Cytotoxic profiling of artesunic and betulinic acids and their synthetic hybrid compound on neurons and gliomas

Name: Work Video:
Duration: 3 min 30 s
Annemarie Ackermann; Aysun Çapcı; Ali Ghoochani; Michael Buchfelder; Ilker Y. Eyüpoglu; Svetlana B. Tsogoeva; Nicolai Ε. Savaskan
{'id': 'https://openalex.org/W2621451161', 'doi': 'https://doi.org/10.18632/oncotarget.18390', 'title': 'Cytotoxic profiling of artesunic and betulinic acids and their synthetic hybrid compound on neurons and gliomas', 'display_name': 'Cytotoxic profiling of artesunic and betulinic acids and their synthetic hybrid compound on neurons and gliomas', 'publication_year': 2017, 'publication_date': '2017-06-07', 'ids': {'openalex': 'https://openalex.org/W2621451161', 'doi': 'https://doi.org/10.18632/oncotarget.18390', 'mag': '2621451161', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28977877', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5617437'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.18390', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=18390&path%5B%5D=59218', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=18390&path%5B%5D=59218', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5016398028', 'display_name': 'Annemarie Ackermann', 'orcid': None}, 'institutions': [], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Annemarie Ackermann', 'raw_affiliation_strings': ['Translational Cell Biology & Neurooncology Laboratory, Universitätsklinikum Medical School Erlangen, Friedrich-Alexander University of Erlangen - Nürnberg (FAU), Erlangen, Germany'], 'affiliations': [{'raw_affiliation_string': 'Translational Cell Biology & Neurooncology Laboratory, Universitätsklinikum Medical School Erlangen, Friedrich-Alexander University of Erlangen - Nürnberg (FAU), Erlangen, Germany', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028156459', 'display_name': 'Aysun Çapcı', 'orcid': 'https://orcid.org/0000-0002-7034-5210'}, 'institutions': [{'id': 'https://openalex.org/I181369854', 'display_name': 'Friedrich-Alexander-Universität Erlangen-Nürnberg', 'ror': 'https://ror.org/00f7hpc57', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I181369854']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Aysun Çapcı Karagöz', 'raw_affiliation_strings': ['Interdisciplinary Center for Molecular Materials (ICMM), Friedrich-Alexander University of Erlangen - Nürnberg (FAU), Erlangen, Germany'], 'affiliations': [{'raw_affiliation_string': 'Interdisciplinary Center for Molecular Materials (ICMM), Friedrich-Alexander University of Erlangen - Nürnberg (FAU), Erlangen, Germany', 'institution_ids': ['https://openalex.org/I181369854']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003625877', 'display_name': 'Ali Ghoochani', 'orcid': 'https://orcid.org/0000-0002-5352-0072'}, 'institutions': [], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Ali Ghoochani', 'raw_affiliation_strings': ['Translational Cell Biology & Neurooncology Laboratory, Universitätsklinikum Medical School Erlangen, Friedrich-Alexander University of Erlangen - Nürnberg (FAU), Erlangen, Germany'], 'affiliations': [{'raw_affiliation_string': 'Translational Cell Biology & Neurooncology Laboratory, Universitätsklinikum Medical School Erlangen, Friedrich-Alexander University of Erlangen - Nürnberg (FAU), Erlangen, Germany', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023048333', 'display_name': 'Michael Buchfelder', 'orcid': 'https://orcid.org/0000-0002-1955-4957'}, 'institutions': [], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Michael Buchfelder', 'raw_affiliation_strings': ['Department of Neurosurgery, Universitätsklinikum Medical School Erlangen, Friedrich-Alexander University of Erlangen - Nürnberg (FAU), Erlangen, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurosurgery, Universitätsklinikum Medical School Erlangen, Friedrich-Alexander University of Erlangen - Nürnberg (FAU), Erlangen, Germany', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085602803', 'display_name': 'Ilker Y. Eyüpoglu', 'orcid': 'https://orcid.org/0000-0002-8185-7764'}, 'institutions': [], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Ilker Eyüpoglu', 'raw_affiliation_strings': ['Department of Neurosurgery, Universitätsklinikum Medical