Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2625961086', 'doi': 'https://doi.org/10.1038/nrmicro.2017.59', 'title': 'Engineering of obligate intracellular bacteria: progress, challenges and paradigms', 'display_name': 'Engineering of obligate intracellular bacteria: progress, challenges and paradigms', 'publication_year': 2017, 'publication_date': '2017-06-19', 'ids': {'openalex': 'https://openalex.org/W2625961086', 'doi': 'https://doi.org/10.1038/nrmicro.2017.59', 'mag': '2625961086', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28626230', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5557331'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/nrmicro.2017.59', 'pdf_url': 'https://www.nature.com/articles/nrmicro.2017.59.pdf', 'source': {'id': 'https://openalex.org/S56802129', 'display_name': 'Nature Reviews Microbiology', 'issn_l': '1740-1526', 'issn': ['1740-1526', '1740-1534'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.nature.com/articles/nrmicro.2017.59.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5043545247', 'display_name': 'Erin E. McClure', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I126744593', 'display_name': 'University of Maryland, Baltimore', 'ror': 'https://ror.org/04rq5mt64', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126744593']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Erin E. McClure', 'raw_affiliation_strings': ['Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, 21201, Maryland, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, 21201, Maryland, USA', 'institution_ids': ['https://openalex.org/I126744593']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057076713', 'display_name': 'Adela S. Oliva Chávez', 'orcid': 'https://orcid.org/0000-0003-2397-0846'}, 'institutions': [{'id': 'https://openalex.org/I126744593', 'display_name': 'University of Maryland, Baltimore', 'ror': 'https://ror.org/04rq5mt64', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126744593']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Adela S. Oliva Chávez', 'raw_affiliation_strings': ['Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, 21201, Maryland, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, 21201, Maryland, USA', 'institution_ids': ['https://openalex.org/I126744593']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031456659', 'display_name': 'Dana K. Shaw', 'orcid': 'https://orcid.org/0000-0002-5212-2494'}, 'institutions': [{'id': 'https://openalex.org/I126744593', 'display_name': 'University of Maryland, Baltimore', 'ror': 'https://ror.org/04rq5mt64', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126744593']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Dana K. Shaw', 'raw_affiliation_strings': ['Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, 21201, Maryland, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, 21201, Maryland, USA', 'institution_ids': ['https://openalex.org/I126744593']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071638135', 'display_name': 'Jason A. Carlyon', 'orcid': 'https://orcid.org/0000-0003-2778-5066'}, 'institutions': [{'id': 'https://openalex.org/I184840846', 'display_name': 'Virginia Commonwealth University', 'ror': 'https://ror.org/02nkdxk79', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I184840846']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jason A. Carlyon', 'raw_affiliation_strings': ['Department of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, Richmond, 23298, Virginia, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, Richmond, 23298, Virginia, USA', 'institution_ids': ['https://openalex.org/I184840846']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003258232', 'display_name': 'Roman R. Ganta', 'orcid': 'https://orcid.org/0000-0001-9794-6158'}, 'institutions': [{'id': 'https://openalex.org/I189590672', 'display_name': 'Kansas State University', 'ror': 'https://ror.org/05p1j8758', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I189590672']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Roman R. Ganta', 'raw_affiliation_strings': ['Department of Diagnostic Medicine/Pathobiology, Center of Excellence for Vector-Borne Diseases, College of Veterinary Medicine, Kansas State University, Manhattan, 66506, Kansas, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Diagnostic Medicine/Pathobiology, Center of Excellence for Vector-Borne Diseases, College of Veterinary Medicine, Kansas State University, Manhattan, 66506, Kansas, USA', 'institution_ids': ['https://openalex.org/I189590672']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008781850', 'display_name': 'Susan M. Noh', 'orcid': 'https://orcid.org/0000-0002-8160-9074'}, 'institutions': [{'id': 'https://openalex.org/I1336096307', 'display_name': 'United States Department of Agriculture', 'ror': 