Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2740234667', 'doi': 'https://doi.org/10.1158/1538-7445.am2017-5234', 'title': 'Abstract 5234: Expression of cytochrome P450 in head and neck cancer cell lines', 'display_name': 'Abstract 5234: Expression of cytochrome P450 in head and neck cancer cell lines', 'publication_year': 2017, 'publication_date': '2017-07-01', 'ids': {'openalex': 'https://openalex.org/W2740234667', 'doi': 'https://doi.org/10.1158/1538-7445.am2017-5234', 'mag': '2740234667'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2017-5234', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5080416581', 'display_name': 'Daniela Presa', 'orcid': 'https://orcid.org/0000-0003-4127-801X'}, 'institutions': [{'id': 'https://openalex.org/I139894009', 'display_name': 'University of Bradford', 'ror': 'https://ror.org/00vs8d940', 'country_code': 'GB', 'type': 'funder', 'lineage': ['https://openalex.org/I139894009']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Daniela F. Presa', 'raw_affiliation_strings': ['1Institute of Cancer Therapeutics, University of Bradford, Bradford, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': '1Institute of Cancer Therapeutics, University of Bradford, Bradford, United Kingdom;', 'institution_ids': ['https://openalex.org/I139894009']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023172521', 'display_name': 'Goreti Ribeiro Morais', 'orcid': 'https://orcid.org/0000-0002-5097-4933'}, 'institutions': [{'id': 'https://openalex.org/I139894009', 'display_name': 'University of Bradford', 'ror': 'https://ror.org/00vs8d940', 'country_code': 'GB', 'type': 'funder', 'lineage': ['https://openalex.org/I139894009']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Goreti Ribeiro Morais', 'raw_affiliation_strings': ['1Institute of Cancer Therapeutics, University of Bradford, Bradford, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': '1Institute of Cancer Therapeutics, University of Bradford, Bradford, United Kingdom;', 'institution_ids': ['https://openalex.org/I139894009']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090400644', 'display_name': 'Mark Sutherland', 'orcid': 'https://orcid.org/0000-0003-3171-2281'}, 'institutions': [{'id': 'https://openalex.org/I139894009', 'display_name': 'University of Bradford', 'ror': 'https://ror.org/00vs8d940', 'country_code': 'GB', 'type': 'funder', 'lineage': ['https://openalex.org/I139894009']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Mark Sutherland', 'raw_affiliation_strings': ['1Institute of Cancer Therapeutics, University of Bradford, Bradford, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': '1Institute of Cancer Therapeutics, University of Bradford, Bradford, United Kingdom;', 'institution_ids': ['https://openalex.org/I139894009']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014129741', 'display_name': 'Jim McCaul', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1325846038', 'display_name': 'Royal Marsden NHS Foundation Trust', 'ror': 'https://ror.org/0008wzh48', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325846038']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Jim McCaul', 'raw_affiliation_strings': ['2The Royal Marsden NHS Foundation Trust, London, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': '2The Royal Marsden NHS Foundation Trust, London, United Kingdom;', 'institution_ids': ['https://openalex.org/I1325846038']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023858440', 'display_name': 'Jacques Robert', 'orcid': 'https://orcid.org/0000-0003-4380-1476'}, 'institutions': [{'id': 'https://openalex.org/I15057530', 'display_name': 'Université de Bordeaux', 'ror': 'https://ror.org/057qpr032', 'country_code': 'FR', 'type': 'funder', 'lineage': ['https://openalex.org/I15057530']}, {'id': 'https://openalex.org/I4210134409', 'display_name': 'Institut Bergonié', 'ror': 'https://ror.org/02yw1f353', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210134409']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Jacques Robert', 'raw_affiliation_strings': ['3Institut Bergonié, University of Bordeaux, Bordeaux-cedex, France.'], 'affiliations': [{'raw_affiliation_string': '3Institut Bergonié, University of Bordeaux, Bordeaux-cedex, France.', 'institution_ids': ['https://openalex.org/I15057530', 'https://openalex.org/I4210134409']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036835305', 'display_name': 'Laurence Patterson', 'orcid': 'https://orcid.org/0000-0002-8656-2383'}, 'institutions': [{'id': 'https://openalex.org/I139894009', 'display_name': 'University of Bradford', 'ror': 'https://ror.org/00vs8d940', 'country_code': 'GB', 'type': 'funder', 'lineage': ['https://openalex.org/I139894009']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Laurence