Publication Information

{'id': 'https://openalex.org/W2734576230', 'doi': 'https://doi.org/10.4049/jimmunol.1700608', 'title': 'The Ox40/Ox40 Ligand Pathway Promotes Pathogenic Th Cell Responses, Plasmablast Accumulation, and Lupus Nephritis in NZB/W F1 Mice', 'display_name': 'The Ox40/Ox40 Ligand Pathway Promotes Pathogenic Th Cell Responses, Plasmablast Accumulation, and Lupus Nephritis in NZB/W F1 Mice', 'publication_year': 2017, 'publication_date': '2017-07-11', 'ids': {'openalex': 'https://openalex.org/W2734576230', 'doi': 'https://doi.org/10.4049/jimmunol.1700608', 'mag': '2734576230', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28696253', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5544932'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.1700608', 'pdf_url': 'https://www.jimmunol.org/content/jimmunol/199/4/1238.full.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.jimmunol.org/content/jimmunol/199/4/1238.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5014322908', 'display_name': 'Jonathan Sitrin', 'orcid': 'https://orcid.org/0009-0001-2496-5793'}, 'institutions': [], 'countries': [], 'is_corresponding': True, 'raw_author_name': 'Jonathan Sitrin', 'raw_affiliation_strings': ['*Department of Human Genetics, Genentech, Inc., South San Francisco, CA 94080;'], 'affiliations': [{'raw_affiliation_string': '*Department of Human Genetics, Genentech, Inc., South San Francisco, CA 94080;', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057064738', 'display_name': 'Eric Suto', 'orcid': 'https://orcid.org/0000-0002-2631-015X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Eric Suto', 'raw_affiliation_strings': ['†Department of Translational Immunology, Genentech, Inc., South San Francisco, CA 94080;'], 'affiliations': [{'raw_affiliation_string': '†Department of Translational Immunology, Genentech, Inc., South San Francisco, CA 94080;', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064293077', 'display_name': 'Arthur Wüster', 'orcid': 'https://orcid.org/0000-0003-4162-5931'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Arthur Wuster', 'raw_affiliation_strings': ['*Department of Human Genetics, Genentech, Inc., South San Francisco, CA 94080;', '‡Department of Bioinformatics and Computational Biology, Genentech, Inc., South San Francisco, CA 94080;'], 'affiliations': [{'raw_affiliation_string': '*Department of Human Genetics, Genentech, Inc., South San Francisco, CA 94080;', 'institution_ids': []}, {'raw_affiliation_string': '‡Department of Bioinformatics and Computational Biology, Genentech, Inc., South San Francisco, CA 94080;', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034385444', 'display_name': 'Jeffrey Eastham‐Anderson', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Jeffrey Eastham-Anderson', 'raw_affiliation_strings': ['§Department of Pathology, Genentech, Inc., South San Francisco, CA 94080; and'], 'affiliations': [{'raw_affiliation_string': '§Department of Pathology, Genentech, Inc., South San Francisco, CA 94080; and', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102849031', 'display_name': 'Jeong Kim', 'orcid': 'https://orcid.org/0009-0006-1422-9203'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Jeong M. Kim', 'raw_affiliation_strings': ['¶Department of Cancer Immunology, Genentech, Inc., South San Francisco, CA 94080'], 'affiliations': [{'raw_affiliation_string': '¶Department of Cancer Immunology, Genentech, Inc., South San Francisco, CA 94080', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062810481', 'display_name': 'Cary D. Austin', 'orcid': 'https://orcid.org/0000-0002-5388-7413'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Cary D. Austin', 'raw_affiliation_strings': ['§Department of Pathology, Genentech, Inc., South San Francisco, CA 94080; and'], 'affiliations': [{'raw_affiliation_string': '§Department of Pathology, Genentech, Inc., South San Francisco, CA 94080; and', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055581115', 'display_name': 'Wyne P. Lee', 'orcid': 'https://orcid.org/0000-0002-3415-2710'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Wyne P. Lee', 