210131199']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I4210091437', 'display_name': 'Sorbonne Paris Cité', 'ror': 'https://ror.org/001z21q04', 'country_code': 'FR', 'type': 'other', 'lineage': ['https://openalex.org/I4210091437']}, {'id': 'https://openalex.org/I204730241', 'display_name': 'Université Paris Cité', 'ror': 'https://ror.org/05f82e368', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I204730241']}, {'id': 'https://openalex.org/I110736937', 'display_name': 'Délégation Paris 5', 'ror': 'https://ror.org/02e0y6e06', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I110736937', 'https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Sheerazed Boulkroun', 'raw_affiliation_strings': ['French National Institute of Health and Medical Research (INSERM), Unité Mixte de Recherche Scientifique (UMRS)_970, Paris Cardiovascular Research Center, France', 'Université Paris Descartes, Sorbonne Paris Cité, France'], 'affiliations': [{'raw_affiliation_string': 'French National Institute of Health and Medical Research (INSERM), Unité Mixte de Recherche Scientifique (UMRS)_970, Paris Cardiovascular Research Center, France', 'institution_ids': ['https://openalex.org/I4210131199', 'https://openalex.org/I154526488']}, {'raw_affiliation_string': 'Université Paris Descartes, Sorbonne Paris Cité, France', 'institution_ids': ['https://openalex.org/I4210091437', 'https://openalex.org/I204730241', 'https://openalex.org/I110736937']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5086172052', 'display_name': 'Fábio L. Fernandes‐Rosa', 'orcid': 'https://orcid.org/0000-0002-0162-0792'}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I4210091437', 'display_name': 'Sorbonne Paris Cité', 'ror': 'https://ror.org/001z21q04', 'country_code': 'FR', 'type': 'other', 'lineage': ['https://openalex.org/I4210091437']}, {'id': 'https://openalex.org/I4210131199', 'display_name': 'Paris Cardiovascular Research Center', 'ror': 'https://ror.org/03gvnh520', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I154526488', 'https://openalex.org/I204730241', 'https://openalex.org/I4210131199']}, {'id': 'https://openalex.org/I110736937', 'display_name': 'Délégation Paris 5', 'ror': 'https://ror.org/02e0y6e06', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I110736937', 'https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I204730241', 'display_name': 'Université Paris Cité', 'ror': 'https://ror.org/05f82e368', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I204730241']}, {'id': 'https://openalex.org/I4210109141', 'display_name': 'Hôpital Européen', 'ror': 'https://ror.org/01tfhsg94', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210109141']}, {'id': 'https://openalex.org/I4210097159', 'display_name': 'Assistance Publique – Hôpitaux de Paris', 'ror': 'https://ror.org/00pg5jh14', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159']}, {'id': 'https://openalex.org/I4210102325', 'display_name': 'Hôpital Européen Georges-Pompidou', 'ror': 'https://ror.org/016vx5156', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159', 'https://openalex.org/I4210102325', 'https://openalex.org/I4210120235']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Fabio Fernandes-Rosa', 'raw_affiliation_strings': ['Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Génétique, France', 'French National Institute of Health and Medical Research (INSERM), Unité Mixte de Recherche Scientifique (UMRS)_970, Paris Cardiovascular Research Center, France', 'Université Paris Descartes, Sorbonne Paris Cité, France'], 'affiliations': [{'raw_affiliation_string': 'French National Institute of Health and Medical Research (INSERM), Unité Mixte de Recherche Scientifique (UMRS)_970, Paris Cardiovascular Research Center, France', 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I4210131199']}, {'raw_affiliation_string': 'Université Paris Descartes, Sorbonne