Real‐time detection of condensin‐driven <scp>DNA</scp> compaction reveals a multistep binding mechanism

Name: Work Video:
Duration: 3 min 30 s
Jorine M. Eeftens; S. Bisht; Jacob Kerssemakers; Marc Kschonsak; Christian H. Haering; Cees Dekker
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'Access': [3], 'Transparent': [4], 'process': [5, 474, 1080, 3579], 'Real-time': [6, 683], 'detection': [7, 684], 'of': [8, 24, 28, 33, 78, 82, 87, 172, 176, 181, 200, 204, 209, 254, 258, 263, 348, 352, 357, 389, 393, 398, 445, 460, 470, 501, 506, 542, 571, 587, 600, 679, 685, 709, 746, 776, 789, 796, 803, 832, 839, 884, 900, 911, 933, 959, 968, 1004, 1007, 1046, 1072, 1077, 1112, 1118, 1171, 1182, 1339, 1370, 1397, 1465, 1509, 1534, 1590, 1614, 1627, 1635, 1651, 1655, 1678, 1697, 1731, 1768, 1800, 1810, 1815, 1830, 1839, 1953, 1956, 1966, 1996, 2041, 2064, 2075, 2107, 2118, 2206, 2227, 2245, 2278, 2337, 2410, 2429, 2431, 2461, 2471, 2482, 2563, 2574, 2583, 2705, 2766, 2780, 2869, 2919, 2964, 2973, 2982, 3023, 3114, 3142, 3156, 3194, 3210, 3237, 3265, 3381, 3445, 3469, 3477, 3488, 3658, 3694, 3730, 3799, 3858, 3865, 3898, 4024, 4062, 4369, 4432, 4448, 4455, 4563, 4593, 4607], 'condensin-driven': [9, 1532, 2133], 'DNA': [10, 544, 562, 596, 638, 649, 657, 669, 686, 721, 728, 743, 754, 760, 1000, 1051, 1074, 1127, 1305, 1390, 1440, 1466, 1505, 1535, 1542, 1591, 1594, 1639, 1660, 1702, 1732, 1765, 1778, 1801, 1811, 1853, 1872, 1881, 1901, 1945, 1968, 1985, 1999, 2015, 2052, 2067, 2109, 2134, 2145, 2274, 2477, 2515, 2521, 2524, 2761, 2772, 2787, 2835, 2879, 2960, 2974, 3088, 3101, 3147, 3214, 3266, 3286, 3303, 3318, 3356, 3505, 3548, 3587, 3616, 3626, 3661, 3686, 3733, 3751, 3768, 3784, 3808, 3817, 3860, 3926, 3969, 3999, 4011, 4026, 4053, 4088, 4169, 4260, 4304, 4338, 4343, 4361, 4370, 4394, 4398, 4406, 4411, 4419, 4423, 4475, 4505, 4513, 4537, 4545, 4590, 4599, 4610], 'compaction': [11, 541, 555, 620, 670, 687, 755, 800, 1048, 1079, 1096, 1100, 1106, 1119, 1149, 1245, 1533, 1595, 1642, 1647, 1730, 1766, 1779, 1809, 1820, 1969, 1995, 2135, 2158, 2166, 2186, 2212, 2234, 2260, 2357, 2370, 2400, 2402, 2453, 2522, 2536, 2560, 2605, 2654, 2788, 2836, 2880, 3013, 3035, 3058, 3082, 3089, 3119, 3133, 3215, 3287, 3404, 3421, 3455, 3506, 3549, 3557, 3572, 3578, 3595, 3617, 3647, 3809, 3842, 3899, 3974, 4194, 4231, 4325, 4399, 4480, 4489, 4514, 4573], 'reveals': [12], 'a': [13, 468, 498, 565, 696, 837, 865, 909, 977, 1033, 1056, 1060, 1124, 1215, 1238, 1444, 1507, 1570, 1848, 1874, 1894, 1900, 1950, 1978, 2008, 2018, 2022, 2026, 2039, 2057, 2100, 2153, 2222, 2384, 2411, 2548, 2558, 2572, 2580, 2610, 2843, 2985, 3149, 3163, 3181, 3235, 3475, 3642, 3731, 3738, 3823, 4108, 4176, 4366, 4422, 4430], 'multistep': [14, 697], 'binding': [15, 663, 698, 744, 886, 1457, 1653, 1877, 1896, 2525, 3304, 3460, 3538, 3608], 'mechanism': [16, 524, 678, 1500, 1677, 1767], 'Jorine': [17, 20, 193, 196, 371], 'M': [18, 21, 194, 197, 372], 'Eeftens': [19, 22, 195, 198, 878], 'Department': [23, 77, 171, 199, 253, 347], 'Bionanoscience,': [25, 79, 173, 201, 255, 349, 390], 'Kavli': [26, 80, 174, 202, 256, 350, 391], 'Institute': [27, 81, 175, 203, 257, 351, 392], 'Nanoscience': [29, 83, 177, 205, 259, 353, 394], 'Delft,': [30, 35, 84, 89, 178, 183, 206, 211, 260, 265, 354, 359, 395, 400], 'Delft': [31, 85, 179, 207, 261, 355, 396], 'University': [32, 86, 180, 208, 262, 356, 397], 'Technology,': [34, 88, 182, 210, 264, 358, 399], 'The': [36, 90, 184, 212, 266, 360, 401, 438, 659, 773, 830, 882, 897, 921, 966, 1020, 1084, 1099, 1147, 1220, 1243, 1257, 1491, 1561, 1819, 2452, 2696, 2715, 2727, 3038, 3099, 3867, 3941, 3982, 4002, 4010, 4043, 4104, 4172, 4197, 4216], 'Netherlands': [37, 91, 185, 213, 267, 361, 402], 'Search': [38, 66, 92, 120, 155, 186, 214, 242, 268, 296, 331, 362], 'for': [39, 67, 93, 121, 156, 187, 215, 243, 269, 297, 332, 363, 513, 610, 617, 667, 675, 695, 1094, 1367, 1530, 1669, 1690, 1963, 2185, 2322, 2340, 2579, 2656, 2691, 2718, 2731, 2774, 2897, 2941, 3118, 3191, 3225, 3275, 3403, 3614, 3765, 3826, 3907, 4540], 'more': [40, 68, 94, 122, 157, 188, 216, 244, 270, 298, 333, 364, 4568], 'papers': [41, 69, 95, 123, 158, 189, 217, 245, 271, 299, 334, 365], 'by': [42, 70, 96, 124, 159, 190, 218, 246, 272, 300, 335, 366, 546, 580, 604, 688, 768, 823, 836, 889, 908, 1104, 1311, 1355, 1413, 1443, 1501, 1733, 1745, 1781, 1885, 2001, 2530, 3090, 3262, 3463, 3518, 3580, 3583, 3640, 3814, 3849, 4420, 4518, 4591], 'this': [43, 71, 97, 125, 160, 191, 219, 247, 273, 301, 336, 367, 446, 1456, 2392, 2617, 2790, 2952, 3207, 3279, 3297, 3543, 3593, 3709, 4250], 'author': [44, 72, 98, 126, 161, 192, 220, 248, 274, 302, 337, 368, 482], 'Shveta': [45, 47, 221, 223, 374], 'Bisht': [46, 48, 222, 224], 'Cell': [49, 103, 138, 225, 279, 314], 'Biology': [50, 57, 61, 104, 111, 115, 139, 146, 150, 226, 233, 237, 280, 287, 291, 315, 322, 326, 404, 411, 415], 'and': [51, 55, 105, 109, 140, 144, 227, 231, 281, 285, 316, 320, 384, 405, 409, 463, 481, 515, 616, 781, 801, 841, 864, 887, 903, 945, 952, 987, 992, 1013, 1027, 1039, 1059, 1065, 1110, 1137, 1201, 1315, 1336, 1387, 1451, 1454, 1512, 1675, 1694, 1744, 1797, 1817, 1827, 1832, 1906, 1970, 2021, 2046, 2086, 2242, 2253, 2331, 2373, 2526, 2543, 2571, 2668, 2681, 2693, 2699, 2722, 2811, 2855, 2876, 3012, 3030, 3051, 3056, 3077, 3081, 3310, 3413, 3461, 3466, 3491, 3512, 3552, 3609, 3664, 3673, 3876, 3900, 3918, 3924, 3953, 3975, 3992, 3997, 4016, 4051, 4102, 