'raw_affiliation_strings': ['†Department of Translational Immunology, Genentech, Inc., South San Francisco, CA 94080;'], 'affiliations': [{'raw_affiliation_string': '†Department of Translational Immunology, Genentech, Inc., South San Francisco, CA 94080;', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5049956204', 'display_name': 'Timothy W. Behrens', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Timothy W. Behrens', 'raw_affiliation_strings': ['*Department of Human Genetics, Genentech, Inc., South San Francisco, CA 94080;'], 'affiliations': [{'raw_affiliation_string': '*Department of Human Genetics, Genentech, Inc., South San Francisco, CA 94080;', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': ['https://openalex.org/A5014322908'], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.958, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 41, 'citation_normalized_percentile': {'value': 0.999918, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '199', 'issue': '4', 'first_page': '1238', 'last_page': '1249'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10031', 'display_name': 'T-cell and B-cell Immunology', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10031', 'display_name': 'T-cell and B-cell Immunology', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10308', 'display_name': 'Systemic Lupus Erythematosus Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11020', 'display_name': 'Immune Cell Function and Interaction', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2779912601', 'wikidata': 'https://www.wikidata.org/wiki/Q1621830', 'display_name': 'Lupus nephritis', 'level': 3, 'score': 0.778224}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.6516227}, {'id': 'https://openalex.org/C2776912625', 'wikidata': 'https://www.wikidata.org/wiki/Q1485', 'display_name': 'Systemic lupus erythematosus', 'level': 3, 'score': 0.61265755}, {'id': 'https://openalex.org/C2778690821', 'wikidata': 'https://www.wikidata.org/wiki/Q212354', 'display_name': 'Cytokine', 'level': 2, 'score': 0.46688998}, {'id': 'https://openalex.org/C2780931953', 'wikidata': 'https://www.wikidata.org/wiki/Q9371', 'display_name': 'Spleen', 'level': 2, 'score': 0.44590792}, {'id': 'https://openalex.org/C2778938600', 'wikidata': 'https://www.wikidata.org/wiki/Q389934', 'display_name': 'Agonist', 'level': 3, 'score': 0.43422627}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.41992506}, {'id': 'https://openalex.org/C2776090121', 'wikidata': 'https://www.wikidata.org/wiki/Q193529', 'display_name': 'T cell', 'level': 3, 'score': 0.41292474}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.3843185}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3822982}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.365825}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.34206313}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.23982644}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.12782839}], 'mesh': [{'descriptor_ui': 'D008181', 'descriptor_name': 'Lupus Nephritis', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010950', 'descriptor_name': 'Plasma Cells', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D053262', 'descriptor_name': 'Receptors, OX40', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D006377', 'descriptor_name': 'T-Lymphocytes, Helper-Inducer', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D048069', 'descriptor_name': 'Tumor Necrosis Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000974', 'descriptor_name': 'Antibodies, Antinuclear', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000974', 'descriptor_name': 'Antibodies, Antinuclear', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D015551', 'descriptor_name': 'Autoimmunity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015496', 'descriptor_name': 'CD4-Positive T-Lymphocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015496', 'descriptor_name': 'CD4-Positive T-Lymphocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015496', 'descriptor_name': 'CD4-Positive T-Lymphocytes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D007678', 'descriptor_name': 