Paris Cité, France', 'institution_ids': ['https://openalex.org/I4210091437', 'https://openalex.org/I110736937', 'https://openalex.org/I204730241']}, {'raw_affiliation_string': 'Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Génétique, France', 'institution_ids': ['https://openalex.org/I4210109141', 'https://openalex.org/I4210097159', 'https://openalex.org/I4210102325']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 8, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3400, 'currency': 'USD', 'value_usd': 3400, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.191, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 79, 'citation_normalized_percentile': {'value': 0.661401, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '38', 'issue': '6', 'first_page': '516', 'last_page': '537'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11839', 'display_name': 'Management of Primary Aldosteronism', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11839', 'display_name': 'Management of Primary Aldosteronism', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11054', 'display_name': 'Pheochromocytoma and Paraganglioma', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T14486', 'display_name': 'Role of Urotensin II in Cardiovascular Physiology and Disease', 'score': 0.9842, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/adrenocortical-carcinoma', 'display_name': 'Adrenocortical Carcinoma', 'score': 0.52943}, {'id': 'https://openalex.org/keywords/aldosterone', 'display_name': 'Aldosterone', 'score': 0.515812}, {'id': 'https://openalex.org/keywords/mineralocorticoid', 'display_name': 'Mineralocorticoid', 'score': 0.47220382}, {'id': 'https://openalex.org/keywords/cyclic-adenosine-monophosphate', 'display_name': 'Cyclic adenosine monophosphate', 'score': 0.44460058}], 'concepts': [{'id': 'https://openalex.org/C2778525890', 'wikidata': 'https://www.wikidata.org/wiki/Q184564', 'display_name': 'Aldosterone', 'level': 2, 'score': 0.82372105}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.6590064}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.63147247}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5823131}, {'id': 'https://openalex.org/C2777977426', 'wikidata': 'https://www.wikidata.org/wiki/Q19065', 'display_name': 'Adrenal cortex', 'level': 2, 'score': 0.5180619}, {'id': 'https://openalex.org/C2776069600', 'wikidata': 'https://www.wikidata.org/wiki/Q422519', 'display_name': 'Mineralocorticoid', 'level': 3, 'score': 0.47220382}, {'id': 'https://openalex.org/C2776668983', 'wikidata': 'https://www.wikidata.org/wiki/Q210041', 'display_name': 'Cyclic adenosine monophosphate', 'level': 3, 'score': 0.44460058}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.21624598}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.07058483}], 'mesh': [{'descriptor_ui': 'D000306', 'descriptor_name': 'Adrenal Cortex Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D018246', 'descriptor_name': 'Adrenocortical Adenoma', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D003480', 'descriptor_name': 'Cushing Syndrome', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D054751', 'descriptor_name': 'Cyclic AMP-Dependent Protein Kinase Catalytic Subunits', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D020022', 'descriptor_name': 'Genetic Predisposition to Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000306', 'descriptor_name': 'Adrenal Cortex Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000306', 'descriptor_name': 'Adrenal Cortex Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D018246', 'descriptor_name': 'Adrenocortical Adenoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018246', 'descriptor_name': 'Adrenocortical Adenoma', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D003480', 'descriptor_name': 'Cushing Syndrome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003480', 