Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2626166698', 'doi': 'https://doi.org/10.1038/eye.2017.111', 'title': 'Identification of time point to best define ‘sub-optimal response’ following intravitreal ranibizumab therapy for diabetic macular edema based on real-life data', 'display_name': 'Identification of time point to best define ‘sub-optimal response’ following intravitreal ranibizumab therapy for diabetic macular edema based on real-life data', 'publication_year': 2017, 'publication_date': '2017-06-16', 'ids': {'openalex': 'https://openalex.org/W2626166698', 'doi': 'https://doi.org/10.1038/eye.2017.111', 'mag': '2626166698', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28622321', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5684452'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/eye.2017.111', 'pdf_url': 'https://www.nature.com/articles/eye2017111.pdf', 'source': {'id': 'https://openalex.org/S167047176', 'display_name': 'Eye', 'issn_l': '0950-222X', 'issn': ['0950-222X', '1476-5454'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.nature.com/articles/eye2017111.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5020123731', 'display_name': 'Irini Chatziralli', 'orcid': 'https://orcid.org/0000-0001-8523-1024'}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}, {'id': 'https://openalex.org/I34931013', 'display_name': 'National Institute for Health Research', 'ror': 'https://ror.org/0187kwz08', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I34931013']}, {'id': 'https://openalex.org/I4210150574', 'display_name': 'Moorfields Eye Hospital', 'ror': 'https://ror.org/03tb37539', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325675289', 'https://openalex.org/I4210150574']}, {'id': 'https://openalex.org/I125671874', 'display_name': 'National Health Service', 'ror': 'https://ror.org/02wnqcb97', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I125671874', 'https://openalex.org/I1311074006']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'I Chatziralli', 'raw_affiliation_strings': ['National Institute for Health Research, Biomedical Research Centre at Moorfields Eye Hospital National Health Service Foundation Trust and UCL Institute of Ophthalmology, London, UK'], 'affiliations': [{'raw_affiliation_string': 'National Institute for Health Research, Biomedical Research Centre at Moorfields Eye Hospital National Health Service Foundation Trust and UCL Institute of Ophthalmology, London, UK', 'institution_ids': ['https://openalex.org/I45129253', 'https://openalex.org/I34931013', 'https://openalex.org/I4210150574', 'https://openalex.org/I125671874']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073187728', 'display_name': 'Martina Santarelli', 'orcid': 'https://orcid.org/0000-0002-2015-1821'}, 'institutions': [{'id': 'https://openalex.org/I125671874', 'display_name': 'National Health Service', 'ror': 'https://ror.org/02wnqcb97', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I125671874', 'https://openalex.org/I1311074006']}, {'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}, {'id': 'https://openalex.org/I34931013', 'display_name': 'National Institute for Health Research', 'ror': 'https://ror.org/0187kwz08', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I34931013']}, {'id': 'https://openalex.org/I4210150574', 'display_name': 'Moorfields Eye Hospital', 'ror': 'https://ror.org/03tb37539', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325675289', 'https://openalex.org/I4210150574']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'M Santarelli', 'raw_affiliation_strings': ['National Institute for Health Research, Biomedical Research Centre at Moorfields Eye Hospital National Health Service Foundation Trust and UCL Institute of Ophthalmology, London, UK'], 'affiliations': [{'raw_affiliation_string': 'National Institute for Health Research, Biomedical Research Centre at Moorfields Eye Hospital National Health Service Foundation Trust and UCL Institute of Ophthalmology, London, UK', 'institution_ids': ['https://openalex.org/I125671874', 'https://openalex.org/I45129253', 'https://openalex.org/I34931013', 'https://openalex.org/I4210150574']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074389890', 'display_name': 'Namritha Patrao', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I125671874', 'display_name': 'National Health Service', 'ror': 'https://ror.org/02wnqcb97', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I125671874', 'https://openalex.org/I1311074006']}, {'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}, {'id': 'https://openalex.org/I34931013', 'display_name': 'National Institute for Health Research', 'ror': 