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242, 802, 824, 1006, 1535, 1905], 'author': [94, 138, 182], ',': [95], 'Ait-OufellaHafid': [97], 'TedguiAlain': [141], 'Originally': [183, 4114], 'published26': [184], 'May': [185, 4040], '2017https://doi.org/10.1161/CIRCRESAHA.116.310371Circulation': [186], 'Research.': [187], '2017;120:1718–1720For': [188], '>10': [189], 'years': [190, 289, 1699], 'ago,': [191, 290], 'an': [192, 701, 918, 951, 1277, 1390, 1543, 1719, 1982, 3477, 4071], 'unexpected': [193], 'role': [194, 400, 412, 468, 1043, 1188, 1279, 1292, 1380, 2348, 3419], 'transforming': [197, 221, 326, 2205, 2264, 3919], 'growth': [198, 222, 327, 2206, 2265, 3460, 3920], 'factor-β': [199, 223, 328, 2266], 'cytokine': [200], 'pathway': [201, 2163, 2665], 'has': [202, 455, 804, 997, 1299, 1752, 1860], 'been': [203, 805, 998, 1300], 'put': [204], 'forward': [205], 'driving': [207], 'thoracic': [208, 226, 244, 2309, 2402, 2602, 3889], 'aortic': [209, 227, 245, 285, 320, 389, 738, 763, 780, 889, 926, 1141, 1253, 1269, 1310, 1328, 1340, 1480, 1612, 1634, 1644, 1674, 1681, 1821, 1986, 2051, 2269, 2373, 2403, 2444, 2510, 2603, 2667, 3078, 3205, 3339, 3388, 3471, 3601, 3742, 3791, 3885, 3890, 3924], 'aneurysms': [210, 228, 246, 2604, 3846], 'dissections.': [212, 230], 'Here,': [213], 'we': [214, 373], 'reassess': [215], 'evidence': [217, 463, 635, 689, 822, 1441, 1709, 1814], 'a': [219, 302, 337, 342, 356, 458, 466, 525, 659, 674, 754, 758, 809, 1008, 1041, 1066, 1166, 1183, 1227, 1379, 1474, 1520, 1766, 1774, 1810, 1989, 2194, 2275, 2347, 2398, 2483, 3042, 3587], 'detrimental': [220, 760, 1067, 1868], 'overdrive': [224, 1720, 1870], 'In': [231, 551, 605, 817, 1090, 1271, 1609, 1724, 2135], 'our': [232, 404], 'view,': [233], 'most': [234, 1726], 'available': [237, 691, 1729], 'mechanistic': [238], 'data': [239, 881, 1075, 1593, 1730], 'argue': [240], 'against': [241, 2049], 'theory.Syndromic': [243], 'dissections': [248, 3848], '(TAADs)': [249], 'develop': [250, 1268], 'patients': [252, 440, 1849], 'with': [253, 382, 408, 517, 532, 549, 911, 917, 981, 1055, 1134, 1156, 1235, 1364, 1456, 1508, 1549, 1616, 1638, 1780, 1850, 2083, 2509, 2540, 2982, 2988, 3139, 3476], 'connective': [254], 'tissue': [255, 810, 927], 'disorders': [256], 'because': [257], 'genetic': [259], 'mutations': [260, 310, 489, 567, 787, 1358, 1371, 1374, 2394], 'that': [261, 346, 376, 464, 487, 524, 692, 722, 751, 823, 883, 906, 967, 1011, 1025, 1080, 1200, 1236, 1302, 1442, 1603, 1710, 1732, 1740, 1815, 1834, 4095], 'affect': [262], 'structural': [263, 281], 'components': [264], 'extracellular': [267, 554, 3788], 'matrix': [268, 3789], 'cell': [271, 552, 3241], 'contractile': [272], 'machinery.': [273], 'Early': [274], 'pathogenic': [275, 411, 1120, 1187, 1702], 'hypotheses': [276], 'attributed': [277, 999, 1349, 1791], 'aortopathy': [279, 935, 990, 1049, 1086, 1108], 'failure': [282], 'tissue.': [286], 'Over': [287], '14': [288], 'Neptune': [291, 1939], 'al,1': [293], 'Habashi': [294, 1973, 2220, 2362], 