Title: SP695REDUCED OXIDATIVE STRESS IN HEMODIALYSIS PATIENTS WITH SECONDARY HYPERPARATHYROIDISM TREATED WITH CINACALCET
Abstract: divided into two groups according to baseline PA: group A included patients with PA 4.5 , while group B included patients with PA <4.5 .RESULTS: A total of 142 patients (77 [54.2%] in group A and 65 [45.8%] in group B) were included and were followed-up for 29 (12, 42) months.Baseline PA was 4.6 6 1.0 .We found that a decrease in PA was associated with an increased risk of death that persisted after adjusting for age, sex, and comorbidities (HR 0.56, 95% CI 0.33 -0.97; P = 0.039).Cardiovascular events were not associated with PA (P = 0.685).Conversely, we found that PA predicted the occurrence of infection, independent of age, sex, and comorbidities (HR 0.65, 95% CI 0.45 -0.94; P = 0.021).Although levels of hemoglobin did not differ between groups during the study period, patients in group B received higher doses of erythropoiesis-stimulating agents and intravenous iron than those in group A (P = 0.004 and 0.044, respectively).In longitudinal analyses, we did not find increases in PA over time in patients who had a mean Kt/V urea 1.4, protein catabolic rate 1.2 g/kg/day, or total carbon dioxide level 22 mmol/L.CONCLUSIONS: Nutritional status can be assessed in a simple manner using BIA, and it provides practical information to predict clinical outcomes such as infection and all-cause death in ESRD patients on maintenance hemodialysis.