Publication Information

{'id': 'https://openalex.org/W2615174644', 'doi': 'https://doi.org/10.1111/j.1432-1033.1989.tb14553.x', 'title': 'The quaternary structure of the dihydrolipoyl transacetylase component of the pyruvate dehydrogenase complex from <i>Azotobacter vinelandii</i>', 'display_name': 'The quaternary structure of the dihydrolipoyl transacetylase component of the pyruvate dehydrogenase complex from <i>Azotobacter vinelandii</i>', 'publication_year': 1989, 'publication_date': '1989-02-01', 'ids': {'openalex': 'https://openalex.org/W2615174644', 'doi': 'https://doi.org/10.1111/j.1432-1033.1989.tb14553.x', 'mag': '2615174644', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/2917567'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1432-1033.1989.tb14553.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210214924', 'display_name': 'European Journal of Biochemistry', 'issn_l': '0014-2956', 'issn': ['0014-2956', '0945-5795', '1432-1033'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5083750885', 'display_name': 'Roeland Hanemaaijer', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Roeland HANEMAAIJER', 'raw_affiliation_strings': ['Department of Biochemistry, Agricultural University, Wageningen'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Agricultural University, Wageningen', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006029709', 'display_name': 'Adrie H. Westphal', 'orcid': 'https://orcid.org/0000-0003-4264-6267'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Adrie H. WESTPHAL', 'raw_affiliation_strings': ['Department of Biochemistry, Agricultural University, Wageningen'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Agricultural University, Wageningen', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108449835', 'display_name': 'T Heiden', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Tini VAN DER HEIDEN', 'raw_affiliation_strings': ['Department of Biochemistry, Agricultural University, Wageningen'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Agricultural University, Wageningen', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113597189', 'display_name': 'Arie de KOK', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': True, 'raw_author_name': 'Arie DE KOK', 'raw_affiliation_strings': ['Department of Biochemistry, Agricultural University, Wageningen'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Agricultural University, Wageningen', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5031172878', 'display_name': 'C. Veeger', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Cees VEEGER', 'raw_affiliation_strings': ['Department of Biochemistry, Agricultural University, Wageningen'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Agricultural University, Wageningen', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': ['https://openalex.org/A5113597189'], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.104, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 20, 'citation_normalized_percentile': {'value': 0.665083, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 85, 'max': 86}, 'biblio': {'volume': '179', 'issue': '2', 'first_page': '287', 'last_page': '292'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12915', 'display_name': 'Biochemical Acid Research Studies', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12915', 'display_name': 'Biochemical Acid Research Studies', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11027', 'display_name': 'Metabolism and Genetic Disorders', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1308', 'display_name': 'Clinical Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11162', 'display_name': 'Enzyme Structure and Function', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/2505', 'display_name': 'Materials Chemistry'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/azotobacter-vinelandii', 'display_name': 'Azotobacter vinelandii', 'score': 0.89007723}, {'id': 'https://openalex.org/keywords/protein-quaternary-structure', 'display_name': 'Protein quaternary structure', 'score': 0.8473743}, {'id': 'https://openalex.org/keywords/dihydrolipoamide-dehydrogenase', 'display_name': 'Dihydrolipoamide dehydrogenase', 'score': 0.82374626}, {'id': 'https://openalex.org/keywords/dihydrolipoyl-transacetylase', 'display_name': 'Dihydrolipoyl transacetylase', 'score': 0.49925494}, {'id': 'https://openalex.org/keywords/molecular-mass', 'display_name': 'Molecular mass', 'score': 0.46132866}, {'id': 'https://openalex.org/keywords/oxoglutarate-dehydrogenase-complex', 'display_name': 'Oxoglutarate dehydrogenase complex', 'score': 0.4193544}], 'concepts': [{'id': 'https://openalex.org/C2776159390', 'wikidata': 'https://www.wikidata.org/wiki/Q2157875', 'display_name': 'Azotobacter vinelandii', 'level': 5, 'score': 