'al,2': [296], 'Lindsay': [298, 1511, 2000, 2385, 3876], 'Dietz3': [300, 1513], 'proposed': [301, 578], 'novel': [303], 'hypothesis': [304, 1522, 1605, 1866], 'explain': [306], 'how': [307], 'fibrillin-1': [308, 2140], '(FBN1)': [309], 'Marfan': [312, 1965, 1993, 2198, 2279, 2312, 2377, 2947, 3046, 3077, 3140, 3927, 3978, 4021], 'syndrome': [313, 419, 1354, 2199, 2231, 2378, 2508], '(MFS)': [314], 'lead': [315], 'pulmonary': [317], 'emphysema': [318], 'aneurysm': [321, 890, 1311, 1822, 1987, 2009, 2052, 2270, 2310, 2374, 2668, 3472], 'pointed': [323], 'increased': [325, 470, 493, 497, 582, 637, 649, 723, 737, 814, 1316, 1351, 1391, 1396, 1503, 1565, 1754, 1770, 4018], '(TGFβ)': [329], 'activation': [330, 724, 1960, 2164], 'as': [331, 1063, 1182, 1688, 1765], 'culprit': [333], 'mechanism.': [334], 'This': [335, 718, 1060, 4069], 'constituted': [336], 'major': [338], 'paradigm': [339, 485], 'shift,': [340], 'new': [343, 1521, 1875], 'hope': [344], 'emerged': [345], 'life-threatening': [348], 'manifestations': [349], 'MFS': [351, 416, 439, 632, 641, 656, 685, 733, 771, 893, 1048, 1365, 1801], 'might': [352, 595], 'be': [353, 597, 644, 698, 827, 900, 1180, 1210, 1307, 1348], 'prevented': [354, 1149], 'simple': [357], 'medical': [358, 3607], 'treatment,': [359], 'losartan,': [360, 1151], 'shown': [361], 'prevent': [363, 1126, 1326, 1677], 'disease': [365, 748, 844, 1147, 1249, 1329, 1778, 3766], 'mice': [367, 380, 657, 865, 894, 910, 993, 1054, 1133, 1178, 1246, 1267, 1314, 1346, 1615, 1637, 2273, 2345, 3930], 'through': [368, 496, 619, 1315], 'its': [369, 547, 1171, 1805], 'TGFβ-antagonizing': [370, 1806], 'properties.2In': [371], '2010,': [372], 'serendipitously': [374], 'discovered': [375], 'TGFβ': [377, 402, 414, 471, 480, 494, 511, 583, 638, 650, 675, 678, 694, 731, 739, 764, 784, 799, 815, 837, 876, 896, 1003, 1029, 1038, 1045, 1083, 1114, 1117, 1123, 1168, 1190, 1205, 1242, 1296, 1317, 1322, 1352, 1383, 1392, 1445, 1468, 1476, 1506, 1529, 1546, 1554, 1651, 1670, 1703, 1722, 1733, 1771, 1829, 1869, 2369], 'neutralization': [378, 830, 1124, 1243, 1320, 3463], 'treated': [381], 'AngII': [383], '(angiotensin': [384], 'II)': [385], 'unexpectedly': [386], 'induced': [387, 1251], 'fatal': [388, 1252], 'dissections.4': [390], 'Despite': [391, 1582], 'differences': [392, 1018], 'mouse': [395, 1798, 1990, 2195, 3211, 3588], 'models,': [396, 3212], 'critical': [398], 'vasculoprotective': [399, 1735], 'experiments': [405], 'highly': [406], 'contrasted': [407], 'reported': [410, 1291], 'Loeys–Dietz': [418], '(LDS),': [420], 'leading': [421, 1563], 'us': [422], 'question': [424], 'validity': [426], 'previous': [429], 'assumptions.': [430], 'Moreover,': [431, 613, 855, 1426, 1646], 'recent': [432], 'clinical': [433], 'testing': [434], 'concept': [437, 1742], 'failed': [441, 1137], 'show': [443, 1079, 1502], 'any': [444, 631, 1784, 1846, 4092], 'benefit': [445, 1847], 'losartan': [447, 1163, 1796, 2077, 3578], 'over': [448], 'placebo': [449], 'or': [450, 1021, 1030, 1099, 1344, 1462, 