Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2734377292', 'doi': 'https://doi.org/10.1016/j.bbrc.2017.07.074', 'title': 'Salicylates promote mitochondrial biogenesis by regulating the expression of PGC-1α in murine 3T3-L1 pre-adipocytes', 'display_name': 'Salicylates promote mitochondrial biogenesis by regulating the expression of PGC-1α in murine 3T3-L1 pre-adipocytes', 'publication_year': 2017, 'publication_date': '2017-07-13', 'ids': {'openalex': 'https://openalex.org/W2734377292', 'doi': 'https://doi.org/10.1016/j.bbrc.2017.07.074', 'mag': '2734377292', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28712868'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.bbrc.2017.07.074', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S151589183', 'display_name': 'Biochemical and Biophysical Research Communications', 'issn_l': '0006-291X', 'issn': ['0006-291X', '1090-2104'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100678513', 'display_name': 'Yimin Yan', 'orcid': 'https://orcid.org/0000-0002-3351-4732'}, 'institutions': [{'id': 'https://openalex.org/I4210120234', 'display_name': 'Zhongnan Hospital of Wuhan University', 'ror': 'https://ror.org/01v5mqw79', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210120234']}, {'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yimin Yan', 'raw_affiliation_strings': ['Department of Endocrinology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, Hubei Province, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Endocrinology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, Hubei Province, China', 'institution_ids': ['https://openalex.org/I4210120234', 'https://openalex.org/I37461747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101827760', 'display_name': 'Xiaohong Yang', 'orcid': 'https://orcid.org/0000-0002-8707-8411'}, 'institutions': [{'id': 'https://openalex.org/I4210106296', 'display_name': 'The Central Hospital of Xiao gan', 'ror': 'https://ror.org/01has8079', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210106296']}, {'id': 'https://openalex.org/I43922553', 'display_name': 'Wuhan University of Science and Technology', 'ror': 'https://ror.org/00e4hrk88', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I43922553']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaohong Yang', 'raw_affiliation_strings': ['Department of Obstetrics and Gynecology, Xiaogan Central Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan 432000, Hubei Province, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Obstetrics and Gynecology, Xiaogan Central Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan 432000, Hubei Province, China', 'institution_ids': ['https://openalex.org/I4210106296', 'https://openalex.org/I43922553']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101476867', 'display_name': 'Tao Zhao', 'orcid': 'https://orcid.org/0000-0002-8619-594X'}, 'institutions': [{'id': 'https://openalex.org/I4210106296', 'display_name': 'The Central Hospital of Xiao gan', 'ror': 'https://ror.org/01has8079', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210106296']}, {'id': 'https://openalex.org/I43922553', 'display_name': 'Wuhan University of Science and Technology', 'ror': 'https://ror.org/00e4hrk88', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I43922553']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Tao Zhao', 'raw_affiliation_strings': ['Department of Endocrinology, Xiaogan Central Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan, 432000, Hubei Province, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Endocrinology, Xiaogan Central Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan, 432000, Hubei Province, China', 'institution_ids': ['https://openalex.org/I4210106296', 'https://openalex.org/I43922553']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084681055', 'display_name': 'Yi Zou', 'orcid': 'https://orcid.org/0000-0001-9288-7275'}, 'institutions': [{'id': 'https://openalex.org/I4210106296', 'display_name': 'The Central Hospital of Xiao gan', 'ror': 'https://ror.org/01has8079', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210106296']}, {'id': 'https://openalex.org/I43922553', 'display_name': 'Wuhan University of Science and Technology', 'ror': 'https://ror.org/00e4hrk88', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I43922553']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yi Zou', 'raw_affiliation_strings': ['Department of Endocrinology, Xiaogan Central Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan, 432000, Hubei Province, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Endocrinology, Xiaogan Central Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan, 432000, Hubei Province, China', 'institution_ids': ['https://openalex.org/I4210106296', 'https://openalex.org/I43922553']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100448573', 'display_name': 'Rui