Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2615218473', 'doi': 'https://doi.org/10.1007/s11427-017-9033-0', 'title': 'Non-viral and viral delivery systems for CRISPR-Cas9 technology in the biomedical field', 'display_name': 'Non-viral and viral delivery systems for CRISPR-Cas9 technology in the biomedical field', 'publication_year': 2017, 'publication_date': '2017-05-01', 'ids': {'openalex': 'https://openalex.org/W2615218473', 'doi': 'https://doi.org/10.1007/s11427-017-9033-0', 'mag': '2615218473', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28527117'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/s11427-017-9033-0', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S45795350', 'display_name': 'Science China Life Sciences', 'issn_l': '1674-7305', 'issn': ['1674-7305', '1869-1889'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5076381011', 'display_name': 'Zhiyao He', 'orcid': 'https://orcid.org/0000-0001-7888-211X'}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhi-Yao He', 'raw_affiliation_strings': ['Department of Pharmacy, and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, 610041, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacy, and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, 610041, China', 'institution_ids': ['https://openalex.org/I24185976']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021210072', 'display_name': 'Ke Men', 'orcid': 'https://orcid.org/0000-0002-0587-9961'}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ke Men', 'raw_affiliation_strings': ['State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, 610041, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, 610041, China', 'institution_ids': ['https://openalex.org/I24185976']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101841960', 'display_name': 'Zhou Qin', 'orcid': 'https://orcid.org/0000-0003-0065-981X'}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhou Qin', 'raw_affiliation_strings': ['Department of Pharmacy, and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, 610041, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacy, and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, 610041, China', 'institution_ids': ['https://openalex.org/I24185976']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101662788', 'display_name': 'Yang Yang', 'orcid': 'https://orcid.org/0000-0002-8190-1825'}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yang Yang', 'raw_affiliation_strings': ['State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, 610041, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, 610041, China', 'institution_ids': ['https://openalex.org/I24185976']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089420346', 'display_name': 'Ting Xu', 'orcid': 'https://orcid.org/0000-0001-8727-9259'}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ting Xu', 'raw_affiliation_strings': ['Department of Pharmacy, and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, 610041, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacy, and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, 610041, China', 'institution_ids': ['https://openalex.org/I24185976']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5090403310', 'display_name': 'Yuquan Wei', 'orcid': 'https://orcid.org/0000-0002-6211-3217'}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yu-Quan Wei', 'raw_affiliation_strings': ['State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, 610041, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, 610041, China', 'institution_ids': ['https://openalex.org/I24185976']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2790, 'currency': 'EUR', 'value_usd': 3590, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.766, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 46, 'citation_normalized_percentile': {'value': 0.999735, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '60', 'issue': '5', 'first_page': '458', 'last_page': '467'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10878', 'display_name': 'Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated proteins', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10878', 'display_name': 'Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated proteins', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12610', 'display_name': 'Functions and Regulation of RNA Editing by ADARs', 'score': 0.9597, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12786', 'display_name': 'Frugal Innovation in Emerging Markets', 'score': 0.9551, 'subfield': {'id': 'https://openalex.org/subfields/1403', 'display_name': 'Business and International Management'}, 'field': {'id': 'https://openalex.org/fields/14', 'display_name': 'Business, Management and Accounting'}, 'domain': {'id': 'https://openalex.org/domains/2', 'display_name': 'Social Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/crispr-systems', 'display_name': 'CRISPR Systems', 'score': 0.589417}, {'id': 'https://openalex.org/keywords/subgenomic-mrna', 'display_name': 'Subgenomic mRNA', 'score': 0.529578}, {'id': 'https://openalex.org/keywords/gene-editing', 'display_name': 'Gene Editing', 'score': 0.507699}, {'id': 'https://openalex.org/keywords/guide-rna', 'display_name': 'Guide RNA', 'score': 0.47775283}], 'concepts': [{'id': 'https://openalex.org/C98108389', 'wikidata': 'https://www.wikidata.org/wiki/Q412563', 'display_name': 'CRISPR', 'level': 3, 'score': 0.9798126}, {'id': 'https://openalex.org/C132455925', 'wikidata': 'https://www.wikidata.org/wiki/Q16965677', 'display_name': 'Cas9', 'level': 4, 'score': 0.8960109}, {'id': 'https://openalex.org/C144501496', 'wikidata': 'https://www.wikidata.org/wiki/Q5533489', 'display_name': 'Genome editing', 'level': 4, 'score': 