Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2625600525', 'doi': 'https://doi.org/10.1093/nar/gkx531', 'title': 'Molecular structures guide the engineering of chromatin', 'display_name': 'Molecular structures guide the engineering of chromatin', 'publication_year': 2017, 'publication_date': '2017-06-13', 'ids': {'openalex': 'https://openalex.org/W2625600525', 'doi': 'https://doi.org/10.1093/nar/gkx531', 'mag': '2625600525', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28609787', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5570049'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/nar/gkx531', 'pdf_url': 'https://academic.oup.com/nar/article-pdf/45/13/7555/22895030/gkx531.pdf', 'source': {'id': 'https://openalex.org/S134668137', 'display_name': 'Nucleic Acids Research', 'issn_l': '0305-1048', 'issn': ['0305-1048', '1362-4954', '1362-4962'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://academic.oup.com/nar/article-pdf/45/13/7555/22895030/gkx531.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5088284913', 'display_name': 'Stefan J. Tekel', 'orcid': 'https://orcid.org/0000-0001-7293-5268'}, 'institutions': [{'id': 'https://openalex.org/I55732556', 'display_name': 'Arizona State University', 'ror': 'https://ror.org/03efmqc40', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I55732556']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Stefan J. Tekel', 'raw_affiliation_strings': ['School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ 85287, USA'], 'affiliations': [{'raw_affiliation_string': 'School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ 85287, USA', 'institution_ids': ['https://openalex.org/I55732556']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5084852592', 'display_name': 'Karmella A. Haynes', 'orcid': 'https://orcid.org/0000-0002-5975-577X'}, 'institutions': [{'id': 'https://openalex.org/I55732556', 'display_name': 'Arizona State University', 'ror': 'https://ror.org/03efmqc40', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I55732556']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Karmella A. Haynes', 'raw_affiliation_strings': ['School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ 85287, USA'], 'affiliations': [{'raw_affiliation_string': 'School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ 85287, USA', 'institution_ids': ['https://openalex.org/I55732556']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5084852592'], 'corresponding_institution_ids': ['https://openalex.org/I55732556'], 'apc_list': {'value': 3630, 'currency': 'USD', 'value_usd': 3630, 'provenance': 'doaj'}, 'apc_paid': {'value': 3630, 'currency': 'USD', 'value_usd': 3630, 'provenance': 'doaj'}, 'fwci': 1.393, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 19, 'citation_normalized_percentile': {'value': 0.813541, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '45', 'issue': '13', 'first_page': '7555', 'last_page': '7570'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12534', 'display_name': 'Targeted Protein Degradation in Biomedical Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12534', 'display_name': 'Targeted Protein Degradation in Biomedical Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10222', 'display_name': 'Regulation of Chromatin Structure and Function', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin-Proteasome Proteolytic Pathway', 'score': 0.9961, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/chia-pet', 'display_name': 'ChIA-PET', 'score': 0.6709682}, {'id': 'https://openalex.org/keywords/scaffold/matrix-attachment-region', 'display_name': 'Scaffold/matrix attachment region', 'score': 0.6502456}, {'id': 'https://openalex.org/keywords/bivalent-chromatin', 'display_name': 'Bivalent chromatin', 'score': 0.5934466}, {'id': 'https://openalex.org/keywords/chromatin', 'display_name': 'Chromatin', 'score': 0.572334}, {'id': 'https://openalex.org/keywords/3d-genome-organization', 'display_name': '3D Genome Organization', 'score': 0.502298}, {'id': 'https://openalex.org/keywords/chip-sequencing', 'display_name': 'ChIP-sequencing', 'score': 0.45059004}, {'id': 'https://openalex.org/keywords/histone-modifying-enzymes', 'display_name': 'Histone-modifying enzymes', 'score': 0.43118346}], 'concepts': [{'id': 'https://openalex.org/C83640560', 'wikidata': 'https://www.wikidata.org/wiki/Q180951', 'display_name': 'Chromatin', 'level': 3, 'score': 0.9325949}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.76672935}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.6795298}, {'id': 