4119, 4139, 4159, 4167, 4192, 4208, 4224, 4249, 4291, 4347, 4477, 4604], 'Biophysics': [52, 106, 141, 228, 282, 317, 406], 'Unit,': [53, 58, 107, 112, 142, 147, 229, 234, 283, 288, 318, 323, 407, 412], 'Structural': [54, 108, 143, 230, 284, 319, 408], 'Computational': [56, 110, 145, 232, 286, 321, 410], 'European': [59, 113, 148, 235, 289, 324, 413], 'Molecular': [60, 114, 149, 236, 290, 325, 414], 'Laboratory': [62, 116, 151, 238, 292, 327, 416], '(EMBL),': [63, 117, 152, 239, 293, 328, 417], 'Heidelberg,': [64, 118, 153, 240, 294, 329, 418], 'Germany': [65, 119, 154, 241, 295, 330, 419], 'Jacob': [73, 75, 249, 251, 376], 'Kerssemakers': [74, 76, 250, 252], 'Marc': [99, 101, 275, 277, 378], 'Kschonsak': [100, 102, 276, 278, 1479, 1525, 3202], 'Christian': [127, 132, 303, 308, 380], 'H': [128, 133, 304, 309, 381], 'Haering': [129, 134, 305, 310, 382], 'Corresponding': [130, 164, 306, 340], 'Author': [131, 165, 307, 341, 369], '[email': [135, 168, 311, 344, 427, 436], 'protected]': [136, 169, 312, 345, 428, 437], 'orcid.org/0000-0001-8301-1722': [137, 313], 'Cees': [162, 166, 338, 342, 385], 'Dekker': [163, 167, 339, 343, 386], 'orcid.org/0000-0001-6273-071X': [170, 346], 'Information': [370], 'Eeftens1,': [373], 'Bisht2,': [375], 'Kerssemakers1,': [377], 'Kschonsak2,': [379], '*,2': [383], '*,1': [387], '1Department': [388], '2Cell': [403], '*Corresponding': [420, 429], 'author.': [421, 430], 'Tel:': [422, 431], '+49': [423], '6221': [424], '3878450;': [425], 'E-mail:': [426, 435], '+31': [432], '15': [433], '2786094;': [434], 'EMBO': [439], 'Journal': [440], '(2017)36:3448-3457https://doi.org/10.15252/embj.201797596': [441], '[The': [442], 'copyright': [443], 'line': [444, 3957], 'article': [447, 461], 'was': [448, 1198, 1204, 2270, 2315, 3018, 3137, 3281, 3501, 3870, 3905, 3927, 3935, 3951, 3984, 4004, 4034, 4045, 4054, 4068, 4089, 4132, 4143, 4154, 4190, 4195, 4200, 4214, 4219, 4228, 4232, 4515, 4605, 4626], 'changed': [449], 'on': [450, 1701, 1823, 1959, 2512, 2601, 2891, 3531, 3536], '1': [451, 1205, 2665, 2685, 2818, 4073, 4120, 4160, 4225], 'December': [452], '2017': [453], 'after': [454, 2189, 2926, 3104, 3627, 4100, 4478, 4492, 4584], 'original': [455, 1114, 2433, 3696], 'online': [456], 'publication.]': [457], 'PDFDownload': [458], 'PDF': [459], 'text': [462], 'main': [464], 'figures.': [465], 'Peer': [466], 'ReviewDownload': [467], 'summary': [469], 'the': [471, 502, 540, 547, 598, 605, 612, 618, 626, 648, 677, 742, 759, 793, 871, 890, 901, 912, 916, 957, 969, 983, 988, 1002, 1008, 1025, 1047, 1069, 1073, 1078, 1090, 1095, 1105, 1113, 1131, 1218, 1241, 1278, 1308, 1312, 1324, 1337, 1356, 1368, 1395, 1414, 1431, 1439, 1468, 1496, 1499, 1531, 1587, 1624, 1628, 1633, 1641, 1646, 1652, 1671, 1692, 1729, 1734, 1764, 1782, 1794, 1803, 1824, 1828, 1869, 1880, 1886, 1909, 1913, 1917, 1954, 1960, 1964, 1993, 2002, 2050, 2061, 2065, 2069, 2091, 2104, 2108, 2115, 2120, 2125, 2128, 2140, 2148, 2165, 2176, 2181, 2200, 2203, 2207, 2211, 2228, 2232, 2237, 2240, 2246, 2313, 2317, 2323, 2335, 2338, 2348, 2354, 2408, 2418, 2424, 2427, 2432, 2439, 2459, 2462, 2488, 2513, 2535, 2620, 2647, 2657, 2669, 2703, 2719, 2723, 2750, 2764, 2778, 2798, 2867, 2898, 2903, 2920, 2930, 2937, 2946, 2962, 2980, 2994, 3021, 3132, 3140, 3143, 3153, 3169, 3175, 3185, 3192, 3223, 3226, 3232, 3238, 3246, 3263, 3273, 3276, 3338, 3349, 3371, 3379, 3425, 3443, 3464, 3470, 3478, 3485, 3489, 3498, 3519, 3528, 3576, 3586, 3615, 3634, 3646, 3655, 3659, 3685, 3701, 3713, 3721, 3728, 3744, 3750, 3755, 3758, 3766, 3778, 3783, 3790, 3797, 3800, 3816, 3827, 3859, 3902, 3910, 3925, 3933, 3946, 3949, 3954, 3959, 3961, 3965, 3978, 3998, 4020, 4031, 4052, 4060, 4065, 4087, 4096, 4129, 4140, 4151, 4168, 4239, 4244, 4259, 4262, 4270, 4278, 4298, 4303, 4342, 4374, 4405, 4479, 4504, 4519, 4542, 4561, 4598, 4601], 'editorial': [472, 476], 'decision': [473, 477], 'including': [475, 792], 'letters,': [478], 'reviewer': [479], 'comments': [480], 'responses': [483], 'to': [484, 487, 535, 573, 646, 736, 750, 850, 956, 1031, 1042, 1097, 1217, 1240, 1277, 1302, 1329, 1331, 1363, 1430, 1438, 1498, 1585, 1592, 1659, 1687, 1727, 1776, 1792, 1867, 1915, 1930, 2043, 2047, 2059, 2090, 2111, 2127, 2187, 2272, 2280, 2376, 2390, 2423, 2475, 2484, 2609, 2646, 2806, 2815, 2936, 2943, 2945, 2950, 3068, 3120, 3139, 3284, 3295, 3440, 3458, 3503, 3525, 3539, 3570, 3625, 3691, 3703, 3720, 3727, 3757, 3780, 3786, 3851, 3938, 3987, 4006, 4019, 4048, 4056, 4091, 4287, 4300, 4337, 4360, 4364, 4392, 4442, 4554, 4628, 4631], 'feedback.': [485], 'ToolsAdd': [486], 'favoritesDownload': [488], 'CitationsTrack': [489], 'CitationsPermissions': [490], 'ShareFacebookTwitterLinked': [491], 'InMendeleyWechatReddit': [492], 'Figures': [493], '&': [494, 815, 1400, 1419, 1526, 1546, 1597, 1708, 2757], 'Info': [495], 'Abstract': [496], 'Condensin,': [497], 'conserved': [499], 'member': [500], 'SMC': [503, 606, 691, 818, 1679, 1699, 1737], 'protein': [504, 509, 819, 910, 1250, 1262, 1738, 1831, 2252, 2472, 2494, 2581, 2618, 2854, 2927, 3002, 3017, 3110, 3312, 3374, 3412, 4097, 4286], 'family': [505], 'ring-shaped': [507], 'multi-subunit': [508], 'complexes,': [510, 942, 1770], 'is': [511, 608, 761, 834, 1053, 1087, 1102, 1212, 1235, 1273, 1494, 1618, 1855, 1864, 1882, 1903, 2180, 2295, 2371, 2404, 2642, 2689, 2883, 2905, 2934, 2977, 2990, 3007, 3014, 3036, 3041, 3059, 3066, 3083, 3116, 3189, 3259, 3361, 3389, 3401, 3415, 3428, 3431, 3438, 