0.8522482}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.60191625}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.596611}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.5560361}, {'id': 'https://openalex.org/C189819185', 'wikidata': 'https://www.wikidata.org/wiki/Q384283', 'display_name': 'Subgenomic mRNA', 'level': 4, 'score': 0.529578}, {'id': 'https://openalex.org/C97702854', 'wikidata': 'https://www.wikidata.org/wiki/Q4039747', 'display_name': 'Guide RNA', 'level': 5, 'score': 0.47775283}, {'id': 'https://openalex.org/C141231307', 'wikidata': 'https://www.wikidata.org/wiki/Q7020', 'display_name': 'Genome', 'level': 3, 'score': 0.4681397}, {'id': 'https://openalex.org/C32470452', 'wikidata': 'https://www.wikidata.org/wiki/Q2298489', 'display_name': 'Viral vector', 'level': 4, 'score': 0.44948655}, {'id': 'https://openalex.org/C111599444', 'wikidata': 'https://www.wikidata.org/wiki/Q213901', 'display_name': 'Genetic enhancement', 'level': 3, 'score': 0.4445271}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.37857553}, {'id': 'https://openalex.org/C40767141', 'wikidata': 'https://www.wikidata.org/wiki/Q285697', 'display_name': 'Recombinant DNA', 'level': 3, 'score': 0.04996726}], 'mesh': [{'descriptor_ui': 'D035843', 'descriptor_name': 'Biomedical Research', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D000072669', 'descriptor_name': 'Gene Editing', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064113', 'descriptor_name': 'CRISPR-Cas Systems', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004720', 'descriptor_name': 'Endonucleases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018014', 'descriptor_name': 'Gene Transfer Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008957', 'descriptor_name': 'Models, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000094704', 'descriptor_name': 'RNA, Guide, CRISPR-Cas Systems', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014780', 'descriptor_name': 'Viruses', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/s11427-017-9033-0', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S45795350', 'display_name': 'Science China Life Sciences', 'issn_l': '1674-7305', 'issn': ['1674-7305', '1869-1889'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28527117', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 83, 'referenced_works': ['https://openalex.org/W1487130580', 'https://openalex.org/W1531723519', 'https://openalex.org/W1571411512', 'https://openalex.org/W1614527229', 'https://openalex.org/W1636931877', 'https://openalex.org/W1804459219', 'https://openalex.org/W1973260880', 'https://openalex.org/W1976404496', 'https://openalex.org/W1978094899', 'https://openalex.org/W1982831423', 'https://openalex.org/W1982969769', 'https://openalex.org/W1996788258', 'https://openalex.org/W1998857871', 'https://openalex.org/W2008147758', 'https://openalex.org/W2008719138', 'https://openalex.org/W2017224987', 'https://openalex.org/W2023422990', 'https://openalex.org/W2041731405', 'https://openalex.org/W2050169742', 'https://openalex.org/W2053542738', 'https://openalex.org/W2056512830', 'https://openalex.org/W2056607224', 'https://openalex.org/W2056833586', 'https://openalex.org/W2061184966', 'https://openalex.org/W2061650108', 'https://openalex.org/W2064815984', 'https://openalex.org/W2067036696', 'https://openalex.org/W2070614858', 'https://openalex.org/W2073217307', 'https://openalex.org/W2103609218', 'https://openalex.org/W2105464583', 'https://openalex.org/W2107959600', 'https://openalex.org/W2108038398', 'https://openalex.org/W2112444085', 'https://openalex.org/W2116534141', 'https://openalex.org/W2119771879', 'https://openalex.org/W2128758977', 'https://openalex.org/W2139658942', 'https://openalex.org/W2156319424', 'https://openalex.org/W2160834915', 'https://openalex.org/W2164934988', 'https://openalex.org/W2172912160', 'https://openalex.org/W2188223075', 'https://openalex.org/W2196662084', 'https://openalex.org/W2203460689', 'https://openalex.org/W2205893844', 'https://openalex.org/W2208696160', 'https://openalex.org/W2224398381', 'https://openalex.org/W2253584908', 'https://openalex.org/W2260024370', 'https://openalex.org/W2298491177', 'https://openalex.org/W2327842290', 'https://openalex.org/W2344409603', 'https://openalex.org/W2344698368', 'https://openalex.org/W2396078929', 'https://openalex.org/W2396982015', 'https://openalex.org/W2402308453', 'https://openalex.org/W2403363143', 'https://openalex.org/W2417922500', 'https://openalex.org/W2426122055', 'https://openalex.org/W2463842282', 'https://openalex.org/W2479027661', 'https://openalex.org/W2517192151', 'https://openalex.org/W2518801575', 'https://openalex.org/W2519098524', 'https://openalex.org/W2519958822', 'https://openalex.org/W2519962384', 'https://openalex.org/W2520545223', 'https://openalex.org/W2523039865', 'https://openalex.org/W2523441707', 'https://openalex.org/W2524115874', 'https://openalex.org/W2525231178', 'https://openalex.org/W2525527208', 'https://openalex.org/W2525840584', 'https://openalex.org/W2526906171', 'https://openalex.org/W2555666209', 'https://openalex.org/W2556055682', 'https://openalex.org/W2558445847', 'https://openalex.org/W2582215039', 'https://openalex.org/W2595351410', 'https://openalex.org/W2734528365', 'https://openalex.org/W2737309984', 'https://openalex.org/W3020907828'], 'related_works': ['https://openalex.org/W4311501380', 'https://openalex.org/W4288777264', 'https://openalex.org/W3137982617', 'https://openalex.org/W3047419816', 'https://openalex.org/W2979204485', 'https://openalex.org/W2667943050', 'https://openalex.org/W2626278962', 'https://openalex.org/W2603161682', 'https://openalex.org/W2590355459', 'https://openalex.org/W2390994276'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2615218473', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 3}], 'updated_date': '2024-09-13T13:11:39.240139', 'created_date': '2017-05-26'}