1713, 1818, 1831, 1914, 2950, 3141, 4109], 'β-blockade.5': [451], 'Thus,': [452, 1338], 'time': [454, 1859], 'come': [456, 1861], 'reassessment': [459], 'scientific': [462], 'supports': [465], 'causal': [467], 'signaling': [472, 495, 651, 765, 870, 1022, 1039, 1118, 1191, 1206, 1323, 1446, 1530, 1547, 1555, 1575, 1652, 1662, 1671, 1694, 1772, 1841, 2227, 2267, 2370, 2534, 2565, 3237, 4019], 'TAADs.What': [474], 'Is': [475, 2792, 2980, 2985], 'Evidence': [477], 'Increased': [479, 875], 'Signaling': [481, 785, 1115, 1469], 'TAADs?Marfan': [483, 879], 'SyndromeThe': [484], 'stipulates': [486], 'FBN1': [488, 527, 534, 566, 592, 600, 627], 'are': [490, 707, 795, 1372, 1482, 1539, 1599, 1716, 1842, 1907, 4111], 'responsible': [491, 1308], 'bioavailability': [498, 2107], 'TGFβ.FBN1': [500], 'contains': [501, 536], '8-cysteine': [502], 'domains': [503], 'similar': [504, 1419], 'those': [506, 588, 1193, 1737, 1910], 'found': [507, 905, 1483], 'LTBPs': [509], '(latent': [510], 'binding': [512, 542, 2342], 'proteins)': [513], 'directly': [515], 'interacts': [516, 1455], 'LTBP1.': [518], 'An': [519], 'vitro': [521, 1403], 'study': [522, 1881], 'showed': [523, 1816], 'recombinant': [526], 'fragment': [528], '(PF10)': [529], 'can': [530, 697, 727, 826], 'interact': [531], 'N-terminal': [533], '(which': [535], 'hybrid': [538, 623], 'domain': [539], 'required': [540], 'LTBP1)': [544], 'inhibits': [546], 'association': [548], 'LTBP1.6': [550], 'layer': [553], 'matrix,': [555, 3381], 'PF10': [556], 'releases': [557], 'endogenous': [558], 'TGFβ1,': [559], 'which': [560, 594, 4085], 'stimulates': [561], 'SMAD2': [562], 'phosphorylation': [563], '(P-SMAD2).': [564], 'Because': [565], 'may': [568, 711, 898, 1306, 1853], 'increase': [569, 611, 1068, 3478], 'proteolytic': [570], 'susceptibility': [571], 'microfibrils,': [573], 'above-described': [575], 'mechanism': [576, 1776], 'was': [577, 915, 957, 972, 1061, 1148, 1743, 1882], 'account': [580], 'activity': [584, 639, 696, 1020, 1305, 1830, 2047], 'MFS.': [586, 1047], 'However,': [587, 801, 962, 1005, 1073, 1129, 1162, 1264, 1319, 1394], 'studies': [589, 1197, 2137], 'used': [590, 1181], 'engineered': [591], 'fragments,': [593], 'not': [596, 610, 629, 868, 899, 1165, 1226, 1325, 1430, 1607, 1808, 1908, 2201, 3577], 'relevant': [598], 'fragments': [601], 'generated': [602], 'vivo.': [604], 'fact,': [606, 818, 1610, 1725], 'tissue-purified': [607], 'microfibrils': [608], 'did': [609, 628], 'P-SMAD2.6': [612], 'direct': [614, 1201, 1826], 'disruption': [615, 2438], 'FBN1/LTBP': [617], 'interaction': [618], 'deletion': [620, 1100, 1618, 1639, 1691], '1': [624, 2705, 3481], 'region': [625], 'induce': [630, 1580], 'phenotype.7The': [633], 'strongest': [634], 'seems': [642], '(1)': [645], 'demonstration': [647], 'lungs': [654], 'using': [658, 1023, 1096], 'GFP': [660], 'reporter': [661, 695], 'under': [662, 994, 4075], 'control': [664, 1424, 2161], 'TGFβ-responsive': [666, 682, 704, 1759], 'promoter': [667, 705], 'elements1': [668], '(2)': [670], 