Publication Information

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1412, 1830, 1865, 2070, 2098, 2152, 2400, 2494, 4016], 'become': [13, 143], 'toxic': [14, 144], 'and': [15, 32, 38, 75, 85, 100, 104, 128, 145, 162, 168, 205, 215, 230, 234, 258, 301, 325, 371, 419, 502, 538, 547, 554, 583, 591, 596, 673, 681, 689, 709, 746, 752, 772, 793, 819, 821, 874, 898, 1003, 1011, 1067, 1069, 1109, 1149, 1200, 1246, 1302, 1354, 1393, 1409, 1414, 1551, 1668, 1706, 1715, 1746, 1787, 1802, 1842, 1887, 1895, 1930, 1993, 2078, 2093, 2095, 2127, 2150, 2155, 2163, 2174, 2191, 2193, 2197, 2205, 2210, 2258, 2261, 2361, 2412, 2453, 2470, 2507, 2525, 2547, 2558, 2627, 2638, 2680, 2692, 2728, 2740, 2852, 2887, 2889, 2995, 3024, 3268, 3276, 3287, 3343, 3401, 3461, 3468, 3506, 3606, 3678, 3712, 3813, 3826, 3872, 3902, 3991, 4055, 4114, 4244, 4290], 'cause': [16, 146, 827], 'cell': [17, 147, 447, 737, 807, 828, 831, 875, 932, 1073, 2142, 2252, 2256], 'death.': [18, 148], 'Selective': [19, 149], 'control': [20, 150, 438, 1775, 2404, 3587], 'of': [21, 28, 62, 110, 124, 151, 158, 192, 240, 254, 363, 415, 432, 439, 462, 479, 491, 542, 550, 559, 612, 645, 652, 712, 716, 743, 774, 806, 882, 906, 912, 930, 938, 977, 983, 1023, 1099, 1107, 1140, 1170, 1183, 1254, 1280, 1286, 1312, 1324, 1357, 1390, 1443, 1456, 1483, 1570, 1584, 1588, 1595, 1609, 1635, 1673, 1681, 1695, 1717, 1733, 1760, 1776, 1783, 1795, 1804, 1890, 1919, 1925, 1958, 1964, 1970, 1995, 2029, 2063, 2067, 2110, 2185, 2239, 2270, 2292, 2389, 2395, 2405, 2420, 2461, 2473, 2611, 2660, 2675, 2711, 2734, 2748, 2760, 2764, 2768, 2803, 2811, 2828, 2855, 2862, 2878, 2907, 2918, 2922, 2947, 2956, 2997, 3028, 3072, 3108, 3148, 3180, 3186, 3227, 3271, 3364, 3371, 3403, 3450, 3474, 3508, 3559, 3583, 3620, 3627, 3634, 3680, 3707, 3718, 3736, 3789, 3807, 3821, 3831, 3855, 3863, 3868, 3958, 3989, 4039, 4051, 4096, 4110, 4127, 4164, 4247, 4350], 'specific': [22, 152, 943, 1767, 2138, 2406], 'targets': [23, 153, 1465, 1617, 1918, 2062, 2086], 'depends': [24, 154], 'on': [25, 50, 155, 180, 267, 577, 936, 1103, 1179, 2059, 2562, 2666, 2671, 4042, 4049], 'spatiotemporal': [26, 156], 'patterning': [27, 157], 'the': [29, 60, 87, 122, 159, 190, 217, 252, 286, 292, 297, 303, 312, 331, 343, 351, 361, 364, 372, 388, 395, 405, 477, 489, 498, 507, 551, 556, 560, 646, 676, 794, 880, 910, 939, 946, 1004, 1044, 1110, 1119, 1138, 1144, 1161, 1180, 1195, 1198, 1201, 1255, 1270, 1296, 1306, 1358, 1386, 1432, 1480, 1497, 1585, 1601, 1606, 1632, 1671, 1679, 1710, 1727, 1863, 1879, 1891, 1915, 1926, 1956, 1961, 1967, 1983, 1990, 2027, 2030, 2060, 2065, 2128, 2141, 2224, 2240, 2293, 2296, 2387, 2474, 2501, 2531, 2556, 2608, 2657, 2661, 2676, 2707, 2712, 2744, 2761, 2765, 2779, 2808, 2825, 2832, 2856, 2919, 2929, 2950, 3029, 3109, 3161, 3181, 3288, 3306, 3368, 3471, 3475, 3524, 3580, 3584, 3592, 3600, 3604, 3613, 3618, 3625, 3631, 3700, 3719, 3742, 3790, 3811, 3818, 3829, 3841, 3861, 3866, 3877, 3884, 3893, 3899, 3903, 3908, 3934, 3959, 3983, 4001, 4011, 4064, 4076, 4087, 4101, 4107, 4122, 4128, 4146, 4153, 4156, 4172, 4293, 4297], 'calcium': [30, 126, 160, 256, 613, 653, 714, 754, 775, 795, 872, 907, 973, 1018, 1045, 1985, 2031, 2298, 2306, 2359, 3738, 3984], 'signal': [31, 161, 755, 796, 941, 1046, 1298, 2890, 3985, 4025], 'decoding': [33, 163], 'it': [34, 164], 'by': [35, 47, 68, 165, 177, 198, 387, 404, 422, 520, 535, 555, 811, 991, 1049, 1219, 1235, 1317, 1436, 1452, 1479, 1574, 1579, 1631, 1699, 1857, 2046, 2170, 2231, 2480, 2490, 2497, 2925, 3231, 3563, 3598, 3699, 3721, 3824, 3846, 3996], 'multiple,': [36, 166], 'tunable,': [37, 167], 'often': [39, 169], 'strategically': [40, 170], 'positioned': [41, 171], 'Ca2+-sensing': [42, 81, 111, 172, 211, 241, 1088, 2396, 4028], 'elements.': [43, 173], 'detected': [46, 176, 3994], 'specialized': [48, 178, 1087, 1555], 'motifs': [49, 179, 1055, 1082, 1274, 3740, 4029], 'proteins': [51, 181, 417, 570, 1064, 1070, 1089, 1114, 1121, 1146, 1188, 1281, 1319, 1374, 1383, 1446, 1501, 1835, 1852, 1889, 2301, 2327, 2383, 2397, 2415, 2879], 'have': [53, 183, 586, 797, 2083, 2117, 2136, 2243, 2550, 2629, 2640, 2903, 3816, 4134], 'been': [54, 66, 184, 196, 2179, 2244, 2630, 2641, 3531, 4047, 4135], 'biochemically': [55, 185], 'characterized': [56, 186, 1451, 1553, 1928], 'decades': [57, 187], 'ago.': [58, 188], 'However,': [59, 189, 314], 'field': [61, 191], 'sensing': [64, 194, 1558, 2924, 4045, 4152], 'has': [65, 195, 1562, 2178, 3530, 4046], 'reenergized': [67, 197], 'recent': [69, 199, 4040], 'progress': [70, 200, 4041], 'in': [71, 121, 201, 251, 285, 296, 302, 311, 348, 376, 428, 436, 671, 886, 909, 1027, 1043, 1058, 1086, 1093, 1240, 1276, 1295, 1305, 1320, 1421, 1426, 1431, 1503, 1535, 1652, 1678, 1684, 1726, 1836, 1989, 2010, 2181, 2208, 2311, 2331, 2342, 2369, 2386, 2408, 2435, 2530, 2555, 2577, 2580, 2607, 2654, 2706, 2882, 2899, 3274, 3527, 3638, 3648, 3710, 3810, 3883, 3898, 3907, 4033, 4081, 4086, 4121, 4155], 'fluorescent': [72, 202], 'technology,': [73, 203], 'genetics,': [74, 204], 'cryo-EM.': [76, 206], 'These': [77, 207, 1054, 1113, 1424, 1876, 4020], 'approaches': [78, 208, 877, 2549], 'exposed': [79, 209, 1612, 4170], 'local': [80, 210, 4043], 'mechanisms': [82, 212, 563, 1703], 'inside': [83, 213], 'organelles': [84, 214, 4054], 'at': [86, 216, 615, 2013, 3114, 3367, 3470, 3534, 3617, 3630, 3840, 4005, 4056], 'organellar': [88, 218, 4057], 'interfaces,': [89, 219], 'revealed': [90, 220, 1478, 1630, 2551, 3230, 3562, 3611, 3817], 'how': [91, 221], 'binding': [93, 223, 1142, 1440, 1509, 1581, 1603, 1759, 1871, 1883, 2233, 2806, 2860, 3183, 3463, 3739, 3867], 'might': [94, 224, 934], 'work': [95, 225], 'to': [96, 107, 116, 226, 237, 246, 309, 400, 467, 525, 666, 668, 674, 748, 798, 