'descriptor_name': 'Cushing Syndrome', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D054751', 'descriptor_name': 'Cyclic AMP-Dependent Protein Kinase Catalytic Subunits', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 7, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1210/er.2017-00189', 'pdf_url': 'https://academic.oup.com/edrv/article-pdf/38/6/516/22189082/er.2017-00189.pdf', 'source': {'id': 'https://openalex.org/S13493133', 'display_name': 'Endocrine Reviews', 'issn_l': '0163-769X', 'issn': ['0163-769X', '1945-7189'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://hal.archives-ouvertes.fr/hal-03845543', 'pdf_url': 'https://hal.science/hal-03845543/document', 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://hal.science/hal-03845543', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://hal.science/hal-03845543/file/Zennaro%20et%20al_.pdf', 'pdf_url': 'https://hal.science/hal-03845543/file/Zennaro%20et%20al_.pdf', 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://hal.archives-ouvertes.fr/hal-03845543/file/Zennaro%20et%20al_.pdf', 'pdf_url': 'https://hal.archives-ouvertes.fr/hal-03845543/file/Zennaro%20et%20al_.pdf', 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://hal.archives-ouvertes.fr/hal-03845543/document', 'pdf_url': 'https://hal.archives-ouvertes.fr/hal-03845543/document', 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28973103', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1210/er.2017-00189', 'pdf_url': 'https://academic.oup.com/edrv/article-pdf/38/6/516/22189082/er.2017-00189.pdf', 'source': {'id': 'https://openalex.org/S13493133', 'display_name': 'Endocrine Reviews', 'issn_l': '0163-769X', 'issn': ['0163-769X', '1945-7189'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.71}], 'grants': [{'funder': 'https://openalex.org/F4320320883', 'funder_display_name': 'Agence Nationale de la Recherche', 'award_id': None}, {'funder': 'https://openalex.org/F4320321589', 'funder_display_name': 'Fondation pour la Recherche Médicale', 'award_id': 'DEQ20140329556'}], 'datasets': [], 'versions': [], 'referenced_works_count': 155, 'referenced_works': ['https://openalex.org/W1552029575', 'https://openalex.org/W1572826937', 'https://openalex.org/W1613453388', 'https://openalex.org/W1671104211', 'https://openalex.org/W1885172161', 'https://openalex.org/W1907427644', 'https://openalex.org/W1911711541', 'https://openalex.org/W1964350908', 'https://openalex.org/W1967440935', 'https://openalex.org/W1975267722', 'https://openalex.org/W1977739423', 'https://openalex.org/W1978253611', 'https://openalex.org/W1979069430', 'https://openalex.org/W1981486350', 'https://openalex.org/W1983210215', 'https://openalex.org/W1985043538', 'https://openalex.org/W1985132407', 'https://openalex.org/W1985327924', 'https://openalex.org/W1990606472', 'https://openalex.org/W1991449126', 'https://openalex.org/W1992384218', 'https://openalex.org/W1993251688', 'https://openalex.org/W1996245314', 'https://openalex.org/W1999873982', 'https://openalex.org/W2002317491', 'https://openalex.org/W2003456330', 'https://openalex.org/W2005005085', 'https://openalex.org/W2008821347', 'https://openalex.org/W2011974331', 'https://openalex.org/W2013253009', 'https://openalex.org/W2014782018', 'https://openalex.org/W2015643702', 'https://openalex.org/W2016071509', 'https://openalex.org/W2016170962', 'https://openalex.org/W2017267089', 'https://openalex.org/W2017446931', 'https://openalex.org/W2032807476', 'https://openalex.org/W2037719895', 'https://openalex.org/W2040816499', 'https://openalex.org/W2040928761', 'https://openalex.org/W2041411519', 'https://openalex.org/W2041931673', 'https://openalex.org/W2048581761', 'https://openalex.org/W2048712799', 'https://openalex.org/W2050413914', 'https://openalex.org/W2051364718', 'https://openalex.org/W2057516375', 'https://openalex.org/W2058567701', 'https://openalex.org/W2059783931', 