School Erlangen, Friedrich-Alexander University of Erlangen - Nürnberg (FAU), Erlangen, Germany', 'Translational Cell Biology & Neurooncology Laboratory, Universitätsklinikum Medical School Erlangen, Friedrich-Alexander University of Erlangen - Nürnberg (FAU), Erlangen, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurosurgery, Universitätsklinikum Medical School Erlangen, Friedrich-Alexander University of Erlangen - Nürnberg (FAU), Erlangen, Germany', 'institution_ids': []}, {'raw_affiliation_string': 'Translational Cell Biology & Neurooncology Laboratory, Universitätsklinikum Medical School Erlangen, Friedrich-Alexander University of Erlangen - Nürnberg (FAU), Erlangen, Germany', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002128015', 'display_name': 'Svetlana B. Tsogoeva', 'orcid': 'https://orcid.org/0000-0003-4845-0951'}, 'institutions': [{'id': 'https://openalex.org/I181369854', 'display_name': 'Friedrich-Alexander-Universität Erlangen-Nürnberg', 'ror': 'https://ror.org/00f7hpc57', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I181369854']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Svetlana B. Tsogoeva', 'raw_affiliation_strings': ['Interdisciplinary Center for Molecular Materials (ICMM), Friedrich-Alexander University of Erlangen - Nürnberg (FAU), Erlangen, Germany'], 'affiliations': [{'raw_affiliation_string': 'Interdisciplinary Center for Molecular Materials (ICMM), Friedrich-Alexander University of Erlangen - Nürnberg (FAU), Erlangen, Germany', 'institution_ids': ['https://openalex.org/I181369854']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5084969160', 'display_name': 'Nicolai Ε. Savaskan', 'orcid': 'https://orcid.org/0000-0003-1348-094X'}, 'institutions': [], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Nicolai Savaskan', 'raw_affiliation_strings': ['BiMECON Ent., Berlin, Germany', 'Department of Neurosurgery, Universitätsklinikum Medical School Erlangen, Friedrich-Alexander University of Erlangen - Nürnberg (FAU), Erlangen, Germany', 'Translational Cell Biology & Neurooncology Laboratory, Universitätsklinikum Medical School Erlangen, Friedrich-Alexander University of Erlangen - Nürnberg (FAU), Erlangen, Germany'], 'affiliations': [{'raw_affiliation_string': 'Translational Cell Biology & Neurooncology Laboratory, Universitätsklinikum Medical School Erlangen, Friedrich-Alexander University of Erlangen - Nürnberg (FAU), Erlangen, Germany', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Neurosurgery, Universitätsklinikum Medical School Erlangen, Friedrich-Alexander University of Erlangen - Nürnberg (FAU), Erlangen, Germany', 'institution_ids': []}, {'raw_affiliation_string': 'BiMECON Ent., Berlin, Germany', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.324, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 26, 'citation_normalized_percentile': {'value': 0.999983, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '8', 'issue': '37', 'first_page': '61457', 'last_page': '61474'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11385', 'display_name': 'Natural product bioactivities and synthesis', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11385', 'display_name': 'Natural product bioactivities and synthesis', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11882', 'display_name': 'Plant biochemistry and biosynthesis', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12763', 'display_name': 'ATP Synthase and ATPases Research', 'score': 0.9924, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/profiling', 'display_name': 'Profiling (computer programming)', 'score': 0.52214557}, {'id': 'https://openalex.org/keywords/betulinic-acid', 'display_name': 'Betulinic acid', 'score': 0.49681118}], 'concepts': [{'id': 'https://openalex.org/C154317977', 'wikidata': 'https://www.wikidata.org/wiki/Q376266', 'display_name': 'Cytotoxic T cell', 'level': 3, 'score': 0.63776916}, {'id': 'https://openalex.org/C187191949', 'wikidata': 'https://www.wikidata.org/wiki/Q1138496', 'display_name': 'Profiling (computer programming)', 'level': 2, 'score': 0.52214557}, {'id': 'https://openalex.org/C2777829905', 'wikidata': 'https://www.wikidata.org/wiki/Q384111', 'display_name': 'Betulinic acid', 'level': 2, 'score': 0.49681118}, {'id': 