'https://ror.org/01na82s61', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1336096307']}, {'id': 'https://openalex.org/I72951846', 'display_name': 'Washington State University', 'ror': 'https://ror.org/05dk0ce17', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I72951846']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Susan M. Noh', 'raw_affiliation_strings': ['U.S. Department of Agriculture and the Paul G. Allen School for Global Animal Health, Animal Disease Research Unit, Agricultural Research Service, Washington State University, Pullman, 99164, Washington, USA'], 'affiliations': [{'raw_affiliation_string': 'U.S. Department of Agriculture and the Paul G. Allen School for Global Animal Health, Animal Disease Research Unit, Agricultural Research Service, Washington State University, Pullman, 99164, Washington, USA', 'institution_ids': ['https://openalex.org/I1336096307', 'https://openalex.org/I72951846']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103583460', 'display_name': 'David O. Wood', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I83809506', 'display_name': 'University of South Alabama', 'ror': 'https://ror.org/01s7b5y08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I83809506']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David O. Wood', 'raw_affiliation_strings': ['Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, 36688, Alabama, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, 36688, Alabama, USA', 'institution_ids': ['https://openalex.org/I83809506']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084152783', 'display_name': 'Patrik M. Bavoil', 'orcid': 'https://orcid.org/0000-0002-7340-5741'}, 'institutions': [{'id': 'https://openalex.org/I126744593', 'display_name': 'University of Maryland, Baltimore', 'ror': 'https://ror.org/04rq5mt64', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126744593']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Patrik M. Bavoil', 'raw_affiliation_strings': ['Department of Microbial Pathogenesis, University of Maryland School of Dentistry, Baltimore, 21201, Maryland, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbial Pathogenesis, University of Maryland School of Dentistry, Baltimore, 21201, Maryland, USA', 'institution_ids': ['https://openalex.org/I126744593']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070930919', 'display_name': 'Kelly A. Brayton', 'orcid': 'https://orcid.org/0000-0001-7077-5424'}, 'institutions': [{'id': 'https://openalex.org/I72951846', 'display_name': 'Washington State University', 'ror': 'https://ror.org/05dk0ce17', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I72951846']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kelly A. Brayton', 'raw_affiliation_strings': ['Department of Veterinary Microbiology and Pathology and the Paul G. Allen School for Global Animal Health, Washington State University, Pullman, 99164, Washington, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Veterinary Microbiology and Pathology and the Paul G. Allen School for Global Animal Health, Washington State University, Pullman, 99164, Washington, USA', 'institution_ids': ['https://openalex.org/I72951846']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100680167', 'display_name': 'Juan J. Martinez', 'orcid': 'https://orcid.org/0000-0003-4746-2117'}, 'institutions': [{'id': 'https://openalex.org/I121820613', 'display_name': 'Louisiana State University', 'ror': 'https://ror.org/05ect4e57', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I121820613']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Juan J. Martinez', 'raw_affiliation_strings': ['Department of Pathobiological Sciences, Vector Borne Disease Laboratories, Louisiana State University School of Veterinary Medicine, Baton Rouge, 70803, Louisiana, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathobiological Sciences, Vector Borne Disease Laboratories, Louisiana State University School of Veterinary Medicine, Baton Rouge, 70803, Louisiana, USA', 'institution_ids': ['https://openalex.org/I121820613']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083648728', 'display_name': 'Jere W. McBride', 'orcid': 'https://orcid.org/0000-0003-3335-1539'}, 'institutions': [{'id': 'https://openalex.org/I55302922', 'display_name': 'The University of Texas Medical Branch at Galveston', 'ror': 'https://ror.org/016tfm930', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I55302922']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jere W. McBride', 'raw_affiliation_strings': ['Department of Pathology, University of Texas Medical Branch, Galveston, 77555, Texas, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, University of Texas Medical Branch, Galveston, 77555, Texas, USA', 'institution_ids': ['https://openalex.org/I55302922']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021498852', 'display_name': 'Raphael H. Valdivia', 'orcid': 