1095, 1136, 1143, 1158, 1172, 1226, 1331, 1341, 1416, 1441, 1513, 1590, 1613, 1662, 1741, 1762, 1821, 1966, 2002, 2019, 2025, 2100, 2234, 2246, 2427, 2446, 2632, 2643, 2722, 2724, 2743, 2778, 2807, 2831, 3578, 3888, 3891, 4010, 4031, 4083, 4099, 4105, 4171, 4296, 4314, 4352, 4354], 'open': [97, 227, 3960, 4012], 'some': [98, 228, 2916], 'channels,': [99, 229, 4014], 'identified': [101, 231, 3361], 'human': [102, 232], 'mutations': [103, 233], 'disorders': [105, 235], 'linked': [106, 236, 2245, 2631, 2642], 'variety': [109, 239, 1098, 2109, 2184], 'proteins.': [112, 242, 1204, 1277, 1997], 'Here': [113, 243], 'we': [114, 244], 'attempt': [115, 245], 'place': [117, 247], 'these': [118, 248, 416, 1318, 2023, 2442, 3643, 3911], 'new': [119, 249, 3915], 'developments': [120, 250, 2898], 'context': [123, 253], 'homeostasis': [127, 257], 'signaling.': [129, 259], 'Intracellular': [260], 'free': [261, 1784], 'concentration': [263], 'varies': [264], 'widely': [265], 'depending': [266, 576, 1102], 'its': [268, 1753, 1850, 1858, 2004, 2235, 2776, 3528, 4142, 4324], 'location.': [269], 'The': [270, 337, 355, 513, 568, 770, 789, 1040, 1205, 1229, 1310, 1692, 2016, 2458, 2483, 2645, 2686, 2944, 3777, 4093, 4344], 'cytoplasmic': [271, 433], '[Ca2+]': [272, 284, 329, 824, 1094, 1325, 1785, 4159], '([Ca2+]c)': [273], 'under': [274, 1722, 1735], 'resting': [275, 378, 677, 791, 1736, 4309], 'conditions': [276], '∼10−7': [278], 'M,': [279], '104': [280], 'times': [281], 'lower': [282, 685], 'than': [283, 330, 2670], 'extracellular': [287, 453, 480], 'milieu': [288], '(∼10−3': [289], 'M).': [290, 336], 'Inside': [291], 'cell,': [293], 'levels': [295], 'nuclear': [298], 'matrix': [299, 305, 1006], '([Ca2+]n)': [300], 'mitochondrial': [304, 406, 883, 1005, 1024, 3346], '([Ca2+]mt)': [306], 'are': [307, 420, 533, 1056, 1083, 1269, 1289, 1611, 1923, 2147, 2328, 2339, 2384, 2444, 2478, 2488, 2773, 3576, 3636, 3645, 4169], 'similar': [308, 1512], 'cytoplasm.': [313, 3909], 'other': [315, 1888, 2225, 2334, 2343, 2484], 'organelles,': [317, 944], 'known': [318, 2120, 4066], 'as': [319, 450, 1019, 1290, 1292, 1380, 2337, 4067], 'stores,': [321, 495], 'accumulate': [323], 'maintain': [326, 1395, 4106], 'higher': [328], 'cytoplasm': [332, 3842], '(1–5': [333], '×': [334], '10−4': [335], 'main': [338, 4094], 'internal': [339, 494], 'store': [341, 398, 4295], 'endoplasmic': [344, 649], 'reticulum': [345, 353, 390, 650], '(ER),': [346], 'and,': [347, 399, 424, 729, 2132], 'muscle': [349, 817, 2194, 2212], 'cells,': [350], 'sarcoplasmic': [352, 647], '(SR).': [354], 'low': [356, 592, 790, 2014], '[Ca2+]c': [357, 429, 440, 463, 514, 526, 530, 672, 734, 792, 940, 4003, 4015], 'maintained': [359], 'through': [360, 1869, 3865, 4161], 'action': [362], 'plasma': [365, 483, 2780, 4077, 4298], 'membrane': [366, 451, 484, 2433, 2454, 2883, 4078], 'transport': [368, 691], 'ATPase': [369], '(PMCA)': [370], 'Na+/Ca2+': [373], 'exchanger': [374], '(NCX)': [375], 'cell.': [379], 'Upon': [380], 'elevated': [381, 1723], '[Ca2+]c,': [382, 1724], 'this': [383, 1755, 1979, 2068, 2655, 3834, 3981], 'activity': [384, 575, 1131, 1175, 1534, 1778, 1994], 'complemented': [386], 'sarcoendoplasmic': [389], 'Ca2+-ATPase': [391], '(SERCA),': [392], 'which': [393, 662, 2493, 4322], 'fills': [394], 'ER/SR': [396, 508], 'lesser': [402], 'extent,': [403], 'uniporter': [408], '(mtCU)': [409], '(Figure': [410, 441, 509, 564, 833, 1079, 1176, 1308, 2456, 4059, 4091], '1A,': [411, 442, 510, 565], 'red': [412], 'arrows).': [413, 444, 512, 567], 'All': [414], 'sense': [418, 2156], 'activated': [421, 4080], 'Ca2+,': [423, 434, 812, 3466], 'therefore,': [425, 2133], 'any': [426, 822], 'elevations': [427, 670, 825], 'stimulate': [430], 'removal': [431, 562], 'resulting': [435, 1677, 2009], 'homeostatic': [437, 557], 'green': [443, 566], 'Nevertheless,': [445], 'various': [446, 1050, 2247, 3997], 'stimuli,': [448], 'such': [449], 'depolarization,': [452], 'signaling': [454, 974, 2101, 2204, 2452], 'molecules,': [455, 2492], 'or': [456, 470, 488, 528, 648, 830, 1125, 1128, 1134, 1670, 1701, 1839, 1973, 2143, 3704], 'messengers,': [458], 'promote': [459], 'an': [460, 1748, 2466, 3873, 4242], 'increase': [461, 473, 515, 2003], 'from': [464, 475, 493, 506, 1338, 1960, 4292], '100': [465], 'nM': [466], '1': [468, 3188, 4007], 'μM': [469], 'more.': [471], 'This': [472, 1278, 1766, 2876, 3609, 3695], 'results': [474], 'either': [476, 1115, 1657], 'influx': [478, 4074], 'via': [482, 497, 2175], '(PM)': [485], 'channels': [487, 553, 745, 2927, 3229, 3292, 3561, 3809, 4289], 'release': [490], 'mostly': [496], '1,4,5-triphosphate': [499], 'receptor': [500, 504, 3112, 3745], '(IP3R)': [501], 'ryanodine': [503, 3030, 3111, 3151, 3277, 3744], '(RyR)': [505], 'blue': [511], 'usually': [517, 2135], 'steep,': [518], 'followed': [519], 'decay': [522], 'giving': [523], 'rise': [524], 'spikes': [527], 'repetitive': [529], 'oscillations': [531], 'supported': [534, 3698], 'multiple': [536, 2084], 'positive': [537], 'negative': [539], 'feedback': [540], 'effects': [541], 'favoring': [544], 'synchronized': [545], 'activation': [546, 1665, 1672, 1694, 1716, 1732, 1803, 2097, 2190, 2207, 2996, 3402, 3507, 3650, 3679, 3717, 3920, 4326], 'rapid': [548], 'deactivation': [549], 'regulation': [558, 911, 929, 1680, 2388], 'Ca2+-regulated': [569], 'present': [571, 1057, 1085, 2416, 2465], 'different': [572, 1335, 2409, 2720, 2725, 3976], 'thresholds': [573], 'for': [574, 589, 687, 695, 878, 948, 987, 1007, 1556, 1774, 1798, 1885, 2006, 2402, 2575, 2775, 2952, 2993, 3304, 3340, 3399, 3465, 3504, 3676, 3785, 3918, 3932, 4026, 4118, 4132, 4151, 4199], 'their': [578, 758, 1104, 1174, 1184, 1457, 1461, 1514, 1596, 1658, 1663, 1674, 1682, 1844, 2011, 