'detection': [672], 'signature': [676, 740, 811, 825, 838, 1768], '(increased': [677], 'ligands,': [679], 'P-SMAD2/3,': [680], 'genes)': [683], 'tissues.2': [686], 'Yet,': [687], 'no': [688, 821, 1074, 1440, 1591, 4107], 'is': [690, 719, 753, 766, 820, 839, 847, 1007, 1050, 1119, 1164, 1225, 1233, 1256, 1355, 1438, 1590, 1606, 1630, 1706, 1734, 2200, 2480, 3196, 3474, 4054, 4070, 4099, 4104], 'abrogated': [699, 828], 'anti-TGFβ': [702, 913], 'antibody.': [703], 'elements': [706], 'SMAD3/SMAD4-binding': [708], 'sequences': [709], 'well': [712], 'respond': [713], 'TGFβ-independent': [715, 1463], 'SMAD': [716], 'activation.': [717], 'likely': [720], 'given': [721, 1010], 'SMAD2/3': [726], 'occur': [728, 743], 'independently': [729], 'tissues.8': [734], 'Furthermore,': [735, 1453], 'tends': [741], 'advanced': [745], 'stages': [746, 845], 'development,': [749], 'suggesting': [750, 1378], 'it': [752, 1298, 1333], 'compensatory,': [755], 'rather': [756, 1685], 'than': [757, 924], 'primary,': [759], 'process.': [761], 'Indeed,': [762], 'unaltered': [767], 'young': [769, 852, 2081], 'Fbn1C1039G/+': [770, 892, 909, 1053, 1110], 'mice,': [772], 'despite': [773], 'presence': [775], 'early': [777], 'signs': [778], 'disease.9Mutations': [781], 'PathwayLDS-associated': [786], '(TGFBR1,': [788], 'TGFBR2,': [789], 'TGFB2,': [790], 'TGFB3,': [791], 'SMAD3,': [792], 'SMAD4)': [794], 'expected': [796], 'disrupt': [798], 'signaling.3': [800], 'explanation': [803], 'challenged': [806], 'based': [807, 1744], 'on': [808, 1515, 1656, 1745, 2005, 2601, 3604, 4056], 'suggestive': [812], 'signaling.10': [816], 'there': [819, 1437, 1589, 1598, 1705], 'TGFβ.': [832], 'As': [833, 1143], 'MFS,': [835, 1145, 1711], 'detected': [840], 'only': [841, 1265], 'at': [842, 943, 959, 1837], 'late': [843], 'absent': [848], 'aortas': [850, 862, 1764], 'LDS': [853, 864, 1175, 1208, 1229, 1803], 'animals.10': [854], 'vascular': [856, 2232, 2568, 2598, 2796, 3199, 3591, 3841], 'smooth': [857, 2167, 2441, 2569, 3200, 3239, 3842], 'muscle': [858, 2168, 2442, 2570, 3201, 3240, 3843], 'cells': [859, 2538, 3844], '(VSMCs)': [860], 'from': [861, 1065, 1416, 1632, 2010, 2714], 'displayed': [866], 'reduced,': [867], 'increased,': [869], 'response': [872, 3838], 'TGFβ.10Does': [874], 'Activity': [877], 'Promote': [878], 'SyndromeNew': [880], 'suggest': [882, 1199, 2274], 'original': [885, 4097], 'finding': [886], 'reduced': [888, 1157, 1303, 2573], 'after': [895, 987, 1690, 1700, 1825], 'neutralization2': [897], 'reproducible.': [901], 'Cook': [902, 2241, 3192], 'al11': [904], 'treatment': [907, 930, 988, 1130, 1153], '1D11': [912, 929, 956, 979, 1135], 'antibody': [914, 1136], 'associated': [916, 2539, 3475], 'appreciable': [919], 'trend': [920], 'toward': [921], 'disrupting': [922], '(rather': [923], 'preserving)': [925], 'architecture.': [928], 'also': [931], 'dramatically': [932], 'exacerbated': [933], 'severe': [938, 1220], 'Fbn1mgR/mgR': [939, 992], 'model,': [940, 1230], 'when': [941, 955], 'initiated': [942, 958], 