3456, 3567, 3882], 'essential': [512, 666, 3190, 3613], 'structuring': [514], 'compacting': [516, 4609], 'chromosomes.': [517], 'Despite': [518], 'its': [519, 522, 652, 668, 1449, 1926, 3256, 3695, 4413, 4426], 'key': [520, 1497], 'role,': [521], 'molecular': [523, 1676], 'has': [525, 672, 893, 1290, 1485, 1565, 1572, 1581], 'remained': [526, 894, 1291, 2332, 4098, 4358, 4490, 4595], 'largely': [527, 895], 'unknown.': [528], 'Here,': [529], 'we': [530, 1771, 1842, 2012, 2162, 2174, 2209, 2230, 2257, 2768, 2784, 2832, 2847, 2851, 2923, 3135, 3161, 3230, 3473, 3545, 3562, 3620, 3653, 3675, 3698, 3762, 3775, 4242, 4275, 4295, 4315, 4322, 4486, 4549, 4570], 'employ': [531, 1773], 'single-molecule': [532, 1683, 1804, 2141, 4484], 'magnetic': [533, 712, 1061, 1720, 1774, 2009, 2019], 'tweezers': [534, 713, 1775, 1788], 'measure,': [536], 'in': [537, 558, 597, 700, 723, 729, 786, 807, 1001, 1130, 1374, 1381, 1391, 1394, 1516, 1898, 1943, 2007, 2025, 2114, 2136, 2147, 2202, 2214, 2316, 2356, 2426, 2438, 2510, 2518, 2557, 2702, 2763, 2777, 2866, 2929, 2961, 2979, 3020, 3148, 3159, 3184, 3245, 3288, 3337, 3378, 3442, 3484, 3507, 3542, 3725, 3743, 3746, 4059, 4211, 4377, 4380, 4461, 4482, 4506, 4560, 4611], 'real': [538, 2137], 'time,': [539, 2103, 2178], 'individual': [543, 1126, 1656, 1698, 1997, 2014, 2157], 'molecules': [545, 563, 722, 1637, 1812, 1986, 2000, 2016], 'budding': [548, 717, 970, 2463], 'yeast': [549, 718, 971, 1009, 2464], 'condensin': [550, 592, 627, 635, 690, 719, 747, 782, 833, 922, 941, 943, 979, 1010, 1064, 1161, 1196, 1285, 1371, 1388, 1434, 1469, 1503, 1539, 1580, 1636, 1657, 1746, 1769, 1785, 1816, 1846, 1887, 1910, 1924, 2005, 2083, 2191, 2269, 2379, 2465, 2506, 2531, 2747, 2753, 2770, 2810, 2864, 2942, 2976, 3029, 3076, 3144, 3157, 3165, 3186, 3195, 3211, 3239, 3309, 3326, 3334, 3351, 3373, 3471, 3479, 3672, 3829, 3915, 4118, 4186, 4333, 4355, 4472, 4501, 4630], 'complex.': [551, 1011], 'We': [552, 1806, 1858, 1948, 2036, 2054, 2079, 2130, 2266, 2367, 2532, 2795, 3085, 3514, 3603, 3630, 3804, 4372, 4510, 4621], 'show': [553, 715, 1807, 1860, 1922, 2709], 'that': [554, 625, 661, 716, 930, 1299, 1433, 1455, 1619, 1845, 1854, 1861, 1923, 1939, 1972, 2029, 2179, 2268, 2286, 2369, 2534, 2863, 2917, 2922, 3063, 3131, 3134, 3151, 3167, 3188, 3241, 3322, 3348, 3370, 3398, 3556, 3605, 3619, 3761, 3806, 3948, 4095, 4354, 4356, 4512, 4533, 4582], 'can': [556, 577, 593, 1621, 2302, 2877, 3251, 3810, 4334, 4451], 'proceed': [557, 3121, 3598], 'large': [559, 724], 'steps,': [560, 633], 'driving': [561], 'into': [564, 1467, 1763, 1873, 4425], 'fully': [566, 1883, 3722, 3812, 4516], 'condensed': [567, 4000], 'state': [568, 1589, 1799], 'against': [569, 733, 1987, 2275, 2304, 2383, 3843], 'forces': [570, 583, 734, 1156, 1990, 2277, 2305, 3667, 4346], 'up': [572, 735, 2279, 2483], '2': [574, 737, 1159, 1167, 2281, 2309, 2628], 'pN.': [575, 738, 2310, 3940, 4029], 'Compaction': [576, 2599, 3437], 'be': [578, 1364, 1662, 1688, 1941, 3638, 3811], 'reversed': [579, 3813, 4517], 'applying': [581, 769, 3641], 'high': [582, 588, 764, 770, 2969, 3045, 3643, 3819, 3852, 3855, 4135, 4204, 4345, 4443], 'or': [584, 767, 1380, 2967, 3111, 3534, 3573, 3854, 4041, 4285, 4428], 'adding': [585, 2190, 3671, 4081, 4567], 'buffer': [586, 2027, 2802, 2816, 2998, 3093, 3107, 4037, 4071, 4282, 4495], 'ionic': [589], 'strength.': [590], 'While': [591, 2250, 4268], 'stably': [594], 'bind': [595, 1041, 1437, 2760, 2944, 4393, 4632], 'absence': [599, 1396, 2765, 2779, 2868, 2963, 2981, 3022, 4061], 'ATP,': [601, 2677, 2767, 2870, 3254, 3674, 4594], 'ATP': [602, 644, 739, 885, 1005, 1066, 1138, 1202, 1353, 1398, 1411, 1462, 1856, 1862, 2087, 2254, 2528, 2541, 2593, 2602, 2614, 2624, 2638, 2820, 2830, 2856, 2882, 2966, 3006, 3050, 3064, 3078, 3095, 3115, 3399, 3414, 3459, 3517, 3532, 3537, 3559, 3565, 3582, 3607, 3610, 3919, 3993, 4040, 4075, 4082, 4122, 4162, 4189, 4227, 4284, 4317, 4363, 4564, 4625], 'hydrolysis': [603, 645, 740, 888, 1354, 1412, 1863, 2529, 2603, 3065, 3400, 3462, 3533, 3566], 'subunits': [607, 905, 929, 951, 990, 1037, 1317, 1326, 3468], 'required': [609, 1366, 1866, 3568, 4539, 4627], 'rendering': [611], 'association': [613, 1369, 1870], 'salt': [614, 765, 2032, 2970, 3046, 3053, 3856, 4136, 4158, 4205, 4223, 4444, 4453, 4552, 4616], 'insensitive': [615], 'subsequent': [619, 2527, 3841], 'process.': [621], 'Our': [622, 1889, 1920], 'results': [623, 1921, 1958], 'indicate': [624, 2862], 'reaction': [628, 2932, 3529, 3648, 4481, 4614], 'cycle': [629], 'involves': [630], 'two': [631, 927, 940, 1082, 1169, 1180, 1927, 2169, 4389], 'distinct': [632, 954, 4390], 'where': [634, 1879, 3945], 'first': [636, 2258], 'binds': [637, 1389, 2865], 'through': [639, 1908, 4400, 4408, 4416, 4429], 'electrostatic': [640, 702, 1850, 4402, 4438, 4534], 'interactions': [641, 703, 4403, 4439, 4535], 'before': [642, 3679, 3863], 'using': [643, 2168], 'encircle': [647], 'topologically': [650, 1306, 4409], 'within': [651, 1307, 4412], 'ring': [653, 1309, 1470, 1911, 4414], 'structure,': [654, 4415], 'which': [655, 701, 844, 947, 981, 1502, 1899, 3554], 'initiates': [656], 'compaction.': [658, 681, 2520, 2710, 4371], 'finding': [660], 'both': [662], 'modes': [664, 1929, 4391, 4434], 'are': [665, 821, 906, 1067, 1141, 1666, 1789, 1891, 1975, 2381, 2443, 2632, 2651, 2713, 2736, 3032, 3054, 3079, 3612, 4440, 4538], 'activity': [671, 756, 3216, 3258, 3618], 'important': [673], 