2096, 2160, 2421, 2436], 'function.': [579], 'For': [580, 1752, 2730], 'example,': [581], 'PMCA': [582], 'SERCA': [584], 'pumps': [585, 747], 'high': [587, 1377], 'affinities': [588], 'pumping': [593], 'rate': [594], '(≈30': [595], '≈10': [597], 'Hz,': [598], 'respectively)': [599], '(Juhaszova': [600], 'et': [601, 629, 698, 762, 854, 952, 1345, 1467, 1518, 1619, 2034, 2346, 2511, 2565, 2593, 2751, 2792, 2836, 2932, 2970, 3013, 3041, 3063, 3084, 3106, 3126, 3164, 3207, 3243, 3294, 3320, 3376, 3419, 3441, 3481, 3539, 3653, 3724, 3759, 3922, 3948, 4176, 4218, 4240, 4263, 4328], 'al.,': [602, 630, 699, 763, 855, 953, 1346, 1468, 1519, 1620, 2035, 2347, 2512, 2566, 2594, 2752, 2793, 2837, 2933, 2971, 3014, 3042, 3085, 3127, 3165, 3208, 3244, 3295, 3321, 3377, 3420, 3482, 3540, 3654, 3725, 3760, 3923, 3949, 4177, 4219, 4264, 4329], '2000Juhaszova': [603], 'M.': [604, 634, 865, 870, 957, 1470, 1474, 1525, 1622, 1626, 1792, 2795, 3177, 3264, 4229, 4333], 'Church': [605], 'P.': [606, 767, 969, 3258], 'Blaustein': [607], 'M.P.': [608, 1350], 'Stanley': [609], 'E.F.': [610], 'Location': [611], 'transporters': [614], 'presynaptic': [616], 'terminals.Eur.': [617], 'J.': [618, 632, 1363, 1523, 2600, 2614, 2782, 2845, 2939, 2990, 3093, 3144, 3396, 3501, 3673, 4179, 4221, 4270, 4335], 'Neurosci.': [619, 2316, 3348], '2000;': [620, 781], '12:': [621], '839-846Crossref': [622], 'PubMed': [623, 724, 784, 848, 892, 923, 998, 1035, 1264, 1367, 1491, 1543, 1643, 1814, 1909, 1945, 2053, 2218, 2282, 2320, 2377, 2541, 2587, 2618, 2699, 2786, 2819, 2871, 2963, 3007, 3035, 3078, 3120, 3156, 3201, 3237, 3282, 3314, 3352, 3413, 3456, 3518, 3569, 3690, 3753, 3799, 3942, 3968, 4212, 4257, 4303, 4364], 'Scopus': [624, 725, 785, 849, 893, 924, 999, 1036, 1368, 1492, 1544, 1644, 1815, 1910, 1946, 2054, 2219, 2283, 2321, 2378, 2542, 2588, 2619, 2700, 2787, 2820, 2872, 2964, 3008, 3036, 3079, 3121, 3157, 3202, 3238, 3283, 3315, 3353, 3414, 3457, 3519, 3570, 3691, 3754, 3800, 3943, 3969, 4213, 4258, 4304], '(75)': [625], 'Google': [626, 660, 727, 787, 851, 895, 926, 1001, 1038, 1265, 1370, 1494, 1546, 1646, 1817, 1912, 1948, 2056, 2221, 2285, 2323, 2380, 2544, 2590, 2621, 2702, 2789, 2822, 2874, 2966, 3010, 3038, 3081, 3123, 3159, 3204, 3240, 3285, 3317, 3355, 3416, 3459, 3521, 3572, 3693, 3756, 3802, 3945, 3971, 4215, 4260, 4306], 'Scholar,': [627, 852, 896, 2591, 2790, 2967, 3011, 3039, 3082, 3124, 3205, 3241, 3318, 3417, 3757, 3946, 4216, 4261], 'Lytton': [628], '1992Lytton': [631], 'Westlin': [633], 'Burk': [635], 'S.E.': [636], 'Shull': [637], 'G.E.': [638], 'MacLennan': [639], 'D.H.': [640], 'Functional': [641], 'comparisons': [642], 'between': [643, 1300, 1406, 2450], 'isoforms': [644, 2739], 'family': [651, 1279, 1893, 2069, 2242, 2877], 'pumps.J.': [654], 'Biol.': [655, 719, 780, 1487, 1539, 1639, 1905, 2214, 2537, 2814, 2866, 3748, 3794, 4203, 4253, 4360], 'Chem.': [656, 720, 2815, 2867, 3749, 3795], '1992;': [657, 1906, 2050], '267:': [658], '14483-14489PubMed': [659], 'Scholar),': [661, 2823, 3160, 3286, 3573], 'makes': [663], 'them': [664, 2426], 'suitable': [665], 'respond': [667, 1415, 2723], 'modest': [669], 'reestablish': [675], 'level.': [679], 'NCX': [680], 'MCU': [682], 'show': [683], 'affinity': [686, 1378, 1403, 2005], 'greater': [690], 'rates': [692], '(150–300': [693], 'Hz': [694], 'NCX;': [696], 'Boyman': [697], '2009Boyman': [700], 'L.': [701, 959, 2041, 3052, 3430, 3772], 'Mikhasenko': [702], 'H.': [703, 971, 2043, 2266, 3169], 'Hiller': [704], 'R.': [705, 2357, 2978, 3020, 3044, 3129, 3301, 3384, 3422, 3489, 3661, 3774, 3929, 3955], 'Khananshvili': [706], 'D.': [707, 961], 'Kinetic': [708], 'equilibrium': [710], 'properties': [711, 1356], 'regulatory': [713, 4319], 'sensors': [715, 1401], 'NCX1': [717], 'protein.J.': [718], '2009;': [721, 995, 1032, 3349], '284:': [722], '6185-6193Crossref': [723], '(53)': [726], 'Scholar)': [728, 1002, 3460], 'thus,': [730], 'limit': [732], 'larger': [733], 'transients.': [735], 'Each': [736, 3850], 'type': [738, 3187], 'presents': [739, 1282, 3836], 'unique': [741, 2418], 'combination': [742], 'create': [749], 'cell-type-': [751], 'agonist-specific': [753], 'suits': [757], 'physiological': [759], 'requirements': [760, 1797], '(Berridge': [761], '2000Berridge': [764], 'M.J.': [765, 2570], 'Lipp': [766], 'Bootman': [768], 'M.D.': [769, 3246, 4239, 4280], 'versatility': [771], 'universality': [773], 'signalling.Nat.': [776, 2314], 'Rev.': [777, 1259, 2315], 'Mol.': [778, 1939], 'Cell': [779, 1904, 4252, 4359], '1:': [782, 1541], '11-21Crossref': [783], '(4440)': [786], 'Scholar).': [788, 927, 1039, 1266, 1371, 1495, 1547, 1647, 1818, 1913, 1949, 2057, 2222, 2286, 2324, 2381, 2545, 2622, 2703, 2875, 3356, 3522, 3694, 3803, 3972, 4307], 'be': [799, 1190, 1867, 2071, 2495, 3889, 4315], 'tightly': [800], 'regulated': [801, 2169, 2230], 'because': [802, 1328], 'almost': [803, 1224], 'every': [804], 'aspect': [805, 2269], 'function': [808, 1427, 1683, 2139], 'controlled': [810], 'including': [813, 1061, 2188, 2250], 'secretion,': [814], 'gene': [815, 980, 985, 1303], 'expression,': [816], 'contraction,': [818], 'metabolism,': [820], 'unregulated': [823], 'would': [826, 1769], 'injury': [829], 'death': [832], '1B;': [834], 'Clapham,': [835], '2007Clapham': [836], 'D.E.': [837], 'Calcium': [838], 'signaling.Cell.': [839], '2007;': [840, 1364, 2317], '131:': [841], '1047-1058Abstract': [842], 'Full': [843, 845, 918, 920, 2277, 2279, 3002, 3004, 3196, 3198, 3408, 3410, 3513, 3515, 3685, 3687, 4207, 4209], 'Text': [844, 846, 919, 921, 2278, 2280, 3003, 3005, 3197, 3199, 3409, 3411, 3514, 3516, 3686, 3688, 4208, 4210], 'PDF': [847, 922, 2281, 3006, 3200, 3412, 3517, 3689, 4211], '(2957)': [850], 'Hajnóczky': [853], '2006Hajnóczky': [856], 