Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2622807556', 'doi': 'https://doi.org/10.1016/j.cell.2017.05.018', 'title': 'A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease', 'display_name': 'A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease', 'publication_year': 2017, 'publication_date': '2017-06-01', 'ids': {'openalex': 'https://openalex.org/W2622807556', 'doi': 'https://doi.org/10.1016/j.cell.2017.05.018', 'mag': '2622807556', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28602351'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.cell.2017.05.018', 'pdf_url': 'http://www.cell.com/article/S0092867417305780/pdf', 'source': {'id': 'https://openalex.org/S110447773', 'display_name': 'Cell', 'issn_l': '0092-8674', 'issn': ['0092-8674', '1097-4172'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'http://www.cell.com/article/S0092867417305780/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5069917573', 'display_name': 'Hadas Keren‐Shaul', 'orcid': 'https://orcid.org/0000-0002-2527-4505'}, 'institutions': [{'id': 'https://openalex.org/I53964585', 'display_name': 'Weizmann Institute of Science', 'ror': 'https://ror.org/0316ej306', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I53964585']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Hadas Keren-Shaul', 'raw_affiliation_strings': ['Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel', 'institution_ids': ['https://openalex.org/I53964585']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008151541', 'display_name': 'Amit Spinrad', 'orcid': 'https://orcid.org/0000-0003-0158-6464'}, 'institutions': [{'id': 'https://openalex.org/I53964585', 'display_name': 'Weizmann Institute of Science', 'ror': 'https://ror.org/0316ej306', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I53964585']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Amit Spinrad', 'raw_affiliation_strings': ['Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel', 'Department of Neurobiology, Weizmann Institute of Science, Rehovot 7610001, Israel'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurobiology, Weizmann Institute of Science, Rehovot 7610001, Israel', 'institution_ids': ['https://openalex.org/I53964585']}, {'raw_affiliation_string': 'Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel', 'institution_ids': ['https://openalex.org/I53964585']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083794799', 'display_name': 'Assaf Weiner', 'orcid': 'https://orcid.org/0000-0002-5389-9668'}, 'institutions': [{'id': 'https://openalex.org/I1322597698', 'display_name': 'Royal Netherlands Academy of Arts and Sciences', 'ror': 'https://ror.org/043c0p156', 'country_code': 'NL', 'type': 'government', 'lineage': ['https://openalex.org/I1322597698']}, {'id': 'https://openalex.org/I53964585', 'display_name': 'Weizmann Institute of Science', 'ror': 'https://ror.org/0316ej306', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I53964585']}], 'countries': ['IL', 'NL'], 'is_corresponding': False, 'raw_author_name': 'Assaf Weiner', 'raw_affiliation_strings': ['Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel', 'Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences), and University Medical Center, Cancer Genomics Netherlands, 3584 CG Utrecht, the Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences), and University Medical Center, Cancer Genomics Netherlands, 3584 CG Utrecht, the Netherlands', 'institution_ids': ['https://openalex.org/I1322597698']}, {'raw_affiliation_string': 'Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel', 'institution_ids': ['https://openalex.org/I53964585']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075695707', 'display_name': 'Orit Matcovitch-Natan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I53964585', 'display_name': 'Weizmann Institute of Science', 'ror': 'https://ror.org/0316ej306', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I53964585']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Orit Matcovitch-Natan', 'raw_affiliation_strings': ['Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel', 'Department of Neurobiology, Weizmann Institute of Science, Rehovot 7610001, Israel'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurobiology, Weizmann Institute of Science, Rehovot 7610001, Israel', 'institution_ids': ['https://openalex.org/I53964585']}, {'raw_affiliation_string': 'Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel', 'institution_ids': ['https://openalex.org/I53964585']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079672806', 