'https://openalex.org/W2061341378', 'https://openalex.org/W2061913524', 'https://openalex.org/W2063599459', 'https://openalex.org/W2068138006', 'https://openalex.org/W2073605969', 'https://openalex.org/W2077000998', 'https://openalex.org/W2078206479', 'https://openalex.org/W2080222094', 'https://openalex.org/W2084343780', 'https://openalex.org/W2085472231', 'https://openalex.org/W2089400376', 'https://openalex.org/W2090912797', 'https://openalex.org/W2091277822', 'https://openalex.org/W2095670260', 'https://openalex.org/W2099488003', 'https://openalex.org/W2100032138', 'https://openalex.org/W2100537280', 'https://openalex.org/W2100690266', 'https://openalex.org/W2103452905', 'https://openalex.org/W2107964427', 'https://openalex.org/W2107999636', 'https://openalex.org/W2110420469', 'https://openalex.org/W2111582520', 'https://openalex.org/W2111995467', 'https://openalex.org/W2113511566', 'https://openalex.org/W2116698088', 'https://openalex.org/W2117663124', 'https://openalex.org/W2120347052', 'https://openalex.org/W2122976239', 'https://openalex.org/W2123036315', 'https://openalex.org/W2123144543', 'https://openalex.org/W2123465466', 'https://openalex.org/W2124108262', 'https://openalex.org/W2125261314', 'https://openalex.org/W2126616537', 'https://openalex.org/W2129950671', 'https://openalex.org/W2130202558', 'https://openalex.org/W2132583358', 'https://openalex.org/W2135367483', 'https://openalex.org/W2136936562', 'https://openalex.org/W2137314174', 'https://openalex.org/W2139179696', 'https://openalex.org/W2140238162', 'https://openalex.org/W2140861044', 'https://openalex.org/W2141197851', 'https://openalex.org/W2145316463', 'https://openalex.org/W2146136214', 'https://openalex.org/W2147066085', 'https://openalex.org/W2149048157', 'https://openalex.org/W2152291380', 'https://openalex.org/W2152333285', 'https://openalex.org/W2154216758', 'https://openalex.org/W2154472615', 'https://openalex.org/W2154485413', 'https://openalex.org/W2154579353', 'https://openalex.org/W2154704880', 'https://openalex.org/W2156939318', 'https://openalex.org/W2157610967', 'https://openalex.org/W2157801554', 'https://openalex.org/W2158058246', 'https://openalex.org/W2159365812', 'https://openalex.org/W2159641345', 'https://openalex.org/W2159980848', 'https://openalex.org/W2164282511', 'https://openalex.org/W2165231206', 'https://openalex.org/W2166045505', 'https://openalex.org/W2167675084', 'https://openalex.org/W2168924012', 'https://openalex.org/W2170896657', 'https://openalex.org/W2172346258', 'https://openalex.org/W2180775593', 'https://openalex.org/W2188408455', 'https://openalex.org/W2236065428', 'https://openalex.org/W2258234189', 'https://openalex.org/W2266820106', 'https://openalex.org/W2269420437', 'https://openalex.org/W2289066916', 'https://openalex.org/W2290633895', 'https://openalex.org/W2312715796', 'https://openalex.org/W2315313444', 'https://openalex.org/W2316788075', 'https://openalex.org/W2317671882', 'https://openalex.org/W2317844196', 'https://openalex.org/W2320400149', 'https://openalex.org/W2325549186', 'https://openalex.org/W2328127416', 'https://openalex.org/W2336613908', 'https://openalex.org/W2336951059', 'https://openalex.org/W2358298039', 'https://openalex.org/W2412918357', 'https://openalex.org/W2417350999', 'https://openalex.org/W2429403923', 'https://openalex.org/W2433784928', 'https://openalex.org/W2470050827', 'https://openalex.org/W2496231646', 'https://openalex.org/W2515576128', 'https://openalex.org/W2519501257', 'https://openalex.org/W2523540775', 'https://openalex.org/W2525990918', 'https://openalex.org/W2528513517', 'https://openalex.org/W2560895843', 'https://openalex.org/W2573330445', 'https://openalex.org/W2586245389', 'https://openalex.org/W2624544718', 'https://openalex.org/W323169530', 'https://openalex.org/W561187501'], 'related_works': ['https://openalex.org/W38820245', 'https://openalex.org/W2156614560', 