'G.': [857, 859, 3210, 3542], 'Csordás': [858], 'Das': [860], 'S.': [861, 868, 1527, 2351, 2754, 3022, 3050, 3058, 3062, 3138, 3248, 3333, 3428, 3436, 3440, 4231, 4343], 'Garcia-Perez': [862], 'C.': [863, 965, 3060, 3091, 3260, 3438], 'Saotome': [864], 'Sinha': [866], 'Roy': [867], 'Yi': [869], 'Mitochondrial': [871, 1017], 'signalling': [873], 'death:': [876], 'assessing': [879], 'role': [881, 2574, 4095], 'uptake': [885], 'apoptosis.Cell': [887], 'Calcium.': [888], '2006;': [889], '40:': [890], '553-560Crossref': [891], '(489)': [894], 'Neher': [897], 'Sakaba,': [899], '2008Neher': [900], 'E.': [901], 'Sakaba': [902], 'T.': [903, 1472, 1624, 2037, 2797, 2841, 3097, 3171, 3173, 4192], 'Multiple': [904], 'roles': [905], 'ions': [908, 3871], 'neurotransmitter': [913], 'release.Neuron.': [914], '2008;': [915, 1942], '59:': [916], '861-872Abstract': [917], '(623)': [925], 'Furthermore,': [928], 'organelle-specific': [931], 'depend': [935, 2561], 'propagation': [937], 'into': [942, 1192, 1987, 2073, 3066, 3444], 'like': [945, 1160, 2398, 2928], 'nucleus,': [947], 'gene-regulatory': [949], 'events': [950], '(Zhang': [951, 1466, 1618], '2009Zhang': [954], 'S.J.': [955, 3222, 3554], 'Zou': [956], 'Lu': [958], 'Lau': [960], 'Ditzel': [962], 'D.A.': [963], 'Delucinge-Vivier': [964], 'Aso': [966], 'Y.': [967, 2349, 3048, 3426, 3768, 3770, 4268], 'Descombes': [968], 'Bading': [970], 'Nuclear': [972], 'expression': [976, 1304, 2394], 'large': [979], 'pool:': [981], 'identification': [982], 'program': [986], 'acquired': [988], 'neuroprotection': [989], 'induced': [990, 1435], 'synaptic': [992], 'activity.PLoS': [993], 'Genet.': [994], '5:': [996, 2697], 'e1000604Crossref': [997], '(229)': [1000], 'oxidative': [1008], 'metabolism': [1009], '(Griffiths': [1010], 'Rutter,': [1012], '2009Griffiths': [1013], 'E.J.': [1014], 'Rutter': [1015], 'G.A.': [1016], 'key': [1021, 3272], 'regulator': [1022], 'ATP': [1025, 1965], 'production': [1026], 'mammalian': [1028, 3150], 'cells.Biochim.': [1029], 'Biophys.': [1030], 'Acta.': [1031], '1787:': [1033], '1324-1333Crossref': [1034], '(255)': [1037], 'information': [1041, 3594], 'encoded': [1042], 'deciphered': [1048], 'Ca2+-binding': [1052, 1081, 1185, 1187, 1209, 1273, 1359, 1373, 2422, 2459, 3614, 4165], 'motifs.': [1053, 1875], 'effector': [1059, 1120, 1145], 'proteins,': [1060, 1197, 1676], 'channel': [1063, 2957, 3070, 3448, 3588, 3720, 3822, 3835, 3919, 4250, 4357], '(i.e.,': [1065, 1075, 2505], 'IP3R': [1066, 3162, 3525, 3607], 'RyR)': [1068], 'mediating': [1071], 'Ca2+-controlled': [1072], 'isocitrate': [1076], 'dehydrogenase': [1077], '[ICDH])': [1078], '2A).': [1080], 'also': [1084, 1154, 1831, 1866, 1999, 2340, 3896], 'couple': [1091], 'changes': [1092, 1434, 1988, 4154], 'wide': [1097, 1284, 1322, 2183], 'localization,': [1105], 'pattern': [1106], 'modulation,': [1108], 'source.': [1112], 'simply': [1116], 'associate': [1117], 'with': [1118, 1334, 1375, 1429, 1463, 1615, 1656, 1743, 1801, 1824, 1833, 1849, 1878, 2719, 4317], '(e.g.,': [1122, 1132, 1666, 1688, 2087, 2123, 2885, 2892], 'calmodulin': [1123, 1799], '[CaM]': [1124], 'troponin': [1126], 'C)': [1127], 'display': [1129], 'enzyme': [1130, 1777, 1981], 'calcineurin': [1133], 'calpain)': [1135], 'relay': [1137], 'effect': [1139], '(Figures': [1147], '2B': [1148], '2C,': [1150], 'respectively).': [1151, 1708], 'CaM': [1152, 1561, 1589, 1610, 1649, 1713, 1828, 1847, 1886, 2021, 2294], 'confer': [1155, 2716], 'sensitivity': [1157], 'enzymes': [1159, 1696, 1719, 1745, 1922, 2024], 'Ca2+/CaM-dependent': [1162], 'protein': [1163, 1554, 1805, 1937, 1976, 2048, 2161, 2481, 2533, 2736, 2769, 2893, 4119, 4149], 'kinase': [1164, 1952, 2089, 2737, 2770, 2894], '(CaMK)': [1165], 'phosphorylates': [1167], 'many': [1168, 1916, 2104, 3975], 'effectors': [1169], 'alter': [1173], '2D).': [1177], 'Depending': [1178, 2058], 'loop': [1181, 1215, 2709], 'geometry': [1182], 'site(s),': [1186], 'classified': [1191, 2072], 'three': [1193], 'families:': [1194], 'EF-hand': [1196, 1206, 1267, 1332, 1361, 1571, 1586, 1892, 2236, 3365, 3708, 3778, 4166], 'annexins,': [1199], 'C2': [1202, 2413, 2646, 2687, 2717, 2732, 2766, 2826, 2857], 'domain': [1203, 2414, 2647, 2662, 2688, 2767, 2810, 2827, 2861, 2946, 3185, 3370, 3477, 3615, 3633, 3881, 4167, 4347], 'denotes': [1207], 'motif': [1210], 'contains': [1212], 'Ca2+-coordinated': [1214], 'flanked': [1218], 'two': [1220, 1563, 2074, 2485, 3853, 3869], 'α': [1221, 2672], 'helices': [1222, 2673], 'orientated': [1223], 'perpendicular': [1225], 'one': [1227, 1924, 2119], 'another.': [1228], 'bound': [1230], 'ion': [1232, 2926], 'coordinated': [1234], 'seven': [1236, 2475], 'ligands': [1237], '(primarily': [1238], 'carboxylate)': [1239], 'pentagonal': [1242], 'bipyramid': [1243], 'arrangement': [1244], '(Strynadka': [1245], 'James,': [1247], '1989Strynadka': [1248], 'N.C.': [1249], 'James': [1250], 'M.N.': [1251, 1935], 'Crystal': [1252, 3178], 'structures': [1253, 2908], 'helix-loop-helix': [1256, 1360, 2468], 'calcium-binding': [1257, 2689, 2762], 'proteins.Annu.': [1258], 'Biochem.': [1260], '1989;': [1261, 2584], '58:': [1262], '951-998Crossref': [1263], 'domains': [1268, 1333, 1587, 2718, 2733, 3273, 3366, 3585, 3709], 'most': [1271], 'common': [1272], 'found': [1275, 4313], 'range': [1285, 1323, 1782, 3988], 'buffering': [1294, 1533], 'cytoplasm,': [1297], 'transduction': [1299, 1531, 2891], 'compartments,': [1301], 'nucleus': [1307], '1B).': [1309, 2457], 'diversity': [1311, 2310], 'biological': [1313, 2186, 2248], 'carried': [1315], 'out': [1316], 'possible': [1327], 'binds': [1330, 2503, 2830], 'affinities,': [1336], 'extending': [1337], '10−6': [1339], 'M': [1340, 1343, 1408, 1411], '10−3': [1342], '(Gifford': [1344], '2007Gifford': [1347], 