Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2727929522', 'doi': 'https://doi.org/10.1038/nature23002', 'title': 'Cryo-EM structures of tau filaments from Alzheimer’s disease', 'display_name': 'Cryo-EM structures of tau filaments from Alzheimer’s disease', 'publication_year': 2017, 'publication_date': '2017-07-01', 'ids': {'openalex': 'https://openalex.org/W2727929522', 'doi': 'https://doi.org/10.1038/nature23002', 'mag': '2727929522', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28678775', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5552202'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/nature23002', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S137773608', 'display_name': 'Nature', 'issn_l': '0028-0836', 'issn': ['0028-0836', '1476-4687'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc5552202?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5087436443', 'display_name': 'Anthony Fitzpatrick', 'orcid': 'https://orcid.org/0000-0002-3527-7961'}, 'institutions': [{'id': 'https://openalex.org/I170203145', 'display_name': 'MRC Laboratory of Molecular Biology', 'ror': 'https://ror.org/00tw3jy02', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I170203145', 'https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Anthony W. P. Fitzpatrick', 'raw_affiliation_strings': ['MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK'], 'affiliations': [{'raw_affiliation_string': 'MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK', 'institution_ids': ['https://openalex.org/I170203145']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091551842', 'display_name': 'Benjamin Falcon', 'orcid': 'https://orcid.org/0000-0002-8176-2618'}, 'institutions': [{'id': 'https://openalex.org/I170203145', 'display_name': 'MRC Laboratory of Molecular Biology', 'ror': 'https://ror.org/00tw3jy02', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I170203145', 'https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Benjamin Falcon', 'raw_affiliation_strings': ['MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK'], 'affiliations': [{'raw_affiliation_string': 'MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK', 'institution_ids': ['https://openalex.org/I170203145']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069681338', 'display_name': 'Shaoda He', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I170203145', 'display_name': 'MRC Laboratory of Molecular Biology', 'ror': 'https://ror.org/00tw3jy02', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I170203145', 'https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Shaoda He', 'raw_affiliation_strings': ['MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK'], 'affiliations': [{'raw_affiliation_string': 'MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK', 'institution_ids': ['https://openalex.org/I170203145']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025834882', 'display_name': 'Alexey G. Murzin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I170203145', 'display_name': 'MRC Laboratory of Molecular Biology', 'ror': 'https://ror.org/00tw3jy02', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I170203145', 'https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Alexey G. Murzin', 'raw_affiliation_strings': ['MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK'], 'affiliations': [{'raw_affiliation_string': 'MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK', 'institution_ids': ['https://openalex.org/I170203145']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058134267', 'display_name': 'Garib N. Murshudov', 'orcid': 'https://orcid.org/0000-0001-6483-3587'}, 'institutions': [{'id': 'https://openalex.org/I170203145', 'display_name': 'MRC Laboratory of Molecular Biology', 'ror': 'https://ror.org/00tw3jy02', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I170203145', 'https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Garib Murshudov', 'raw_affiliation_strings': ['MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK'], 'affiliations': [{'raw_affiliation_string': 'MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK', 'institution_ids': ['https://openalex.org/I170203145']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050959761', 'display_name': 'Holly J. Garringer', 'orcid': 'https://orcid.org/0000-0002-1899-7676'}, 'institutions': [{'id': 'https://openalex.org/I55769427', 'display_name': 'Indiana University – Purdue University Indianapolis', 'ror': 'https://ror.org/05gxnyn08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I55769427', 'https://openalex.org/I592451']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Holly J. Garringer', 'raw_affiliation_strings': ['Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, 46202, Indiana, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, 46202, Indiana, USA', 'institution_ids': ['https://openalex.org/I55769427']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030636499', 'display_name': 'R. Anthony Crowther', 'orcid': 'https://orcid.org/0000-0003-0568-1426'}, 'institutions': [{'id': 'https://openalex.org/I170203145', 'display_name': 'MRC Laboratory of Molecular Biology', 'ror': 'https://ror.org/00tw3jy02', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I170203145', 'https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'R. Anthony Crowther', 'raw_affiliation_strings': ['MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK'], 'affiliations': [{'raw_affiliation_string': 'MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK', 'institution_ids': ['https://openalex.org/I170203145']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047929315', 'display_name': 'Bernardino Ghetti', 'orcid': 'https://orcid.org/0000-0002-1842-8019'}, 'institutions': [{'id': 'https://openalex.org/I55769427', 'display_name': 'Indiana University – Purdue University Indianapolis', 'ror': 'https://ror.org/05gxnyn08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I55769427', 'https://openalex.org/I592451']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Bernardino Ghetti', 'raw_affiliation_strings': ['Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, 46202, Indiana, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, 46202, Indiana, USA', 'institution_ids': ['https://openalex.org/I55769427']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037379608', 'display_name': 'Michel Goedert', 'orcid': 'https://orcid.org/0000-0002-5214-7886'}, 'institutions': [{'id': 'https://openalex.org/I170203145', 'display_name': 'MRC Laboratory of Molecular Biology', 'ror': 'https://ror.org/00tw3jy02', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I170203145', 'https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Michel Goedert', 'raw_affiliation_strings': ['MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK'], 'affiliations': [{'raw_affiliation_string': 'MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK', 'institution_ids': ['https://openalex.org/I170203145']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5061952716', 'display_name': 'Sjors H. W. Scheres', 'orcid': 'https://orcid.org/0000-0002-0462-6540'}, 'institutions': [{'id': 'https://openalex.org/I170203145', 'display_name': 'MRC Laboratory of Molecular Biology', 'ror': 'https://ror.org/00tw3jy02', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I170203145', 'https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Sjors H. W. Scheres', 'raw_affiliation_strings': ['MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK'], 'affiliations': [{'raw_affiliation_string': 'MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK', 'institution_ids': ['https://openalex.org/I170203145']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 9750, 'currency': 'EUR', 'value_usd': 11690, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 132.149, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 1604, 'citation_normalized_percentile': {'value': 0.999953, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '547', 'issue': '7662', 'first_page': '185', 'last_page': '190'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10086', 'display_name': "Mechanisms