'postnatal': [944, 2440], 'day': [945, 960], '16.11': [946], 'Intriguingly,': [947], 'authors': [949, 1013], 'suggested': [950], 'improvement': [952], 'survival': [954, 971, 982], '45.': [961], 'Kaplan–Meier': [964], 'curves': [965, 983], 'indicate': [966, 1731, 2346], 'difference': [969], 'already': [973, 1660], 'present': [974], 'before': [975], 'initiation': [977], 'injections,': [980], 'being': [984], 'almost': [985], 'parallel': [986], 'initiation.Reduced': [989], 'Ltbp3−/−': [995, 1034], 'background': [996], 'normalization': [1001], 'activity.12': [1004], 'speculation': [1009], 'were': [1014, 1076, 1400, 1418], 'unable': [1015], 'detect': [1017], 'antibodies': [1024], 'recognize': [1026], 'either': [1027], 'active': [1028], 'phosphorylated': [1031], 'SMADs': [1032], 'mice.13Genetic': [1035], 'manipulations': [1036], 'support': [1040, 1595, 1626], 'protective': [1042, 1172], 'aggravated': [1051, 1106, 1247], 'disrupted': [1056], 'canonical': [1057], 'SMAD4': [1058], '(Smad4+/−).14': [1059], 'interpreted': [1062], 'resulting': [1064], 'TGFβ-dependent': [1070, 1433, 1461, 1840], 'noncanonical': [1071], 'pathway.14': [1072], 'presented': [1077], 'blockade': [1081, 1202], 'abolishes': [1084], 'Fbn1C1039G/+Smad4+/−': [1088], 'mice.': [1089, 1263], 'contrast,': [1091], 'further': [1092], 'reduction': [1093], 'TGFβ2': [1095, 1413], 'Tgfb2+/−': [1097], 'mice15': [1098], 'Tgfbr2': [1102, 1214, 1620, 1641, 1693, 2437], 'VSMCs9,16': [1104], 'substantially': [1105], 'mice.Mutations': [1111], 'PathwayIf': [1116], 'LDS,': [1122, 1712], 'should': [1125, 1684], 'disease.': [1128, 1857], 'Tgfbr2G357W/+': [1132, 1239], 'rescue': [1139], 'phenotype.10': [1142], 'efficacy': [1154], 'correlated': [1155], 'TGFβ1': [1158], 'expression': [1159, 1755, 3482], 'P-SMAD2.': [1161], 'selective': [1167, 1617], 'antagonist,': [1169, 1984], 'effects': [1173, 2262], '(or': [1176], 'MFS)': [1177], 'cannot': [1179, 1347], 'proof': [1184], 'settings.': [1194], 'Actually,': [1195], 'other': [1196, 1460, 1714, 1785], 'strongly': [1198], 'residual': [1204], 'would': [1209, 1559, 1648], 'detrimental.': [1211], 'Deletion': [1212, 2767], 'selectively': [1215], 'VSMCs': [1217, 1492, 1501, 1538, 1558, 1578, 1655, 1665], '(Myh11CreERT2Tgfbr2fl/fl)': [1218], 'induces': [1219, 1335], 'TAAD.16': [1221], 'Although': [1222], 'model': [1224, 1991, 2196, 3589], 'true': [1228], 'phenotype': [1232, 1341, 1449, 1613, 1635, 3467], 'consistent': [1234], 'strain.10': [1240], 'Interestingly,': [1241], 'Myh11CreERT2Tgfbr2fl/fl': [1245], 'ruptures.16Other': [1254], 'TAADsElastogenesis': [1255], 'altered': [1257, 1382, 2204], 'both': [1259], 'Fibulin-4–': [1260], 'Fibulin-5–deficient': [1262], 'Fibulin-4–deficient': [1266, 1313, 1345], 'aneurysm.': [1270], 'contrast': [1272], 'Fibulin-5,': [1274], 'Fibulin-4': [1275], 'plays': [1276], 'additional': [1278], 'targeting': [1281], 'enzyme': [1283], 'lysyl': [1284, 2574], 'oxidase': [1285, 2575], '(LOX)': [1286], 'microfibrils.': [1288], 'Given': [1289], 'LOX': [1294, 1304], 