'J.L.': [1348], 'Walsh': [1349], 'Vogel': [1351], 'H.J.': [1352], 'Structures': [1353], 'metal-ion-binding': [1355], 'motifs.Biochem.': [1362], '405:': [1365], '199-221Crossref': [1366], '(652)': [1369], 'Some': [1372, 2325], 'relatively': [1376], 'behave': [1379], 'buffer': [1382, 1500], 'modulate': [1385], 'shape': [1387], 'and/or': [1388], 'duration': [1389], 'signals': [1392, 1986, 2032], 'help': [1394], 'homeostasis.': [1397], 'In': [1398, 1709, 1819, 2113, 2623, 3804], 'contrast,': [1399, 2114], 'having': [1402], 'constants': [1404], 'ranging': [1405], '10−5': [1407], '10−7': [1410], 'detect': [1413, 2026], 'physiologically': [1418], 'relevant': [1419], 'change': [1420, 1450], '[Ca2+].': [1423], 'differences': [1425, 1430], 'correlate': [1428], 'conformational': [1433, 1449, 1476, 1628, 1860, 3025], 'binding.': [1438], 'EF-hands': [1442, 3628, 3644], 'sensor': [1445, 2299, 2307, 3851, 4197, 4285], 'induces': [1447], 'significant': [1454, 1593], 'opening': [1455, 1594], 'structure': [1458, 1482, 1634, 2659, 3179, 3526, 3957], 'permits': [1460], 'interaction': [1462, 1714, 1800, 1823, 1848, 1864], 'downstream': [1464, 1616, 1825, 1917, 2061, 2085, 2105, 2121], '1995Zhang': [1469, 1621], 'Tanaka': [1471, 1623], 'Ikura': [1473, 1625, 3176, 3263], 'Calcium-induced': [1475, 1627], 'transition': [1477, 1629], 'solution': [1481, 1633], 'apo': [1484, 1636], 'calmodulin.Nat.': [1485, 1637], 'Struct.': [1486, 1538, 1638, 2536], '1995;': [1488, 1640, 2538], '2:': [1489, 1641, 2539], '758-767Crossref': [1490, 1642], '(651)': [1493, 1645], 'On': [1496, 2223], 'contrary,': [1498], 'stay': [1502], '"closed"': [1505], 'conformation': [1506], 'upon': [1507], 'Ca2+-free': [1515, 1827, 3814], 'state': [1516, 1992], '(Skelton': [1517], '1994Skelton': [1520], 'N.J.': [1521], 'Kördel': [1522], 'Akke': [1524], 'Forsén': [1526], 'Chazin': [1528], 'W.J.': [1529], 'Signal': [1530], 'versus': [1532], 'Ca(2+)-binding': [1536], 'proteins.Nat.': [1537], '1994;': [1540], '239-245Crossref': [1542], '(148)': [1545], 'A': [1548, 2267, 2573, 4036], 'ubiquitously': [1549], 'expressed': [1550, 2330, 2341], 'well': [1552], 'CaM.': [1560, 2176], 'globular': [1564], 'domains,': [1565], 'each': [1566, 1583], 'containing': [1567], 'pair': [1569, 3363, 3626, 4163], 'motifs,': [1572, 1877], 'connected': [1573, 3890], 'central': [1576, 1607, 3369, 3632, 3878], 'helix.': [1577], 'Activation': [1578, 3788], 'causes': [1582], 'undergo': [1591], 'structure.': [1597], 'As': [1598, 1950, 2439], 'result,': [1600, 2441], 'hydrophobic': [1602], 'sites': [1604, 1872, 1884, 2423, 2460, 2477, 2487, 2763, 3464], 'within': [1605, 1779, 1975, 2140, 3741, 4053], 'helix': [1608], 'interact': [1614, 1651, 1742, 1832], 'Ca2+-activated': [1648, 3289], '(Ca2+/CaM)': [1650], 'Ca2+-dependent': [1654, 1686, 2804], 'manner': [1655, 1687, 1841], 'target': [1659, 1675, 1718, 1744, 1834, 1851, 1996, 2122], 'enzymes,': [1660], 'leading': [1661], 'own': [1664], 'CaMK': [1667, 1705, 1921, 1954, 1998, 2017, 2088], 'calcineurin),': [1669], 'Orai;': [1689], 'Figure': [1690], '3B).': [1691, 4092], 'CaM-dependent': [1693, 1980], 'may': [1697], 'occur': [1698, 1721], 'direct': [1700], 'sequential': [1702, 1728], '(e.g.': [1704], 'calcineurin,': [1707], 'first': [1711], 'case,': [1712, 2656], 'only': [1720, 1855, 2118, 2471, 3593], 'whereas,': [1725], 'mechanism,': [1729], 'partial': [1730], 'CaM,': [1734, 1920, 2007], 'conditions,': [1738, 4310], 'enough': [1740], 'form': [1747], 'inactive': [1749], 'low-affinity': [1750, 4027], 'complex.': [1751], 'activation,': [1754], 'complex': [1756], 'requires': [1757], 'further': [1758], "CaM's": [1763], 'EF': [1764], 'hands.': [1765], 'mechanism': [1768, 2524, 3027], 'provide': [1770, 1882, 2401, 2447, 4022], 'sensitive': [1772], 'switch': [1773, 3026], 'narrow': [1781], '(Kincaid': [1786], 'Vaughan,': [1788], '1986Kincaid': [1789], 'R.L.': [1790], 'Vaughan': [1791], 'Direct': [1793], 'comparison': [1794], 'phosphatase.Proc.': [1806], 'Natl.': [1807], 'Acad.': [1808], 'Sci.': [1809, 1941, 2695], 'USA.': [1810], '1986;': [1811], '83:': [1812], '1193-1197Crossref': [1813], '(31)': [1816], 'addition': [1820], 'Ca2+/CaM': [1822], 'targets,': [1826], '(apo-CaM)': [1829], 'reversible': [1838], 'irreversible': [1840], 'regulate': [1843, 2365, 3860, 4355], 'activities.': [1845], 'Therefore,': [1846, 1978, 3910], 'not': [1854, 2464, 3646, 3715], 'facilitated': [1856], 'Ca2+-induced': [1859], 'change,': [1861], 'mediated': [1868], 'Ca2+-independent': [1870], 'called': [1873], 'IQ': [1874], 'sequence': [1880, 3601, 3705], 'IQXXXRGXXXR,': [1881], '(Cheney': [1894], 'Mooseker,': [1896], '1992Cheney': [1897], 'R.E.': [1898], 'Mooseker': [1899], 'M.S.': [1900, 4341], 'Unconventional': [1901], 'myosins.Curr.': [1902], 'Opin.': [1903], '4:': [1907], '27-35Crossref': [1908], '(336)': [1911], 'Among': [1914, 4138], 'best': [1927], '(Swulius': [1929], 'Waxham,': [1931], '2008Swulius': [1932], 'M.T.': [1933], 'Waxham': [1934], 'Ca(2+)/calmodulin-dependent': [1936], 'kinases.Cell.': [1938], 'Life': [1940], '65:': [1943], '2637-2657Crossref': [1944], '(235)': [1947, 2589], 'enzyme,': [1953], 'catalyzes': [1955], 'transfer': [1957], 'phosphate': [1959], 'gamma': [1962], 'position': [1963], 'hydroxyl': [1968], 'group': [1969, 2528, 2747], 'Ser,': [1971], 'Thr,': [1972], 'Tyr': [1974], 'substrates.': [1977], 'transduces': [1982], 'phosphorylation': [1991], 'performs': [2000], 'autophosphorylation': [2001], 'thus': [2008, 3640], 'association': [2012], '[Ca2+]c.': [2015, 4035], 'capacity': [2018], 'trap': [2020], 'enables': [2022], 'frequency': [2028], '(Meyer': [2033], '1992Meyer': [2036], 'Hanson': [2038], 'P.I.': [2039], 'Stryer': [2040], 'Schulman': [2042], 'Calmodulin': [2044], 