of Alzheimer's Disease", 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10086', 'display_name': "Mechanisms of Alzheimer's Disease", 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11335', 'display_name': 'Prion Diseases: Causes and Molecular Basis', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Dynamics and Reactive Oxygen Species Regulation', 'score': 0.9821, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cryo-electron-microscopy', 'display_name': 'Cryo-electron microscopy', 'score': 0.65978694}, {'id': 'https://openalex.org/keywords/tau-protein', 'display_name': 'Tau protein', 'score': 0.6391993}, {'id': 'https://openalex.org/keywords/amyloid', 'display_name': 'Amyloid (mycology)', 'score': 0.5366359}, {'id': 'https://openalex.org/keywords/neurofibrillary-tangle', 'display_name': 'Neurofibrillary tangle', 'score': 0.5007143}, {'id': 'https://openalex.org/keywords/neurodegeneration', 'display_name': 'Neurodegeneration', 'score': 0.500509}, {'id': 'https://openalex.org/keywords/helix', 'display_name': 'Helix (gastropod)', 'score': 0.45472658}], 'concepts': [{'id': 'https://openalex.org/C68026918', 'wikidata': 'https://www.wikidata.org/wiki/Q1970256', 'display_name': 'Senile plaques', 'level': 4, 'score': 0.7293048}, {'id': 'https://openalex.org/C14228908', 'wikidata': 'https://www.wikidata.org/wiki/Q2920483', 'display_name': 'Protein filament', 'level': 2, 'score': 0.6628393}, {'id': 'https://openalex.org/C20702342', 'wikidata': 'https://www.wikidata.org/wiki/Q5190506', 'display_name': 'Cryo-electron microscopy', 'level': 2, 'score': 0.65978694}, {'id': 'https://openalex.org/C2778670691', 'wikidata': 'https://www.wikidata.org/wiki/Q419507', 'display_name': 'Tau protein', 'level': 4, 'score': 0.6391993}, {'id': 'https://openalex.org/C27523624', 'wikidata': 'https://www.wikidata.org/wiki/Q14860849', 'display_name': 'Fibril', 'level': 2, 'score': 0.59969026}, {'id': 'https://openalex.org/C2777633098', 'wikidata': 'https://www.wikidata.org/wiki/Q2736051', 'display_name': 'Amyloid (mycology)', 'level': 2, 'score': 0.5366359}, {'id': 'https://openalex.org/C502032728', 'wikidata': 'https://www.wikidata.org/wiki/Q11081', 'display_name': "Alzheimer's disease", 'level': 3, 'score': 0.5119754}, {'id': 'https://openalex.org/C2779721402', 'wikidata': 'https://www.wikidata.org/wiki/Q767442', 'display_name': 'Neurofibrillary tangle', 'level': 5, 'score': 0.5007143}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.49597844}, {'id': 'https://openalex.org/C93877712', 'wikidata': 'https://www.wikidata.org/wiki/Q132560', 'display_name': 'Electron microscope', 'level': 2, 'score': 0.4700716}, {'id': 'https://openalex.org/C2778530040', 'wikidata': 'https://www.wikidata.org/wiki/Q1937315', 'display_name': 'Helix (gastropod)', 'level': 3, 'score': 0.45472658}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4534488}, {'id': 'https://openalex.org/C2994168385', 'wikidata': 'https://www.wikidata.org/wiki/Q6740853', 'display_name': 'Amyloid fibril', 'level': 4, 'score': 0.43403956}, {'id': 'https://openalex.org/C87555872', 'wikidata': 'https://www.wikidata.org/wiki/Q3141316', 'display_name': 'Ultrastructure', 'level': 2, 'score': 0.41414848}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.35084003}, {'id': 'https://openalex.org/C3019447875', 'wikidata': 'https://www.wikidata.org/wiki/Q417667', 'display_name': 'Amyloid β', 'level': 3, 'score': 0.29272482}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2868188}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.25866908}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.2273261}, {'id': 'https://openalex.org/C105702510', 'wikidata': 'https://www.wikidata.org/wiki/Q514', 'display_name': 'Anatomy', 'level': 1, 'score': 0.21782166}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.17458501}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.13867274}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.1336821}, {'id': 'https://openalex.org/C120665830', 'wikidata': 'https://www.wikidata.org/wiki/Q14620', 'display_name': 'Optics', 'level': 1, 'score': 