Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2739274500', 'doi': 'https://doi.org/10.18632/oncotarget.19334', 'title': 'Transcatheter hepatic arterial chemoembolization and sorafenib for hepatocellular carcinoma: a meta-analysis of randomized, double-blind controlled trials', 'display_name': 'Transcatheter hepatic arterial chemoembolization and sorafenib for hepatocellular carcinoma: a meta-analysis of randomized, double-blind controlled trials', 'publication_year': 2017, 'publication_date': '2017-07-18', 'ids': {'openalex': 'https://openalex.org/W2739274500', 'doi': 'https://doi.org/10.18632/oncotarget.19334', 'mag': '2739274500', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28938663', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5601759'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.19334', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=19334&path%5B%5D=61854', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=19334&path%5B%5D=61854', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101694878', 'display_name': 'Jun Li', 'orcid': 'https://orcid.org/0000-0002-7387-1283'}, 'institutions': [{'id': 'https://openalex.org/I2802939634', 'display_name': 'Chinese PLA General Hospital', 'ror': 'https://ror.org/04gw3ra78', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802939634']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jun Li', 'raw_affiliation_strings': ['Department of Gastroenterology, Chinese PLA General Hospital, Beijing 100853, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology, Chinese PLA General Hospital, Beijing 100853, China', 'institution_ids': ['https://openalex.org/I2802939634']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100429026', 'display_name': 'Wenhui Liu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802939634', 'display_name': 'Chinese PLA General Hospital', 'ror': 'https://ror.org/04gw3ra78', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802939634']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wenhui Liu', 'raw_affiliation_strings': ['Department of Gastroenterology, Chinese PLA General Hospital, Beijing 100853, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology, Chinese PLA General Hospital, Beijing 100853, China', 'institution_ids': ['https://openalex.org/I2802939634']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038036634', 'display_name': 'Wenhua Zhu', 'orcid': 'https://orcid.org/0000-0001-8011-0274'}, 'institutions': [{'id': 'https://openalex.org/I4210144506', 'display_name': "The 309th Hospital of Chinese People's Liberation Army", 'ror': 'https://ror.org/046x15q93', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210144506']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wenhua Zhu', 'raw_affiliation_strings': ['Department of Oncology, Chinese 309th Hospital of PLA, Beijing 100091, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, Chinese 309th Hospital of PLA, Beijing 100091, China', 'institution_ids': ['https://openalex.org/I4210144506']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048049438', 'display_name': 'Yinqiao Wu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802939634', 'display_name': 'Chinese PLA General Hospital', 'ror': 'https://ror.org/04gw3ra78', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802939634']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yinqiao Wu', 'raw_affiliation_strings': ['Department of Gastroenterology, Chinese PLA General Hospital, Beijing 100853, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology, Chinese PLA General Hospital, Beijing 100853, China', 'institution_ids': ['https://openalex.org/I2802939634']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5108094695', 'display_name': 'Benyan Wu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802939634', 'display_name': 'Chinese PLA General Hospital', 'ror': 'https://ror.org/04gw3ra78', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802939634']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Benyan Wu', 'raw_affiliation_strings': ['Department of Gastroenterology, Chinese PLA General Hospital, Beijing 100853, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology, Chinese PLA General Hospital, Beijing 100853, China', 'institution_ids': ['https://openalex.org/I2802939634']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5108094695'], 'corresponding_institution_ids': ['https://openalex.org/I2802939634'], 