Publication Information

{'id': 'https://openalex.org/W2616933475', 'doi': 'https://doi.org/10.1111/jphp.12752', 'title': 'Daily oral administration of low-dose methotrexate has greater antirheumatic effects in collagen-induced arthritis rats', 'display_name': 'Daily oral administration of low-dose methotrexate has greater antirheumatic effects in collagen-induced arthritis rats', 'publication_year': 2017, 'publication_date': '2017-05-31', 'ids': {'openalex': 'https://openalex.org/W2616933475', 'doi': 'https://doi.org/10.1111/jphp.12752', 'mag': '2616933475', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28560778', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5575561'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/jphp.12752', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jphp.12752', 'source': {'id': 'https://openalex.org/S118304455', 'display_name': 'Journal of Pharmacy and Pharmacology', 'issn_l': '0022-3573', 'issn': ['0022-3573', '2042-7158'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jphp.12752', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5025819395', 'display_name': 'Aoi Koyama', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I42766147', 'display_name': 'University of Toyama', 'ror': 'https://ror.org/0445phv87', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I42766147']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Aoi Koyama', 'raw_affiliation_strings': ['Department of Medical Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama, Japan', 'institution_ids': ['https://openalex.org/I42766147']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075646627', 'display_name': 'Aki Tanaka', 'orcid': 'https://orcid.org/0000-0001-9925-9992'}, 'institutions': [{'id': 'https://openalex.org/I42766147', 'display_name': 'University of Toyama', 'ror': 'https://ror.org/0445phv87', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I42766147']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Aki Tanaka', 'raw_affiliation_strings': ['Department of Medical Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama, Japan', 'institution_ids': ['https://openalex.org/I42766147']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5070620529', 'display_name': 'Hideto To', 'orcid': 'https://orcid.org/0000-0001-7868-3479'}, 'institutions': [{'id': 'https://openalex.org/I42766147', 'display_name': 'University of Toyama', 'ror': 'https://ror.org/0445phv87', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I42766147']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Hideto To', 'raw_affiliation_strings': ['Department of Medical Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama, Japan', 'institution_ids': ['https://openalex.org/I42766147']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5070620529'], 'corresponding_institution_ids': ['https://openalex.org/I42766147'], 'apc_list': {'value': 2665, 'currency': 'GBP', 'value_usd': 3268, 'provenance': 'doaj'}, 'apc_paid': {'value': 2665, 'currency': 'GBP', 'value_usd': 3268, 'provenance': 'doaj'}, 'fwci': 1.81, 'has_fulltext': False, 'cited_by_count': 29, 'citation_normalized_percentile': {'value': 0.830287, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '69', 'issue': '9', 'first_page': '1145', 'last_page': '1154'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10200', 'display_name': 'Rheumatoid Arthritis Research and Therapies', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10200', 'display_name': 'Rheumatoid Arthritis Research and Therapies', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11616', 'display_name': 'Autoimmune and Inflammatory Disorders Research', 'score': 0.9938, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11735', 'display_name': 'Peripheral Neuropathies and Disorders', 'score': 0.9877, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.9001721}, {'id': 'https://openalex.org/C2781059491', 'wikidata': 'https://www.wikidata.org/wiki/Q422232', 'display_name': 'Methotrexate', 'level': 2, 'score': 0.8674426}, {'id': 'https://openalex.org/C2777575956', 'wikidata': 'https://www.wikidata.org/wiki/Q187255', 'display_name': 'Rheumatoid arthritis', 'level': 2, 'score': 0.8551582}, {'id': 'https://openalex.org/C2777288759', 'wikidata': 'https://www.wikidata.org/wiki/Q4164182', 'display_name': 'Dosing', 'level': 2, 'score': 0.80623186}, {'id': 'https://openalex.org/C2777077863', 'wikidata': 'https://www.wikidata.org/wiki/Q170990', 'display_name': 'Arthritis', 'level': 2, 'score': 0.783298}, {'id': 'https://openalex.org/C2777014857', 'wikidata': 'https://www.wikidata.org/wiki/Q1383410', 'display_name': 'Exacerbation', 'level': 2, 'score': 0.6751604}, {'id': 'https://openalex.org/C197934379', 'wikidata': 'https://www.wikidata.org/wiki/Q2047938', 'display_name': 'Adverse effect', 'level': 2, 'score': 0.5482658}, {'id': 'https://openalex.org/C2777056448', 'wikidata': 'https://www.wikidata.org/wiki/Q285166', 'display_name': 'Oral administration', 'level': 2, 'score': 0.45218676}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.44836023}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.43446106}], 'mesh': [{'descriptor_ui': 'D018501', 'descriptor_name': 'Antirheumatic Agents', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D001169', 'descriptor_name': 'Arthritis, Experimental', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D001172', 'descriptor_name': 'Arthritis, Rheumatoid', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D008727', 'descriptor_name': 'Methotrexate', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D000284', 'descriptor_name': 'Administration, Oral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018501', 'descriptor_name': 'Antirheumatic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018501', 'descriptor_name': 