Title: Proton Magnetic Resonance Spectroscopy: Virtual non invasiveexploration for the biochemical characterization of brain tumors.
Abstract: Proton Magnetic Resonance Spectroscopy (MRS) is a noninvasive technique
that could be describe as a virtual biopsy used to evaluate the
biochemical content of the brain, providing additional metabolic
information to anatomic changes that can be evident on Magnetic
Resonance Imaging (MRI) studies. The aim of this study is to
characterize the metabolic pattern of most common brain tumors based on
the spectroscopic markers that best differentiate between them using
the technique of Multivoxel MRS. 20 patients (5 of each type) with
diagnosis of Glioblastoma Multiforme, Glioma, Pilocytic Astrocytoma,
and Brain Breast Metastasis were studied. MRI and MRS were performed on
a 3-Tesla scanner (Signa Excite, General Electric®). Multivoxel
MRS was performed using the PRESS sequence (Point Resolved Spectroscopy
Sequence). Data were tabulated and expressed as Cho/Cr, NAA/Cr, Lac/Cr
and Lip/Cr ratios. They were statistically analyzed using Analysis of
Variance (ANOVA) and Student-Neuman- Keuls test for multiple
comparisons among means. The results obtained allow us to conclude that
the elevation of Cho/Cr together with the decrease in NAA/Cr suggests a
higher degree of aggressiveness or malignancy of the tumor while an
increase of Lac/Cr and/or Lip/Cr indicates an important degree of
necrosis and anaerobic metabolism of glucose.
Publication Year: 2012
Publication Date: 2012-11-16
Language: en
Type: article
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