'https://orcid.org/0000-0003-0961-073X'}, 'institutions': [{'id': 'https://openalex.org/I170897317', 'display_name': 'Duke University', 'ror': 'https://ror.org/00py81415', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170897317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Raphael H. Valdivia', 'raw_affiliation_strings': ['Department for Molecular Genetics and Microbiology, Duke University, Durham, 27710, North Carolina, USA'], 'affiliations': [{'raw_affiliation_string': 'Department for Molecular Genetics and Microbiology, Duke University, Durham, 27710, North Carolina, USA', 'institution_ids': ['https://openalex.org/I170897317']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089410308', 'display_name': 'Ulrike G. Munderloh', 'orcid': 'https://orcid.org/0000-0001-7935-2874'}, 'institutions': [{'id': 'https://openalex.org/I130238516', 'display_name': 'University of Minnesota', 'ror': 'https://ror.org/017zqws13', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130238516']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ulrike G. Munderloh', 'raw_affiliation_strings': ['Department of Entomology, University of Minnesota, St. Paul, 55108, Minnesota, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Entomology, University of Minnesota, St. Paul, 55108, Minnesota, USA', 'institution_ids': ['https://openalex.org/I130238516']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5011934705', 'display_name': 'Joao H. F. Pedra', 'orcid': 'https://orcid.org/0000-0001-8740-2667'}, 'institutions': [{'id': 'https://openalex.org/I126744593', 'display_name': 'University of Maryland, Baltimore', 'ror': 'https://ror.org/04rq5mt64', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126744593']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Joao H. F. Pedra', 'raw_affiliation_strings': ['Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, 21201, Maryland, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, 21201, Maryland, USA', 'institution_ids': ['https://openalex.org/I126744593']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 10, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.055, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 134, 'citation_normalized_percentile': {'value': 0.99322, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '15', 'issue': '9', 'first_page': '544', 'last_page': '558'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10296', 'display_name': 'Tick-Borne Diseases and Pathogens Transmission', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2405', 'display_name': 'Parasitology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10296', 'display_name': 'Tick-Borne Diseases and Pathogens Transmission', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2405', 'display_name': 'Parasitology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10428', 'display_name': 'Vaginal Microbiome and Sexually Transmitted Infections', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2404', 'display_name': 'Microbiology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11780', 'display_name': 'Rabies Virus Transmission and Control', 'score': 0.998, 'subfield': {'id': 'https://openalex.org/subfields/2406', 'display_name': 'Virology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/obligate', 'display_name': 'Obligate', 'score': 0.95727485}, {'id': 'https://openalex.org/keywords/intracellular-parasite', 'display_name': 'Intracellular parasite', 'score': 0.84964645}, {'id': 'https://openalex.org/keywords/pathogenesis', 'display_name': 'Pathogenesis', 'score': 0.461657}], 'concepts': [{'id': 'https://openalex.org/C24990904', 'wikidata': 'https://www.wikidata.org/wiki/Q7075144', 'display_name': 'Obligate', 'level': 2, 'score': 0.95727485}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.86568874}, {'id': 'https://openalex.org/C153726182', 'wikidata': 'https://www.wikidata.org/wiki/Q3720909', 'display_name': 'Intracellular parasite', 'level': 3, 'score': 0.84964645}, {'id': 'https://openalex.org/C2776460866', 'wikidata': 'https://www.wikidata.org/wiki/Q170065', 'display_name': 'Pathogen', 'level': 2, 'score': 0.42808583}, {'id': 'https://openalex.org/C523546767', 'wikidata': 'https://www.wikidata.org/wiki/Q10876', 'display_name': 'Bacteria', 'level': 2, 'score': 0.41023564}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.3924362}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.37871554}, {'id': 'https://openalex.org/C18903297', 'wikidata': 'https://www.wikidata.org/wiki/Q7150', 'display_name': 'Ecology', 'level': 1, 'score': 0.16621193}], 'mesh': [{'descriptor_ui': 'D001424', 'descriptor_name': 'Bacterial Infections', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D001424', 'descriptor_name': 'Bacterial Infections', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D001427', 'descriptor_name': 'Bacterial