'inactivation,': [1297], 'argued': [1301], 'activation.3': [1318], 'does': [1324, 1429], 'LOX-deficient': [1331, 1343], 'embryos;': [1332], 'instead': [1334], 'numerous': [1336], 'hemorrhages.17': [1337], 'signaling.Shprintzen–Goldberg': [1353], 'caused': [1356], 'SKI': [1360, 1427, 1454, 2505], 'shares': [1362], 'features': [1363], 'LDS.': [1367], 'Most': [1368], 'missense': [1373], 'within': [1375], 'R-SMADs,': [1377], 'signaling.18': [1384], 'Patient': [1385], 'fibroblasts': [1386], 'seem': [1387], 'display': [1389], 'signature.18': [1393], 'P-SMAD2/3': [1397, 1757], 'P-ERK': [1399], 'seen': [1401], 'absence': [1406], 'TGFβ,': [1408, 1568], 'intriguingly,': [1410], 'responses': [1411], 'stimulation': [1414], '(increase': [1415], 'baseline)': [1417], 'between': [1420], 'patient': [1422], 'fibroblasts.18': [1425], 'knockdown': [1428], 'necessarily': [1431, 1909], 'impair': [1432], 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'Fuente‐Alonso': [2654], 'Campanero': [2656], 'M': [2657, 2759, 2818, 2914, 2938, 3068, 3126, 3301, 3375, 3877, 3971], 'Redondo': [2659], '(2021)': [2661, 2760, 2822, 2915, 2942, 2976, 3022, 3072, 3127], 'NO': [2663], 'signalling': [2664], 'dissection,': [2670], 'Journal': [2672, 2845, 2995, 3342, 3486, 3987], 'Pharmacology,': [2674], '10.1111/bph.15694,': [2675], '179:7,': [2676], '(1287-1303),': [2677], 'Online': [2678, 2723, 2780, 2892, 2957, 3055, 3092, 3149, 3217, 3316, 3351, 3397, 3433, 3493, 3540, 3615, 3722, 3754, 3773, 3799, 3823, 3858, 3896, 3900, 3904, 3908, 3940, 3993, 4036], 'publication': [2679, 2724, 2781, 2893, 2958, 3056, 3093, 3150, 3218, 3317, 3352, 3398, 3434, 3494, 3541, 3616, 3723, 3755, 3774, 3800, 3824, 3859, 3897, 3901, 3905, 3909, 3941, 3994, 4037], 'date:': [2680, 2725, 2782, 2894, 2959, 3057, 3094, 3151, 3219, 3318, 3353, 3399, 3435, 3495, 3542, 3617, 3724, 3756, 3775, 3801, 3825, 3860, 3898, 3902, 3906, 3910, 3942, 3995, 4038], '1-Apr-2022.': [2681], 'Abrial': [2682], 'Basu': [2684], 'Butty': [2688], 'Schwertner': [2690], 'Jeffrey': [2692], 'Jordan': [2694], 'Burns': [2696, 2699], 'C': [2697, 2700, 3230, 3780, 3913], '(2022)': [2701, 2791], 'Latent': [2702], 'TGFβ-binding': [2703], 'proteins': [2704], '3': [2707], 'protect': [2708], 'larval': [2710], 'zebrafish': [2711], 'outflow': [2712, 3246], 'tract': [2713], 'dilatation,': [2716], 'Disease': [2717], 'Models': [2718], '&': [2719, 3391, 3935], 'Mechanisms,': [2720], '10.1242/dmm.046979,': [2721], '15:3,': [2722], '1-Mar-2022.': [2726, 2783], 'Rodrigues-Díez': [2727, 2735, 2820], 'Tejera-Muñoz': [2729, 2803], 'Esteban': [2731], 'Steffensen': [2733], 'Orejudo': [2737, 2811], 'Rayego-Mateos': [2739, 2809], 'Falke': [2741], 'Cannata-Ortiz': [2743], 'Ortiz': [2745], 'Egido': [2747], 'Briones': [2751], 'Bajo': [2753], 'Goldschmeding': [2755], 'R': [2756, 2821, 3759, 3809, 3916], 'Ruiz-Ortega': [2758], 'CCN2': [2761, 2823, 2838], '(Cellular': [2762], 'Communication': [2763], 'Network': 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4029], 