'https://openalex.org/C2778227246', 'wikidata': 'https://www.wikidata.org/wiki/Q1365309', 'display_name': 'Glioma', 'level': 2, 'score': 0.49092513}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.3999126}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.3795156}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.3685442}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.35498425}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3448236}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.29424134}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.19368729}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.16175362}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.12810707}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.11264151}, {'id': 'https://openalex.org/C111919701', 'wikidata': 'https://www.wikidata.org/wiki/Q9135', 'display_name': 'Operating system', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.18390', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=18390&path%5B%5D=59218', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5617437', 'pdf_url': 'https://europepmc.org/articles/pmc5617437?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617437', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28977877', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.18390', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=18390&path%5B%5D=59218', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.68}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 37, 'referenced_works': ['https://openalex.org/W1159651283', 'https://openalex.org/W1928741718', 'https://openalex.org/W1965003536', 'https://openalex.org/W1966091165', 'https://openalex.org/W1966600968', 'https://openalex.org/W1981953479', 'https://openalex.org/W1986303437', 'https://openalex.org/W1990285247', 'https://openalex.org/W1992913416', 'https://openalex.org/W2000178617', 'https://openalex.org/W2007943664', 'https://openalex.org/W2008230870', 'https://openalex.org/W2009295553', 'https://openalex.org/W2014023055', 'https://openalex.org/W2020605686', 'https://openalex.org/W2024758998', 'https://openalex.org/W2036044314', 'https://openalex.org/W2049422105', 'https://openalex.org/W2058790453', 'https://openalex.org/W2060145133', 'https://openalex.org/W2072274768', 'https://openalex.org/W2078082769', 'https://openalex.org/W2093156396', 'https://openalex.org/W2093916545', 'https://openalex.org/W2096526848', 'https://openalex.org/W2101093124', 'https://openalex.org/W2104958914', 'https://openalex.org/W2117048089', 'https://openalex.org/W2117596444', 'https://openalex.org/W2125227046', 'https://openalex.org/W2143580218', 'https://openalex.org/W2158408725', 'https://openalex.org/W2206358580', 'https://openalex.org/W2256742438', 'https://openalex.org/W2268238118', 'https://openalex.org/W2309471677', 'https://openalex.org/W2418439210'], 'related_works': ['https://openalex.org/W911845349', 'https://openalex.org/W4319984117', 'https://openalex.org/W3200057063', 'https://openalex.org/W2394340714', 'https://openalex.org/W2376213619', 'https://openalex.org/W2373452650', 'https://openalex.org/W2373431535', 'https://openalex.org/W2370613685', 'https://openalex.org/W2034988225', 'https://openalex.org/W1969225559'], 'abstract_inverted_index': {'//': [0], 'Annemarie': [1], 'Ackermann': [2], '1,': [3, 22, 32], '*': [4, 10, 93], ',': [5, 11, 15, 19, 24], 'Aysun': [6], 'Çapcı': [7], 'Karagöz': [8], '2,': [9], 'Ali': [12], 'Ghoochani': [13], '1': [14, 35], 'Michael': [16], 'Buchfelder': [17], '3': [18, 23, 71], 'Ilker': [20], 'Eyüpoglu': [21], 'Svetlana': [25, 110], 'B.': [26, 111], 'Tsogoeva': [27], '2': [28, 55], 'and': [29, 179, 193, 215, 223, 226, 269, 282, 313, 332, 356], 'Nicolai': [30, 104], 'Savaskan': [31], '3,': [33], '4': [34, 88], 'Translational': [36], 'Cell': [37], 'Biology': [38], '&': [39], 'Neurooncology': [40], 'Laboratory,': [41], 'Universitätsklinikum': [42, 75], 'Medical': [43, 76], 'School': [44, 77], 'Erlangen,': [45, 53, 69, 78, 86], 'Friedrich-Alexander': [46, 62, 79], 'University': [47, 63, 80], 'of': [48, 64, 73, 81, 155, 213, 300, 308, 385], 'Erlangen': [49, 65, 82], '–': [50, 66, 83], 'Nürnberg': [51, 67, 84], '(FAU),': [52, 68, 85], 'Germany': [54, 70, 87, 92], 'Interdisciplinary': [56], 'Center': [57], 