Toxins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D004269', 'descriptor_name': 'DNA, Bacterial', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D005818', 'descriptor_name': 'Genetic Engineering', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D054884', 'descriptor_name': 'Host-Pathogen Interactions', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D054884', 'descriptor_name': 'Host-Pathogen Interactions', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D001424', 'descriptor_name': 'Bacterial Infections', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001424', 'descriptor_name': 'Bacterial Infections', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D001427', 'descriptor_name': 'Bacterial Toxins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001427', 'descriptor_name': 'Bacterial Toxins', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D004269', 'descriptor_name': 'DNA, Bacterial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016680', 'descriptor_name': 'Genome, Bacterial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016680', 'descriptor_name': 'Genome, Bacterial', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D054884', 'descriptor_name': 'Host-Pathogen Interactions', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/nrmicro.2017.59', 'pdf_url': 'https://www.nature.com/articles/nrmicro.2017.59.pdf', 'source': {'id': 'https://openalex.org/S56802129', 'display_name': 'Nature Reviews Microbiology', 'issn_l': '1740-1526', 'issn': ['1740-1526', '1740-1534'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5557331', 'pdf_url': 'https://europepmc.org/articles/pmc5557331?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557331', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/10161/15149', 'pdf_url': 'https://dukespace.lib.duke.edu/dspace/bitstream/10161/15149/1/nrmicro.2017.59.pdf', 'source': {'id': 'https://openalex.org/S4306400687', 'display_name': 'DukeSpace (Duke University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I170897317', 'host_organization_name': 'Duke University', 'host_organization_lineage': ['https://openalex.org/I170897317'], 'host_organization_lineage_names': ['Duke University'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28626230', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/nrmicro.2017.59', 'pdf_url': 'https://www.nature.com/articles/nrmicro.2017.59.pdf', 'source': {'id': 'https://openalex.org/S56802129', 'display_name': 'Nature Reviews Microbiology', 'issn_l': '1740-1526', 'issn': ['1740-1526', '1740-1534'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.52, 'display_name': 'Responsible consumption and production', 'id': 'https://metadata.un.org/sdg/12'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 111, 'referenced_works': ['https://openalex.org/W1486215974', 'https://openalex.org/W1526931327', 'https://openalex.org/W1527100782', 'https://openalex.org/W160238758', 'https://openalex.org/W1662809715', 'https://openalex.org/W1756560109', 'https://openalex.org/W1779180564', 'https://openalex.org/W1920123894', 'https://openalex.org/W1964034349', 'https://openalex.org/W1964252660', 'https://openalex.org/W1965305538', 'https://openalex.org/W1969303240', 'https://openalex.org/W1972139300', 'https://openalex.org/W1973457840', 'https://openalex.org/W1983969058', 'https://openalex.org/W1988493489', 'https://openalex.org/W1997494619', 'https://openalex.org/W2001389136', 'https://openalex.org/W2003056121', 'https://openalex.org/W2007018689', 'https://openalex.org/W2014189869', 'https://openalex.org/W2014723793', 'https://openalex.org/W2017426055', 'https://openalex.org/W2021751029', 'https://openalex.org/W2022069644', 'https://openalex.org/W2027558100', 'https://openalex.org/W2036807306', 'https://openalex.org/W2040434499', 'https://openalex.org/W2040802288', 'https://openalex.org/W2042073732', 'https://openalex.org/W2048611089', 'https://openalex.org/W2054939407', 'https://openalex.org/W2055265391', 'https://openalex.org/W2060702462', 'https://openalex.org/W2060935595', 'https://openalex.org/W2060961438', 'https://openalex.org/W2061880687', 'https://openalex.org/W2062418171', 'https://openalex.org/W2064735771', 'https://openalex.org/W2071793393', 'https://openalex.org/W2073173494', 'https://openalex.org/W2077269211', 'https://openalex.org/W2079816108', 'https://openalex.org/W2082499478', 'https://openalex.org/W2084384873', 'https://openalex.org/W2086787888', 'https://openalex.org/W2094119638', 'https://openalex.org/W2094983592', 'https://openalex.org/W2095433689', 'https://openalex.org/W2097564187', 'https://openalex.org/W2099006359', 'https://openalex.org/W2099397046', 'https://openalex.org/W2103304202', 'https://openalex.org/W2103871766', 'https://openalex.org/W2108004029', 'https://openalex.org/W2109122955', 'https://openalex.org/W2113347449', 'https://openalex.org/W2114593800', 'https://openalex.org/W2117414599', 