'implications': [674, 1955], 'understanding': [676, 1650], 'chromosome': [680, 777, 790, 4449], 'Synopsis': [682], 'purified': [689, 3474], 'complexes': [692, 779, 820, 1286, 1658, 1700, 1748, 2380, 2507], 'provides': [693], 'evidence': [694, 1298, 1844], 'mechanism,': [699, 1648], 'may': [704], 'precede': [705], 'ATP-hydrolysis-dependent': [706], 'topological': [707, 1876, 4446], 'entrapment': [708, 4447], 'DNA.': [710, 1165, 2947, 3330, 3344], 'Single-molecule': [711, 1664], 'experiments': [714, 1295, 1617, 1722, 2861, 4383, 4464], 'compacts': [720, 727, 999, 1984], 'steps.': [725], 'Condensin': [726, 752, 998, 1134, 1983, 2956, 3301, 3622, 3991, 4387, 4395], 'an': [730, 857, 1461, 1649, 3883, 4507, 4612], 'ATP-dependent': [731, 4508, 4613], 'manner': [732, 3150], 'converts': [741], 'mode': [745], 'from': [748, 1750, 2199, 2236, 3789, 3886], 'salt-sensitive': [749], 'salt-resistant.': [751], 'maintains': [753], 'even': [757, 1393, 2762, 4254, 4339], 'when': [758, 2378, 2850, 2881, 2975, 4340, 4548], 'de-compacted': [762], 'under': [763], 'conditions': [766, 1938, 4521], 'forces.': [771, 2265], 'Introduction': [772], 'structural': [774], 'maintenance': [775], '(SMC)': [778], 'cohesin': [780], 'play': [783], 'central': [784], 'roles': [785], 'many': [787, 2298, 4381], 'aspects': [788], 'biology,': [791], 'successful': [794], 'segregation': [795], 'mitotic': [797, 960, 1751], 'chromosomes,': [798], 'chromatin': [799], 'regulation': [802], 'gene': [804], 'expression': [805], '(reviewed': [806, 1515], 'Hirano,': [808, 1401, 1420, 1598, 2758], '2016;': [809, 1556, 1706, 1710, 1714], 'Aragon': [810], 'et': [811, 875, 879, 963, 1319, 1344, 1348, 1377, 1384, 1404, 1423, 1472, 1476, 1480, 1518, 1522, 1550, 1554, 1558, 1601, 1605, 1609, 1704, 1712, 1716, 1741, 1757, 2328, 2887, 3199, 3203, 3268, 3833, 4466], 'al,': [812, 876, 880, 964, 1320, 1345, 1349, 1378, 1385, 1405, 1424, 1473, 1477, 1481, 1519, 1523, 1551, 1555, 1559, 1602, 1606, 1610, 1705, 1713, 1717, 1742, 1758, 2329, 2888, 3200, 3204, 3269, 3834, 4467], '2013;': [813], 'Nasmyth': [814], 'Haering,': [816, 1527], '2009).': [817, 1611], 'characterized': [822, 2164], 'their': [824, 1017], 'unique': [825], 'ring-like': [826, 917, 1034], 'structure': [827, 918, 1674, 4142], '(Fig': [828, 919, 994, 2034, 2072, 2094, 2160, 2195, 2218, 2292, 2350, 2365, 2467, 2496, 2551, 2595, 2793, 2837, 2858, 2909, 3218, 3291, 3601, 3668, 3680, 3706, 3772, 3802, 4266, 4308, 4326, 4522, 4574], '1A).': [829, 920, 995], 'architecture': [831], 'formed': [835, 1310], 'heterodimer': [838], 'Smc2': [840, 902, 1012, 1026, 3465, 3490], 'Smc4': [842, 904, 1014, 1028, 1314, 3467, 3492], 'subunits,': [843, 1453], 'each': [845, 2341], 'fold': [846], 'back': [847], 'onto': [848, 1334, 3196, 4589], 'themselves': [849], 'form': [851], '~45-nm-long': [852], 'flexible': [853], 'coiled': [854], 'coils,': [855], 'with': [856, 1024, 1081, 1288, 1372, 1448, 1638, 1852, 1871, 1893, 1977, 2284, 2289, 2353, 2362, 2458, 2539, 2613, 2679, 2771, 2801, 2842, 2997, 2999, 3044, 3092, 3106, 3146, 3174, 3234, 3272, 3335, 3481, 3818, 3822, 4036, 4070, 4072, 4134, 4156, 4203, 4221, 4281, 4349, 4404, 4474, 4494, 4536, 4597], 'ATPase': [858, 1358, 1416, 2697, 3257, 3307, 3493], '"head"': [859], 'domain': [860, 869, 3340], 'at': [861, 870, 1143, 1802, 2068, 2139, 2192, 2224, 2262, 2480, 2492, 2502, 2545, 2591, 2623, 2968, 3363, 3391, 3433, 3662, 3769, 3796, 3872, 3912, 3964, 4027, 4272, 4344], 'one': [862], 'end': [863, 873, 2226, 2349], 'globular': [866], '"hinge"': [867], 'heterodimerization': [868], 'other': [872], '(Anderson': [874], '2002;': [877, 1607], '2016).': [881], 'role': [883], 'head': [891, 898, 1029], 'domains': [892, 899, 1030], 'unclear.': [896], 'connected': [907], 'kleisin': [913, 923, 984, 1021, 1452, 3176], 'family,': [914], 'completing': [915], 'subunit': [924, 985, 3177], 'furthermore': [925], 'recruits': [926], 'additional': [928, 2823, 3001, 4165, 4320], 'consist': [931], 'mainly': [932], 'HEAT-repeat': [934, 989, 1036, 1325, 1450, 3171], 'motifs.': [935], 'Most': [936], 'metazoan': [937], 'cells': [938], 'express': [939], 'I': [944, 1747, 2754, 3830], 'II,': [946], 'contain': [948], 'different': [949, 1125, 2144, 2263, 3893, 3896, 4109, 4177], 'non-SMC': [950], 'make': [953], 'contributions': [955], 'formation': [958, 1338], 'chromosomes': [961, 1289, 1335, 1342, 1373, 3197], '(Ono': [962], '2003).': [965], 'genome': [967], 'Saccharomyces': [972], 'cerevisiae,': [973], 'however,': [974, 1409, 3837, 4311], 'encodes': [975], 'only': [976, 1622, 2343, 2682, 2812, 3520, 3569], 'single': [978], 'complex,': [980, 3278, 3472], 'contains': [982, 3242], 'Brn1': [986, 1022, 1316], 'Ycg1': [991, 1040, 3170, 3179], 'Ycs4': [993, 1038], 'Figure': [996, 2394, 2597, 2954, 3299, 3846], '1.': [997], 'presence': [1003, 2704, 3264, 3380, 3444, 4562], 'Cartoon': [1006], 'dimerize': [1015], 'via': [1016], 'hinge': [1018], 'domains.': [1019], 'associates': [1023], 'create': [1032], 'structure.': [1035], 'Brn1.': [1043], 'Schematic': [1044], 'representation': [1045], 'experiment.': [1049, 1133, 2726, 4110, 4178], 'A': [1050, 2553, 2911], 'molecule': [1052, 1902, 3687], 'tethered': [1054, 2013, 2051], 'between': [1055, 1108, 2017, 2156, 2239], 'glass': [1057, 2023], 'slide': [1058], 'bead.': [1062], 'When': [1063, 3774, 4294], 'added,': [1068, 3055, 4191], 'end-to-end': [1070, 1115, 1795, 2062, 2105, 2204, 2248, 2434, 3656, 3714, 3759, 3970, 3980, 4012, 4212, 4264], 