'trapping': [2045], 'calcium-calmodulin-dependent': [2047], 'kinase.Science.': [2049], '256:': [2051], '1199-1202Crossref': [2052], '(513)': [2055], 'CaMK,': [2064], 'members': [2066, 2335], 'classes:': [2075], 'multifunctional': [2076], 'kinases': [2077, 2082, 2116], 'substrate-specific': [2079, 2115], 'kinases.': [2080], 'Multifunctional': [2081], '[CaMKK],': [2090], 'CaMKI,': [2091], 'CaMKII,': [2092], 'CaMKIV),': [2094], 'lead': [2099], 'affects': [2103, 2159], 'pathways': [2106, 2407], 'controlling': [2107], 'functions.': [2112, 2392, 3978], 'CaMKIII,': [2124], 'phosphorylase': [2125], 'kinase,': [2126], 'myosin': [2129], 'light-chain': [2130], 'kinases),': [2131], 'they': [2134, 2146], 'tissue': [2144], 'where': [2145], 'expressed.': [2148], 'Calcineurin': [2149, 2167, 2177, 2203], 'calpain': [2151, 2227, 2241, 2271], 'directly': [2153, 2173], 'bind': [2154, 2742], 'phosphatase': [2162], 'protease': [2164], 'function,': [2165], 'respectively.': [2166], 'both': [2172, 3341, 3892], 'implicated': [2180, 2385], 'responses,': [2187], 'lymphocyte': [2189], 'neuronal': [2192, 2297, 2312, 2391], 'development': [2195], '(Schulz': [2196], 'Yutzey,': [2198], '2004Schulz': [2199], 'R.A.': [2200, 2984, 3136, 3390, 3495, 3667], 'Yutzey': [2201], 'K.E.': [2202, 3335], 'NFAT': [2206], 'cardiovascular': [2209], 'skeletal': [2211, 3743], 'development.Dev.': [2213], '2004;': [2215, 3750], '266:': [2216], '1-16Crossref': [2217], '(236)': [2220], 'hand,': [2226], 'uniquely': [2229, 2329], 'domains.': [2237], 'Members': [2238], 'processes,': [2249], 'integrin-mediated': [2251], 'migration,': [2253], 'cytoskeletal': [2254], 'remodeling,': [2255], 'differentiation,': [2257], 'apoptosis': [2259], '(Suzuki': [2260], 'Sorimachi,': [2262], '1998Suzuki': [2263], 'K.': [2264, 2799, 3175, 3325, 4227], 'Sorimachi': [2265], 'novel': [2268], 'activation.FEBS': [2272], 'Lett.': [2273], '1998;': [2274, 2868], '433:': [2275], '1-4Abstract': [2276], '(140)': [2284], 'Emerging': [2287], 'literature': [2288], 'highlights': [2289], 'sub-branch': [2291], 'family,': [2295], '(NCS)': [2300], '(Burgoyne,': [2302], '2007Burgoyne': [2303], 'R.D.': [2304, 2572], 'Neuronal': [2305, 2358], 'proteins:': [2308], 'generating': [2309], '8:': [2318], '182-193Crossref': [2319], '(418)': [2322], 'NCS': [2326, 2382, 2399], 'neurons,': [2332], 'whereas': [2333, 2634, 2824, 3624], '(such': [2336], 'NCS-1)': [2338], 'tissues': [2344], '(Kapp-Barnea': [2345], '2003Kapp-Barnea': [2348], 'Melnikov': [2350], 'Shefler': [2352], 'I.': [2353, 3167], 'Jeromin': [2354], 'A.': [2355, 2974, 3018, 3134, 3327, 3380, 3485, 3657, 4331], 'Sagi-Eisenberg': [2356], 'sensor-1': [2360], 'phosphatidylinositol': [2362], '4-kinase': [2363], 'beta': [2364], 'IgE': [2366], 'receptor-triggered': [2367], 'exocytosis': [2368, 2559, 2579], 'cultured': [2370], 'mast': [2371], 'cells.J.': [2372], 'Immunol.': [2373], '2003;': [2374, 2615], '171:': [2375], '5320-5327Crossref': [2376], '(36)': [2379], 'several': [2390], 'Tissue-specific': [2393], 'selective': [2403], 'paradigms.': [2410], 'Annexins': [2411], 'architecture': [2419, 3582], 'allows': [2425, 2915], 'peripherally': [2428], 'dock': [2429], 'onto': [2430], 'negatively': [2431], 'charged': [2432], 'surfaces': [2434], 'Ca2+-bound': [2437, 3812], 'conformation.': [2438], 'families': [2443], 'considered': [2445], 'link': [2449], 'annexins': [2462], 'do': [2463], 'EF-hand-type': [2467], 'structure,': [2469], 'five': [2472], 'coordination': [2476, 2486], 'provided': [2479, 2489], 'oxygen.': [2482], 'water': [2491], 'replaced': [2496], 'phosphoryl': [2498], 'groups': [2499], 'when': [2500], 'annexin': [2502, 2534, 2563, 2625, 2635, 2677], 'lipid': [2504, 2859], 'Ca2+-': [2506], 'phospholipid-binding': [2508, 2651], 'motif)': [2509], '(Swairjo': [2510], '1995Swairjo': [2513], 'M.A.': [2514, 2518], 'Concha': [2515], 'N.O.': [2516], 'Kaetzel': [2517], 'Dedman': [2519], 'J.R.': [2520], 'Seaton': [2521], 'B.A.': [2522], 'Ca(2+)-bridging': [2523], 'phospholipid': [2526, 2805], 'head': [2527, 2746], 'recognition': [2529], 'membrane-binding': [2532], 'V.Nat.': [2535], '968-974Crossref': [2540], '(281)': [2543], 'Knockout': [2546], 'knockdown': [2548], 'multiples': [2553], 'steps': [2554], 'endocytosis': [2557], 'process': [2560, 4065], '(Ali': [2564], '1989Ali': [2567], 'S.M.': [2568], 'Geisow': [2569], 'Burgoyne': [2571], 'calpactin': [2576], 'calcium-dependent': [2578, 2858], 'adrenal': [2581], 'chromaffin': [2582], 'cells.Nature.': [2583], '340:': [2585], '313-315Crossref': [2586], 'Mayran': [2592], '2003Mayran': [2595], 'N.': [2596, 2943, 3250], 'Parton': [2597], 'R.G.': [2598, 3016], 'Gruenberg': [2599], 'Annexin': [2601], 'II': [2602], 'regulates': [2603, 3974], 'multivesicular': [2604], 'endosome': [2605], 'biogenesis': [2606], 'degradation': [2609], 'pathway': [2610, 3917], 'animal': [2612], 'cells.EMBO': [2613], '22:': [2616], '3242-3253Crossref': [2617], '(170)': [2620], 'particular,': [2624], '2': [2626], '13': [2628], 'endocytosis,': [2633], '1,': [2636], '2,': [2637], '6': [2639], 'exocytosis.': [2644], 'another': [2649], 'Ca2+-and': [2650], 'motif,': [2652], 'but,': [2653], 'core': [2658, 2715], 'based': [2664], 'entirely': [2665], 'β': [2667, 2713], 'sheets': [2668], 'rather': [2669], '(characteristic': [2674], 'structure)': [2678], '(Nalefski': [2679, 2835], 'Falke,': [2681], '1996Nalefski': [2682], 'E.A.': [2683, 2839], 'Falke': [2684, 2846], 'J.J.': [2685, 2847], 'motif:': [2690], 'structural': [2691, 2920], 'functional': [2693, 3269], 'diversity.Protein': [2694], '1996;': [2696, 2816], '2375-2390Crossref': [2698], '(689)': [2701], 'Slight': [2704], 'variations': [2705], 'interconnecting': [2708], 'residues': [2710], 'sandwich': [2714], 'abilities': [2721], 