Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2735978010', 'doi': 'https://doi.org/10.1186/s12929-017-0352-x', 'title': 'PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression', 'display_name': 'PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression', 'publication_year': 2017, 'publication_date': '2017-07-15', 'ids': {'openalex': 'https://openalex.org/W2735978010', 'doi': 'https://doi.org/10.1186/s12929-017-0352-x', 'mag': '2735978010', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28711067', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5513211'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/s12929-017-0352-x', 'pdf_url': 'https://jbiomedsci.biomedcentral.com/track/pdf/10.1186/s12929-017-0352-x', 'source': {'id': 'https://openalex.org/S52607827', 'display_name': 'Journal of Biomedical Science', 'issn_l': '1021-7770', 'issn': ['1021-7770', '1423-0127'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'diamond', 'oa_url': 'https://jbiomedsci.biomedcentral.com/track/pdf/10.1186/s12929-017-0352-x', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5059644378', 'display_name': 'Jun Yuan', 'orcid': 'https://orcid.org/0000-0001-6542-4654'}, 'institutions': [{'id': 'https://openalex.org/I3018483916', 'display_name': 'University Medical Center Utrecht', 'ror': 'https://ror.org/0575yy874', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018483916']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Yuan Ji', 'raw_affiliation_strings': ['Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, Yalelaan 50, 3584 CM, Utrecht, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, Yalelaan 50, 3584 CM, Utrecht, The Netherlands', 'institution_ids': ['https://openalex.org/I3018483916']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090403218', 'display_name': 'Marlieke G. Veldhuis', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I3018483916', 'display_name': 'University Medical Center Utrecht', 'ror': 'https://ror.org/0575yy874', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018483916']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Marlieke G. Veldhuis', 'raw_affiliation_strings': ['Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, Yalelaan 50, 3584 CM, Utrecht, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, Yalelaan 50, 3584 CM, Utrecht, The Netherlands', 'institution_ids': ['https://openalex.org/I3018483916']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053846358', 'display_name': 'Jantien Zandvoort', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I3018483916', 'display_name': 'University Medical Center Utrecht', 'ror': 'https://ror.org/0575yy874', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018483916']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Jantien Zandvoort', 'raw_affiliation_strings': ['Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, Yalelaan 50, 3584 CM, Utrecht, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, Yalelaan 50, 3584 CM, Utrecht, The Netherlands', 'institution_ids': ['https://openalex.org/I3018483916']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042556798', 'display_name': 'Fee L. Romunde', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I3018483916', 'display_name': 'University Medical Center Utrecht', 'ror': 'https://ror.org/0575yy874', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018483916']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Fee L. Romunde', 'raw_affiliation_strings': ['Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, Yalelaan 50, 3584 CM, Utrecht, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, Yalelaan 50, 3584 CM, Utrecht, The Netherlands', 'institution_ids': ['https://openalex.org/I3018483916']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085224883', 'display_name': 'Marien J. C. Houtman', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I3018483916', 'display_name': 'University Medical Center Utrecht', 'ror': 'https://ror.org/0575yy874', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018483916']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Marien