'length': [1071, 1796, 2063, 2106, 2205, 3715, 3760, 3862, 3971, 4013, 4023, 4213, 4265], 'decreases.': [1075], 'Characterization': [1076], 'parameters.': [1083, 2172], 'lag': [1085, 1221, 1258, 2102, 2177, 2359, 2489, 2716, 2728, 2893, 2913], 'time': [1086, 1091, 1144, 1222, 1259, 2076, 2096, 2138, 2182, 2193, 2635, 2717, 2729, 2791, 2914, 2938, 3947, 4112, 4147, 4180, 4251], 'defined': [1088, 2171], 'as': [1089, 1152, 1214, 1224, 1237, 1249, 1261, 1275, 2320, 2399, 2436, 2637, 2644, 2846, 3417, 3678, 3684, 4125, 4312, 4314, 4459], 'it': [1092, 2183, 2939, 3736, 3793, 4252, 4585], 'takes': [1093, 2374, 2940], 'initiate.': [1098], 'rate': [1101, 1150, 1246, 1821, 2213, 2235, 2314, 2398, 2403, 2425, 2454, 2537, 2561, 2606, 2621, 2655, 2845], 'set': [1103], 'speed': [1107], '90': [1109, 2241], '10%': [1111, 2243], 'length.': [1116, 2249, 3981], 'Examples': [1117], 'traces.': [1120], 'Each': [1121], 'colour': [1122], 'represents': [1123], 'tether': [1128, 3861], 'measured': [1129, 2175, 2210, 2321, 2437, 2849, 3764], 'same': [1132, 2149, 2318, 2514, 3791, 4240], '(8.6': [1135, 2084, 3916], 'nM)': [1136, 2085, 3917], '(1': [1139, 2088, 3920], 'mM)': [1140, 2089, 3921], 'added': [1142, 1213, 1236, 1274, 2082, 2643, 2853, 2885, 2978, 3008, 3080, 3362, 3390, 3416, 3432, 3923, 4124, 4316], 'point': [1145, 2077, 2097, 3482, 3960], 'zero.': [1146], 'average': [1148, 1244, 2233, 2397, 2892, 3868], 'decreases': [1151, 1260, 2636, 2730], 'force': [1153, 1225, 1826, 2045, 2070, 2291, 2364, 3644, 3702, 3711, 3779, 3853, 3911, 3934, 3983, 4003, 4044, 4271, 4299], 'increases.': [1154, 1226, 1252, 1264, 2640], 'At': [1155, 1166, 1177, 3025, 3072, 3408, 4111, 4146, 4179], 'higher': [1157, 2307, 2385, 2493, 2503, 2626], 'than': [1158, 2308, 2627], 'pN,': [1160, 1168, 1179, 2282, 2661, 3782, 3914, 4050, 4274, 4302], 'does': [1162, 1360, 2957, 3327, 3341, 3353, 3375, 3838], 'not': [1163, 1175, 1186, 1361, 1486, 1573, 2708, 2906, 2958, 3260, 3316, 3328, 3342, 3354, 3376, 3597, 3717, 3839, 4057, 4306], 'compact': [1164, 1932, 2273, 2959, 3317, 3329, 3343, 3355, 3377, 3787, 4058, 4307], 'out': [1170, 1181], 'nine': [1172], 'tethers': [1173, 1184, 2146, 3894], 'did': [1174, 1185, 3596, 3716, 4305], 'condense.': [1176, 1187], '1.75': [1178], 'eight': [1183], 'Error': [1188, 1227, 1253, 1265, 2441, 2630, 2649, 2711, 2734], 'bars': [1189, 1228, 1254, 1266, 2442, 2631, 2650, 2712, 2735], 'represent': [1190, 1229, 1255, 1267], 'SEM.': [1191, 1230, 1256, 1268, 2633, 2652, 2714, 2737], 'For': [1192, 1681, 2616], 'all': [1193, 2124, 2808, 3754, 4289], 'these': [1194, 4433], 'experiments,': [1195], 'concentration': [1197, 1203, 1251, 1263, 2460, 2582, 2639], '8.6': [1199, 2584, 2662, 2674, 4116, 4184], 'nM': [1200, 2663, 2675, 4117, 4185], 'mM': [1206, 2550, 2578, 2666, 2686, 2819, 4074, 4121, 4161, 4226, 4457, 4498, 4558], 'ATP.': [1207, 1818, 1834, 2781, 2983, 3024, 3112, 4063], 'An': [1208, 1231, 1269], 'exponential': [1209, 1232, 1270], 'curve': [1210, 1233, 1271], '(line)': [1211, 1234, 1272], 'guide': [1216, 1239, 1276, 2645], 'eye.': [1219, 1242, 1279, 2648], 'increases': [1223, 1247, 2607], 'linearly': [1248, 2457], 'Download': [1280, 1282, 2448, 2450, 2738, 2740, 3125, 3127, 3447, 3449, 4234, 4236], 'figure': [1281, 2449, 2739, 3126, 3448, 4235], 'PowerPoint': [1283, 2451, 2741, 3128, 3450, 4237], 'How': [1284], 'associate': [1287], 'incompletely': [1292], 'understood.': [1293], 'Biochemical': [1294], 'have': [1296, 1428, 1723], 'provided': [1297], 'condensin,': [1300, 3306, 4583], 'similar': [1301, 2690, 2844], 'cohesin,': [1303], 'embraces': [1304], 'Smc2,': [1313], '(Cuylen': [1318, 4465], '2011).': [1321, 4468], 'In': [1322, 1351, 3592, 4238], 'addition,': [1323, 2831], 'were': [1327, 2473, 2588, 2895, 3922, 3994, 4123], 'found': [1328, 2267, 2533, 4511], 'contribute': [1330], "condensin's": [1332], 'loading': [1333, 3193], 'properly': [1340], 'structured': [1341], '(Piazza': [1343, 3198], '2014;': [1346, 1478, 3201], 'Kinoshita': [1347], '2015).': [1350, 1528], 'contrast,': [1352], 'Smc2–Smc4': [1357, 1415], 'heads': [1359, 1417], 'seem': [1362], 'absolutely': [1365], 'vivo': [1375], '(Hudson': [1376], '2008)': [1379, 1743], 'extracts': [1382, 1755], '(Kinoshita': [1383], '2015)': [1386], 'vitro': [1392], '(Kimura': [1399, 1418, 1596, 2756], '1997;': [1402, 1599], 'Strick': [1403], '2004).': [1406, 1759, 2889, 3835], 'DNA,': [1407, 1629, 1933, 2208], 'can,': [1408], 'stimulate': [1410], '2000;': [1421], 'Piazza': [1422, 1475], '2014).': [1425], 'These': [1426, 2498, 2860], 'findings': [1427, 1890, 1974, 2499, 4375], 'led': [1429], 'speculation': [1432], 'might': [1435, 1458, 2508, 4396], 'initially': [1436], 'double': [1441], 'helix': [1442], 'direct': [1445, 1849, 4401], 'interaction,': [1446], 'possibly': [1447], 'subsequently': [1459, 2884, 3776, 3985, 4550], 'trigger': [1460], 'hydrolysis-dependent': [1463], 'transport': [1464], '(Strick': [1471, 1756, 2327, 2886, 3832], '2004;': [1474], '2017).': [1482, 1578, 1718, 3205, 3270], 'This': [1483, 2294, 3061, 3249, 3880, 4328, 4531, 4580], 'hypothesis': [1484], 'yet': [1487, 1574], 'been': [1488, 1575, 1583, 1724, 3589, 3689, 4587, 4619], 'confirmed,': [1489], 'however.': [1490], 'condensin–DNA': [1492, 3635], 'interaction': [1493, 1634, 1851, 3141, 3636], 'presumably': [1495], 'drives': [1504], 'compaction,': [1506, 3677, 3932, 4128], 'subject': [1508], 'keen': [1510], 'interest': [1511], 'intense': [1513], 