Patterson', 'raw_affiliation_strings': ['1Institute of Cancer Therapeutics, University of Bradford, Bradford, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': '1Institute of Cancer Therapeutics, University of Bradford, Bradford, United Kingdom;', 'institution_ids': ['https://openalex.org/I139894009']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5084095542', 'display_name': 'Klaus Pors', 'orcid': 'https://orcid.org/0000-0002-0837-5208'}, 'institutions': [{'id': 'https://openalex.org/I139894009', 'display_name': 'University of Bradford', 'ror': 'https://ror.org/00vs8d940', 'country_code': 'GB', 'type': 'funder', 'lineage': ['https://openalex.org/I139894009']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Klaus Pors', 'raw_affiliation_strings': ['1Institute of Cancer Therapeutics, University of Bradford, Bradford, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': '1Institute of Cancer Therapeutics, University of Bradford, Bradford, United Kingdom;', 'institution_ids': ['https://openalex.org/I139894009']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 63}, 'biblio': {'volume': '77', 'issue': '13_Supplement', 'first_page': '5234', 'last_page': '5234'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10417', 'display_name': 'Lung Cancer Treatments and Mutations', 'score': 0.9408, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10417', 'display_name': 'Lung Cancer Treatments and Mutations', 'score': 0.9408, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cyp1b1', 'display_name': 'CYP1B1', 'score': 0.5573708}, {'id': 'https://openalex.org/keywords/mtt-assay', 'display_name': 'MTT assay', 'score': 0.4500582}], 'concepts': [{'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.5965945}, {'id': 'https://openalex.org/C155701950', 'wikidata': 'https://www.wikidata.org/wiki/Q14905165', 'display_name': 'CYP1B1', 'level': 4, 'score': 0.5573708}, {'id': 'https://openalex.org/C114246631', 'wikidata': 'https://www.wikidata.org/wiki/Q187661', 'display_name': 'Carcinogen', 'level': 2, 'score': 0.5537035}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5377939}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.50341576}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.4952306}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.48212695}, {'id': 'https://openalex.org/C109316439', 'wikidata': 'https://www.wikidata.org/wiki/Q246181', 'display_name': 'Cytotoxicity', 'level': 3, 'score': 0.47877184}, {'id': 'https://openalex.org/C526171541', 'wikidata': 'https://www.wikidata.org/wiki/Q407693', 'display_name': 'Cytochrome P450', 'level': 3, 'score': 0.47631156}, {'id': 'https://openalex.org/C2780783641', 'wikidata': 'https://www.wikidata.org/wiki/Q738686', 'display_name': 'MTT assay', 'level': 3, 'score': 0.4500582}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.44228056}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.42275804}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.41780216}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.400953}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.24844906}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.24624702}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.18744099}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.18684822}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.14702457}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.11567134}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2017-5234', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2605453051', 'https://openalex.org/W2371672261', 'https://openalex.org/W2364607912', 'https://openalex.org/W2353941012', 'https://openalex.org/W2188232776', 'https://openalex.org/W2170423316', 'https://openalex.org/W2097529071', 'https://openalex.org/W2044540929', 'https://openalex.org/W1993084845', 'https://openalex.org/W1933341309'], 'abstract_inverted_index': {'Abstract': [0], 'Background:': [1], 'The': [2], 'high': [3], 'expression': [4, 101, 136, 149, 189, 294], 'of': [5, 42, 79, 84, 102, 120, 221, 241, 258, 300, 311, 335, 397, 410], 'cytochrome': [6, 362, 398], 'P450': [7, 363, 399], '(CYP)': [8], 'enzymes': [9, 87], 'including': [10, 88], 'isoforms': [11], 'CYP1A1,': [12, 103, 131, 273], '1B1': [13], 'and': [14, 50, 62, 81, 105, 111, 116, 133, 154, 160, 173, 200, 213, 216, 230, 243, 247, 275, 284, 322, 345, 402], '2W1': [15, 364], 'in': [16, 34, 39, 53, 72, 107, 150, 157, 211, 217, 279, 302, 400], 'some': [17], 'tumor': [18, 285, 370], 'types': [19], 'compared': [20], 'to': [21, 76, 90, 146, 318], 'normal': [22], 'tissue': [23], 'make': [24], 'these': [25, 259, 267], 'potential': [26], 'targets': [27], 'for': [28, 130, 198, 347, 414], 'targeted': [29], 'drug': [30], 'discovery.': [31], 'Our': [32], 'efforts': [33], 