J. C. Houtman', 'raw_affiliation_strings': ['Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, Yalelaan 50, 3584 CM, Utrecht, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, Yalelaan 50, 3584 CM, Utrecht, The Netherlands', 'institution_ids': ['https://openalex.org/I3018483916']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034277027', 'display_name': 'Karen Duran', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I3018483916', 'display_name': 'University Medical Center Utrecht', 'ror': 'https://ror.org/0575yy874', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018483916']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Karen Duran', 'raw_affiliation_strings': ['Center for Molecular Medicine, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Center for Molecular Medicine, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands', 'institution_ids': ['https://openalex.org/I3018483916']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007478590', 'display_name': 'Gijs van Haaften', 'orcid': 'https://orcid.org/0000-0003-3033-0329'}, 'institutions': [{'id': 'https://openalex.org/I3018483916', 'display_name': 'University Medical Center Utrecht', 'ror': 'https://ror.org/0575yy874', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018483916']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Gijs van Haaften', 'raw_affiliation_strings': ['Center for Molecular Medicine, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Center for Molecular Medicine, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands', 'institution_ids': ['https://openalex.org/I3018483916']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084395646', 'display_name': 'Eva-Maria Zangerl-Plessl', 'orcid': 'https://orcid.org/0000-0002-2484-115X'}, 'institutions': [{'id': 'https://openalex.org/I129774422', 'display_name': 'University of Vienna', 'ror': 'https://ror.org/03prydq77', 'country_code': 'AT', 'type': 'education', 'lineage': ['https://openalex.org/I129774422']}], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Eva-Maria Zangerl-Plessl', 'raw_affiliation_strings': ['Department of Pharmacology and Toxicology, University of Vienna, Vienna, Austria'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Toxicology, University of Vienna, Vienna, Austria', 'institution_ids': ['https://openalex.org/I129774422']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045687599', 'display_name': 'Hiroki Takanari', 'orcid': 'https://orcid.org/0000-0001-9348-9877'}, 'institutions': [{'id': 'https://openalex.org/I3018483916', 'display_name': 'University Medical Center Utrecht', 'ror': 'https://ror.org/0575yy874', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018483916']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Hiroki Takanari', 'raw_affiliation_strings': ['Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, Yalelaan 50, 3584 CM, Utrecht, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, Yalelaan 50, 3584 CM, Utrecht, The Netherlands', 'institution_ids': ['https://openalex.org/I3018483916']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009058982', 'display_name': 'Anna Stary‐Weinzinger', 'orcid': 'https://orcid.org/0000-0002-9202-0484'}, 'institutions': [{'id': 'https://openalex.org/I129774422', 'display_name': 'University of Vienna', 'ror': 'https://ror.org/03prydq77', 'country_code': 'AT', 'type': 'education', 'lineage': ['https://openalex.org/I129774422']}], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Anna Stary-Weinzinger', 'raw_affiliation_strings': ['Department of Pharmacology and Toxicology, University of Vienna, Vienna, Austria'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Toxicology, University of Vienna, Vienna, Austria', 'institution_ids': ['https://openalex.org/I129774422']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5009852139', 'display_name': 'Marcel A. G. van der Heyden', 'orcid': 'https://orcid.org/0000-0002-4225-7942'}, 'institutions': [{'id': 'https://openalex.org/I3018483916', 'display_name': 'University Medical Center Utrecht', 'ror': 