'https://ror.org/0187kwz08', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I34931013']}, {'id': 'https://openalex.org/I4210150574', 'display_name': 'Moorfields Eye Hospital', 'ror': 'https://ror.org/03tb37539', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325675289', 'https://openalex.org/I4210150574']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'N Patrao', 'raw_affiliation_strings': ['National Institute for Health Research, Biomedical Research Centre at Moorfields Eye Hospital National Health Service Foundation Trust and UCL Institute of Ophthalmology, London, UK'], 'affiliations': [{'raw_affiliation_string': 'National Institute for Health Research, Biomedical Research Centre at Moorfields Eye Hospital National Health Service Foundation Trust and UCL Institute of Ophthalmology, London, UK', 'institution_ids': ['https://openalex.org/I125671874', 'https://openalex.org/I45129253', 'https://openalex.org/I34931013', 'https://openalex.org/I4210150574']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081237680', 'display_name': 'Luke Nicholson', 'orcid': 'https://orcid.org/0000-0001-6685-4402'}, 'institutions': [{'id': 'https://openalex.org/I125671874', 'display_name': 'National Health Service', 'ror': 'https://ror.org/02wnqcb97', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I125671874', 'https://openalex.org/I1311074006']}, {'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}, {'id': 'https://openalex.org/I34931013', 'display_name': 'National Institute for Health Research', 'ror': 'https://ror.org/0187kwz08', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I34931013']}, {'id': 'https://openalex.org/I4210150574', 'display_name': 'Moorfields Eye Hospital', 'ror': 'https://ror.org/03tb37539', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325675289', 'https://openalex.org/I4210150574']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'L Nicholson', 'raw_affiliation_strings': ['National Institute for Health Research, Biomedical Research Centre at Moorfields Eye Hospital National Health Service Foundation Trust and UCL Institute of Ophthalmology, London, UK'], 'affiliations': [{'raw_affiliation_string': 'National Institute for Health Research, Biomedical Research Centre at Moorfields Eye Hospital National Health Service Foundation Trust and UCL Institute of Ophthalmology, London, UK', 'institution_ids': ['https://openalex.org/I125671874', 'https://openalex.org/I45129253', 'https://openalex.org/I34931013', 'https://openalex.org/I4210150574']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082470092', 'display_name': 'Marta Zola', 'orcid': 'https://orcid.org/0000-0003-1432-4201'}, 'institutions': [{'id': 'https://openalex.org/I125671874', 'display_name': 'National Health Service', 'ror': 'https://ror.org/02wnqcb97', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I125671874', 'https://openalex.org/I1311074006']}, {'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}, {'id': 'https://openalex.org/I34931013', 'display_name': 'National Institute for Health Research', 'ror': 'https://ror.org/0187kwz08', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I34931013']}, {'id': 'https://openalex.org/I4210150574', 'display_name': 'Moorfields Eye Hospital', 'ror': 'https://ror.org/03tb37539', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325675289', 'https://openalex.org/I4210150574']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'M Zola', 'raw_affiliation_strings': ['National Institute for Health Research, Biomedical Research Centre at Moorfields Eye Hospital National Health Service Foundation Trust and UCL Institute of Ophthalmology, London, UK'], 'affiliations': [{'raw_affiliation_string': 'National Institute for Health Research, Biomedical Research Centre at Moorfields Eye Hospital National Health Service Foundation Trust and UCL Institute of Ophthalmology, London, UK', 'institution_ids': ['https://openalex.org/I125671874', 'https://openalex.org/I45129253', 'https://openalex.org/I34931013', 'https://openalex.org/I4210150574']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003259452', 'display_name': 'Pearse A. Keane', 'orcid': 'https://orcid.org/0000-0002-9239-745X'}, 'institutions': [{'id': 'https://openalex.org/I125671874', 'display_name': 'National Health Service', 'ror': 'https://ror.org/02wnqcb97', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I125671874', 'https://openalex.org/I1311074006']}, {'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}, {'id': 'https://openalex.org/I34931013', 'display_name': 'National Institute for Health Research', 'ror': 'https://ror.org/0187kwz08', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I34931013']}, {'id': 'https://openalex.org/I4210150574', 'display_name': 'Moorfields