'https://openalex.org/C67258246', 'wikidata': 'https://www.wikidata.org/wiki/Q5065897', 'display_name': 'ChIA-PET', 'level': 5, 'score': 0.6709682}, {'id': 'https://openalex.org/C56262557', 'wikidata': 'https://www.wikidata.org/wiki/Q3931949', 'display_name': 'Scaffold/matrix attachment region', 'level': 5, 'score': 0.6502456}, {'id': 'https://openalex.org/C137338518', 'wikidata': 'https://www.wikidata.org/wiki/Q4919210', 'display_name': 'Bivalent chromatin', 'level': 5, 'score': 0.5934466}, {'id': 'https://openalex.org/C167227067', 'wikidata': 'https://www.wikidata.org/wiki/Q5113739', 'display_name': 'Chromatin remodeling', 'level': 4, 'score': 0.54695153}, {'id': 'https://openalex.org/C41091548', 'wikidata': 'https://www.wikidata.org/wiki/Q26939', 'display_name': 'Epigenetics', 'level': 3, 'score': 0.50555396}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.46924782}, {'id': 'https://openalex.org/C176619506', 'wikidata': 'https://www.wikidata.org/wiki/Q5065899', 'display_name': 'ChIP-sequencing', 'level': 5, 'score': 0.45059004}, {'id': 'https://openalex.org/C56952853', 'wikidata': 'https://www.wikidata.org/wiki/Q5773144', 'display_name': 'Histone-modifying enzymes', 'level': 5, 'score': 0.43118346}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.4190774}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.37322462}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.2626813}], 'mesh': [{'descriptor_ui': 'D002843', 'descriptor_name': 'Chromatin', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D002843', 'descriptor_name': 'Chromatin', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D005818', 'descriptor_name': 'Genetic Engineering', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002843', 'descriptor_name': 'Chromatin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044127', 'descriptor_name': 'Epigenesis, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005818', 'descriptor_name': 'Genetic Engineering', 'qualifier_ui': 'Q000639', 'qualifier_name': 'trends', 'is_major_topic': False}, {'descriptor_ui': 'D005818', 'descriptor_name': 'Genetic Engineering', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006657', 'descriptor_name': 'Histones', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D006657', 'descriptor_name': 'Histones', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006657', 'descriptor_name': 'Histones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008957', 'descriptor_name': 'Models, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015394', 'descriptor_name': 'Molecular Structure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009707', 'descriptor_name': 'Nucleosomes', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D009707', 'descriptor_name': 'Nucleosomes', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009707', 'descriptor_name': 'Nucleosomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012313', 'descriptor_name': 'RNA', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012313', 'descriptor_name': 'RNA', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D012313', 'descriptor_name': 'RNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058615', 'descriptor_name': 'Synthetic Biology', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/nar/gkx531', 'pdf_url': 'https://academic.oup.com/nar/article-pdf/45/13/7555/22895030/gkx531.pdf', 'source': {'id': 'https://openalex.org/S134668137', 'display_name': 'Nucleic Acids Research', 'issn_l': '0305-1048', 'issn': ['0305-1048', '1362-4954', '1362-4962'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5570049', 'pdf_url': 'https://europepmc.org/articles/pmc5570049?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/2286/R.I.45297', 'pdf_url': 'https://keep.lib.asu.edu/system/files/c160/Molecular_structures_guide_2017.pdf', 'source': {'id': 'https://openalex.org/S4306400254', 'display_name': 'Arizona State University Library Digital Repository (Arizona State University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I55732556', 'host_organization_name': 'Arizona State University', 'host_organization_lineage': ['https://openalex.org/I55732556'], 'host_organization_lineage_names': ['Arizona State University'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570049', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28609787', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/nar/gkx531', 'pdf_url': 'https://academic.oup.com/nar/article-pdf/45/13/7555/22895030/gkx531.pdf', 'source': {'id': 