'https://ror.org/0575yy874', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018483916']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Marcel A. G. van der Heyden', 'raw_affiliation_strings': ['Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, Yalelaan 50, 3584 CM, Utrecht, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, Yalelaan 50, 3584 CM, Utrecht, The Netherlands', 'institution_ids': ['https://openalex.org/I3018483916']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 0, 'currency': 'USD', 'value_usd': 0, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.509, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 15, 'citation_normalized_percentile': {'value': 0.850406, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '24', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10217', 'display_name': 'Molecular Mechanisms of Cardiac Arrhythmias', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10217', 'display_name': 'Molecular Mechanisms of Cardiac Arrhythmias', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10493', 'display_name': 'Molecular Mechanisms of Ion Channels Regulation', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11178', 'display_name': 'Structure and Function of G Protein-Coupled Receptors', 'score': 0.9858, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/potassium-channels', 'display_name': 'Potassium Channels', 'score': 0.532034}], 'concepts': [{'id': 'https://openalex.org/C94924445', 'wikidata': 'https://www.wikidata.org/wiki/Q841456', 'display_name': 'Inward-rectifier potassium ion channel', 'level': 4, 'score': 0.8189666}, {'id': 'https://openalex.org/C147944092', 'wikidata': 'https://www.wikidata.org/wiki/Q176366', 'display_name': 'Patch clamp', 'level': 3, 'score': 0.74230444}, {'id': 'https://openalex.org/C50254741', 'wikidata': 'https://www.wikidata.org/wiki/Q62536', 'display_name': 'Ion channel', 'level': 3, 'score': 0.561052}, {'id': 'https://openalex.org/C83743174', 'wikidata': 'https://www.wikidata.org/wiki/Q423778', 'display_name': 'Potassium channel', 'level': 2, 'score': 0.52552694}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.52283865}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.51117474}, {'id': 'https://openalex.org/C181911157', 'wikidata': 'https://www.wikidata.org/wiki/Q389844', 'display_name': 'Membrane potential', 'level': 2, 'score': 0.5024922}, {'id': 'https://openalex.org/C146403970', 'wikidata': 'https://www.wikidata.org/wiki/Q205729', 'display_name': 'Repolarization', 'level': 3, 'score': 0.49819136}, {'id': 'https://openalex.org/C2776415932', 'wikidata': 'https://www.wikidata.org/wiki/Q48743', 'display_name': 'Western blot', 'level': 3, 'score': 0.469749}, {'id': 'https://openalex.org/C100837961', 'wikidata': 'https://www.wikidata.org/wiki/Q10290897', 'display_name': 'Voltage clamp', 'level': 3, 'score': 0.45986462}, {'id': 'https://openalex.org/C185263204', 'wikidata': 'https://www.wikidata.org/wiki/Q1154774', 'display_name': 'Electrophysiology', 'level': 2, 'score': 0.45147836}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.38166535}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2659484}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.2456932}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.1495744}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.061422676}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D010419', 'descriptor_name': 'Pentamidine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D010419', 'descriptor_name': 'Pentamidine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D026902', 'descriptor_name': 'Potassium Channel Blockers', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D024661', 'descriptor_name': 'Potassium Channels, Inwardly Rectifying', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D024661', 'descriptor_name': 'Potassium Channels, Inwardly Rectifying', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000200', 'descriptor_name': 'Action Potentials', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057809', 'descriptor_name': 'HEK293 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008564', 'descriptor_name': 