'this': [35, 320], 'space': [36], 'have': [37, 58], 'resulted': [38], 'the': [40, 82, 100, 170, 179, 184, 195, 238, 250, 298, 327, 336, 411], 'discovery': [41], 'duocarmycin': [43, 262, 337, 366], 'bioprecursors': [44, 341], 'that': [45, 60, 71, 272, 292], 'are': [46, 277], 'bioactivated': [47], 'by': [48, 228, 297], 'CYP1A1': [49, 199, 344], 'CYP2W1': [51, 106, 134, 203, 208, 276, 293, 346], 'expressed': [52, 210, 278], 'malignant': [54], 'tissues1-2.': [55], 'Epidemiological': [56], 'studies': [57], 'shown': [59, 193], 'head': [61, 401], 'neck': [63, 403], 'cancer': [64, 404], '(HNC)': [65], 'is': [66, 295], 'a': [67, 77, 218, 306], 'complex': [68], 'multistage': [69], 'process': [70], 'part': [73], 'involves': [74], 'exposure': [75], 'combination': [78], 'carcinogens': [80], 'capacity': [83], 'certain': [85], 'drug-metabolising': [86], 'CYPs': [89], 'detoxify': [91], 'or': [92], 'activate': [93], 'such': [94], 'carcinogens.': [95], 'Here,': [96], 'we': [97, 269], 'report': [98], 'on': [99], 'CYP1B1': [104, 132, 201, 274], 'HNC': [108, 121, 151, 163, 185, 224, 253, 281, 313], 'cell': [109, 122, 152, 186, 254, 282, 405], 'lines': [110, 123, 153, 187, 255, 283, 406], 'human': [112, 162, 223], 'primary': [113], 'tissues.': [114], 'Materials': [115], 'methods:': [117], 'A': [118], 'panel': [119], '(FaDu,': [124], 'Detroit-562,': [125], 'A253,': [126], 'OSC19)': [127], 'was': [128, 144, 167, 176, 192, 204, 209], 'characterized': [129], 'gene': [135, 196], 'using': [137, 169, 178], 'real': [138], 'time': [139], 'PCR.': [140], 'Furthermore,': [141], 'immunofluorescence': [142], '(IF)': [143], 'used': [145, 317], 'detect': [147], 'protein': [148], 'immunohistochemistry': [155], '(IHC)': [156], 'xenografts,': [158], 'paraffin-embedded': [159], 'snap-frozen': [161], 'tissue.': [164, 286], 'Anti-proliferative': [165], 'activity': [166], 'measured': [168, 177, 227], 'MTT': [171], 'assay': [172], 'DNA': [174], 'damage': [175], 'comet': [180], 'assay.': [181], 'Results:': [182], 'In': [183, 233, 287], 'significant': [188], '(5-10': [190], 'fold)': [191], 'at': [194, 326], 'level': [197], 'whereas': [202], 'hardly': [205], 'detected.': [206], 'However,': [207], 'FaDu': [212, 246], 'Detroit': [214], 'xenografts': [215], 'small': [219], 'cohort': [220, 308], '10': [222], 'samples': [225, 314], 'as': [226, 249], 'IF': [229], 'IHC,': [231], 'respectively.': [232], 'agreement': [234], 'with': [235], 'CYP1': [236], 'expression,': [237], 'cytotoxicity': [239], 'results': [240], 'ICT2700': [242], 'ICT2706': [244], 'revealed': [245], 'Detroit-562': [248], 'most': [251], 'sensitive': [252], 'suggesting': [256], 'bioactivation': [257], 'two': [260], 'lead': [261], 'bioprecursors.': [263], 'Conclusion:': [264], 'Accordingly,': [265], 'from': [266], 'data': [268], 'can': [270], 'conclude': [271], 'selected': [280], 'addition,': [288], 'early': [289], 'evidence': [290], 'suggests': [291], 'stimulated': [296], 'presence': [299], 'an': [301], 'vivo': [303], 'microenvironment.': [304], 'However': [305], 'larger': [307], '(≥': [309], '60)': [310], 'clinical': [312], 'will': [315, 323], 'be': [316, 324], 'confirm': [319], 'observation': [321], 'reported': [325], 'annual': [328], 'AACR': [329], 'meeting.': [330], '[1]': [331], 'Sheldrake': [332], 'et': [333, 358], 'al.Reengineering': [334], 'structural': [338], 'architecture': [339], 'enables': [340], 'development': [342], 'targeting': [343], 'biological': [348], 'activity.': [349], 'J': [350], 'Med': [351], 'Chem.': [352], '2013,': [353, 375], '56,': [354], '62737.': [355], '[2]': [356], 'Travica': [357], 'al.': [359], 'Colon': [360], 'cancer-specific': [361], 'converts': [365], 'analogues': [367], 'into': [368], 'potent': [369], 'cytotoxins.': [371], 'Clin': [372], 'Cancer': [373, 415, 428], 'Res.': [374], '19,': [376], '295261.': [377], 'Citation': [378], 'Format:': [379], 'Daniela': [380], 'F.': [381], 'Presa,': [382], 'Goreti': [383], 'Ribeiro': [384], 'Morais,': [385], 'Mark': [386], 'Sutherland,': [387], 'Jim': [388], 'McCaul,': [389], 'Jacques': [390], 'Robert,': [391], 'Laurence': [392], 'Patterson,': [393], 'Klaus': [394], 'Pors.': [395], 'Expression': [396], '[abstract].': [407], 'In:': [408], 'Proceedings': [409], 'American': [412], 'Association': [413], 'Research': [416], 'Annual': [417], 'Meeting': [418], '2017;': [419], '2017': [420], 'Apr': [421], '1-5;': [422], 'Washington,': [423], 'DC.': [424], 'Philadelphia': [425], '(PA):': [426], 'AACR;': [427], 'Res': [429], '2017;77(13': [430], 'Suppl):Abstract': [431], 'nr': [432], '5234.': [433], 'doi:10.1158/1538-7445.AM2017-5234': [434]}, 'abstract_inverted_index_v3': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2740234667', 'counts_by_year': [], 'updated_date': '2025-01-28T02:01:47.261576', 'created_date': '2017-08-08'}