Abstract: Hypertension is heritable and is a major global health problem. Identifying genetic variants contributing to the disorder has been challenging, but from 2009, there have been significant advances in our understanding of the genetic basis of hypertension and continuous blood pressure (BP) variation. Meta-analyses of genome-wide association studies and large-scale analyses of samples genotyped using arrays with bespoke content have led to the discovery of 125 distinct BP loci. In this chapter, we describe an overview of the key association studies, highlighting specific candidate genes and mechanisms and their contribution to our understanding of disease pathology. We also review the overlap of BP genetic variants with other cardiovascular traits and report the utility of BP genetic variants for predicting risk of hypertension and cardiovascular disease.
Publication Year: 2017
Publication Date: 2017-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
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