Inhibition of aldehyde dehydrogenase 1 enhances the cytotoxic effect of retinaldehyde on A549 cancer cells

Name: Work Video:
Duration: 3 min 30 s
Jin Won Park; Kyung‐Ho Jung; Jin Hee Lee; Seung Hwan Moon; Young Seok Cho; Kyung-Han Lee
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'confirmed': [152], 'N,': [154], 'N-diethylaminobenzaldehyde': [155], '(DEAB)': [156], 'inhibits': [157], 'ALDH-mediated': [158], 'disposal': [159], 'retinaldehyde': [161, 172, 197, 236, 246], 'lysates.': [166], 'Treatment': [167], 'with': [171, 223], 'presence': [175], 'DEAB': [177, 191, 213], 'augmented': [178], 'reactive': [179], 'oxygen': [180, 188], 'species': [181], 'production': [182], 'decreased': [184], 'glucose': [185], 'uptake': [186], 'consumption.': [189], 'Importantly,': [190], 'substantially': [192], 'potentiated': [193], 'ability': [195], 'to': [198, 230], 'dose-dependently': [199], 'suppress': [200], 'survival': [202], 'whereas': [208], 'added': [210], 'minor': [215], 'Gene': [221], 'silencing': [222], 'specific': [224], 'siRNA': [225], 'revealed': [226], 'contributed': [229], 'protection': [231, 244], 'against': [235, 245], 'toxicity.': [237], 'These': [238], 'results': [239], 'demonstrate': [240], 'ALDH1': [242], 'confers': [243], 'toxicity': [247]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2738279687', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 1}], 'updated_date': '2025-01-10T14:22:53.299646', 'created_date': '2017-07-31'}
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