'display_name': 'Raz Dvir-Szternfeld', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I53964585', 'display_name': 'Weizmann Institute of Science', 'ror': 'https://ror.org/0316ej306', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I53964585']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Raz Dvir-Szternfeld', 'raw_affiliation_strings': ['Department of Neurobiology, Weizmann Institute of Science, Rehovot 7610001, Israel'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurobiology, Weizmann Institute of Science, Rehovot 7610001, Israel', 'institution_ids': ['https://openalex.org/I53964585']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016691718', 'display_name': 'Tyler K. Ulland', 'orcid': 'https://orcid.org/0000-0002-6507-4989'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Tyler K. Ulland', 'raw_affiliation_strings': ['Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030630152', 'display_name': 'Eyal David', 'orcid': 'https://orcid.org/0000-0002-9020-2364'}, 'institutions': [{'id': 'https://openalex.org/I53964585', 'display_name': 'Weizmann Institute of Science', 'ror': 'https://ror.org/0316ej306', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I53964585']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Eyal David', 'raw_affiliation_strings': ['Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel', 'institution_ids': ['https://openalex.org/I53964585']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068281538', 'display_name': 'Kuti Baruch', 'orcid': 'https://orcid.org/0000-0002-1466-8795'}, 'institutions': [{'id': 'https://openalex.org/I53964585', 'display_name': 'Weizmann Institute of Science', 'ror': 'https://ror.org/0316ej306', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I53964585']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Kuti Baruch', 'raw_affiliation_strings': ['Department of Neurobiology, Weizmann Institute of Science, Rehovot 7610001, Israel'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurobiology, Weizmann Institute of Science, Rehovot 7610001, Israel', 'institution_ids': ['https://openalex.org/I53964585']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062648549', 'display_name': 'David Lara-Astaiso', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I53964585', 'display_name': 'Weizmann Institute of Science', 'ror': 'https://ror.org/0316ej306', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I53964585']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'David Lara-Astaiso', 'raw_affiliation_strings': ['Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel', 'institution_ids': ['https://openalex.org/I53964585']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102879876', 'display_name': 'Beáta Tóth', 'orcid': 'https://orcid.org/0000-0002-6124-3028'}, 'institutions': [{'id': 'https://openalex.org/I53964585', 'display_name': 'Weizmann Institute of Science', 'ror': 'https://ror.org/0316ej306', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I53964585']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Beata Toth', 'raw_affiliation_strings': ['Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel', 'institution_ids': ['https://openalex.org/I53964585']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042875880', 'display_name': 'Shalev Itzkovitz', 'orcid': 'https://orcid.org/0000-0003-0685-2522'}, 'institutions': [{'id': 'https://openalex.org/I53964585', 'display_name': 'Weizmann Institute of Science', 'ror': 'https://ror.org/0316ej306', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I53964585']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Shalev Itzkovitz', 'raw_affiliation_strings': ['Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel', 'institution_ids': ['https://openalex.org/I53964585']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055691289', 'display_name': 'Marco Colonna', 'orcid': 'https://orcid.org/0000-0001-5222-4987'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Marco Colonna', 'raw_affiliation_strings': ['Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102841602', 'display_name': 'Michal Schwartz', 'orcid': 'https://orcid.org/0000-0003-4015-7507'}, 'institutions': [{'id': 'https://openalex.org/I53964585', 'display_name': 'Weizmann Institute of Science', 'ror': 'https://ror.org/0316ej306', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I53964585']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Michal Schwartz', 'raw_affiliation_strings': ['Department