'Kidney Glomerulus', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D007678', 'descriptor_name': 'Kidney Glomerulus', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D007678', 'descriptor_name': 'Kidney Glomerulus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008181', 'descriptor_name': 'Lupus Nephritis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008181', 'descriptor_name': 'Lupus Nephritis', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008814', 'descriptor_name': 'Mice, Inbred NZB', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053278', 'descriptor_name': 'OX40 Ligand', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010950', 'descriptor_name': 'Plasma Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011507', 'descriptor_name': 'Proteinuria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011507', 'descriptor_name': 'Proteinuria', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D053262', 'descriptor_name': 'Receptors, OX40', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006377', 'descriptor_name': 'T-Lymphocytes, Helper-Inducer', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006377', 'descriptor_name': 'T-Lymphocytes, Helper-Inducer', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048069', 'descriptor_name': 'Tumor Necrosis Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.1700608', 'pdf_url': 'https://www.jimmunol.org/content/jimmunol/199/4/1238.full.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5544932', 'pdf_url': 'https://europepmc.org/articles/pmc5544932?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544932', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28696253', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.1700608', 'pdf_url': 'https://www.jimmunol.org/content/jimmunol/199/4/1238.full.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.82}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 80, 'referenced_works': ['https://openalex.org/W1616429334', 'https://openalex.org/W1635613420', 'https://openalex.org/W1795316817', 'https://openalex.org/W1846376083', 'https://openalex.org/W1857622889', 'https://openalex.org/W1858003552', 'https://openalex.org/W1913188064', 'https://openalex.org/W1929236283', 'https://openalex.org/W1936607706', 'https://openalex.org/W1965786965', 'https://openalex.org/W1972701848', 'https://openalex.org/W1977523123', 'https://openalex.org/W1977715526', 'https://openalex.org/W1978259263', 'https://openalex.org/W1978860647', 'https://openalex.org/W1979007905', 'https://openalex.org/W1979689648', 'https://openalex.org/W1985533946', 'https://openalex.org/W2001775594', 'https://openalex.org/W2027086837', 'https://openalex.org/W2029306037', 'https://openalex.org/W2031622194', 'https://openalex.org/W2034513835', 'https://openalex.org/W2037473487', 'https://openalex.org/W2054582797', 'https://openalex.org/W2055056105', 'https://openalex.org/W2058089640', 'https://openalex.org/W2070443202', 'https://openalex.org/W2070991129', 'https://openalex.org/W2073391461', 'https://openalex.org/W2080882856', 'https://openalex.org/W2084419000', 'https://openalex.org/W2087843772', 'https://openalex.org/W2088047133', 'https://openalex.org/W2089417354', 'https://openalex.org/W2096869658', 'https://openalex.org/W2098723557', 'https://openalex.org/W2102364213', 'https://openalex.org/W2106273198', 'https://openalex.org/W2108207992', 'https://openalex.org/W2109033058', 'https://openalex.org/W2112055789', 'https://openalex.org/W2120358882', 'https://openalex.org/W2121244867', 'https://openalex.org/W2125942998', 'https://openalex.org/W2126101979', 'https://openalex.org/W2126217474', 'https://openalex.org/W2126302587', 'https://openalex.org/W2134342374', 'https://openalex.org/W2137526110', 'https://openalex.org/W2137639957', 'https://openalex.org/W2139237097', 'https://openalex.org/W2142209244', 'https://openalex.org/W2143488332', 'https://openalex.org/W2144224481', 'https://openalex.org/W2149719081', 'https://openalex.org/W2153268818', 'https://openalex.org/W2154656443', 'https://openalex.org/W2156253561', 'https://openalex.org/W2162055377', 'https://openalex.org/W2162457090', 