'concentrations': [2727], 'lipids.': [2729], 'instance,': [2731], 'classical': [2735], 'C': [2738, 2895], 'synaptotagmins': [2741, 2886], 'anionic': [2745], 'phosphatidylserine': [2749], '(Corbalán-García': [2750], '1999Corbalán-García': [2753], 'Rodríguez-Alfaro': [2755], 'J.A.': [2756, 4235, 4272], 'Gómez-Fernández': [2757], 'J.C.': [2758], 'Determination': [2759], 'Calpha': [2771], 'critical': [2774], 'translocation': [2777], 'membrane.Biochem.': [2781], '1999;': [2783], '337:': [2784], '513-521Crossref': [2785], '(60)': [2788], 'Fukuda': [2791], '1996Fukuda': [2794], 'Kojima': [2796], 'Mikoshiba': [2798, 3174], 'Phospholipid': [2800], 'composition': [2801], 'dependence': [2802], 'C2A': [2809], 'synaptotagmin': [2812], 'IV.J.': [2813], '271:': [2817], '8430-8434Crossref': [2818], '(94)': [2821], 'cPLA2': [2829], 'neutral': [2833], 'phosphatidylcholine': [2834], '1998Nalefski': [2838], 'McDonagh': [2840], 'Somers': [2842], 'W.': [2843, 3099, 3220, 3552, 3729, 3762], 'Seehra': [2844], 'Clark': [2848], 'J.D.': [2849, 3727], 'Independent': [2850], 'folding': [2851, 4120], 'ligand': [2853, 3182], 'specificity': [2854], 'cytosolic': [2863], 'phospholipase': [2864], 'A2.J.': [2865], '273:': [2869], '1365-1372Crossref': [2870], '(113)': [2873], 'involved': [2881, 3647], 'trafficking': [2884], 'E-synaptotagmins)': [2888], 'isoforms).': [2896], 'Recent': [2897], 'cryoelectron': [2900], 'microscopy': [2901], '(cryo-EM)': [2902], 'enabled': [2904], 'high-resolution': [2905], 'determination': [2906], 'resisted': [2910], 'X-ray': [2911], 'crystallography.': [2912], 'cryo-EM': [2913, 3360], 'technologies': [2914], 'illumination': [2917], 'aspects': [2921], 'RyR': [2930, 3605], '(Bai': [2931], '2016Bai': [2934], 'X.C.': [2935, 3089], 'Yan': [2936, 2942, 3083, 3090], 'Z.': [2937, 2941, 3087, 3095, 3214, 3546, 3766], 'Wu': [2938, 3092], 'Li': [2940, 3061, 3094, 3102, 3259, 3439], 'Central': [2945], 'RyR1': [2948, 3113, 3372, 3621, 3635, 3713], 'transducer': [2951], 'long-range': [2953, 3068, 3446], 'allosteric': [2954, 3069, 3447], 'gating': [2955, 2994, 3071, 3305, 3400, 3449, 3505, 3677, 3823, 3933], 'opening.Cell': [2958], 'Res.': [2959, 3074, 3452], '2016;': [2960, 2999, 3075, 3405, 3453, 3510, 3682, 3796], '26:': [2961, 3076, 3454], '995-1006Crossref': [2962], '(76)': [2965], 'des': [2968, 3132], 'Georges': [2969, 2973, 3133, 3375, 3379, 3480, 3484, 3652, 3656], '2016des': [2972, 3378, 3483, 3655], 'Clarke': [2975, 3130, 3381, 3486, 3658], 'O.B.': [2976, 3131, 3382, 3487, 3659], 'Zalk': [2977, 3125, 3383, 3488, 3660], 'Yuan': [2979, 3385, 3490, 3662, 4338], 'Q.': [2980, 3054, 3386, 3432, 3491, 3663], 'Condon': [2981, 3387, 3492, 3664], 'K.J.': [2982, 3388, 3493, 3665], 'Grassucci': [2983, 3135, 3389, 3494, 3666], 'Hendrickson': [2985, 3141, 3391, 3496, 3668], 'W.A.': [2986, 3142, 3392, 3497, 3669], 'Marks': [2987, 3145, 3393, 3498, 3670], 'A.R.': [2988, 3146, 3394, 3499, 3671], 'Frank': [2989, 3143, 3395, 3500, 3672], 'Structural': [2991, 3267, 3302, 3397, 3502, 3674, 3930], 'basis': [2992, 3303, 3398, 3503, 3675, 3820, 3931], 'RyR1.Cell.': [2998, 3404, 3509, 3681], '167:': [3000, 3406, 3511, 3683], '145-157.e17Abstract': [3001, 3407, 3512, 3684], '(231)': [3009, 3415, 3520, 3692], 'Efremov': [3012], '2015Efremov': [3015], 'Leitner': [3017], 'Aebersold': [3019], 'Raunser': [3021], 'Architecture': [3023], 'receptor.Nature.': [3031, 3152], '2015;': [3032, 3117, 3153, 3234, 3566], '517:': [3033, 3118, 3154], '39-43Crossref': [3034], '(234)': [3037], 'Wei': [3040, 3418], '2016Wei': [3043, 3421], 'Wang': [3045, 3213, 3423, 3545, 3769, 3773], 'X.': [3046, 3056, 3103, 3299, 3424, 3434, 3927, 3951], 'Zhang': [3047, 3051, 3425, 3429, 3771, 4230, 4262], 'Mukherjee': [3049, 3427], 'Chen': [3053, 3431, 3775], 'Huang': [3055, 3433], 'Jing': [3057, 3435], 'Liu': [3059, 3437, 3767], 'al.Structural': [3064, 3442], 'insights': [3065, 3443], 'Ca(2+)-activated': [3067, 3308, 3445, 3936, 3962], 'RyR1.Cell': [3073, 3451], '977-994Crossref': [3077, 3455], '(66)': [3080, 3458], '2015Yan': [3086], 'Bai': [3088], 'Xie': [3096], 'Peng': [3098], 'Yin': [3100], 'C.C.': [3101], 'Scheres': [3104], 'S.H.': [3105], 'al.Structure': [3107], 'rabbit': [3110], 'near-atomic': [3115, 3535], 'resolution.Nature.': [3116], '50-55Crossref': [3119], '(321)': [3122], '2015Zalk': [3128], 'Reiken': [3137], 'Mancia': [3139], 'F.': [3140, 3331], 'Structure': [3147], '44-49Crossref': [3155], '(292)': [3158], '(Bosanac': [3163], '2005Bosanac': [3166], 'Yamazaki': [3168], 'Matsu-Ura': [3170], 'Michikawa': [3172], 'suppressor': [3184], 'inositol': [3189], '1,4,5-trisphosphate': [3190], 'receptor.Mol.': [3191], 'Cell.': [3192], '2005;': [3193, 4204, 4254, 4300], '17:': [3194], '193-203Abstract': [3195], '(138)': [3203], 'Fan': [3206], '2015Fan': [3209, 3541], 'Baker': [3211, 3215, 3543, 3547], 'M.L.': [3212, 3544, 4181], 'M.R.': [3216, 3548], 'Sinyagovskiy': [3217, 3549], 'P.A.': [3218, 3550], 'Chiu': [3219, 3551], 'Ludtke': [3221, 3553], 'Serysheva': [3223, 3555], 'I.I.': [3224, 3556], 'Gating': [3225, 3557], 'machinery': [3226, 3558, 4130], 'InsP3R': [3228, 3560], 'electron': [3232, 3564], 'cryomicroscopy.Nature.': [3233, 3565], '527:': [3235, 3567], '336-341Crossref': [3236, 3568], '(153)': [3239, 3571], 'Seo': [3242], '2012Seo': [3245], 'Velamakanni': [3247], 'Ishiyama': [3249], 'Stathopulos': [3251], 'P.B.': [3252], 'Rossi': [3253], 'A.M.': [3254], 'Khan': [3255], 'S.A.': [3256], 'Dale': [3257], 'Ames': [3261], 'J.B.': [3262], 'Taylor': [3265], 'C.W.': [3266], 'conservation': [3270, 3602], 'InsP3': [3275], 'receptors.Nature.': [3278], '2012;': [3279], '483:': [3280], '108-112Crossref': [3281], '(141)': [3284], 'K+': [3290, 3856, 3864], '(BK)': [3291], '(Hite': [3293, 3921], '2017Hite': [3296, 