'apc_list': None, 'apc_paid': None, 'fwci': 1.245, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 8, 'citation_normalized_percentile': {'value': 0.616333, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 83, 'max': 84}, 'biblio': {'volume': '8', 'issue': '35', 'first_page': '59601', 'last_page': '59608'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10073', 'display_name': 'Hepatocellular Carcinoma Treatment and Prognosis', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10073', 'display_name': 'Hepatocellular Carcinoma Treatment and Prognosis', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10351', 'display_name': 'Liver Disease Diagnosis and Treatment', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10966', 'display_name': 'Liver physiology and pathology', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/transcatheter-arterial-chemoembolization', 'display_name': 'Transcatheter arterial chemoembolization', 'score': 0.6706289}], 'concepts': [{'id': 'https://openalex.org/C2778695046', 'wikidata': 'https://www.wikidata.org/wiki/Q421136', 'display_name': 'Sorafenib', 'level': 3, 'score': 0.86142975}, {'id': 'https://openalex.org/C2778019345', 'wikidata': 'https://www.wikidata.org/wiki/Q1148337', 'display_name': 'Hepatocellular carcinoma', 'level': 2, 'score': 0.8581451}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8572538}, {'id': 'https://openalex.org/C95190672', 'wikidata': 'https://www.wikidata.org/wiki/Q815382', 'display_name': 'Meta-analysis', 'level': 2, 'score': 0.7215913}, {'id': 'https://openalex.org/C2778455285', 'wikidata': 'https://www.wikidata.org/wiki/Q221788', 'display_name': 'Transcatheter arterial chemoembolization', 'level': 3, 'score': 0.6706289}, {'id': 'https://openalex.org/C168563851', 'wikidata': 'https://www.wikidata.org/wiki/Q1436668', 'display_name': 'Randomized controlled trial', 'level': 2, 'score': 0.59510404}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5931196}, {'id': 'https://openalex.org/C2991744798', 'wikidata': 'https://www.wikidata.org/wiki/Q608510', 'display_name': 'Double blind', 'level': 4, 'score': 0.557922}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.5257055}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.38104886}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.21048519}, {'id': 'https://openalex.org/C27081682', 'wikidata': 'https://www.wikidata.org/wiki/Q269829', 'display_name': 'Placebo', 'level': 3, 'score': 0.096895546}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.19334', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=19334&path%5B%5D=61854', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5601759', 'pdf_url': 'https://europepmc.org/articles/pmc5601759?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601759', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28938663', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.19334', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=19334&path%5B%5D=61854', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.65, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 30, 'referenced_works': ['https://openalex.org/W1601002325', 'https://openalex.org/W1965309017', 'https://openalex.org/W1975154077', 'https://openalex.org/W1986826277', 'https://openalex.org/W1994193851', 'https://openalex.org/W1996229105', 'https://openalex.org/W1996703005', 'https://openalex.org/W2019166464', 'https://openalex.org/W2019634979', 'https://openalex.org/W2020830322', 'https://openalex.org/W2053526872', 'https://openalex.org/W2068638436', 'https://openalex.org/W2089580059', 'https://openalex.org/W2100066495', 'https://openalex.org/W2112716777', 'https://openalex.org/W2125763116', 'https://openalex.org/W2140765540', 'https://openalex.org/W2154907534', 'https://openalex.org/W2155459657', 'https://openalex.org/W2156098321', 'https://openalex.org/W2156410597', 'https://openalex.org/W2156871508', 'https://openalex.org/W2271549170', 'https://openalex.org/W2286222994', 'https://openalex.org/W2321700333', 'https://openalex.org/W2345864436', 'https://openalex.org/W2591655368', 'https://openalex.org/W2917837889', 'https://openalex.org/W4210973123', 'https://openalex.org/W4256513592'], 'related_works': ['https://openalex.org/W4362622788', 'https://openalex.org/W4361816912', 'https://openalex.org/W4285206599', 'https://openalex.org/W3018861914', 'https://openalex.org/W2769323635', 'https://openalex.org/W2415536161', 