'https://openalex.org/W2118554077', 'https://openalex.org/W2119021881', 'https://openalex.org/W2119045185', 'https://openalex.org/W2119766894', 'https://openalex.org/W2123485925', 'https://openalex.org/W2126043487', 'https://openalex.org/W2127900907', 'https://openalex.org/W2127911794', 'https://openalex.org/W2128255243', 'https://openalex.org/W2133032443', 'https://openalex.org/W2135253524', 'https://openalex.org/W2136709798', 'https://openalex.org/W2138065849', 'https://openalex.org/W2139755139', 'https://openalex.org/W2143608477', 'https://openalex.org/W2147050596', 'https://openalex.org/W2148248876', 'https://openalex.org/W2153959709', 'https://openalex.org/W2155273531', 'https://openalex.org/W2156119500', 'https://openalex.org/W2156718046', 'https://openalex.org/W2158408029', 'https://openalex.org/W2158795149', 'https://openalex.org/W2159352958', 'https://openalex.org/W2160098512', 'https://openalex.org/W2162195506', 'https://openalex.org/W2162832155', 'https://openalex.org/W2163327255', 'https://openalex.org/W2166375583', 'https://openalex.org/W2192116738', 'https://openalex.org/W2211243458', 'https://openalex.org/W2238275403', 'https://openalex.org/W2259151740', 'https://openalex.org/W2306895687', 'https://openalex.org/W2319970581', 'https://openalex.org/W2332232022', 'https://openalex.org/W2343929623', 'https://openalex.org/W2344599923', 'https://openalex.org/W2345916383', 'https://openalex.org/W2416295358', 'https://openalex.org/W2417174404', 'https://openalex.org/W2432525717', 'https://openalex.org/W2469632569', 'https://openalex.org/W2518409228', 'https://openalex.org/W2520991277', 'https://openalex.org/W2523951497', 'https://openalex.org/W2525644600', 'https://openalex.org/W2537143620', 'https://openalex.org/W2549713124', 'https://openalex.org/W2561856169', 'https://openalex.org/W2596691892', 'https://openalex.org/W4211108838'], 'related_works': ['https://openalex.org/W95506451', 'https://openalex.org/W4388566379', 'https://openalex.org/W4362601983', 'https://openalex.org/W2625961086', 'https://openalex.org/W2515255268', 'https://openalex.org/W2227774892', 'https://openalex.org/W2117068772', 'https://openalex.org/W2026999897', 'https://openalex.org/W2007318579', 'https://openalex.org/W170106668'], 'abstract_inverted_index': {'In': [0, 112], 'this': [1, 113], 'Review,': [2, 114], 'Pedra': [3], 'and': [4, 9, 19, 37, 84, 155, 157], 'colleagues': [5], 'describe': [6, 116], 'the': [7, 12, 24, 62, 103, 117, 123, 127, 141, 159, 167], 'advances': [8], 'challenges': [10], 'in': [11, 72, 88, 173], 'genetic': [13, 93, 96, 132], 'engineering': [14, 160], 'of': [15, 22, 26, 34, 51, 106, 130, 143, 152, 161, 169], 'obligate': [16, 54, 107, 135, 162], 'intracellular': [17, 55, 108, 136, 163], 'bacteria,': [18, 56], 'highlight': [20, 139], 'examples': [21], 'how': [23, 140, 158], 'use': [25, 142], 'genetically': [27, 144], 'manipulated': [28, 145], 'pathogens': [29, 146], 'has': [30, 147], 'improved': [31], 'our': [32], 'understanding': [33, 151], 'microbial': [35, 153], 'pathogenesis': [36, 154], 'host–pathogen': [38, 174], 'interactions.': [39, 175], 'It': [40], 'is': [41, 59], 'estimated': [42], 'that': [43, 65, 125], 'approximately': [44], 'one': [45], 'billion': [46], 'people': [47], 'are': [48], 'at': [49], 'risk': [50], 'infection': [52], 'with': [53], 'but': [57], 'little': [58], 'known': [60], 'about': [61], 'underlying': [63], 'mechanisms': [64], 'govern': [66], 'their': [67, 92], 'life': [68], 'cycles.': [69], 'The': [70], 'difficulty': [71], 'studying': [73], 'Chlamydia': [74], 'spp.,': [75, 77, 79, 81], 'Coxiella': [76], 'Rickettsia': [78], 'Anaplasma': [80], 'Ehrlichia': [82], 'spp.': [83, 86], 'Orientia': [85], 'is,': [87], 'part,': [89], 'due': [90], 'to': [91], 'intractability.': [94], 'Recently,': [95], 'tools': [97], 'have': [98], 'been': [99], 'developed;': [100], 'however,': [101], 'optimizing': [102], 'genomic': [104], 'manipulation': [105], 'bacteria': [109, 164], 'remains': [110], 'challenging.': [111], 'we': [115], 'progress': [118], 'in,': [119], 'as': [120, 122], 'well': [121], 'constraints': [124], 'hinder,': [126], 'systematic': [128], 'development': [129], 'a': [131, 149], 'toolbox': [133], 'for': [134], 'bacteria.': [137], 'We': [138], 'facilitated': [148], 'better': [150], 'immunity,': [156], 'could': [165], 'enable': [166], 'discovery': [168], 'novel': [170], 'signalling': [171], 'circuits': [172]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2625961086', 'counts_by_year': [{'year': 2024, 'cited_by_count': 19}, {'year': 2023, 'cited_by_count': 28}, {'year': 2022, 'cited_by_count': 18}, {'year': 2021, 'cited_by_count': 23}, {'year': 2020, 'cited_by_count': 11}, {'year': 2019, 'cited_by_count': 18}, {'year': 2018, 'cited_by_count': 12}, {'year': 2017, 'cited_by_count': 4}], 'updated_date': '2024-09-09T16:11:02.145203', 'created_date': '2017-06-23'}