'Sciences,': [2848], '10.3390/ijms23010375,': [2849], '23:1,': [2850], '(375)': [2851], 'Dorst': [2853], 'Wagenaar': [2856], 'N,': [2857, 3064, 3174, 3178, 3545, 3667, 3947], 'der': [2859, 3362], 'Pluijm': [2860], 'Roos-Hesselink': [2862], 'Essers': [2864], 'Danser': [2867], '(2020)': [2869, 3194, 3234, 3302, 3329, 3357], 'Renin-Angiotensin': [2875], 'System': [2876], 'Syndromic': [2878], 'Thoracic': [2879, 3705], 'Aneurysms:': [2881], 'Treatment,': [2884], 'Drugs': [2886], 'Therapy,': [2888], '10.1007/s10557-020-07116-4,': [2889], '35:6,': [2890], '(1233-1252),': [2891], '1-Dec-2021.': [2895], 'Arun': [2896], 'Munir': [2898], 'Schmitt': [2900], 'Vyas': [2902], 'Ravindran': [2904], 'Bashir': [2906], 'Williams': [2908], 'Velayudhan': [2910], 'B': [2911, 3514], 'Idhrees': [2913], 'Exploring': [2916], 'Correlation': [2918], 'Protective': [2920], 'Diabetes': [2923, 2983, 3740], 'Mellitus': [2924], 'Disease,': [2928, 2994, 4032], 'Frontiers': [2929], '10.3389/fcvm.2021.769343,': 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'(81-96),': [3432], '1-Nov-2019.': [3436], 'Raffort': [3437, 3726], 'Lareyre': [3439, 3728], 'Clément': [3441, 3730], 'Moratal': [3443], 'Jean-Baptiste': [3445], 'Hassen-Khodja': [3447, 3732], 'Burel-Vandenbos': [3449], 'Bruneval': [3451], 'Chinetti': [3453, 3734], 'β': [3462, 3922], 'finely': [3464], 'tunes': [3465], 'macrophage': [3466], 'elastase-induced': [3469], 'abdominal': [3470], 'arginase': [3480], '10.1016/j.jvs.2018.09.045,': [3490], '70:2,': [3491], '(588-598.e2),': [3492], '1-Aug-2019.': [3496], 'Petsophonsakul': [3497], 'Furmanik': [3499], 'Forsythe': [3501], 'Dweck': [3503], 'Schurink': [3505], 'Natour': [3507], 'Reutelingsperger': [3509], 'Jacobs': [3511], 'Mees': [3513], 'Schurgers': [3516], 'L': [3517], 'Phenotypic': [3525, 3712], 'Switching': [3526], 'Calcification': [3528], '39:7,': [3538], '(1351-1368),': [3539], '1-Jul-2019.': [3543], 'Dubacher': [3544], 'Münger': [3546], 'Gorosabel': [3548], 'Crabb': [3550], 'Ksiazek': [3552], 'Caspar': [3554], 'Bakker': [3556], 'Bavel': [3559], 'Ziegler': [3561], 'U,': [3562, 3953], 'Carrel': [3563], 'T,': [3564, 3669], 'Steinmann': [3565], 'Zeisberger': [3567], 'Meienberg': [3569], 'Matyas': [3572], 'Celiprolol': [3575], 'improves': [3579, 3884], 'biomechanical': [3581], 'integrity': [3582], 'aorta': [3585], 'Ehlers–Danlos': [3592], 'syndrome,': [3593, 4022], 'Research,': [3595, 3750, 3854], '10.1093/cvr/cvz095': [3596], '(2018)': [3599, 3697, 3739, 3760, 3784, 3810, 3834, 3917, 3975, 4010], 'Abdominal': [3600], 'aneurysm:': [3602, 3743], 'update': [3603], 'treatments,': [3608], 'Nature': [3609], 'Reviews': [3610], 'Cardiology,': [3611], '10.1038/s41569-018-0114-9,': [3612], '16:4,': [3613], '(225-242),': [3614], '1-Apr-2019.': [3618], 'Suzuki': [3619, 3641], 'Sawaki': [3622, 3638], 'Acute': [3627, 3650], 'Syndrome': [3629, 3979], 'Surgical': [3630, 3652], 'Management': [3631, 3653], 'Pathology,': [3634, 3656, 3989], '10.1007/978-3-7091-4874-7_16,': [3635], '(233-241),': [3636], 'Insights': [3644], 'into': [3645], 'Mechanisms': [3648], 