Li', 'orcid': 'https://orcid.org/0000-0002-9669-2245'}, 'institutions': [{'id': 'https://openalex.org/I4210106296', 'display_name': 'The Central Hospital of Xiao gan', 'ror': 'https://ror.org/01has8079', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210106296']}, {'id': 'https://openalex.org/I43922553', 'display_name': 'Wuhan University of Science and Technology', 'ror': 'https://ror.org/00e4hrk88', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I43922553']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Rui Li', 'raw_affiliation_strings': ['Department of Cardiovascular, Xiaogan Central Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan, 432000, Hubei Province, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiovascular, Xiaogan Central Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan, 432000, Hubei Province, China', 'institution_ids': ['https://openalex.org/I4210106296', 'https://openalex.org/I43922553']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5052492909', 'display_name': 'Yancheng Xu', 'orcid': 'https://orcid.org/0000-0002-3298-5110'}, 'institutions': [{'id': 'https://openalex.org/I4210120234', 'display_name': 'Zhongnan Hospital of Wuhan University', 'ror': 'https://ror.org/01v5mqw79', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210120234']}, {'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Yancheng Xu', 'raw_affiliation_strings': ['Department of Endocrinology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, Hubei Province, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Endocrinology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, Hubei Province, China', 'institution_ids': ['https://openalex.org/I4210120234', 'https://openalex.org/I37461747']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5052492909'], 'corresponding_institution_ids': ['https://openalex.org/I4210120234', 'https://openalex.org/I37461747'], 'apc_list': {'value': 2770, 'currency': 'USD', 'value_usd': 2770, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.064, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 12, 'citation_normalized_percentile': {'value': 0.792635, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': '491', 'issue': '2', 'first_page': '436', 'last_page': '441'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11457', 'display_name': 'Brown Adipose Tissue Function and Physiology', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11457', 'display_name': 'Brown Adipose Tissue Function and Physiology', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11339', 'display_name': 'Role of AMP-Activated Protein Kinase in Cellular Metabolism', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11051', 'display_name': 'Role of Sirtuins in Health and Aging', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/2717', 'display_name': 'Geriatrics and Gerontology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/tfam', 'display_name': 'TFAM', 'score': 0.98219454}, {'id': 'https://openalex.org/keywords/nrf1', 'display_name': 'NRF1', 'score': 0.87961257}, {'id': 'https://openalex.org/keywords/ppargc1a', 'display_name': 'PPARGC1A', 'score': 0.58321655}, {'id': 'https://openalex.org/keywords/organelle-biogenesis', 'display_name': 'Organelle biogenesis', 'score': 0.52309036}, {'id': 'https://openalex.org/keywords/insulin-signaling', 'display_name': 'Insulin Signaling', 'score': 0.510935}], 'concepts': [{'id': 'https://openalex.org/C169415338', 'wikidata': 'https://www.wikidata.org/wiki/Q18031951', 'display_name': 'TFAM', 'level': 4, 'score': 0.98219454}, {'id': 'https://openalex.org/C2777229759', 'wikidata': 'https://www.wikidata.org/wiki/Q6881848', 'display_name': 'Mitochondrial biogenesis', 'level': 3, 'score': 0.93439674}, {'id': 'https://openalex.org/C74438686', 'wikidata': 'https://www.wikidata.org/wiki/Q18030218', 'display_name': 'NRF1', 'level': 4, 'score': 0.87961257}, {'id': 'https://openalex.org/C28859421', 'wikidata': 'https://www.wikidata.org/wiki/Q39572', 'display_name': 'Mitochondrion', 'level': 2, 'score': 0.622017}, {'id': 'https://openalex.org/C12304452', 'wikidata': 'https://www.wikidata.org/wiki/Q21118081', 'display_name': 'PPARGC1A', 'level': 5, 'score': 0.58321655}, {'id': 'https://openalex.org/C2780124434', 'wikidata': 'https://www.wikidata.org/wiki/Q12357464', 'display_name': 'AMPK', 'level': 4, 'score': 0.53329897}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5250775}, {'id': 'https://openalex.org/C155432671', 'wikidata': 'https://www.wikidata.org/wiki/Q17073362', 'display_name': 'Organelle biogenesis', 'level': 4, 'score': 0.52309036}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.4643664}, {'id': 'https://openalex.org/C111133373', 'wikidata': 'https://www.wikidata.org/wiki/Q21132608', 'display_name': 'Citrate synthase', 'level': 3, 'score': 0.43508095}, {'id': 'https://openalex.org/C24586158', 'wikidata': 'https://www.wikidata.org/wiki/Q27075', 