of Neurobiology, Weizmann Institute of Science, Rehovot 7610001, Israel'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurobiology, Weizmann Institute of Science, Rehovot 7610001, Israel', 'institution_ids': ['https://openalex.org/I53964585']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5048280875', 'display_name': 'Ido Amit', 'orcid': 'https://orcid.org/0000-0003-2968-877X'}, 'institutions': [{'id': 'https://openalex.org/I53964585', 'display_name': 'Weizmann Institute of Science', 'ror': 'https://ror.org/0316ej306', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I53964585']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Ido Amit', 'raw_affiliation_strings': ['Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel', 'institution_ids': ['https://openalex.org/I53964585']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 10100, 'currency': 'USD', 'value_usd': 10100, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 173.206, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 3666, 'citation_normalized_percentile': {'value': 0.999802, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '169', 'issue': '7', 'first_page': '1276', 'last_page': '1290.e17'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11266', 'display_name': 'Role of Microglia in Neurological Disorders', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11266', 'display_name': 'Role of Microglia in Neurological Disorders', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10086', 'display_name': "Mechanisms of Alzheimer's Disease", 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11313', 'display_name': 'Macrophage Activation and Polarization', 'score': 0.9927, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/trem2', 'display_name': 'TREM2', 'score': 0.9806626}, {'id': 'https://openalex.org/keywords/cell-type', 'display_name': 'Cell type', 'score': 0.55647516}, {'id': 'https://openalex.org/keywords/microglia', 'display_name': 'Microglia', 'score': 0.529182}, {'id': 'https://openalex.org/keywords/amyloid', 'display_name': 'Amyloid (mycology)', 'score': 0.41672456}], 'concepts': [{'id': 'https://openalex.org/C2779685842', 'wikidata': 'https://www.wikidata.org/wiki/Q18040973', 'display_name': 'TREM2', 'level': 4, 'score': 0.9806626}, {'id': 'https://openalex.org/C2779830541', 'wikidata': 'https://www.wikidata.org/wiki/Q1622829', 'display_name': 'Microglia', 'level': 3, 'score': 0.963357}, {'id': 'https://openalex.org/C2776925932', 'wikidata': 'https://www.wikidata.org/wiki/Q1755122', 'display_name': 'Neurodegeneration', 'level': 3, 'score': 0.8287785}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.805053}, {'id': 'https://openalex.org/C189014844', 'wikidata': 'https://www.wikidata.org/wiki/Q189118', 'display_name': 'Cell type', 'level': 3, 'score': 0.55647516}, {'id': 'https://openalex.org/C127561419', 'wikidata': 'https://www.wikidata.org/wiki/Q224527', 'display_name': 'Downregulation and upregulation', 'level': 3, 'score': 0.5521895}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.5430088}, {'id': 'https://openalex.org/C502032728', 'wikidata': 'https://www.wikidata.org/wiki/Q11081', 'display_name': "Alzheimer's disease", 'level': 3, 'score': 0.52338773}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.45948586}, {'id': 'https://openalex.org/C141035611', 'wikidata': 'https://www.wikidata.org/wiki/Q5532934', 'display_name': 'Genetically modified mouse', 'level': 4, 'score': 0.44112512}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.43847334}, {'id': 'https://openalex.org/C2777633098', 'wikidata': 'https://www.wikidata.org/wiki/Q2736051', 'display_name': 'Amyloid (mycology)', 'level': 2, 'score': 0.41672456}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.4128637}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.41074452}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.39175949}, {'id': 'https://openalex.org/C102230213', 'wikidata': 'https://www.wikidata.org/wiki/Q430117', 'display_name': 'Transgene', 'level': 3, 'score': 0.3580172}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.22743246}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.1596196}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.12013471}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.11806089}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.104103446}, {'id': 'https://openalex.org/C59822182', 'wikidata': 'https://www.wikidata.org/wiki/Q441', 'display_name': 'Botany', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D017628', 