0.89007723}, {'id': 'https://openalex.org/C7927669', 'wikidata': 'https://www.wikidata.org/wiki/Q898529', 'display_name': 'Protein quaternary structure', 'level': 4, 'score': 0.8473743}, {'id': 'https://openalex.org/C120763696', 'wikidata': 'https://www.wikidata.org/wiki/Q419337', 'display_name': 'Dihydrolipoamide dehydrogenase', 'level': 4, 'score': 0.82374626}, {'id': 'https://openalex.org/C88099638', 'wikidata': 'https://www.wikidata.org/wiki/Q412856', 'display_name': 'Pyruvate dehydrogenase complex', 'level': 3, 'score': 0.73184466}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.6985289}, {'id': 'https://openalex.org/C2779546866', 'wikidata': 'https://www.wikidata.org/wiki/Q531306', 'display_name': 'Dimer', 'level': 2, 'score': 0.6604475}, {'id': 'https://openalex.org/C2776317432', 'wikidata': 'https://www.wikidata.org/wiki/Q412547', 'display_name': 'Dehydrogenase', 'level': 3, 'score': 0.6134021}, {'id': 'https://openalex.org/C80097345', 'wikidata': 'https://www.wikidata.org/wiki/Q419036', 'display_name': 'Dihydrolipoyl transacetylase', 'level': 5, 'score': 0.49925494}, {'id': 'https://openalex.org/C8010536', 'wikidata': 'https://www.wikidata.org/wiki/Q160398', 'display_name': 'Crystallography', 'level': 1, 'score': 0.49724677}, {'id': 'https://openalex.org/C58121356', 'wikidata': 'https://www.wikidata.org/wiki/Q182854', 'display_name': 'Molecular mass', 'level': 3, 'score': 0.46132866}, {'id': 'https://openalex.org/C126093377', 'wikidata': 'https://www.wikidata.org/wiki/Q309518', 'display_name': 'Oxoglutarate dehydrogenase complex', 'level': 5, 'score': 0.4193544}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.41091973}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.38177517}, {'id': 'https://openalex.org/C190098323', 'wikidata': 'https://www.wikidata.org/wiki/Q14912712', 'display_name': 'Pyruvate dehydrogenase phosphatase', 'level': 4, 'score': 0.21417576}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.19578654}, {'id': 'https://openalex.org/C104292427', 'wikidata': 'https://www.wikidata.org/wiki/Q899781', 'display_name': 'Protein subunit', 'level': 3, 'score': 0.12337148}, {'id': 'https://openalex.org/C141280058', 'wikidata': 'https://www.wikidata.org/wiki/Q410381', 'display_name': 'Nitrogenase', 'level': 4, 'score': 0.08266544}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.072481036}, {'id': 'https://openalex.org/C181440489', 'wikidata': 'https://www.wikidata.org/wiki/Q272467', 'display_name': 'Nitrogen fixation', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C537208039', 'wikidata': 'https://www.wikidata.org/wiki/Q627', 'display_name': 'Nitrogen', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000123', 'descriptor_name': 'Acetyltransferases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D001395', 'descriptor_name': 'Azotobacter', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D011768', 'descriptor_name': 'Pyruvate Dehydrogenase Complex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000123', 'descriptor_name': 'Acetyltransferases', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': False}, {'descriptor_ui': 'D001395', 'descriptor_name': 'Azotobacter', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003432', 'descriptor_name': 'Cross-Linking Reagents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051047', 'descriptor_name': 'Dihydrolipoyllysine-Residue Acetyltransferase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008027', 'descriptor_name': 'Light', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D046911', 'descriptor_name': 'Macromolecular Substances', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008970', 'descriptor_name': 'Molecular Weight', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010446', 'descriptor_name': 'Peptide Fragments', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010446', 'descriptor_name': 'Peptide Fragments', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D011487', 'descriptor_name': 'Protein Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011768', 'descriptor_name': 'Pyruvate Dehydrogenase Complex', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': False}, {'descriptor_ui': 'D012542', 'descriptor_name': 'Scattering, Radiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1432-1033.1989.tb14553.