Eye Hospital', 'ror': 'https://ror.org/03tb37539', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325675289', 'https://openalex.org/I4210150574']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'R Rajendram', 'raw_affiliation_strings': ['National Institute for Health Research, Biomedical Research Centre at Moorfields Eye Hospital National Health Service Foundation Trust and UCL Institute of Ophthalmology, London, UK'], 'affiliations': [{'raw_affiliation_string': 'National Institute for Health Research, Biomedical Research Centre at Moorfields Eye Hospital National Health Service Foundation Trust and UCL Institute of Ophthalmology, London, UK', 'institution_ids': ['https://openalex.org/I125671874', 'https://openalex.org/I45129253', 'https://openalex.org/I34931013', 'https://openalex.org/I4210150574']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055076524', 'display_name': 'Philip Hykin', 'orcid': 'https://orcid.org/0000-0003-0459-0055'}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}, {'id': 'https://openalex.org/I4210150574', 'display_name': 'Moorfields Eye Hospital', 'ror': 'https://ror.org/03tb37539', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325675289', 'https://openalex.org/I4210150574']}, {'id': 'https://openalex.org/I125671874', 'display_name': 'National Health Service', 'ror': 'https://ror.org/02wnqcb97', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I125671874', 'https://openalex.org/I1311074006']}, {'id': 'https://openalex.org/I34931013', 'display_name': 'National Institute for Health Research', 'ror': 'https://ror.org/0187kwz08', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I34931013']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'P Hykin', 'raw_affiliation_strings': ['National Institute for Health Research, Biomedical Research Centre at Moorfields Eye Hospital National Health Service Foundation Trust and UCL Institute of Ophthalmology, London, UK'], 'affiliations': [{'raw_affiliation_string': 'National Institute for Health Research, Biomedical Research Centre at Moorfields Eye Hospital National Health Service Foundation Trust and UCL Institute of Ophthalmology, London, UK', 'institution_ids': ['https://openalex.org/I45129253', 'https://openalex.org/I4210150574', 'https://openalex.org/I125671874', 'https://openalex.org/I34931013']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5066434934', 'display_name': 'Sobha Sivaprasad', 'orcid': 'https://orcid.org/0000-0001-8952-0659'}, 'institutions': [{'id': 'https://openalex.org/I125671874', 'display_name': 'National Health Service', 'ror': 'https://ror.org/02wnqcb97', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I125671874', 'https://openalex.org/I1311074006']}, {'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}, {'id': 'https://openalex.org/I34931013', 'display_name': 'National Institute for Health Research', 'ror': 'https://ror.org/0187kwz08', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I34931013']}, {'id': 'https://openalex.org/I4210150574', 'display_name': 'Moorfields Eye Hospital', 'ror': 'https://ror.org/03tb37539', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325675289', 'https://openalex.org/I4210150574']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'S Sivaprasad', 'raw_affiliation_strings': ['National Institute for Health Research, Biomedical Research Centre at Moorfields Eye Hospital National Health Service Foundation Trust and UCL Institute of Ophthalmology, London, UK'], 'affiliations': [{'raw_affiliation_string': 'National Institute for Health Research, Biomedical Research Centre at Moorfields Eye Hospital National Health Service Foundation Trust and UCL Institute of Ophthalmology, London, UK', 'institution_ids': ['https://openalex.org/I125671874', 'https://openalex.org/I45129253', 'https://openalex.org/I34931013', 'https://openalex.org/I4210150574']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3890, 'currency': 'EUR', 'value_usd': 4990, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 23, 'citation_normalized_percentile': None, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '31', 'issue': '11', 'first_page': '1594', 'last_page': '1599'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10170', 'display_name': 'Age-Related Macular Degeneration Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2731', 'display_name': 'Ophthalmology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10170', 'display_name': 'Age-Related Macular Degeneration Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2731', 'display_name': 'Ophthalmology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11438', 'display_name': 'Detection and Management of Retinal Diseases', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10250', 