'debate': [1514], 'Swedlow': [1517], '2003;': [1520], 'Thadani': [1521], '2012': [1524], 'Models': [1529], 'include': [1536], 'random': [1537], 'cross-linking,': [1538], 'multimerization,': [1540], 'and/or': [1541], 'loop': [1543, 1562, 1979, 4424], 'extrusion': [1544, 1563, 1980], '(Alipour': [1545], 'Marko,': [1547], '2012;': [1548], 'Wilhelm': [1549], '2015;': [1552], 'Fudenberg': [1553], 'Goloborodko': [1557], '2016a,b).': [1560], 'model': [1564], 'recently': [1566], 'gained': [1567], 'support,': [1568], 'but': [1569, 1630, 2414, 3255, 4076, 4083, 4163, 4187], 'consensus': [1571], 'reached': [1576], '(Dolgin,': [1577], 'Finally,': [1579, 3561], 'also': [1582, 3282], 'suggested': [1584], 'alter': [1586], 'supercoiled': [1588], 'promote': [1593], 'Kimura': [1600], '1999;': [1603], 'Bazett-Jones': [1604], 'St-Pierre': [1608], 'One': [1612], 'caveat': [1613], 'most': [1615], 'biochemical': [1616], 'they': [1620], 'probe': [1623], 'final': [1625], 'geometry': [1626], 'cannot': [1631], 'address': [1632], 'during': [1640, 2789, 2873, 3575, 4476, 4600], 'cycle.': [1643], 'To': [1644, 1760, 1991, 2220, 2742, 3129, 3220, 3451, 4469], 'resolve': [1645], 'properties': [1654, 3155], 'will': [1661], 'essential.': [1663], 'techniques': [1665], 'especially': [1667], 'suitable': [1668], 'investigating': [1670], 'mechanical': [1672], 'properties,': [1673], 'proteins.': [1680], 'example,': [1682], 'imaging': [1684], 'methods': [1685], 'proved': [1686], 'crucial': [1689], 'revealing': [1691], 'sliding': [1693], 'motor': [1695, 2300], 'action': [1696], '(Davidson': [1703], 'Kim': [1707], 'Loparo,': [1709], 'Stigler': [1711], 'Terakawa': [1715], 'Likewise,': [1719], 'tweezer': [1721, 2010], 'successfully': [1725, 1931], 'used': [1726, 2038], 'describe': [1728], 'Escherichia': [1735], 'coli': [1736], 'MukB': [1739], '(Cui': [1740], 'immunopurified': [1749], 'Xenopus': [1752, 2324, 3828], 'laevis': [1753, 2752], 'egg': [1754], 'obtain': [1761], 'insights': [1762], 'here': [1772, 2389, 2949, 3294], 'study': [1777, 1793], 'induced': [1780], 'S.': [1783, 2003, 2745], 'cerevisiae': [1784, 2004, 2746], 'holocomplex.': [1786], 'Magnetic': [1787], 'exquisitely': [1790], 'fit': [1791, 2555], 'supercoiling': [1798], 'level.': [1805, 2142], 'real-time': [1808, 1994], 'upon': [1813], 'addition': [1814, 2671, 2725, 2900, 2928, 3864], 'depends': [1822, 2600, 3530], 'applied': [1825, 2071, 2264, 2276, 2386], 'availability': [1829], 'hydrolysable': [1833, 2965, 3522], 'Through': [1835], 'rigorous': [1836], 'systematic': [1837], 'testing': [1838], 'experimental': [1840], 'conditions,': [1841], 'provide': [1843], 'makes': [1847], 'independent.': [1857], 'further': [1859, 3452, 3600], 'then': [1865, 2037, 2080, 2683, 2796, 2813, 3042, 3515, 4046, 4201, 4276, 4296], 'render': [1868], 'salt-resistant': [1875, 3070], 'mode,': [1878, 1897], 'encircled': [1884], 'ring.': [1888, 1919], 'inconsistent': [1892], '"pseudo-topological"': [1895], 'sharply': [1904], 'bent': [1905], 'pushed': [1907], 'without': [1912, 3094, 3108, 4038, 4283, 4566], 'need': [1914], 'open': [1916], 'SMC–kleisin': [1918], 'uses': [1925, 4388], 'DNA-binding': [1928, 3182, 3228, 3247, 3339], 'thus': [1934, 2131, 4080], 'setting': [1935], 'clear': [1936], 'boundary': [1937], 'must': [1940], 'considered': [1942], 'any': [1944, 3599, 4039], 'organization': [1946], 'model.': [1947, 1981], 'present': [1949, 3996], 'critical': [1951], 'discussion': [1952], 'our': [1957, 1973, 3289, 3508, 4483], 'various': [1961], 'models': [1962], 'mechanics': [1965], 'condensin-mediated': [1967, 4543], 'conclude': [1971, 2368, 3604, 3805], 'compatible': [1976], 'Results': [1982], 'low': [1988, 3844], 'physical': [1989], 'measure': [1992], 'linear': [1998], 'holocomplex': [2006, 3240], 'set-up,': [2011, 2901, 4485], 'bead': [2020, 2121], 'surface': [2024], 'condition': [2028], 'reflects': [2030, 3152], 'physiological': [2031, 3052, 3154, 4157, 4222, 4350, 4555], 'concentrations': [2033, 2255, 2495, 2542, 2546, 2594, 2625, 4454, 4553, 4617], '1B).': [2035], 'pair': [2040], 'magnets': [2042], 'apply': [2044], 'thereby': [2048], 'stretch': [2049], 'molecules.': [2053], 'routinely': [2055], 'performed': [2056], 'pre-measurement': [2058], 'determine': [2060], 'bare': [2066, 3660, 3732, 3767, 4025], '1C,': [2073, 2095], 'left': [2074], 'zero).': [2078, 2098], 'simultaneously': [2081, 2857], 'flow': [2092, 2799, 2995, 3039, 3426, 4032, 4066, 4130, 4152, 4198, 4217, 4279], 'cell': [2093, 2800, 2996, 3040, 3427, 4033, 4067, 4131, 4153, 4199, 4218, 4280], 'Following': [2099], 'short': [2101], 'started': [2110, 3785, 3795], 'decrease': [2112, 2201, 2238, 2355], 'until,': [2113], 'vast': [2116], 'majority': [2117], 'cases,': [2119], 'had': [2122, 2848, 2852, 2924, 3588, 3649, 3688, 3752, 3763, 3794, 4357, 4502, 4586, 4618], 'moved': [2123], 'way': [2126, 3756], 'surface.': [2129], 'observe': [2132], 'As': [2143, 2782, 3496, 3682], 'experiment': [2150, 2339, 2659, 2672, 2721, 3233, 3801], 'typically': [2151], 'displayed': [2152], 'sizeable': [2154], 'variation': [2155], 'traces': [2159, 2167], '1D),': [2161], 'quantitatively': [2163], 'clearly': [2170], 'First,': [2173, 3652], 'took': [2184, 3737, 4253], 'initiate': [2188, 2377, 3571, 4365], 'zero': [2194], '1C).': [2196, 2219], 'Second,': [2197], 'starting': [2198], 'nanometres': [2215], 'per': [2216], 'second': [2217], 'avoid': [2221], 'bias': [2223], 'either': [2225], 'curve,': [2229], 'extracted': [2231], 