'Membrane Potentials', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D062105', 'descriptor_name': 'Molecular Docking Simulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010419', 'descriptor_name': 'Pentamidine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010419', 'descriptor_name': 'Pentamidine', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D026902', 'descriptor_name': 'Potassium Channel Blockers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D026902', 'descriptor_name': 'Potassium Channel Blockers', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D024661', 'descriptor_name': 'Potassium Channels, Inwardly Rectifying', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D024661', 'descriptor_name': 'Potassium Channels, Inwardly Rectifying', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/s12929-017-0352-x', 'pdf_url': 'https://jbiomedsci.biomedcentral.com/track/pdf/10.1186/s12929-017-0352-x', 'source': {'id': 'https://openalex.org/S52607827', 'display_name': 'Journal of Biomedical Science', 'issn_l': '1021-7770', 'issn': ['1021-7770', '1423-0127'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/efbd78c2599d487c96e896e9cb6f2763', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513211', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28711067', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/s12929-017-0352-x', 'pdf_url': 'https://jbiomedsci.biomedcentral.com/track/pdf/10.1186/s12929-017-0352-x', 'source': {'id': 'https://openalex.org/S52607827', 'display_name': 'Journal of Biomedical Science', 'issn_l': '1021-7770', 'issn': ['1021-7770', '1423-0127'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320321545', 'funder_display_name': 'China Sponsorship Council', 'award_id': 'n.a.'}], 'datasets': [], 'versions': [], 'referenced_works_count': 41, 'referenced_works': ['https://openalex.org/W1542147120', 'https://openalex.org/W1587470262', 'https://openalex.org/W1985718987', 'https://openalex.org/W1997946428', 'https://openalex.org/W2006047900', 'https://openalex.org/W2007092585', 'https://openalex.org/W2015642465', 'https://openalex.org/W2015933522', 'https://openalex.org/W2018256150', 'https://openalex.org/W2023143117', 'https://openalex.org/W2034943103', 'https://openalex.org/W2040382630', 'https://openalex.org/W2046252841', 'https://openalex.org/W2046336333', 'https://openalex.org/W2054590326', 'https://openalex.org/W2056072103', 'https://openalex.org/W2059217828', 'https://openalex.org/W2069545616', 'https://openalex.org/W2077203000', 'https://openalex.org/W2089421439', 'https://openalex.org/W2094122978', 'https://openalex.org/W2096261252', 'https://openalex.org/W2104247752', 'https://openalex.org/W2119327737', 'https://openalex.org/W2124148610', 'https://openalex.org/W2129393568', 'https://openalex.org/W2129434797', 'https://openalex.org/W2137007692', 'https://openalex.org/W2138472697', 'https://openalex.org/W2138937314', 'https://openalex.org/W2139222531', 'https://openalex.org/W2154122229', 'https://openalex.org/W2160845018', 'https://openalex.org/W2161227647', 'https://openalex.org/W2161424604', 'https://openalex.org/W2168083354', 'https://openalex.org/W2200918804', 'https://openalex.org/W2502289403', 'https://openalex.org/W2607136456', 'https://openalex.org/W2618086917', 'https://openalex.org/W3030533492'], 'related_works': ['https://openalex.org/W567288251', 'https://openalex.org/W4297959886', 'https://openalex.org/W3083456528', 'https://openalex.org/W2352426073', 'https://openalex.org/W2080229154', 'https://openalex.org/W2073113095', 'https://openalex.org/W2031466416', 'https://openalex.org/W2028247996', 'https://openalex.org/W2019781590', 'https://openalex.org/W1906936638'], 'abstract_inverted_index': {'The': [0], 'inward': [1], 'rectifier': [2], 'potassium': [3], 'current': [4], 'IK1': [5, 58, 243], 'contributes': [6], 'to': [7], 'a': [8, 346], 'stable': [9], 'resting': [10], 'membrane': [11, 112], 'potential': [12], 'and': [13, 26, 37, 56, 97, 100, 130, 150, 161, 169, 186, 196, 206, 214, 254, 261, 285, 290, 310, 317, 338, 358], 'phase': [14], '3': [15, 36], 'repolarization': [16], 