'https://openalex.org/W2143300626', 'https://openalex.org/W2081491491', 'https://openalex.org/W2039734702', 'https://openalex.org/W2023063360', 'https://openalex.org/W2017221000', 'https://openalex.org/W1985643404', 'https://openalex.org/W1964001371', 'https://openalex.org/W1027088072'], 'abstract_inverted_index': {'Aldosterone': [0], 'and': [1, 6, 98, 195, 228], 'cortisol,': [2], 'the': [3, 14, 33, 42, 50, 72, 75, 80, 120, 136, 161, 199, 202, 218, 232, 236], 'main': [4, 121], 'mineralocorticoid': [5], 'glucocorticoid': [7], 'hormones': [8], 'in': [9, 13, 92, 104, 132, 170, 179], 'humans,': [10], 'are': [11], 'produced': [12], 'adrenal': [15, 171], 'cortex,': [16], 'which': [17], 'is': [18], 'composed': [19], 'of': [20, 36, 46, 52, 79, 83, 87, 117, 153, 193, 209], 'three': [21], 'concentric': [22], 'zone': [23], 'with': [24, 115, 189, 220, 231], 'specific': [25, 159], 'functional': [26], 'characteristics.Adrenocortical': [27], 'adenomas': [28], '(ACA)': [29], 'may': [30, 214], 'lead': [31, 56], 'to': [32, 57, 151, 157, 165, 224], 'autonomous': [34], 'secretion': [35], 'aldosterone': [37, 105, 124, 181, 194], 'responsible': [38, 216], 'for': [39, 123, 135, 217], 'primary': [40], 'aldosteronism,': [41], 'most': [43], 'frequent': [44], 'form': [45], 'secondary': [47], 'arterial': [48], 'hypertension.In': [49], 'case': [51], 'cortisol': [53, 126, 154, 185, 196], 'production,': [54], 'ACA': [55], 'overt': [58], 'or': [59], 'subclinical': [60], 'Cushing': [61], 'syndrome.Genetic': [62], 'analysis': [63], 'driven': [64], 'by': [65], 'next': [66], 'generation': [67], 'sequencing': [68], 'technology': [69], 'has': [70], 'enabled': [71], 'discovery,': [73], 'during': [74], 'last': [76], 'seven': [77], 'years,': [78], 'genetic': [81, 210], 'causes': [82], 'a': [84, 206], 'large': [85], 'subset': [86], 'ACA.In': [88], 'particular,': [89], 'somatic': [90, 130], 'mutations': [91, 108, 131, 175], 'genes': [93], 'regulating': [94], 'intracellular': [95, 112], 'ionic': [96], 'homeostasis': [97], 'membrane': [99], 'potential': [100], 'have': [101, 176], 'been': [102, 177], 'identified': [103, 178], 'producing': [106, 127, 186], 'adenoma.These': [107], 'all': [109], 'promote': [110], 'increased': [111], 'calcium': [113, 118], 'concentrations,': [114], 'activation': [116, 152], 'signaling,': [119, 149], 'trigger': [122], 'production.In': [125], 'adenomas,': [128], 'recurrent': [129], 'PRKACA': [133], '(coding': [134], 'cAMP-dependent': [137], 'protein': [138, 146], 'kinase': [139, 147], 'catalytic': [140], 'subunit': [141], 'alpha)': [142], 'affect': [143], 'cyclic': [144], 'AMP-dependent': [145], 'A': [148], 'leading': [150, 223], 'biosynthesis.In': [155], 'addition': [156], 'these': [158], 'pathways,': [160], 'Wnt/β-catenin': [162], 'pathway': [163], 'appears': [164], 'play': [166], 'an': [167], 'important': [168], 'role': [169], 'tumorigenesis,': [172], 'as': [173, 182, 184], 'βcatenin': [174], 'both': [180], 'well': [183], 'adenomas.This,': [187], 'together': [188], 'different': [190, 212], 'intermediate': [191], 'states': [192], 'cosecretion,': [197], 'raises': [198], 'possibility': [200], 'that': [201], 'two': [203], 'conditions': [204], 'share': [205], 'certain': [207], 'degree': [208], 'susceptibility.Alternatively,': [211], 'hits': [213], 'be': [215], 'diseases,': [219], 'one': [221, 234], 'hit': [222], 'adrenocortical': [225], 'cell': [226], 'proliferation': [227], 'nodule': [229], 'formation,': [230], 'second': [233], 'specifying': [235], 'hormonal': [237], 'secretory': [238], 'pattern.': [239]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2741012772', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 13}, {'year': 2021, 'cited_by_count': 13}, {'year': 2020, 'cited_by_count': 10}, {'year': 2019, 'cited_by_count': 20}, {'year': 2018, 'cited_by_count': 12}], 'updated_date': '2024-09-09T12:51:16.089781', 'created_date': '2017-08-08'}