'levels': [2244, 4556], 'initial': [2247], 'keeping': [2251, 4269], 'constant,': [2256], 'determined': [2259], 'rates': [2261, 2285, 2481, 3897], 'able': [2271, 2474, 4090], 'albeit': [2283], 'strongly': [2287], 'decreased': [2288, 2491], 'increasing': [2290, 2363, 2540], '1E).': [2293], 'surprising,': [2296], 'since': [2297], 'biological': [2299], 'proteins': [2301], 'work': [2303, 2509], 'much': [2306, 2478, 2589], 'On': [2311], 'average,': [2312], 'range': [2319], 'complex': [2325, 2466, 2755, 3145, 3166, 3187, 3280, 3480, 3500, 3831], 'previously': [2326], '2004)': [2330], 'constant': [2333], 'over': [2334, 2407], 'course': [2336, 2409], 'tether,': [2342], 'slowing': [2344], 'down': [2345, 2416], 'slightly': [2346], 'towards': [2347, 2417], 'EV1).': [2351], 'Concurrent': [2352], 'rates,': [2358], 'times': [2360, 2490, 2587, 2894], 'increased': [2361, 2455, 2538, 3700, 3937, 4005, 4015], '1F).': [2366], 'slower': [2372], 'longer': [2375, 2590, 4255], 'acting': [2382], 'force.': [2387, 3845], 'Click': [2388, 2948, 3293], 'expand': [2391, 2951, 3296], 'figure.': [2393, 2953, 3298], 'EV1.': [2395], 'Relative': [2396], 'progressesThe': [2401], 'relatively': [2405], 'steady': [2406], 'condensation': [2412, 2989], 'experiment,': [2413, 3544, 3594, 4241], 'slows': [2415], 'end.': [2419], 'Rate': [2420, 2688], 'depicted': [2421], 'relative': [2422], 'interval': [2428], '0.9–0.8': [2430], 'distance': [2435], 'pre-measurement.': [2440], 'SEM,': [2444], 'N': [2445, 2839, 3887, 4528], '=': [2446, 2840, 3004, 3010, 3027, 3074, 3097, 3123, 3358, 3365, 3384, 3393, 3406, 3410, 3423, 3435, 3888, 4113, 4148, 4181, 4385, 4525, 4529, 4577], '16.': [2447], 'approximately': [2456], '1G).': [2468], 'Higher': [2469], 'amounts': [2470], 'condense': [2476, 4092], 'faster,': [2479], '200': [2485], 'nm/s.': [2486], 'Similarly,': [2487], '1H).': [2497], 'suggest': [2500, 2916], 'that,': [2501, 4331], 'concentrations,': [2504, 4445], 'multiple': [2505], 'parallel': [2511], 'molecule,': [2516], 'resulting': [2517], 'faster': [2519], 'requires': [2523, 3558, 4362], 'saturated': [2544], 'above': [2547], 'few': [2549, 3739], '2A).': [2552], 'Michaelis–Menten': [2554, 2611], 'resulted': [2556], 'maximum': [2559], 'vmax': [2562], '85': [2564], '±': [2565, 2576], '28': [2566, 3889], 'nm/s': [2567], '(95%': [2568], 'confidence': [2569], 'interval)': [2570], 'KM': [2573], '1.4': [2575], '1.5': [2577], 'nM.': [2585], 'Lag': [2586, 2634], 'lower': [2592], '2B).': [2596], '2.': [2598], 'Average': [2604, 2653], 'according': [2608], 'relation': [2612], 'concentration.': [2615], 'concentration,': [2619], 'saturates': [2622], 'mM.': [2629], 'Line': [2641], 'standard': [2658, 2692, 2720, 2931], '(0.75': [2660], 'protein,': [2664, 4086, 4166], 'ATP)': [2667], 'sequential': [2670, 2694, 2724, 2732, 2899], '(first': [2673], 'protein/no': [2676], 'wash': [2678, 4603], 'buffer,': [2680], 'add': [2684], 'ATP).': [2687], 'addition.': [2695, 2733], 'mutant': [2698, 3250, 3305, 3308, 3352, 3499], 'wild': [2700], 'type': [2701], 'ATPγS': [2706, 3031, 3314, 3382, 3388, 3430, 3524, 3584], 'do': [2707, 3315], 'test': [2743, 3222, 3453], 'whether': [2744, 3454, 3527, 3564, 3633, 4488, 4624], 'could,': [2748], 'like': [2749], 'X.': [2751], '1997),': [2759], 'incubated': [2769], 'substrates': [2773], '20': [2775], 'min': [2776], 'expected,': [2783, 3497], 'observed': [2785, 2833, 2925, 3136, 3546, 3676, 4055, 4324, 4572], 'no': [2786, 2804, 2822, 2988, 3000, 3034, 3057, 3213, 3547, 4077, 4084, 4164, 4188, 4193, 4209, 4319], 'period': [2792], 'EV2A).': [2794], 'washed': [2797, 3043, 4035, 4069, 4133, 4155, 4202, 4220, 4277], 'containing': [2803, 2817, 4496], 'nucleotides': [2805], 'remove': [2807, 4288], 'unbound': [2809, 4292], 'switched': [2814], '(but': [2821, 4318, 4565], 'protein;': [2824], 'hereafter': [2825], 'called': [2826], '"sequential': [2827], 'addition").': [2828], 'After': [2829, 2984, 2992, 3419, 3670, 3929, 4079, 4127], 'robust': [2834], 'EV2A,': [2838], '11)': [2841], '2C).': [2859], 'remains': [2871, 3102, 3623], 'attached': [2872], 'washing': [2874, 2993, 3105, 4348, 4493], 'steps': [2875], 'start': [2878], 'Interestingly,': [2890], 'shorter': [2896, 2912], 'although': [2902], 'difference': [2904], 'statistically': [2907], 'significant': [2908], '2D).': [2910], 'could': [2915, 3637], 'part': [2918], 'delay': [2921], 'set-up': [2933], 'due': [2935, 3138, 3457], 'EV2.': [2955], 'Example': [2971, 3319, 3331], 'trace': [2972, 3320, 3332, 3346, 3368, 3396, 3881, 4106, 4174], '20-min': [2986], 'incubation,': [2987], 'observed.': [2991, 3037, 3060, 4196, 4233], '(t': [3003, 3009, 3096, 3122, 3422], '1,300),': [3005], '1,500)': [3011], 'observed,': [3015], 'indicating': [3016, 4094], 'bound': [3019, 3624, 4099, 4336, 4359], 't': [3026, 3073, 3364, 3392, 3409, 3434, 4524, 4576], '0,': [3028, 3075, 3411], 'added;': [3033], '(500': [3047, 4137, 4206], 'mM).': [3048], 'Next,': [3049, 4030, 4064], 'indicates': [3062, 3944, 3958, 4532], 'necessary': [3067, 3117, 3402], 'achieve': [3069], 'binding.': [3071], 'initiated.': [3084], 'interrupt': [3086], 'ongoing': [3087], 'flushing': [3091], '150).': [3098], 'compacted': [3100, 3103, 3590, 3690, 4141, 4170, 4503, 4544], 'extra': [3109, 4085], 'Addition': [3113], '700).': [3124], 'verify': [3130], 'function': [3158], 'vivo,': [3160], 'tested': [3162, 3563, 3632, 4623], 'tetrameric': [3164, 3208, 3277], 'lacked': [3168], 'subunit.': [3172], 'Together': [3173], 