'descriptor_name': 'Microglia', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D010586', 'descriptor_name': 'Phagocytes', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008822', 'descriptor_name': 'Mice, Transgenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017628', 'descriptor_name': 'Microglia', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017628', 'descriptor_name': 'Microglia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019636', 'descriptor_name': 'Neurodegenerative Diseases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019636', 'descriptor_name': 'Neurodegenerative Diseases', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D019636', 'descriptor_name': 'Neurodegenerative Diseases', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D019636', 'descriptor_name': 'Neurodegenerative Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010586', 'descriptor_name': 'Phagocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010586', 'descriptor_name': 'Phagocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011971', 'descriptor_name': 'Receptors, Immunologic', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011971', 'descriptor_name': 'Receptors, Immunologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017423', 'descriptor_name': 'Sequence Analysis, RNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059010', 'descriptor_name': 'Single-Cell Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.cell.2017.05.018', 'pdf_url': 'http://www.cell.com/article/S0092867417305780/pdf', 'source': {'id': 'https://openalex.org/S110447773', 'display_name': 'Cell', 'issn_l': '0092-8674', 'issn': ['0092-8674', '1097-4172'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28602351', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.cell.2017.05.018', 'pdf_url': 'http://www.cell.com/article/S0092867417305780/pdf', 'source': {'id': 'https://openalex.org/S110447773', 'display_name': 'Cell', 'issn_l': '0092-8674', 'issn': ['0092-8674', '1097-4172'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.68}], 'grants': [{'funder': 'https://openalex.org/F4320320878', 'funder_display_name': 'Minerva Foundation', 'award_id': None}, {'funder': 'https://openalex.org/F4320320948', 'funder_display_name': 'Ministry of Science, Technology and Space', 'award_id': None}, {'funder': 'https://openalex.org/F4320322252', 'funder_display_name': 'Israel Science Foundation', 'award_id': None}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': '5T32CA009547-30'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'RF1AG05148501'}, {'funder': 'https://openalex.org/F4320334678', 'funder_display_name': 'European Research Council', 'award_id': '232835'}], 'datasets': [], 'versions': [], 'referenced_works_count': 88, 'referenced_works': ['https://openalex.org/W1545421865', 'https://openalex.org/W1569729025', 'https://openalex.org/W1631320694', 'https://openalex.org/W1813068103', 'https://openalex.org/W1841850981', 'https://openalex.org/W1847843341', 'https://openalex.org/W1913122697', 'https://openalex.org/W1918237073', 'https://openalex.org/W1960367851', 'https://openalex.org/W1964951991', 'https://openalex.org/W1976775990', 'https://openalex.org/W1979283544', 'https://openalex.org/W1979545739', 'https://openalex.org/W1982754708', 'https://openalex.org/W1987391422', 'https://openalex.org/W1993287310', 'https://openalex.org/W1999516517', 'https://openalex.org/W2003674452', 'https://openalex.org/W2004492484', 'https://openalex.org/W2005483591', 'https://openalex.org/W2010683624', 'https://openalex.org/W2011041653', 'https://openalex.org/W2012136117', 'https://openalex.org/W2023887100', 'https://openalex.org/W2026970282', 'https://openalex.org/W2036362108', 'https://openalex.org/W2040578796', 'https://openalex.org/W2058669152', 'https://openalex.org/W2068881679', 'https://openalex.org/W2070847731', 'https://openalex.org/W2071010503', 'https://openalex.org/W2081117923', 'https://openalex.org/W2082414904', 'https://openalex.org/W2087845192', 'https://openalex.org/W2089159998', 'https://openalex.org/W2096401612', 'https://openalex.org/W2096410114', 'https://openalex.org/W2100533805', 'https://openalex.org/W2102278945', 'https://openalex.org/W2102769637', 'https://openalex.org/W2104648879', 'https://openalex.org/W2107768418', 'https://openalex.org/W2108398194', 'https://openalex.org/W2111789241', 'https://openalex.org/W2112499304', 'https://openalex.org/W2115855931', 'https://openalex.org/W2117601071', 'https://openalex.org/W2118751252', 'https://openalex.org/W2119958966', 