'https://openalex.org/S134668137', 'display_name': 'Nucleic Acids Research', 'issn_l': '0305-1048', 'issn': ['0305-1048', '1362-4954', '1362-4962'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Zero hunger', 'score': 0.69, 'id': 'https://metadata.un.org/sdg/2'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 168, 'referenced_works': ['https://openalex.org/W1509466986', 'https://openalex.org/W154704142', 'https://openalex.org/W1572088192', 'https://openalex.org/W160853306', 'https://openalex.org/W1625510017', 'https://openalex.org/W180065705', 'https://openalex.org/W1907909844', 'https://openalex.org/W1931010989', 'https://openalex.org/W1967381498', 'https://openalex.org/W1967596247', 'https://openalex.org/W1968094971', 'https://openalex.org/W1968637358', 'https://openalex.org/W1974225684', 'https://openalex.org/W1976109331', 'https://openalex.org/W1976242511', 'https://openalex.org/W1976913448', 'https://openalex.org/W1976962550', 'https://openalex.org/W1977199336', 'https://openalex.org/W1984449945', 'https://openalex.org/W1987158041', 'https://openalex.org/W1987205155', 'https://openalex.org/W1990174038', 'https://openalex.org/W1993984481', 'https://openalex.org/W1996224069', 'https://openalex.org/W1999144014', 'https://openalex.org/W2000160108', 'https://openalex.org/W2002133515', 'https://openalex.org/W2002698073', 'https://openalex.org/W2004315839', 'https://openalex.org/W2006703184', 'https://openalex.org/W2007916651', 'https://openalex.org/W2008241299', 'https://openalex.org/W2009949436', 'https://openalex.org/W2010671327', 'https://openalex.org/W2010792569', 'https://openalex.org/W2012206989', 'https://openalex.org/W2012317303', 'https://openalex.org/W2012935454', 'https://openalex.org/W2016818916', 'https://openalex.org/W2019219956', 'https://openalex.org/W2021510847', 'https://openalex.org/W2021865989', 'https://openalex.org/W2022159376', 'https://openalex.org/W2023096418', 'https://openalex.org/W2025450279', 'https://openalex.org/W2025496265', 'https://openalex.org/W2025553576', 'https://openalex.org/W2026627428', 'https://openalex.org/W2028434128', 'https://openalex.org/W2028927305', 'https://openalex.org/W2029001448', 'https://openalex.org/W2029799334', 'https://openalex.org/W2030775866', 'https://openalex.org/W2033955213', 'https://openalex.org/W2034518808', 'https://openalex.org/W2034619626', 'https://openalex.org/W2035420256', 'https://openalex.org/W2036158314', 'https://openalex.org/W2038235796', 'https://openalex.org/W2038849570', 'https://openalex.org/W2041535798', 'https://openalex.org/W2046345187', 'https://openalex.org/W2048131815', 'https://openalex.org/W2048335012', 'https://openalex.org/W2050256263', 'https://openalex.org/W2051053236', 'https://openalex.org/W2054301876', 'https://openalex.org/W2055262788', 'https://openalex.org/W2055790209', 'https://openalex.org/W2058673308', 'https://openalex.org/W2059016225', 'https://openalex.org/W2062186651', 'https://openalex.org/W2063943009', 'https://openalex.org/W2065055008', 'https://openalex.org/W2066264051', 'https://openalex.org/W2066783444', 'https://openalex.org/W2067707738', 'https://openalex.org/W2069157717', 'https://openalex.org/W2069328568', 'https://openalex.org/W2069403737', 'https://openalex.org/W2070867144', 'https://openalex.org/W2072815676', 'https://openalex.org/W2076333986', 'https://openalex.org/W2076468459', 'https://openalex.org/W2080896401', 'https://openalex.org/W2084885369', 'https://openalex.org/W2085109653', 'https://openalex.org/W2085299836', 'https://openalex.org/W2085788675', 'https://openalex.org/W2086473824', 'https://openalex.org/W2086524378', 'https://openalex.org/W2087546116', 'https://openalex.org/W2087916708', 'https://openalex.org/W2090017665', 'https://openalex.org/W2090460767', 'https://openalex.org/W2093655203', 'https://openalex.org/W2095111919', 'https://openalex.org/W2095718399', 'https://openalex.org/W2096083625', 'https://openalex.org/W2098103685', 'https://openalex.org/W2098767990', 'https://openalex.org/W2098952156', 'https://openalex.org/W2100634503', 'https://openalex.org/W2106134616', 'https://openalex.org/W2110399580', 'https://openalex.org/W2111460423', 'https://openalex.org/W2111648798', 'https://openalex.org/W2113024865', 'https://openalex.org/W2114475204', 'https://openalex.org/W2115593774', 'https://openalex.org/W2115862579', 'https://openalex.org/W2117847381', 'https://openalex.org/W2118240383', 'https://openalex.org/W2120277258', 'https://openalex.org/W2120572492', 'https://openalex.org/W2123647733', 'https://openalex.org/W2126504590', 