'display_name': 'Global Prevalence and Treatment of Glaucoma', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2731', 'display_name': 'Ophthalmology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/diabetic-macular-edema', 'display_name': 'Diabetic macular edema', 'score': 0.6613138}, {'id': 'https://openalex.org/keywords/diabetic-retinopathy', 'display_name': 'Diabetic Retinopathy', 'score': 0.513655}], 'concepts': [{'id': 'https://openalex.org/C2781100027', 'wikidata': 'https://www.wikidata.org/wiki/Q414270', 'display_name': 'Ranibizumab', 'level': 4, 'score': 0.97712255}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.9144033}, {'id': 'https://openalex.org/C2778257484', 'wikidata': 'https://www.wikidata.org/wiki/Q555066', 'display_name': 'Visual acuity', 'level': 2, 'score': 0.85096514}, {'id': 'https://openalex.org/C2985127711', 'wikidata': 'https://www.wikidata.org/wiki/Q631361', 'display_name': 'Diabetic macular edema', 'level': 4, 'score': 0.6613138}, {'id': 'https://openalex.org/C118487528', 'wikidata': 'https://www.wikidata.org/wiki/Q161437', 'display_name': 'Ophthalmology', 'level': 1, 'score': 0.6537744}, {'id': 'https://openalex.org/C167135981', 'wikidata': 'https://www.wikidata.org/wiki/Q2146302', 'display_name': 'Retrospective cohort study', 'level': 2, 'score': 0.4665515}, {'id': 'https://openalex.org/C2779829184', 'wikidata': 'https://www.wikidata.org/wiki/Q631361', 'display_name': 'Diabetic retinopathy', 'level': 3, 'score': 0.41742665}, {'id': 'https://openalex.org/C2780347916', 'wikidata': 'https://www.wikidata.org/wiki/Q1813737', 'display_name': 'Macular edema', 'level': 3, 'score': 0.41309306}, {'id': 'https://openalex.org/C2778818243', 'wikidata': 'https://www.wikidata.org/wiki/Q899552', 'display_name': 'Optical coherence tomography', 'level': 2, 'score': 0.41302255}, {'id': 'https://openalex.org/C119767625', 'wikidata': 'https://www.wikidata.org/wiki/Q618211', 'display_name': 'Optometry', 'level': 1, 'score': 0.33610272}, {'id': 'https://openalex.org/C141071460', 'wikidata': 'https://www.wikidata.org/wiki/Q40821', 'display_name': 'Surgery', 'level': 1, 'score': 0.3200901}, {'id': 'https://openalex.org/C555293320', 'wikidata': 'https://www.wikidata.org/wiki/Q12206', 'display_name': 'Diabetes mellitus', 'level': 2, 'score': 0.2624693}, {'id': 'https://openalex.org/C2777802072', 'wikidata': 'https://www.wikidata.org/wiki/Q413299', 'display_name': 'Bevacizumab', 'level': 3, 'score': 0.2132701}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.058748662}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D003930', 'descriptor_name': 'Diabetic Retinopathy', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D008269', 'descriptor_name': 'Macular Edema', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000069579', 'descriptor_name': 'Ranibizumab', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D014792', 'descriptor_name': 'Visual Acuity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D020533', 'descriptor_name': 'Angiogenesis Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020533', 'descriptor_name': 'Angiogenesis Inhibitors', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D003930', 'descriptor_name': 'Diabetic Retinopathy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003930', 'descriptor_name': 'Diabetic Retinopathy', 'qualifier_ui': 'Q000150', 'qualifier_name': 'complications', 'is_major_topic': False}, {'descriptor_ui': 'D003930', 'descriptor_name': 'Diabetic Retinopathy', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005500', 'descriptor_name': 'Follow-Up Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058449', 'descriptor_name': 'Intravitreal Injections', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008269', 'descriptor_name': 'Macular Edema', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D008269', 'descriptor_name': 'Macular Edema', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D008269', 'descriptor_name': 'Macular Edema', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000069579', 'descriptor_name': 'Ranibizumab', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012189', 'descriptor_name': 'Retrospective Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D041623', 'descriptor_name': 'Tomography, Optical Coherence', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D041623', 'descriptor_name': 'Tomography, Optical Coherence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042461', 'descriptor_name': 'Vascular Endothelial Growth Factor A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042461', 'descriptor_name': 'Vascular Endothelial Growth Factor A', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/eye.2017.111', 