0.061709285}, {'id': 'https://openalex.org/C179104552', 'wikidata': 'https://www.wikidata.org/wiki/Q11165', 'display_name': 'Inorganic chemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C18903297', 'wikidata': 'https://www.wikidata.org/wiki/Q7150', 'display_name': 'Ecology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C2779965526', 'wikidata': 'https://www.wikidata.org/wiki/Q308841', 'display_name': 'Snail', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D016875', 'descriptor_name': 'tau Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000682', 'descriptor_name': 'Amyloid', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020285', 'descriptor_name': 'Cryoelectron Microscopy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066263', 'descriptor_name': 'Protein Aggregation, Pathological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/nature23002', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S137773608', 'display_name': 'Nature', 'issn_l': '0028-0836', 'issn': ['0028-0836', '1476-4687'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5552202', 'pdf_url': 'https://europepmc.org/articles/pmc5552202?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552202', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/1805/16284', 'pdf_url': 'https://scholarworks.iupui.edu/bitstreams/3da46bbd-ff43-4777-8523-200f6c688360/download', 'source': {'id': 'https://openalex.org/S4306400987', 'display_name': 'IUScholarWorks (Indiana University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I592451', 'host_organization_name': 'Indiana University', 'host_organization_lineage': ['https://openalex.org/I592451'], 'host_organization_lineage_names': ['Indiana University'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28678775', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5552202', 'pdf_url': 'https://europepmc.org/articles/pmc5552202?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 58, 'referenced_works': ['https://openalex.org/W126369564', 'https://openalex.org/W133512539', 'https://openalex.org/W1569576869', 'https://openalex.org/W1764460837', 'https://openalex.org/W1830376997', 'https://openalex.org/W1878810938', 'https://openalex.org/W1970297250', 'https://openalex.org/W1973855353', 'https://openalex.org/W1989390298', 'https://openalex.org/W2010084913', 'https://openalex.org/W2018908557', 'https://openalex.org/W2020631323', 'https://openalex.org/W2024041849', 'https://openalex.org/W2024424098', 'https://openalex.org/W2026823930', 'https://openalex.org/W2028605133', 'https://openalex.org/W2036008741', 'https://openalex.org/W2038840577', 'https://openalex.org/W2051896853', 'https://openalex.org/W2054770020', 'https://openalex.org/W2057682957', 'https://openalex.org/W2060004104', 'https://openalex.org/W2060775457', 'https://openalex.org/W2066604274', 'https://openalex.org/W2070494722', 'https://openalex.org/W2072613948', 'https://openalex.org/W2081855136', 'https://openalex.org/W2085899859', 'https://openalex.org/W2091305524', 'https://openalex.org/W2096321704', 'https://openalex.org/W2098021220', 'https://openalex.org/W2098356282', 'https://openalex.org/W2117537971', 'https://openalex.org/W2122191853', 'https://openalex.org/W2124019813', 'https://openalex.org/W2124026197', 'https://openalex.org/W2142366168', 'https://openalex.org/W2146656482', 'https://openalex.org/W2153323361', 'https://openalex.org/W2154714625', 'https://openalex.org/W2159377066', 'https://openalex.org/W2165186407', 'https://openalex.org/W2169033080', 'https://openalex.org/W2192012340', 'https://openalex.org/W2317462515', 'https://openalex.org/W2317760348', 'https://openalex.org/W2474799636', 'https://openalex.org/W2487730443', 'https://openalex.org/W2512527296', 'https://openalex.org/W2521817318', 'https://openalex.org/W2534587007', 'https://openalex.org/W2545421204', 'https://openalex.org/W2555151293', 'https://openalex.org/W2560158394', 'https://openalex.org/W2563169901', 'https://openalex.org/W2593511418', 'https://openalex.org/W2950967305', 'https://openalex.org/W2951384153'], 'related_works': ['https://openalex.org/W77456778', 