3924], 'R.K.': [3297, 3925, 3953], 'Tao': [3298, 3926, 3947], 'MacKinnon': [3300, 3928, 3954], 'high-conductance': [3307, 3935, 3961], 'K(+)': [3309, 3937, 3963], 'channel.Nature.': [3310, 3938, 3964], '2017;': [3311, 3939, 3965], '541:': [3312, 3940, 3966], '52-57Crossref': [3313, 3941], '(105)': [3316, 3944], 'Russo': [3319], '2009Russo': [3322], 'G.J.': [3323], 'Louie': [3324], 'Wellington': [3326], 'Macleod': [3328], 'G.T.': [3329], 'Hu': [3330], 'Panchumarthi': [3332], 'Zinsmaier': [3334], 'Drosophila': [3336], 'Miro': [3337], 'required': [3339], 'anterograde': [3342], 'retrograde': [3344], 'axonal': [3345], 'transport.J.': [3347], '29:': [3350], '5443-5455Crossref': [3351], '(162)': [3354], 'Studies': [3357], 'using': [3358], 'single-particle': [3359], '(4060–4134)': [3373], '(des': [3374, 3479, 3651], 'modulator': [3462], 'ATP,': [3467], 'caffeine': [3469], 'interdomain': [3472], 'interfaces': [3473, 4058], 'C-terminal': [3476, 3619], '(4957–5037)': [3478], 'Although': [3523, 4000], 'apo-state': [3529], 'recently': [3532, 4136], 'elucidated': [3533], '(4.7-Å)': [3536], 'resolution': [3537], '(Fan': [3538], 'more': [3574], 'studies': [3575, 3806], 'needed': [3577], 'define': [3579], 'molecular': [3581, 3819, 4129], 'gating.': [3589], 'To': [3590, 3979], 'date,': [3591], 'available': [3595], 'given': [3597], 'mapping': [3599], 'across': [3603, 4075], 'family.': [3608], 'analysis': [3610, 3735], 'described': [3616], 'conserved,': [3623], 'located': [3629, 3897, 3906], 'absent': [3637], 'IP3R,': [3639], 'suggesting': [3641], 'hypothesis': [3696], 'fact': [3701], 'deletion': [3703], 'scrambling': [3706], 'RyR2': [3711], 'did': [3714], 'affect': [3716], '(Fessenden': [3723], '2004Fessenden': [3726], 'Feng': [3728], 'Pessah': [3730], 'I.N.': [3731], 'Allen': [3732], 'P.D.': [3733], 'Mutational': [3734], 'putative': [3737], 'isoform,': [3746], 'RyR1.J.': [3747], '279:': [3751], '53028-53035Crossref': [3752], '(46)': [3755], 'Guo': [3758], '2016Guo': [3761], 'Sun': [3763], 'B.': [3764], 'Xiao': [3765], 'S.R.': [3776], 'Binding': [3780], 'Domain': [3781], 'Is': [3782], 'Not': [3783], 'Required': [3784], 'Cytosolic': [3786], 'Cardiac': [3791], 'Ryanodine': [3792], 'Receptor.J.': [3793], '291:': [3797], '2150-2160Crossref': [3798], '(35)': [3801], 'addition,': [3805], 'BK': [3808], 'states': [3815], 'voltage': [3825, 3894], 'Ca2+.': [3827], 'At': [3828], 'level': [3830], 'sensing,': [3833], '"gating': [3838], 'ring"': [3839], 'formed': [3845], 'four': [3847], 'sensors.': [3849, 3999], 'includes': [3852], 'regulators': [3854], 'conductance': [3857, 3862], '(RCK)': [3858], 'Mg2+': [3874], 'ion.': [3875], 'Moreover,': [3876], 'pore': [3879], 'gate': [3880], '(located': [3882], 'transmembrane': [3885, 3900, 4148], 'domain)': [3886], 'appeared': [3887], 'sensors,': [3895, 3905], 'domain,': [3901], 'data': [3912], 'suggest': [3913], 'shared': [3916], '2017Tao': [3950], 'Hite': [3952], 'Cryo-EM': [3956], '46-51Crossref': [3967], '(139)': [3970], 'achieve': [3980], 'versatility,': [3982], 'displays': [3986], 'spatial': [3990], 'temporal': [3992], 'patterns': [3993], 'differently': [3995], 'bulk': [4002], 'peaks': [4004], 'around': [4006], 'μM,': [4008], 'close': [4009], 'reach': [4017], '10–100': [4018], 'μM.': [4019], '"nanodomains"': [4021], 'meaningful': [4024], 'unresponsive': [4030], 'fluctuations': [4032], 'global': [4034], 'major': [4037], 'direction': [4038], 'focused': [4048], 'detection': [4050], '3A).': [4060], 'An': [4061], 'example': [4062], 'store-operated': [4068, 4248], 'entry': [4070], '(SOCE),': [4071], 'whereby': [4072], 'response': [4082], 'decrease': [4085], 'ER': [4088, 4123, 4147, 4157, 4173], 'content': [4090], 'SOCE': [4097, 4133], 'refill': [4100], 'stores': [4104], 'primary': [4108], 'source': [4109], 'mobilization': [4113], 'favorable': [4116], 'environment': [4117], 'lumen.': [4124], 'Essential': [4125], 'components': [4126], 'responsible': [4131, 4150], 'discovered.': [4137], 'them,': [4139], 'STIM1': [4140, 4281, 4311, 4345], '(and': [4141], 'STIM2': [4143], 'isoform)': [4144], 'luminal': [4158], '([Ca2+]ER)': [4160], 'lumen': [4174], '(Liou': [4175], '2005Liou': [4178], 'Kim': [4180, 4340], 'Heo': [4182], 'W.D.': [4183], 'Jones': [4184], 'J.T.': [4185], 'Myers': [4186], 'J.W.': [4187], 'Ferrell': [4188], 'Jr.,': [4189], 'J.E.': [4190], 'Meyer': [4191], 'STIM': [4193], 'essential': [4198, 4243], 'Ca2+-store-depletion-triggered': [4200], 'influx.Curr.': [4202], '15:': [4205], '1235-1241Abstract': [4206], '(1751)': [4214], 'Roos': [4217, 4269], '2005Roos': [4220], 'DiGregorio': [4222], 'P.J.': [4223], 'Yeromin': [4224], 'A.V.': [4225], 'Ohlsen': [4226], 'Lioudyno': [4228], 'Safrina': [4232], 'O.': [4233], 'Kozak': [4234, 4271], 'Wagner': [4236], 'S.L.': [4237, 4266], 'Cahalan': [4238, 4279], 'al.STIM1,': [4241], 'conserved': [4245], 'component': [4246], 'function.J.': [4251, 4358], '169:': [4255], '435-445Crossref': [4256], '(1519)': [4259], '2005Zhang': [4265], 'Yu': [4267], 'Deerinck': [4273], 'T.J.': [4274], 'Ellisman': [4275], 'M.H.': [4276], 'Stauderman': [4277], 'K.A.': [4278], 'activates': [4287], 'CRAC': [4288], 'migrates': [4291], 'membrane.Nature.': [4299], '437:': [4301], '902-905Crossref': [4302], '(1133)': [4305], 'Under': [4308], 'associated': [4316], 'SOCE-associated': [4318], 'factor': [4320], '(SARAF),': [4321], 'prevents': [4323], 'spontaneous': [4325], '(Jha': [4327], '2013Jha': [4330], 'Ahuja': [4332], 'Maléth': [4334], 'Moreno': [4336], 'C.M.': [4337], 'J.P.': [4339], 'Muallem': [4342], 'CTID': [4346], 'determines': [4348], 'access': [4349], 'SARAF': [4351], 'SOAR': [4353], 'Orai1': [4356], '2013;': [4361], '202:': [4362], '71-79Crossref': [4363], 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