'display_name': 'Mitochondrial DNA', 'level': 3, 'score': 0.41759107}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.38892034}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.34978563}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3362323}, {'id': 'https://openalex.org/C77445288', 'wikidata': 'https://www.wikidata.org/wiki/Q637488', 'display_name': 'Coactivator', 'level': 4, 'score': 0.33584422}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.2490766}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.22708398}, {'id': 'https://openalex.org/C131934819', 'wikidata': 'https://www.wikidata.org/wiki/Q135390', 'display_name': 'Biogenesis', 'level': 3, 'score': 0.16886294}, {'id': 'https://openalex.org/C97029542', 'wikidata': 'https://www.wikidata.org/wiki/Q281417', 'display_name': 'Protein kinase A', 'level': 3, 'score': 0.096090525}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.086155295}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D017667', 'descriptor_name': 'Adipocytes', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D007004', 'descriptor_name': 'Hypoglycemic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D001678', 'descriptor_name': 'Organelle Biogenesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000071248', 'descriptor_name': 'Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D020156', 'descriptor_name': 'Salicylic Acid', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D041721', 'descriptor_name': '3T3-L1 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055372', 'descriptor_name': 'AMP-Activated Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055372', 'descriptor_name': 'AMP-Activated Protein Kinases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D055372', 'descriptor_name': 'AMP-Activated Protein Kinases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D055372', 'descriptor_name': 'AMP-Activated Protein Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017667', 'descriptor_name': 'Adipocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017667', 'descriptor_name': 'Adipocytes', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D017667', 'descriptor_name': 'Adipocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002950', 'descriptor_name': 'Citrate (si)-Synthase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002950', 'descriptor_name': 'Citrate (si)-Synthase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002950', 'descriptor_name': 'Citrate (si)-Synthase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004272', 'descriptor_name': 'DNA, Mitochondrial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004272', 'descriptor_name': 'DNA, Mitochondrial', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004272', 'descriptor_name': 'DNA, Mitochondrial', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000819', 'qualifier_name': 'agonists', 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D042967', 'descriptor_name': 'Electron Transport Complex I', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D042967', 'descriptor_name': 'Electron Transport Complex I', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D042967', 'descriptor_name': 'Electron Transport Complex I', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006609', 'descriptor_name': 'High Mobility Group Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006609', 'descriptor_name': 'High Mobility Group Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006609', 'descriptor_name': 'High Mobility Group Proteins', 'qualifier_ui': 'Q000819', 'qualifier_name': 'agonists', 'is_major_topic': False}, {'descriptor_ui': 'D006609', 'descriptor_name': 'High Mobility Group Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007004', 'descriptor_name': 'Hypoglycemic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051266', 'descriptor_name': 'Nuclear Respiratory Factor 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051266', 'descriptor_name': 'Nuclear Respiratory Factor 1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051266', 'descriptor_name': 'Nuclear Respiratory Factor 1', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051266', 'descriptor_name': 'Nuclear Respiratory Factor 1', 'qualifier_ui': 'Q000819', 'qualifier_name': 'agonists', 'is_major_topic': False}, {'descriptor_ui': 'D000071248', 'descriptor_name': 'Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071248', 'descriptor_name': 'Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000071248', 'descriptor_name': 'Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha', 'qualifier_ui': 'Q000819', 'qualifier_name': 'agonists', 'is_major_topic': False}, {'descriptor_ui': 'D000071248', 'descriptor_name': 'Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011720', 'descriptor_name': 'Pyrazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011720', 'descriptor_name': 'Pyrazoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011743', 'descriptor_name': 'Pyrimidines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011743', 'descriptor_name': 'Pyrimidines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D020156', 'descriptor_name': 'Salicylic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.bbrc.2017.07.074', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S151589183', 'display_name': 'Biochemical and Biophysical Research Communications', 'issn_l': '0006-291X', 'issn': ['0006-291X', '1090-2104'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28712868', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.7}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 27, 'referenced_works': ['https://openalex.org/W1976369993', 'https://openalex.org/W1979731957', 'https://openalex.org/W2019054179', 'https://openalex.org/W2019593983', 'https://openalex.org/W2027966172', 'https://openalex.org/W2042651226', 'https://openalex.org/W2049481764', 'https://openalex.org/W2051674591', 'https://openalex.org/W2052754106', 'https://openalex.org/W2060431825', 'https://openalex.org/W2061075485', 'https://openalex.org/W2063104169', 'https://openalex.org/W2071975518', 'https://openalex.org/W2077645437', 'https://openalex.org/W2085567056', 'https://openalex.org/W2098791907', 'https://openalex.org/W2100779832', 'https://openalex.org/W2106643427', 'https://openalex.org/W2107324877', 'https://openalex.org/W2125344123', 'https://openalex.org/W2130616416', 'https://openalex.org/W2133444149', 'https://openalex.org/W2136942127', 'https://openalex.org/W2140751228', 'https://openalex.org/W2151672809', 'https://openalex.org/W2152101492', 'https://openalex.org/W2165096496'], 'related_works': ['https://openalex.org/W4294339176', 'https://openalex.org/W3047271249', 'https://openalex.org/W2986664441', 'https://openalex.org/W2767660835', 'https://openalex.org/W2734377292', 'https://openalex.org/W2593702220', 'https://openalex.org/W2462999518', 'https://openalex.org/W2103340995', 'https://openalex.org/W1977110604', 'https://openalex.org/W1971082641'], 'abstract_inverted_index': {'Mitochondrial': [0], 'dysfunction': [1, 201], 'has': [2, 33, 48, 66, 194], 'been': [3, 18, 49, 67], 'associated': [4], 'with': [5, 99], 'insulin': [6], 'resistance': [7], 'and': [8, 13, 29, 89, 106, 115, 139, 169], 'diabetes.': [9, 40, 203], 'Decreased': [10], 'mitochondrial': [11, 14, 31, 64, 90, 116, 140, 187, 200], 'density': [12], 'copy': [15], 'numbers': [16], 'have': [17], 'found': [19], 'in': [20, 46, 50, 92, 163, 202], 'insulin-resistant': [21], 'individuals.': [22], 'Restoration': [23], 'of': [24, 27, 39, 61, 76, 104, 128, 134, 158, 166, 173, 184], 'the': [25, 42, 59, 74, 79, 102, 126, 146, 156, 164, 182], 'number': [26, 127], 'mitochondria': [28], 'normal': [30], 'function': [32, 65], 'become': [34], 'an': [35], 'important': [36], 'therapeutic': [37, 197], 'target': [38], 'Salicylate,': [41], 'main': [43], 'active': [44], 'ingredient': [45], 'aspirin,': [47], 'medicinal': [51], 'use': [52], 'since': [53], 'ancient': [54], 'times.': [55], 'Little': [56], 'information': [57], 'regarding': [58], 'effects': [60, 75, 183], 'salicylate': [62, 77, 100, 122, 153, 185, 193], 'on': [63, 78, 186], 'reported.': [68], 'In': [69], 'this': [70], 'study,': [71], 'we': [72], 'assessed': [73], 'peroxisome': [80], 'proliferator-activated': [81], 'receptor': [82], 'γ': [83], 'coactivator': [84], '1α': [85], '(PGC-1α)': [86], 'signaling': [87], 'pathway': [88], 'biogenesis': [91], 'pre-adipocytes.': [93], 'Our': [94], 'findings': [95], 'demonstrate': [96], 'that': [97, 192], 'treatment': [98, 123, 154], 'promoted': [101], 'expression': [103, 133, 175], 'PGC-1α': [105, 174, 177], 'its': [107], 'downstream': [108], 'targets': [109], 'nuclear': [110], 'respiratory': [111, 135], 'factor': [112, 118], '1': [113], '(NRF1)': [114], 'transcription': [117], 'A': [119], '(TFAM).': [120], 'Importantly,': [121, 171], 'significantly': [124], 'increased': [125], 'mDNA,': [129], 'citrate': [130], 'synthase': [131], 'activity,': [132], 'chain': [136], 'complex': [137], 'I,': [138], 'mass,': [141], 'which': [142, 160], 'were': [143], 'suppressed': [144], 'by': [145], 'specific': [147], 'AMPK': [148], 'inhibitor': [149], 'Compound': [150], 'C.': [151], 'Indeed,': [152], 'induced': [155], 'phosphorylation': [157], 'AMPK,': [159], 'was': [161], 'involved': [162], 'induction': [165], 'PGC-1α,': [167], 'NRF1,': [168], 'TFAM.': [170], 'inhibition': [172], 'using': [176], 'small': [178], 'RNA': [179], 'interference': [180], 'abolished': [181], 'biogenesis.': [188], 'These': [189], 'results': [190], 'suggest': [191], 'a': [195], 'potential': [196], 'capacity': [198], 'against': [199]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2734377292', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}], 'updated_date': '2024-09-17T19:18:29.172317', 'created_date': '2017-07-21'}