'of': [17, 67, 153, 181, 239, 279, 330, 355], 'the': [18, 63, 68, 110, 120, 147, 154, 175, 320], 'cardiac': [19], 'action': [20], 'potential.': [21], 'KCNJ2': [22, 313], 'gain-of-function': [23, 314], 'mutations': [24, 185, 315], 'V93I': [25, 99, 197, 260, 286, 316], 'D172N': [27, 101, 217, 262, 291, 318], 'associate': [28], 'with': [29, 51, 62, 96, 119, 200], 'increased': [30, 275], 'IK1,': [31, 331], 'short': [32], 'QT': [33], 'syndrome': [34], 'type': [35], 'congenital': [38, 356], 'atrial': [39], 'fibrillation.': [40], 'Pentamidine-Analogue': [41], '6': [42], '(PA-6)': [43], 'is': [44, 345], 'an': [45], 'efficient': [46], '(IC50': [47, 203, 222], '=': [48, 204, 223], '14': [49], 'nM': [50, 208, 225], 'inside-out': [52, 151, 230], 'patch': [53, 155], 'clamp': [54, 156], 'methodology)': [55], 'specific': [57], 'inhibitor': [59], 'that': [60, 92, 184, 269], 'interacts': [61], 'cytoplasmic': [64], 'pore': [65], 'region': [66], 'KIR2.1': [69, 82, 102, 122, 132, 158, 182, 276, 301, 321, 335, 341], 'ion': [70, 322], 'channel,': [71], 'encoded': [72], 'by': [73, 165, 247], 'KCNJ2.': [74], 'At': [75], '10': [76, 255], 'μM,': [77, 272], 'PA-6': [78, 93, 193, 240, 270, 305, 327, 333, 344], 'increases': [79], 'wild-type': [80], '(WT)': [81], 'expression': [83, 108, 159, 277, 337], 'in': [84, 136, 146, 174, 319, 353], 'HEK293T': [85], 'cells': [86], 'upon': [87], 'chronic': [88, 304], 'treatment.': [89], 'We': [90], 'hypothesized': [91], 'will': [94], 'interact': [95], 'inhibit': [98], 'channels,': [103], 'whereas': [104, 216], 'impact': [105], 'on': [106], 'channel': [107, 323], 'at': [109, 209, 226, 244], 'plasma': [111], 'requires': [113], 'higher': [114], 'concentrations.Molecular': [115], 'modelling': [116], 'was': [117], 'performed': [118, 145], 'human': [121], 'closed': [123], 'state': [124], 'homology': [125, 179], 'model': [126, 180], 'using': [127, 229], 'FlexX.': [128], 'WT': [129, 195, 213, 280], 'mutant': [131, 178], 'channels': [133, 263], 'were': [134, 144, 163, 219], 'expressed': [135], 'HEK293': [137], 'cells.': [138], 'Patch-clamp': [139], 'single': [140], 'cell': [141, 149, 235], 'electrophysiology': [142], 'measurements': [143], 'whole': [148, 234], 'mode': [152], 'method.': [157], 'level': [160], 'localization': [162], 'determined': [164], 'western': [166], 'blot': [167, 266], 'analysis': [168, 267], 'immunofluorescence': [170], 'microscopy,': [171], 'respectively.PA-6': [172], 'docking': [173], 'V93I/D172N': [176], 'double': [177], 'demonstrated': [183, 268, 298], 'drug-binding': [187], 'site': [188], 'are': [189], '>30': [190], 'Å': [191], 'apart.': [192], 'inhibited': [194, 241], 'outward': [198, 242], 'currents': [199, 218], 'similar': [201], 'potency': [202], '35.5': [205], '43.6': [207], '+50': [210, 227], 'mV': [211, 246], 'for': [212, 258, 349], 'V93I),': [215], 'less': [220], 'sensitive': [221], '128.9': [224], 'mV)': [228], 'patch-clamp': [231], 'electrophysiology.': [232], 'In': [233], 'mode,': [236], '1': [237, 309], 'μM': [238], '-50': [245], '28': [248], '±': [249, 252, 256, 282, 288, 293], '36%,': [250], '18': [251], '20%': [253], '6%,': [257], 'WT,': [259], 'respectively.': [264], 'Western': [265], '(5': [271], '24': [273], 'h)': [274], 'levels': [278], '(6.3': [281], '1.5': [283], 'fold),': [284], '(3.9': [287], '0.9)': [289], '(4.8': [292], '2.0)': [294], 'mutants.': [295], 'Immunofluorescent': [296], 'microscopy': [297], 'dose-dependent': [299], 'intracellular': [300, 340], 'accumulation': [302], 'following': [303], 'application': [306], '(24': [307], 'h,': [308], '5': [311], 'μM).1)': [312], 'do': [324], 'not': [325], 'impair': [326], 'mediated': [328], 'inhibition': [329], '2)': [332], 'elevates': [334], 'protein': [336], 'induces': [339], 'accumulation,': [342], '3)': [343], 'strong': [347], 'candidate': [348], 'further': [350], 'preclinical': [351], 'evaluation': [352], 'treatment': [354], 'SQT3': [357], 'AF.': [359]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2735978010', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 4}], 'updated_date': '2024-09-17T07:15:00.114241', 'created_date': '2017-07-21'}