'Dissection': [3651], '10.1007/978-3-7091-4874-7_12,': [3657], '(181-189),': [3658], 'Nogi': [3660], 'Satoh': [3662, 3668], 'Sunamura': [3664], 'Kikuchi': [3666], 'Kurosawa': [3670], 'Omura': [3672], 'Elias-Al-Mamun': [3674], 'Abdul': [3676], 'Hai': [3677], 'Siddique': [3678], 'Numano': [3680], 'Kudo': [3682], 'Miyata': [3684], 'Akiyama': [3686], 'Kumagai': [3688], 'Kawamoto': [3690], 'Saiki': [3692], 'Shimokawa': [3695], 'H': [3696], 'Small': [3698], 'GTP-Binding': [3699], 'Protein': [3700], 'GDP': [3701], 'Dissociation': [3702], 'Stimulator': [3703], 'Rupture': [3710], 'Preservation': [3713], 'Cells,': [3718], 'Circulation,': [3719], '138:21,': [3720], '(2413-2433),': [3721], '20-Nov-2018.': [3725], 'current': [3744], 'state': [3745], 'art,': [3748], '10.1093/cvr/cvy174,': [3751], '114:13,': [3752], '(1702-1713),': [3753], '1-Nov-2018.': [3757, 3776], 'Mecham': [3758, 3808], 'Elastin': [3761], 'lung': [3763], '10.1016/j.matbio.2018.01.005,': [3770], '73,': [3771], '(6-20),': [3772], 'Lin': [3777, 3779], 'Stitziel': [3782], 'N': [3783], 'Genetics': [3785], '10.1016/j.matbio.2018.04.005,': [3796], '71-72,': [3797, 3821], '(128-143),': [3798], '1-Oct-2018.': [3802, 3826], 'Craft': [3803], 'Broekelmann': [3805], 'Microfibril-associated': [3811], 'glycoproteins': [3812], 'MAGP-1': [3813], 'MAGP-2': [3815], 'disease,': [3817], '10.1016/j.matbio.2018.03.006,': [3820], '(100-111),': [3822], 'Jondeau': [3829], 'genetics': [3836], 'injury:': [3840], '10.1093/cvr/cvy006,': [3855], '114:4,': [3856], '(578-589),': [3857], '15-Mar-2018.': [3861], 'Lino': [3862], 'Cardenas': [3863], 'Kessinger': [3865], 'MacDonald': [3867], 'Jassar': [3869], 'Isselbacher': [3871], 'Jaffer': [3873], '(2018)(2018)(2018)(2018)': [3878], 'Inhibition': [3879, 3976], 'methyltranferase': [3882], 'EZH2': [3883], 'performance': [3886], 'experimental': [3888], 'JCI': [3892], 'Insight,': [3893], '10.1172/jci.insight.97493,': [3894], '8-Mar-2018.,': [3899, 3903, 3907], '8-Mar-2018.': [3911], 'Yu': [3912], 'Jeremy': [3915], 'Angiotensin,': [3918], 'dilatation': [3925], 'syndrome:': [3928], 'Of': [3929], 'humans,': [3932], 'IJC': [3933], 'Vasculature,': [3936], '10.1016/j.ijcha.2018.02.009,': [3937], '18,': [3938], '(71-80),': [3939], '1-Mar-2018.': [3943, 3996], 'Sellers': [3944], 'Chan': [3948], 'Mielnik': [3950], 'Jermilova': [3952], 'Crom': [3957], 'Hirota': [3959], 'Hogg': [3961], 'Van': [3965], 'Dilation': [3982], '10.1016/j.ajpath.2017.11.006,': [3990], '188:3,': [3991], '(574-585),': [3992], 'Siegert': [3997], 'Serra-Peinado': [3999], 'Gutiérrez-Martínez': [4001], 'Rodríguez-Pascual': [4003], 'I': [4006], 'Altered': [4011], 'endocytic': [4013], 'trafficking': [4014], 'Biochimica': [4023], 'Biophysica': [4025], 'Acta': [4026], '(BBA)': [4027], '-': [4028], 'Basis': [4030], '10.1016/j.bbadis.2017.11.015,': [4033], '1864:2,': [4034], '(554-562),': [4035], '1-Feb-2018.': [4039], '26,': [4041, 4116], '2017Vol': [4042], 'Issue': [4044], '11': [4045], 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