'https://openalex.org/W2280419820', 'https://openalex.org/W2087356637', 'https://openalex.org/W2034139851', 'https://openalex.org/W1970460092'], 'abstract_inverted_index': {'//': [0], 'Jun': [1], 'Li': [2], '1,': [3, 8], '*': [4, 9, 14, 46], ',': [5, 10, 15], 'Wenhui': [6], 'Liu': [7], 'Wenhua': [11], 'Zhu': [12], '2,': [13], 'Yinqiao': [16, 51], 'Wu': [17, 21], '1': [18, 22, 23], 'and': [19, 131, 155, 204, 211, 263], 'Benyan': [20, 55], 'Department': [24, 35], 'of': [25, 36, 41, 90, 115, 146, 202, 236, 249, 267, 281, 307, 311], 'Gastroenterology,': [26], 'Chinese': [27, 38], 'PLA': [28], 'General': [29], 'Hospital,': [30], 'Beijing': [31, 43], '100853,': [32], 'China': [33, 45, 154], '2': [34], 'Oncology,': [37], '309th': [39], 'Hospital': [40], 'PLA,': [42], '100091,': [44], 'Co-first': [47], 'authors': [48], 'Correspondence': [49], 'to:': [50], 'Wu,': [52, 56], 'email:': [53, 57], '[email protected]': [54], '[email protected]': [58], 'Keywords:': [59], 'randomized': [60, 107], 'controlled': [61, 108], 'trial,': [62], 'transcatheter': [63, 91], 'hepatic': [64, 92], 'arterial': [65, 93], 'chemoembolization,': [66], 'hepatocellular': [67, 100], 'carcinoma,': [68], 'disease': [69, 125], 'progression,': [70], 'overall': [71, 128], 'survival': [72, 129], 'Received:': [73], 'November': [74], '04,': [75], '2016': [76], 'Accepted:': [77], 'July': [78, 82], '06,': [79], '2017': [80, 84], 'Published:': [81], '18,': [83], 'ABSTRACT': [85], 'We': [86], 'performed': [87], 'a': [88, 264, 278, 319], 'meta-analysis': [89], 'chemoembolization': [94], '(TACE)': [95], 'combined': [96, 117], 'with': [97, 118, 196], 'sorafenib': [98, 119, 296, 314], 'for': [99, 224], 'carcinoma': [101], '(HCC),': [102], 'which': [103], 'included': [104, 159], '4': [105], 'double-blind,': [106], 'trials': [109], '(RCTs)': [110], 'that': [111, 269], 'investigated': [112], 'the': [113, 140, 156, 168, 197, 217, 230, 234, 247, 274, 305, 308], 'effects': [114], 'TACE': [116, 294, 312], '(experimental': [120], 'groups)': [121], 'on': [122], 'time': [123], 'to': [124, 137, 227], 'progression': [126], '(TTP),': [127], '(OS),': [130], 'various': [132], 'sorafenib-related': [133], 'adverse': [134, 309], 'events,': [135], 'compared': [136, 195, 226], 'those': [138, 228], 'in': [139, 160, 167, 216, 229, 273], 'placebo': [141], '(control)': [142], 'groups.': [143, 199], 'A': [144], 'total': [145], '877': [147], 'HCC': [148], 'cases': [149], 'from': [150], '14': [151], 'countries,': [152], 'including': [153], 'USA,': [157], 'were': [158, 213], 'our': [161], 'meta-analysis.': [162], 'The': [163, 200], 'TTP': [164], 'increased': [165], 'significantly': [166, 186, 214], 'experimental': [169, 218], 'groups': [170, 219], '(hazard': [171], 'ration': [172], '[HR]:': [173], '0.82;': [174], '95%': [175, 189, 257, 285], 'CI:': [176, 190, 258, 286], '0.69–0.97;': [177], 'p': [178, 192, 221, 242, 260, 288], '=': [179, 193, 261], '0.02),': [180], 'but': [181], 'OS': [182], 'did': [183], 'not': [184, 301], 'improve': [185, 302], '(HR:': [187], '0.97;': [188], '0.72–1.29;': [191], '0.82),': [194], 'control': [198, 231], 'risks': [201], 'hand': [203], 'foot': [205], 'skin': [206], 'reactions': [207], '(HFSR),': [208], 'rash,': [209], 'fatigue,': [210], 'diarrhea': [212], 'greater': [215], '(': [220, 241], '<': [222, 289], '0.05': [223], 'all),': [225], 'groups,': [232], 'whereas': [233], 'risk': [235, 248, 280, 306], 'nausea': [237], 'was': [238, 251], 'statistically': [239], 'similar': [240], '>': [243], '0.05).': [244, 290], 'Among': [245], 'these,': [246], 'HFSR': [250, 275, 282], 'highest': [252], '(risk': [253], 'ratio': [254], '[RR]:': [255], '5.93;': [256], '2.00–17.53;': [259], '0.001),': [262], 'subgroup': [265], 'analysis': [266], 'studies': [268], 'lacked': [270], 'significant': [271], 'heterogeneity': [272], 'data': [276], 'showed': [277], 'higher': [279], '(RR:': [283], '10.96;': [284], '5.54–21.69;': [287], 'In': [291], 'conclusion,': [292], 'although': [293], 'plus': [295, 313], 'increases': [297], 'TTP,': [298], 'it': [299], 'does': [300], 'OS.': [303], 'Therefore,': [304], 'events': [310], 'should': [315], 'be': [316], 'considered': [317], 'as': [318], 'potential': [320], 'therapeutic': [321], 'limitation.': [322]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2739274500', 'counts_by_year': [{'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 4}], 'updated_date': '2024-12-17T08:50:21.452588', 'created_date': '2017-07-31'}