'pdf_url': 'https://www.nature.com/articles/eye2017111.pdf', 'source': {'id': 'https://openalex.org/S167047176', 'display_name': 'Eye', 'issn_l': '0950-222X', 'issn': ['0950-222X', '1476-5454'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684452', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28622321', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/eye.2017.111', 'pdf_url': 'https://www.nature.com/articles/eye2017111.pdf', 'source': {'id': 'https://openalex.org/S167047176', 'display_name': 'Eye', 'issn_l': '0950-222X', 'issn': ['0950-222X', '1476-5454'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.56, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 28, 'referenced_works': ['https://openalex.org/W1496977463', 'https://openalex.org/W1574902248', 'https://openalex.org/W1782108791', 'https://openalex.org/W1786299986', 'https://openalex.org/W1980342089', 'https://openalex.org/W1981173869', 'https://openalex.org/W2049036672', 'https://openalex.org/W2074395684', 'https://openalex.org/W2091729420', 'https://openalex.org/W2095260304', 'https://openalex.org/W2102463203', 'https://openalex.org/W2123123877', 'https://openalex.org/W2143429362', 'https://openalex.org/W2161279821', 'https://openalex.org/W2161588304', 'https://openalex.org/W2176004800', 'https://openalex.org/W2216901845', 'https://openalex.org/W2225262989', 'https://openalex.org/W2226585534', 'https://openalex.org/W2228089124', 'https://openalex.org/W2289200040', 'https://openalex.org/W2418354957', 'https://openalex.org/W2473184791', 'https://openalex.org/W2520557556', 'https://openalex.org/W2548174628', 'https://openalex.org/W2567410172', 'https://openalex.org/W2588053974', 'https://openalex.org/W922383587'], 'related_works': ['https://openalex.org/W779330272', 'https://openalex.org/W4301459889', 'https://openalex.org/W4233774607', 'https://openalex.org/W4224713499', 'https://openalex.org/W3173434637', 'https://openalex.org/W3010970561', 'https://openalex.org/W2916156160', 'https://openalex.org/W2905476920', 'https://openalex.org/W2739332146', 'https://openalex.org/W2549614271'], 'abstract_inverted_index': {'To': [0], 'determine': [1], 'the': [2, 24, 59, 102, 113, 117], 'average': [3], 'time-point': [4], 'at': [5, 88, 139, 149, 175], 'which': [6], 'it': [7], 'is': [8, 172], 'best': [9, 173], 'to': [10, 156, 182], 'define': [11], "'sub-optimal": [12, 167], "response'": [13, 168], 'after': [14, 112, 169], 'ranibizumab': [15, 51, 161, 170], 'treatment': [16, 38], 'for': [17], 'diabetic': [18], 'macular': [19], 'edema': [20], '(DME)': [21], 'based': [22, 55], 'on': [23, 56, 62, 79], 'data': [25], 'obtained': [26], 'from': [27], 'real-life': [28], 'clinical': [29], 'practice.': [30], 'In': [31], 'this': [32, 135], 'retrospective': [33], 'observational': [34], 'study,': [35], '322': [36], 'consecutive': [37], 'naïve': [39], 'eyes': [40], 'with': [41, 45, 126, 145, 160, 184], 'DME': [42], 'were': [43, 86, 154], 'treated': [44], 'three': [46], 'loading': [47, 114], 'doses': [48], 'of': [49, 58, 122, 124], 'intravitreal': [50], 'followed': [52], 'by': [53], 're-treatment': [54], 'decision': [57], 'treating': [60], 'physician': [61], 'a': [63, 166], 'case-by-case': [64], 'basis.': [65], 'The': [66], 'demographic': [67], 'data,': [68], 'clinic-based': [69], 'visual': [70, 105, 129, 147], 'acuity': [71, 106, 130, 148], 'measurements': [72], 'and': [73, 96, 107], 'central': [74], 'subfield': [75], 'thickness': [76], '(CST)': [77], 'assessed': [78], 'spectral': [80], 'domain': [81], 'optical': [82], 'coherence': [83], 'tomography': [84], '(OCT)': [85], 'evaluated': [87], 'baseline': [89, 150], '(month': [90], '0),': [91], '1,': [92], '2,': [93], '3,': [94], '6,': [95], '12': [97, 140, 177], 'months.': [98, 141], 'On': [99, 163], 'an': [100, 164], 'average,': [101, 165], 'improvement': [103, 127], 'in': [104, 120, 128, 134], 'CST': [108, 133], 'was': [109, 137], 'first': [110], 'seen': [111], 'dose.': [115], 'However,': [116], 'maximal': [118], 'response': [119], 'terms': [121], 'proportion': [123], 'patients': [125, 179], 'and/': [131], 'or': [132], 'cohort': [136], 'observed': [138], 'Patients': [142], 'who': [143], 'presented': [144], 'low': [146], '(<37': [151], 'ETDRS': [152], 'letters)': [153], 'unlikely': [155], 'attain': [157], 'driving': [158], 'vision': [159], 'therapy.': [162], 'therapy': [171], 'defined': [174], 'month': [176], 'as': [178], 'may': [180], 'continue': [181], 'improve': [183], 'treatment.': [185]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2626166698', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 9}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 5}], 'updated_date': '2024-09-17T17:23:13.175675', 'created_date': '2017-06-23'}