'Brn1,': [3178], 'creates': [3180], 'groove': [3183], 'Indeed,': [3206], 'version': [3209, 3236, 3476], 'showed': [3212, 3895], 'whatsoever': [3217], 'EV3A).': [3219], 'specifically': [3221], 'requirement': [3224], 'Ycg1–Brn1': [3227], 'groove,': [3229], 'repeated': [3231, 4243], 'charge-reversal': [3243], 'mutations': [3244, 3336, 3483], 'groove.': [3248], 'still': [3252, 3995], 'hydrolyse': [3253], 'stimulated': [3261], '(Kschonsak': [3267], 'Consistent': [3271], 'result': [3274, 3904, 4329], 'unable': [3283, 3439, 3502], 'induce': [3285, 3504], 'assay': [3290, 3509, 4470], 'EV3B).': [3292], 'EV3.': [3300], 'tetramer,': [3302], 'wild-type': [3311, 3372], '+': [3313, 3387], 'showing': [3321, 3333, 3347, 3369, 3397], 'tetramer': [3323], '(lacking': [3324], 'Ycg1)': [3325], 'Representative': [3345, 3367, 3395], 'Q-loop': [3350, 3486], '(N': [3357, 3383, 3405, 4384], '12).': [3359], 'Protein': [3360, 3386], '0.': [3366, 3394], '11).': [3385], '6).': [3407], 'normal.': [3418, 4126], 'half': [3420, 3693], '90),': [3424], 'washed.': [3429], '400.': [3436], 'continue': [3441], 'ATPγS.': [3446], 'motifs': [3487], 'sites': [3494], '(Smc2Q147L–Smc4Q302L).': [3495], '(Figs': [3510, 3550], '2C': [3511, 3551], 'EV3C).': [3513], 'replaced': [3516], 'slowly': [3521], 'analog': [3523], 'distinguish': [3526], 'merely': [3535], 'condensin.': [3540, 3866, 4293], 'Also': [3541], 'EV3D),': [3553], 'demonstrates': [3555, 4330, 4581], 'hydrolysis.': [3560], 'continuously': [3574], 'active': [3577], 'exchanging': [3581], 'once': [3585, 3645, 4500, 4615], 'halfway.': [3591], 'EV3E).': [3602], 'both,': [3606], 'hydrolysis,': [3611], 'observe.': [3621], 'force-induced': [3628], 'decompaction': [3629], 'next': [3631, 4622], 'disrupted': [3639], 'taken': [3650, 3885], 'place.': [3651], 'quantified': [3654], 'extension': [3657], '10': [3663, 3704, 3770, 3873, 3939, 3966, 4007, 4028, 4245, 4273], '0.75': [3665, 3781, 3877, 3913, 3988, 4049, 4301], 'pN': [3666, 3705, 3771, 3874, 3878, 3967, 3989, 4008, 4246], '3A).': [3669, 3773], '3B).': [3681], 'soon': [3683, 4313], 'about': [3692, 3930], 'length,': [3697], 'abruptly': [3699], '3C).': [3707], 'Upon': [3708], 'sudden': [3710], 'increase,': [3712], 'immediately': [3718], 'recover': [3719], 'extended': [3723, 3753, 4144], 'level,': [3724], 'contrast': [3726], 'response': [3729], 'molecule.': [3734], 'Instead,': [3735], 'seconds': [3740], '(~5': [3741], 's': [3742], 'example': [3745, 3884], 'Fig': [3747, 4378], '3C)': [3748], 'until': [3749, 4258], 'lowered': [3777, 3986, 4047, 4297, 4551], 'again': [3788, 4014, 4323, 4571, 4608], 'level': [3792], 'beginning': [3798], '3D).': [3803], 'condensin-dependent': [3807], 'stretching': [3815, 4341], 'forces,': [3820], 'consistent': [3821], 'previous': [3824], 'report': [3825], 'This,': [3836], 'hinder': [3840], '3.': [3847], 'Decompaction': [3848], 'switching': [3850], 'Pre-measurements': [3857], 'end-to-length': [3869], 'recorded': [3871], '(left)': [3875], '(right).': [3879], 'independent': [3890, 4382], 'experiments.': [3891], 'Although': [3892], 'decompaction,': [3901], 'qualitative': [3903], 'identical': [3906], 'all.': [3908], 'With': [3909], 'compacted.': [3928], '50%': [3931], 'suddenly': [3936], 'grey': [3942], 'area': [3943], 'magnet': [3950, 3962], 'moving,': [3952], 'black': [3955], 'vertical': [3956], 'arrived': [3963], 'position.': [3968], 'increased,': [3972], 'reversing': [3973], 'eventually': [3976, 4017], 'recovering': [3977], 'full': [3979, 4022, 4263], 'again.': [3990, 4001, 4009, 4145, 4171], 'recovered': [4018, 4261], 'premeasured': [4021], 'protein.': [4042, 4078], 'again,': [4093], 'pulling': [4101, 4247], 'washing.': [4103], 'green': [4105], 'shows': [4107, 4175], '0': [4114, 4182], 's,': [4115, 4150, 4183, 4527], 'mM),': [4138, 4207], '900': [4149], 'purple': [4173], 'change': [4210], 'detected.': [4215], 'added.': [4229], 'No': [4230], 'step,': [4248], '(~25': [4256], 's)': [4257], '3E).': [4267], 'nucleotide': [4290], '3F).': [4309], 'Strikingly,': [4310, 4547], 'protein),': [4321, 4569], '3G).': [4327], 'first,': [4332], 'stay': [4335], 'buffers': [4351], 'and,': [4352], 'second,': [4353], 'new': [4367], 'round': [4368], 'confirmed': [4373], 'outlined': [4376], '3A–G': [4379], '28).': [4386], 'mediate': [4397], 'helix,': [4407], 'encircling': [4410], 'pseudo-topologically': [4417], 'entrapping': [4418], 'inserting': [4421], 'ring,': [4427], 'combination': [4431], '(see': [4435], 'Discussion).': [4436], 'Whereas': [4437], 'sensitive': [4441], 'fibres': [4450], 'resist': [4452], '500–1,000': [4456], 'NaCl,': [4458], 'shown': [4460], 'bulk': [4462], 'biochemistry': [4463], 'how': [4471], 'interacts': [4473], 'assayed': [4487], 'stable': [4491], '500': [4497], 'NaCl': [4499], 'manner.': [4509], 'high-salt': [4520, 4602], '3H,': [4523], '450': [4526], '7).': [4530], 'maintaining': [4541], 'state.': [4546], '(125': [4557], 'NaCl)': [4559], '3I,': [4575], '1,050': [4578], 's).': [4579], 'loaded': [4588], 'use': [4592], 'associated': [4596], 'capable': [4606], 'lowered.': [4620], 'allow': [4629], 'DN': [4633]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2624734568', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 12}, {'year': 2019, 'cited_by_count': 23}, {'year': 2018, 'cited_by_count': 12}, {'year': 2017, 'cited_by_count': 5}], 'updated_date': '2024-12-19T22:09:51.558445', 'created_date': '2017-06-23'}
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