'Antirheumatic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D001169', 'descriptor_name': 'Arthritis, Experimental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001169', 'descriptor_name': 'Arthritis, Experimental', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D001172', 'descriptor_name': 'Arthritis, Rheumatoid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001172', 'descriptor_name': 'Arthritis, Rheumatoid', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D003094', 'descriptor_name': 'Collagen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018450', 'descriptor_name': 'Disease Progression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004334', 'descriptor_name': 'Drug Administration Schedule', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008727', 'descriptor_name': 'Methotrexate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008727', 'descriptor_name': 'Methotrexate', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011917', 'descriptor_name': 'Rats, Inbred Lew', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/jphp.12752', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jphp.12752', 'source': {'id': 'https://openalex.org/S118304455', 'display_name': 'Journal of Pharmacy and Pharmacology', 'issn_l': '0022-3573', 'issn': ['0022-3573', '2042-7158'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5575561', 'pdf_url': 'https://europepmc.org/articles/pmc5575561?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575561', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28560778', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/jphp.12752', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jphp.12752', 'source': {'id': 'https://openalex.org/S118304455', 'display_name': 'Journal of Pharmacy and Pharmacology', 'issn_l': '0022-3573', 'issn': ['0022-3573', '2042-7158'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.75}], 'grants': [{'funder': 'https://openalex.org/F4320310756', 'funder_display_name': 'Japan Research Foundation for Clinical Pharmacology', 'award_id': None}], 'datasets': [], 'versions': [], 'referenced_works_count': 24, 'referenced_works': ['https://openalex.org/W1974843585', 'https://openalex.org/W2025236816', 'https://openalex.org/W2030415183', 'https://openalex.org/W2040623773', 'https://openalex.org/W2056909025', 'https://openalex.org/W2059454672', 'https://openalex.org/W2064949253', 'https://openalex.org/W2065419533', 'https://openalex.org/W2066409058', 'https://openalex.org/W2088893866', 'https://openalex.org/W2094584583', 'https://openalex.org/W2097265582', 'https://openalex.org/W2103775523', 'https://openalex.org/W2118281867', 'https://openalex.org/W2133692536', 'https://openalex.org/W2152348310', 'https://openalex.org/W2168751860', 'https://openalex.org/W2265946565', 'https://openalex.org/W2319957449', 'https://openalex.org/W24568342', 'https://openalex.org/W2466607817', 'https://openalex.org/W2783958383', 'https://openalex.org/W3146223861', 'https://openalex.org/W4318598683'], 'related_works': ['https://openalex.org/W4391224393', 'https://openalex.org/W4288738052', 'https://openalex.org/W3166797618', 'https://openalex.org/W3034286462', 'https://openalex.org/W2915644342', 'https://openalex.org/W2911677179', 'https://openalex.org/W2159406923', 'https://openalex.org/W2151922639', 'https://openalex.org/W2124818340', 'https://openalex.org/W1992426253'], 'abstract_inverted_index': {'Abstract': [0], 'Objectives': [1], 'Methotrexate': [2, 50], '(MTX)': [3], 'is': [4, 22], 'administered': [5, 24, 53], 'once': [6, 54, 59, 126], 'or': [7], 'thrice': [8, 56], 'weekly': [9, 57], 'to': [10, 61, 105, 181], 'patients': [11], 'with': [12], 'rheumatoid': [13], 'arthritis': [14, 43, 46, 65, 82, 114, 155], '(RA).': [15], 'Even': [16], 'though': [17], 'RA': [18, 184], 'continually': [19], 'progresses,': [20], 'MTX': [21, 38, 76, 139, 178], 'not': [23, 140], 'daily.': [25], 'Therefore,': [26], 'we': [27], 'investigated': [28], 'whether': [29], 'the': [30, 40, 72, 79, 88, 93, 97, 100, 109, 120, 125, 152, 159, 168, 175], 'daily': [31, 60, 132], 'administration': [32, 133], 'of': [33, 37, 42, 75, 81, 108, 134, 138, 154, 170, 177], 'a': [34, 135], 'low': [35, 136], 'dose': [36, 74, 98, 137], 'inhibits': [39], 'progression': [41, 153], 'in': [44, 87, 92, 99, 119, 124, 190], 'collagen-induced': [45], '(CIA)': [47], 'rats.': [48], 'Methods': [49], 'was': [51, 77, 83, 103], 'orally': [52], 'weekly,': [55], 'and': [58, 64, 127], 'CIA': [62], 'rats,': [63], 'scores': [66, 115], 'were': [67, 116], 'measured.': [68], 'Key': [69], 'findings': [70], 'When': [71, 96], 'same': [73], 'administered,': [78], 'exacerbation': [80], 'inhibited': [84], 'significantly': [85, 156], 'more': [86, 157, 182], 'once-daily': [89, 101, 121], 'group': [90, 102, 122], 'than': [91, 123, 158, 186], 'other': [94], 'groups.': [95, 129], 'reduced': [104], 'one-fourth': [106], 'that': [107, 145, 167, 187], 'current': [110, 160], 'standard': [111, 161], 'dosing': [112, 162, 171], 'method,': [113], 'markedly': [117], 'lower': [118], 'thrice-weekly': [128], 'Conclusions': [130], 'The': [131, 164], 'only': [141], 'maintained': [142], 'normal': [143], 'levels': [144], 'estimated': [146], 'adverse': [147], 'effects': [148], 'but': [149], 'also': [150], 'suppressed': [151], 'method.': [163], 'results': [165], 'indicate': [166], 'reconsideration': [169], 'schedules': [172], 'based': [173], 'on': [174], 'characteristics': [176], 'will': [179], 'lead': [180], 'effective': [183], 'therapy': [185], 'currently': [188], 'used': [189], 'clinical': [191], 'practice.': [192]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2616933475', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 2}], 'updated_date': '2024-12-12T15:33:24.659166', 'created_date': '2017-06-05'}