'https://openalex.org/W2163229826', 'https://openalex.org/W2163749231', 'https://openalex.org/W2165470016', 'https://openalex.org/W2169466773', 'https://openalex.org/W2170007827', 'https://openalex.org/W2172399299', 'https://openalex.org/W2259139274', 'https://openalex.org/W2272550089', 'https://openalex.org/W2337275183', 'https://openalex.org/W2473178057', 'https://openalex.org/W2474869522', 'https://openalex.org/W2559146979', 'https://openalex.org/W2566593195', 'https://openalex.org/W2589429492', 'https://openalex.org/W2607741101', 'https://openalex.org/W3149947358', 'https://openalex.org/W4292083220', 'https://openalex.org/W4292232933', 'https://openalex.org/W980174965'], 'related_works': ['https://openalex.org/W3214891379', 'https://openalex.org/W3166910253', 'https://openalex.org/W2778847013', 'https://openalex.org/W2776803289', 'https://openalex.org/W2471395144', 'https://openalex.org/W2364717911', 'https://openalex.org/W2177092523', 'https://openalex.org/W2158944380', 'https://openalex.org/W2121244867', 'https://openalex.org/W2098134050'], 'abstract_inverted_index': {'Ox40': [0, 58], 'ligand': [1], '(Ox40L)': [2], 'locus': [3], 'genetic': [4], 'variants': [5], 'are': [6], 'associated': [7], 'with': [8, 79, 88, 161], 'the': [9, 31, 48, 69, 127, 137, 169, 180, 183, 201], 'risk': [10], 'for': [11], 'systemic': [12], 'lupus': [13, 158, 193], 'erythematosus': [14], '(SLE);': [15], 'however,': [16], 'it': [17], 'is': [18], 'unclear': [19], 'how': [20], 'Ox40L': [21, 34], 'contributes': [22], 'to': [23, 141], 'SLE': [24], 'pathogenesis.': [25], 'In': [26, 153], 'this': [27, 207], 'study,': [28], 'we': [29], 'evaluated': [30], 'contribution': [32], 'of': [33, 56, 73, 83, 101, 129, 144, 171, 205], 'and': [35, 44, 71, 76, 105, 114, 134, 139, 147, 174, 188, 199], 'its': [36], 'cognate': [37], 'receptor,': [38], 'Ox40,': [39], 'using': [40], 'in': [41, 47, 68, 118, 136, 195, 209], 'vivo': [42], 'agonist': [43, 89, 109], 'antagonist': [45, 163], 'approaches': [46], 'NZB': [49], '×': [50], 'NZW': [51], '(NZB/W)': [52], 'F1': [53, 86, 197], 'mouse': [54], 'model': [55], 'SLE.': [57], 'was': [59, 97], 'highly': [60], 'expressed': [61], 'on': [62], 'several': [63], 'CD4': [64, 120], 'Th': [65], 'cell': [66], 'subsets': [67], 'spleen': [70], 'kidney': [72], 'diseased': [74], 'mice,': [75], 'expression': [77, 117], 'correlated': [78], 'disease': [80], 'severity.': [81], 'Treatment': [82], 'aged': [84], 'NZB/W': [85, 196], 'mice': [87, 198], 'anti-Ox40': [90], 'mAbs': [91, 110], 'potently': [92], 'exacerbated': [93], 'renal': [94, 149], 'disease,': [95], 'which': [96], 'accompanied': [98], 'by': [99], 'activation': [100, 113], 'kidney-infiltrating': [102], 'T': [103, 121, 132], 'cells': [104, 133], 'cytokine': [106], 'production.': [107], 'The': [108], 'also': [111], 'induced': [112], 'inflammatory': [115], 'gene': [116], 'splenic': [119], 'cells,': [122], 'including': [123], 'IFN-regulated': [124], 'genes,': [125], 'increased': [126], 'number': [128], 'follicular': [130], 'helper': [131], 'plasmablasts': [135], 'spleen,': [138], 'led': [140], 'elevated': [142], 'levels': [143], 'serum': [145], 'IgM': [146, 151], 'enhanced': [148], 'glomerular': [150], 'deposition.': [152], 'a': [154], 'type': [155], 'I': [156], 'IFN-accelerated': [157], 'model,': [159], 'treatment': [160], 'an': [162], 'Ox40:Fc': [164], 'fusion': [165], 'protein': [166], 'significantly': [167], 'delayed': [168], 'onset': [170], 'severe': [172], 'proteinuria': [173], 'improved': [175], 'survival.': [176], 'These': [177], 'data': [178], 'support': [179], 'hypothesis': [181], 'that': [182], 'Ox40/Ox40L': [184], 'pathway': [185, 208], 'drives': [186], 'cellular': [187], 'humoral': [189], 'autoimmune': [190], 'responses': [191], 'during': [192], 'nephritis': [194], 'emphasize': [200], 'potential': [202], 'clinical': [203], 'value': [204], 'targeting': [206], 'human': [210], 'lupus.': [211]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2734576230', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 11}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 1}], 'updated_date': '2024-12-24T11:22:55.764552', 'created_date': '2017-07-21'}