'for': [58, 379, 399], 'Molecular': [59], 'Materials': [60], '(ICMM),': [61], 'Department': [72], 'Neurosurgery,': [74], 'BiMECON': [89], 'Ent.,': [90], 'Berlin,': [91], 'These': [94], 'authors': [95], 'have': [96], 'contributed': [97], 'equally': [98], 'to': [99, 162, 200, 203, 246, 259, 325], 'this': [100], 'work': [101], 'Correspondence': [102], 'to:': [103], 'Savaskan,': [105], 'email:': [106, 113], '[email protected]': [107], 'or': [108], '[email protected]': [109], 'Tsogoeva,': [112], '[email protected]': [114], 'Keywords:': [115], 'cell': [116, 343], 'death,': [117], 'cancer': [118], 'cytotoxicity,': [119], 'artesunic': [120, 176, 190], 'acid,': [121, 123], 'betulinic': [122, 183], 'hybrid': [124, 160, 205, 302, 316, 334, 373, 392], 'synthesis': [125, 374], 'Received:': [126], 'October': [127], '11,': [128], '2016': [129], 'Accepted:': [130], 'May': [131], '07,': [132, 136], '2017': [133, 137], 'Published:': [134], 'June': [135], 'ABSTRACT': [138], 'Gliomas': [139], 'are': [140], 'brain-born': [141], 'tumors': [142], 'with': [143, 304, 360, 403], 'devastating': [144], 'impact': [145, 212, 340], 'on': [146, 169, 219, 231, 241, 254, 265, 280, 341], 'their': [147], 'brain': [148], 'microenvironment.': [149], 'Novel': [150], 'approaches': [151], 'employ': [152], 'multiple': [153], 'combinations': [154], 'chemical': [156, 171, 372], 'compounds': [157, 218, 264, 311, 354], 'in': [158, 320], 'synthetic': [159, 391], 'molecules': [161], 'target': [163], 'malignant': [164], 'tumors.': [165], 'Here,': [166], 'we': [167, 296], 'report': [168], 'the': [170, 204, 211, 298, 301, 305, 333, 371], 'hybridization': [172], 'approach': [173, 378], 'exemplified': [174], 'by': [175], 'acid': [177, 184, 191], '(ARTA)': [178, 192], 'naturally': [180, 194], 'occurring': [181, 195], 'triterpene': [182, 196], '(BETA).': [185], 'Artemisinin': [186], 'derived': [187, 353], 'semisynthetic': [188], 'compound': [189, 206, 327], 'BETA': [197, 227, 249, 285, 357], 'were': [198], 'used': [199], 'synthetically': [201], 'couple': [202], 'termed': [207], '212A.': [208], 'We': [209, 261], 'investigated': [210, 262], '212A': [214, 289, 303, 317, 335], 'its': [216, 309], 'parent': [217, 310], 'glioma': [220, 232, 243, 256, 322, 342], 'cells,': [221], 'astrocytes': [222, 281], 'neurons.': [224], 'ARTA': [225, 237, 274, 312, 331, 355], 'showed': [228, 275], 'cytotoxic': [229, 339], 'effects': [230, 253, 279], 'cells': [233, 244, 257, 268, 323], 'at': [234, 292], 'micromolar': [235], 'concentrations.': [236, 294], 'was': [238, 318], 'more': [239], 'effective': [240], 'rodent': [242], 'compared': [245, 258, 297, 324], 'BETA,': [247], 'whereas': [248, 284], 'exhibited': [250], 'higher': [251, 293], 'toxic': [252, 278], 'human': [255], 'ARTA.': [260], 'these': [263, 347], 'non-transformed': [266], 'glial': [267], 'neurons': [270], 'as': [271, 286, 288, 395], 'well.': [272], 'Noteworthy,': [273], 'almost': [276], 'no': [277], 'neurons,': [283], 'well': [287], 'displayed': [290, 336], 'neurotoxicity': [291], 'Hence': [295], 'efficacy': [299], 'combinational': [306], 'treatment': [307, 328], 'BETA.': [314], 'The': [315], 'efficient': [319], 'killing': [321], 'single': [326], 'strategies.': [329], 'Moreover,': [330], 'a': [337, 376], 'significant': [338], 'migration.': [344], 'Taken': [345], 'together,': [346], 'results': [348], 'demonstrate': [349], 'that': [350, 370], 'both': [351], 'plant': [352], 'operate': [358], 'gliomatoxic': [359], 'minor': [361], 'neurotoxic': [362, 405], 'side': [363], 'effects.': [364], 'Altogether,': [365], 'our': [366], 'proof-of-principle': [367], 'study': [368], 'demonstrates': [369], 'is': [375], 'valid': [377], 'generating': [380], 'efficacious': [381], 'anti-cancer': [382], 'drugs': [383], 'out': [384], 'virtually': [386], 'any': [387], 'given': [388], 'structure.': [389], 'Thus,': [390], 'therapeutics': [393], 'emerge': [394], 'an': [396], 'innovative': [397], 'field': [398], 'new': [400], 'chemotherapeutic': [401], 'developments': [402], 'low': [404], 'profile.': [406]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2621451161', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 1}], 'updated_date': '2024-12-15T16:16:02.704966', 'created_date': '2017-06-15'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