'https://openalex.org/W2071031995', 'https://openalex.org/W2067264953', 'https://openalex.org/W2034378924', 'https://openalex.org/W1999085269', 'https://openalex.org/W1982614767', 'https://openalex.org/W1979692455', 'https://openalex.org/W1979545503', 'https://openalex.org/W1977990572', 'https://openalex.org/W112027537'], 'abstract_inverted_index': {'Alzheimer’s': [0, 87, 172], 'disease': [1, 15, 175], 'is': [2, 16, 176], 'the': [3, 19, 29, 81, 111, 148, 166, 179, 189, 256], 'most': [4], 'common': [5], 'neurodegenerative': [6, 49, 156, 212, 287], 'disease,': [7], 'and': [8, 25, 37, 70, 77, 109, 118, 146, 185, 199, 204, 236, 247, 253, 278], 'there': [9], 'are': [10, 57, 91, 129, 194, 230], 'no': [11], 'mechanism-based': [12], 'therapies.': [13], 'The': [14, 192], 'defined': [17, 177], 'by': [18, 178], 'presence': [20, 180], 'of': [21, 54, 74, 83, 93, 100, 140, 152, 155, 160, 168, 181, 196, 218, 227, 251, 258, 272, 286], 'abundant': [22, 182], 'neurofibrillary': [23, 169, 183], 'lesions': [24, 33, 170, 184, 193], 'neuritic': [26, 186], 'plaques': [27, 187], 'in': [28, 122, 171, 188], 'cerebral': [30, 190], 'cortex.': [31, 191], 'Neurofibrillary': [32], 'comprise': [34], 'paired': [35, 75, 197], 'helical': [36, 76, 117, 198], 'straight': [38, 78, 119, 200], 'tau': [39, 42, 55, 101, 114, 161, 201, 208, 220, 228], 'filaments,': [40], 'whereas': [41], 'filaments': [43, 56, 79, 120, 142, 162, 202, 209, 229, 274], 'with': [44, 86, 261], 'different': [45], 'morphologies': [46], 'characterize': [47, 210], 'other': [48, 211], 'diseases.': [50, 157, 288], 'No': [51, 224], 'high-resolution': [52, 225], 'structures': [53, 159, 226], 'available.': [58, 232], 'Here': [59], 'we': [60], 'present': [61, 238], 'cryo-electron': [62, 239], 'microscopy': [63, 240], '(cryo-EM)': [64, 241], 'maps': [65, 242], 'at': [66, 243], '3.4–3.5': [67], 'Å': [68, 245], 'resolution': [69, 246], 'corresponding': [71, 248], 'atomic': [72, 138, 249, 270], 'models': [73, 250], 'from': [80, 143, 255, 275], 'brain': [82, 257], 'an': [84, 259], 'individual': [85, 260], 'disease.': [88, 173, 263], 'Filament': [89], 'cores': [90], 'made': [92, 195], 'two': [94], 'identical': [95], 'protofilaments': [96], 'comprising': [97], 'residues': [98], '306–378': [99], 'protein,': [102], 'which': [103], 'adopt': [104], 'a': [105, 153, 284], 'combined': [106], 'cross-β/β-helix': [107], 'structure': [108], 'define': [110], 'seed': [112], 'for': [113, 150], 'aggregation.': [115], 'Paired': [116], 'differ': [121], 'their': [123], 'inter-protofilament': [124], 'packing,': [125], 'showing': [126], 'that': [127, 135, 215, 267], 'they': [128], 'ultrastructural': [130], 'polymorphs.': [131], 'These': [132], 'findings': [133], 'demonstrate': [134], 'cryo-EM': [136, 268], 'allows': [137], 'characterization': [139, 271], 'amyloid': [141, 273], 'patient-derived': [144, 276], 'material,': [145], 'pave': [147], 'way': [149], 'investigation': [151], 'range': [154, 285], 'High-resolution': [158], 'shed': [163], 'light': [164], 'on': [165], 'ultrastructure': [167], "Alzheimer's": [174, 262], '(PHFs': [203], 'SFs,': [205], 'respectively).': [206], 'Different': [207], 'diseases,': [213], 'suggesting': [214], 'molecular': [216], 'conformers': [217], 'aggregated': [219], 'underlie': [221], 'human': [222], 'tauopathies.': [223], 'currently': [231], 'Here,': [233], 'Sjors': [234], 'Scheres': [235], 'colleagues': [237], '3.5': [244], 'PHFs': [252], 'SFs': [254], 'Their': [264], 'results': [265], 'show': [266], 'enables': [269], 'material': [277], 'could': [279], 'be': [280], 'used': [281], 'to': [282], 'study': [283]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2727929522', 'counts_by_year': [{'year': 2024, 'cited_by_count': 138}, {'year': 2023, 'cited_by_count': 242}, {'year': 2022, 'cited_by_count': 225}, {'year': 2021, 'cited_by_count': 246}, {'year': 2020, 'cited_by_count': 283}, {'year': 2019, 'cited_by_count': 235}, {'year': 2018, 'cited_by_count': 199}, {'year': 2017, 'cited_by_count': 31}], 'updated_date': '2024-09-13T05:51:53.453875', 'created_date': '2017-07-14'}