'https://openalex.org/W2124490243', 'https://openalex.org/W2126020723', 'https://openalex.org/W2128613449', 'https://openalex.org/W2131686384', 'https://openalex.org/W2135768865', 'https://openalex.org/W2140139281', 'https://openalex.org/W2149538964', 'https://openalex.org/W2150318471', 'https://openalex.org/W2151153178', 'https://openalex.org/W2154267987', 'https://openalex.org/W2155344647', 'https://openalex.org/W2157648547', 'https://openalex.org/W2159443316', 'https://openalex.org/W2162070793', 'https://openalex.org/W2163410184', 'https://openalex.org/W2166267133', 'https://openalex.org/W2170644095', 'https://openalex.org/W2171280873', 'https://openalex.org/W2172511511', 'https://openalex.org/W2177432730', 'https://openalex.org/W2200279205', 'https://openalex.org/W2252060117', 'https://openalex.org/W2271499489', 'https://openalex.org/W2272042925', 'https://openalex.org/W2273901578', 'https://openalex.org/W2275354472', 'https://openalex.org/W2339534121', 'https://openalex.org/W2408084759', 'https://openalex.org/W2437177691', 'https://openalex.org/W2468501494', 'https://openalex.org/W2488417892', 'https://openalex.org/W2500839489', 'https://openalex.org/W2504925882', 'https://openalex.org/W2506892818', 'https://openalex.org/W2510684933', 'https://openalex.org/W2528543174', 'https://openalex.org/W2554948325', 'https://openalex.org/W2561508962', 'https://openalex.org/W3023013291'], 'related_works': ['https://openalex.org/W4385372854', 'https://openalex.org/W4380893801', 'https://openalex.org/W4376648595', 'https://openalex.org/W4360609725', 'https://openalex.org/W4309593279', 'https://openalex.org/W4308968236', 'https://openalex.org/W4283317699', 'https://openalex.org/W4229004030', 'https://openalex.org/W2796284128', 'https://openalex.org/W2763445772'], 'abstract_inverted_index': {"Alzheimer's": [0], 'disease': [1, 7], '(AD)': [2], 'is': [3, 105, 112], 'a': [4, 50, 108, 115, 128], 'detrimental': [5], 'neurodegenerative': [6, 56, 152], 'with': [8, 55, 67, 80], 'no': [9], 'effective': [10], 'treatments.': [11], 'Due': [12], 'to': [13, 137], 'cellular': [14], 'heterogeneity,': [15], 'defining': [16], 'the': [17, 102, 135], 'roles': [18], 'of': [19, 72, 86, 121, 127, 148], 'immune': [20, 39], 'cell': [21], 'subsets': [22], 'in': [23, 41, 88, 107, 114], 'AD': [24, 149], 'onset': [25], 'and': [26, 43, 59, 64, 74, 90, 150], 'progression': [27], 'has': [28, 134], 'been': [29], 'challenging.': [30], 'Using': [31], 'transcriptional': [32], 'single-cell': [33], 'sorting,': [34], 'we': [35], 'comprehensively': [36], 'map': [37], 'all': [38], 'populations': [40], 'wild-type': [42], 'AD-transgenic': [44], '(Tg-AD)': [45], 'mouse': [46], 'brains.': [47], 'We': [48], 'describe': [49], 'novel': [51], 'microglia': [52, 122], 'type': [53], 'associated': [54, 66], 'diseases': [57], '(DAM)': [58], 'identify': [60], 'markers,': [61], 'spatial': [62], 'localization,': [63], 'pathways': [65], 'these': [68], 'cells.': [69], 'Immunohistochemical': [70], 'staining': [71], 'mice': [73], 'human': [75], 'brain': [76], 'slices': [77], 'shows': [78], 'DAM': [79, 87, 103], 'intracellular/phagocytic': [81], 'Aβ': [82], 'particles.': [83], 'Single-cell': [84], 'analysis': [85], 'Tg-AD': [89, 99], 'triggering': [91], 'receptor': [92], 'expressed': [93], 'on': [94], 'myeloid': [95], 'cells': [96], '2': [97], '(Trem2)-/-': [98], 'reveals': [100], 'that': [101, 118], 'program': [104], 'activated': [106], 'two-step': [109], 'process.': [110], 'Activation': [111], 'initiated': [113], 'Trem2-independent': [116], 'manner': [117], 'involves': [119], 'downregulation': [120], 'checkpoints,': [123], 'followed': [124], 'by': [125], 'activation': [126], 'Trem2-dependent': [129], 'program.': [130], 'This': [131], 'unique': [132], 'microglia-type': [133], 'potential': [136], 'restrict': [138], 'neurodegeneration,': [139], 'which': [140], 'may': [141], 'have': [142], 'important': [143], 'implications': [144], 'for': [145], 'future': [146], 'treatment': [147], 'other': [151], 'diseases.': [153], 'VIDEO': [154], 'ABSTRACT.': [155]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2622807556', 'counts_by_year': [{'year': 2024, 'cited_by_count': 463}, {'year': 2023, 'cited_by_count': 694}, {'year': 2022, 'cited_by_count': 698}, {'year': 2021, 'cited_by_count': 619}, {'year': 2020, 'cited_by_count': 482}, {'year': 2019, 'cited_by_count': 356}, {'year': 2018, 'cited_by_count': 255}, {'year': 2017, 'cited_by_count': 40}], 'updated_date': '2024-09-17T04:43:32.250517', 'created_date': '2017-06-15'}