'https://openalex.org/W2126740537', 'https://openalex.org/W2128029143', 'https://openalex.org/W2128438064', 'https://openalex.org/W2130037181', 'https://openalex.org/W2130479394', 'https://openalex.org/W2134072110', 'https://openalex.org/W2139516530', 'https://openalex.org/W2143351999', 'https://openalex.org/W2144379757', 'https://openalex.org/W2144792857', 'https://openalex.org/W2145668963', 'https://openalex.org/W2145924925', 'https://openalex.org/W2146641795', 'https://openalex.org/W2147276719', 'https://openalex.org/W2147524392', 'https://openalex.org/W2148121673', 'https://openalex.org/W2154031030', 'https://openalex.org/W2156213441', 'https://openalex.org/W2167732604', 'https://openalex.org/W2168012760', 'https://openalex.org/W2169102080', 'https://openalex.org/W2231352968', 'https://openalex.org/W2239511084', 'https://openalex.org/W2264862529', 'https://openalex.org/W2270756322', 'https://openalex.org/W2279123229', 'https://openalex.org/W2283206150', 'https://openalex.org/W2319972745', 'https://openalex.org/W2322756986', 'https://openalex.org/W2326025506', 'https://openalex.org/W2328008926', 'https://openalex.org/W2332365177', 'https://openalex.org/W2338344824', 'https://openalex.org/W2346619380', 'https://openalex.org/W2407843420', 'https://openalex.org/W2411087639', 'https://openalex.org/W2412647772', 'https://openalex.org/W2470462608', 'https://openalex.org/W2511666606', 'https://openalex.org/W2515130998', 'https://openalex.org/W2522031854', 'https://openalex.org/W2526246975', 'https://openalex.org/W2540331622', 'https://openalex.org/W2559776465', 'https://openalex.org/W2568322231', 'https://openalex.org/W2586972673', 'https://openalex.org/W2592276570', 'https://openalex.org/W2605316830', 'https://openalex.org/W2952631944', 'https://openalex.org/W2979218585', 'https://openalex.org/W4210384175'], 'related_works': ['https://openalex.org/W4307826623', 'https://openalex.org/W2140301715', 'https://openalex.org/W2100542882', 'https://openalex.org/W2077609606', 'https://openalex.org/W2063111950', 'https://openalex.org/W2046031452', 'https://openalex.org/W2037920273', 'https://openalex.org/W2012661761', 'https://openalex.org/W2008077261', 'https://openalex.org/W1449897346'], 'abstract_inverted_index': {'Chromatin': [0, 23], 'is': [1, 48], 'a': [2, 49, 137], 'system': [3], 'of': [4, 44, 69, 88, 101, 157], 'proteins,': [5], 'RNA,': [6], 'and': [7, 16, 41, 60, 86, 104, 123, 143], 'DNA': [8, 30, 35], 'that': [9, 95, 117], 'interact': [10], 'with': [11], 'each': [12], 'other': [13], 'to': [14, 130, 150], 'organize': [15], 'regulate': [17], 'genetic': [18], 'information': [19, 107], 'within': [20, 38], 'eukaryotic': [21], 'nuclei.': [22], 'proteins': [24, 103], 'carry': [25], 'out': [26], 'essential': [27], 'functions:': [28], 'packing': [29], 'during': [31], 'cell': [32], 'division,': [33], 'partitioning': [34], 'into': [36], 'sub-regions': [37], 'the': [39, 67, 73, 80, 83, 98, 155], 'nucleus,': [40], 'controlling': [42], 'levels': [43], 'gene': [45], 'expression.': [46], 'There': [47], 'growing': [50], 'interest': [51], 'in': [52, 58, 63, 124, 153], 'manipulating': [53], 'chromatin': [54, 74, 89, 102, 149], 'dynamics': [55], 'for': [56, 72, 111, 139, 147], 'applications': [57], 'medicine': [59], 'agriculture.': [61], 'Progress': [62], 'this': [64, 106], 'area': [65], 'requires': [66], 'identification': [68], 'design': [70, 109, 142], 'rules': [71, 110], 'system.': [75], 'Here,': [76], 'we': [77, 135], 'focus': [78], 'on': [79], 'relationship': [81], 'between': [82], 'physical': [84], 'structure': [85], 'function': [87], 'proteins.': [90], 'We': [91], 'discuss': [92, 144], 'key': [93], 'research': [94], 'has': [96], 'elucidated': [97], 'intrinsic': [99], 'properties': [100], 'how': [105], 'informs': [108], 'synthetic': [112, 158], 'systems.': [113], 'Recent': [114], 'work': [115], 'demonstrates': [116], 'chromatin-derived': [118], 'peptide': [119], 'motifs': [120], 'are': [121], 'portable': [122], 'some': [125], 'cases': [126], 'can': [127], 'be': [128], 'customized': [129], 'alter': [131], 'their': [132], 'function.': [133], 'Finally,': [134], 'present': [136], 'workflow': [138], 'fusion': [140], 'protein': [141], 'best': [145], 'practices': [146], 'engineering': [148], 'assist': [151], 'scientists': [152], 'advancing': [154], 'field': [156], 'epigenetics.': [159]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2625600525', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 2}], 'updated_date': '2024-08-29T06:43:57.051536', 'created_date': '2017-06-23'}