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210214924', 'display_name': 'European Journal of Biochemistry', 'issn_l': '0014-2956', 'issn': ['0014-2956', '0945-5795', '1432-1033'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/2917567', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Clean water and sanitation', 'id': 'https://metadata.un.org/sdg/6', 'score': 0.57}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 31, 'referenced_works': ['https://openalex.org/W1510728289', 'https://openalex.org/W1516242195', 'https://openalex.org/W1518644765', 'https://openalex.org/W1521674969', 'https://openalex.org/W1544647740', 'https://openalex.org/W1572050726', 'https://openalex.org/W1582602870', 'https://openalex.org/W1592077310', 'https://openalex.org/W1840947721', 'https://openalex.org/W1864809073', 'https://openalex.org/W1884642153', 'https://openalex.org/W1967108390', 'https://openalex.org/W1972754494', 'https://openalex.org/W1974505904', 'https://openalex.org/W1981140292', 'https://openalex.org/W1988738960', 'https://openalex.org/W2018244729', 'https://openalex.org/W2048886489', 'https://openalex.org/W2057407269', 'https://openalex.org/W2063495377', 'https://openalex.org/W2063931458', 'https://openalex.org/W2065549309', 'https://openalex.org/W2092711667', 'https://openalex.org/W2100837269', 'https://openalex.org/W2106359341', 'https://openalex.org/W2108110716', 'https://openalex.org/W2148529609', 'https://openalex.org/W2231152299', 'https://openalex.org/W2323039469', 'https://openalex.org/W2600806307', 'https://openalex.org/W656943484'], 'related_works': ['https://openalex.org/W2369281961', 'https://openalex.org/W2334169074', 'https://openalex.org/W2162230237', 'https://openalex.org/W2116829542', 'https://openalex.org/W2020431276', 'https://openalex.org/W2015269539', 'https://openalex.org/W2000725524', 'https://openalex.org/W1583528288', 'https://openalex.org/W1516242195', 'https://openalex.org/W1490403537'], 'abstract_inverted_index': {'After': [0], 'limited': [1], 'proteolysis': [2], 'of': [3, 11, 33, 43, 61, 79, 95, 102, 111, 121, 135, 144, 150, 173, 210, 218, 234, 240, 250, 254, 274], 'the': [4, 25, 30, 39, 44, 47, 51, 77, 85, 90, 108, 112, 119, 122, 136, 142, 148, 174, 178, 188, 193, 203, 215, 229, 241, 247, 251, 263, 270], 'dihydrolipoyl': [5], 'transacetylase': [6, 26], 'component': [7], '(E': [8], '2': [9, 35, 81, 97, 153, 196, 220, 232], ')': [10], 'Azotobacter': [12], 'vinelandii': [13], 'pyruvate': [14, 54], 'dehydrogenase': [15, 55], 'complex': [16], '(PDC),': [17], 'a': [18, 99, 129, 161, 208, 258], 'C‐terminal': [19], 'domain': [20, 63, 190], 'was': [21, 64, 105, 155], 'obtained': [22], 'which': [23, 224], 'retained': [24], 'active': [27], 'site': [28, 259], 'and': [29, 46, 56, 71, 89, 118, 201], 'quaternary': [31, 216], 'structure': [32, 131, 138, 217], 'E': [34, 80, 96, 152, 195, 219, 231], 'but': [36], 'had': [37], 'lost': [38], 'lipoyl‐containing': [40], 'N‐terminal': [41], 'part': [42], 'chain': [45], 'binding': [48], 'sites': [49], 'for': [50, 214], 'peripheral': [52, 255], 'components,': [53], 'lipoamide': [57], 'dehydrogenase.': [58], 'The': [59], 'C‐terminus': [60, 78], 'this': [62], 'determined': [65, 87], 'by': [66], 'treatment': [67], 'with': [68, 76, 84, 167, 187, 262], 'carboxypeptidase': [69], 'Y': [70], 'shown': [72], 'to': [73, 257], 'be': [74], 'identical': [75], '.': [82], 'Together': [83], 'previously': [86], 'N‐terminus': [88], 'known': [91], 'amino': [92], 'acid': [93], 'sequence': [94], ',': [98], 'molecular': [100, 109], 'mass': [101, 110, 170, 176], '27.5': [103], 'kDa': [104], 'calculated.': [106], 'From': [107, 141], 'native': [113], 'catalytic': [114, 189], 'domain,': [115], '530': [116], 'kDa,': [117], 'symmetry': [120], 'cubic': [123, 264], 'structures': [124], 'observed': [125], 'on': [126, 147], 'electron': [127], 'micrographs,': [128], '24‐meric': [130], 'is': [132, 197, 221, 226, 236], 'concluded': [133, 156], 'instead': [134], '32‐meric': [137], 'proposed': [139], 'previously.': [140], 'effect': [143], 'guanidine': [145], 'hydrochloride': [146], 'light‐scattering': [149], 'intact': [151], 'it': [154, 225], 'that': [157, 172, 192, 202, 228, 260], 'dissociation': [158], 'occurs': [159], 'in': [160, 165, 223, 269], 'two‐step': [162], 'reaction': [163], 'resulting': [164, 268], 'particles': [166], 'an': [168], 'average': [169], '1/6': [171], 'original': [175], 'before': [177], 'N': [179], '→': [180], 'D': [181], 'transition': [182], 'takes': [183], 'place.': [184], 'Cross‐linking': [185], 'experiments': [186], 'indicated': [191], 'multimeric': [194], 'built': [198], 'from': [199, 238], 'tetramers': [200, 204], 'are': [205], 'arranged': [206], 'as': [207], 'dimer': [209], 'dimers.': [211], 'A': [212], 'model': [213], 'given,': [222], 'assumed': [227], 'tetrameric': [230], 'core': [233], 'PDC': [235, 273], 'formed': [237], 'each': [239], 'six': [242], 'morphological': [243], 'subunits': [244], 'located': [245], 'at': [246], 'lateral': [248], 'face': [249], 'cube.': [252], 'Binding': [253], 'components': [256], 'interferes': [261], 'assembly': [265], 'causes': [266], 'dissociation,': [267], 'unique': [271], 'small': [272], 'A.': [275], 'vinelandii.': [276]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2615174644', 'counts_by_year': [{'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-12-08T03:20:58.213709', 'created_date': '2017-05-26'}