Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2614589553', 'doi': 'https://doi.org/10.18632/oncotarget.18018', 'title': 'ABCG2 downregulation in glioma stem cells enhances the therapeutic efficacy of demethoxycurcumin', 'display_name': 'ABCG2 downregulation in glioma stem cells enhances the therapeutic efficacy of demethoxycurcumin', 'publication_year': 2017, 'publication_date': '2017-05-19', 'ids': {'openalex': 'https://openalex.org/W2614589553', 'doi': 'https://doi.org/10.18632/oncotarget.18018', 'mag': '2614589553', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28591733', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5522142'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.18018', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=18018&path%5B%5D=57712', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=18018&path%5B%5D=57712', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100336388', 'display_name': 'Long Chen', 'orcid': 'https://orcid.org/0000-0002-2050-8050'}, 'institutions': [{'id': 'https://openalex.org/I3923682', 'display_name': 'Soochow University', 'ror': 'https://ror.org/05t8y2r12', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I3923682']}, {'id': 'https://openalex.org/I4210153519', 'display_name': 'First Affiliated Hospital of Soochow University', 'ror': 'https://ror.org/051jg5p78', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153519']}, {'id': 'https://openalex.org/I4210124018', 'display_name': 'Traditional Chinese Medicine Hospital of Kunshan', 'ror': 'https://ror.org/038dfxb83', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210124018']}, {'id': 'https://openalex.org/I4210098460', 'display_name': 'Shanghai University of Traditional Chinese Medicine', 'ror': 'https://ror.org/00z27jk27', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210098460']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Long Chen', 'raw_affiliation_strings': ['Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, P. R. China', 'Department of Neurosurgery, Traditional Chinese Medicine Hospital of Kunshan, Affiliated Nanjing University of Traditional Chinese Medicine, Suzhou 215300, P. R. China'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, P. R. China', 'institution_ids': ['https://openalex.org/I3923682', 'https://openalex.org/I4210153519']}, {'raw_affiliation_string': 'Department of Neurosurgery, Traditional Chinese Medicine Hospital of Kunshan, Affiliated Nanjing University of Traditional Chinese Medicine, Suzhou 215300, P. R. China', 'institution_ids': ['https://openalex.org/I4210124018', 'https://openalex.org/I4210098460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102024839', 'display_name': 'Lei Shi', 'orcid': 'https://orcid.org/0000-0001-9258-9454'}, 'institutions': [{'id': 'https://openalex.org/I115592961', 'display_name': 'Jiangsu University', 'ror': 'https://ror.org/03jc41j30', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I115592961']}, {'id': 'https://openalex.org/I4210110396', 'display_name': "First People's Hospital of Kunshan", 'ror': 'https://ror.org/01kzsq416', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210110396']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lei Shi', 'raw_affiliation_strings': ["Department of Neurosurgery, The First People's Hospital of Kunshan Affiliated with Jiangsu University, Suzhou 215300, P. R. China"], 'affiliations': [{'raw_affiliation_string': "Department of Neurosurgery, The First People's Hospital of Kunshan Affiliated with Jiangsu University, Suzhou 215300, P. R. China", 'institution_ids': ['https://openalex.org/I115592961', 'https://openalex.org/I4210110396']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100738581', 'display_name': 'Wenhua Wang', 'orcid': 'https://orcid.org/0000-0001-9274-5402'}, 'institutions': [{'id': 'https://openalex.org/I4210124018', 'display_name': 'Traditional Chinese Medicine Hospital of Kunshan', 'ror': 'https://ror.org/038dfxb83', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210124018']}, {'id': 'https://openalex.org/I4210098460', 'display_name': 'Shanghai University of Traditional Chinese Medicine', 'ror': 'https://ror.org/00z27jk27', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210098460']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wenhua Wang', 'raw_affiliation_strings': ['Department of Neurosurgery, Traditional Chinese Medicine Hospital of Kunshan, Affiliated Nanjing University of Traditional Chinese Medicine, Suzhou 215300, P. R. China'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurosurgery, Traditional Chinese Medicine Hospital of Kunshan, Affiliated Nanjing University of Traditional Chinese Medicine, Suzhou 215300, P. R. China', 'institution_ids': ['https://openalex.org/I4210124018', 'https://openalex.org/I4210098460']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5039680882', 'display_name': 'Youxin Zhou', 'orcid': 'https://orcid.org/0000-0002-2835-8376'}, 'institutions': [{'id': 'https://openalex.org/I3923682', 'display_name': 'Soochow University', 'ror': 'https://ror.org/05t8y2r12', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I3923682']}, {'id': 'https://openalex.org/I4210153519', 'display_name': 'First Affiliated Hospital of Soochow University', 'ror': 'https://ror.org/051jg5p78', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153519']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Youxin Zhou', 'raw_affiliation_strings': ['Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, P. R. China'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, P. R. China', 'institution_ids': ['https://openalex.org/I3923682', 'https://openalex.org/I4210153519']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 6, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.373, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 24, 'citation_normalized_percentile': {'value': 0.737888, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '8', 'issue': '26', 'first_page': '43237', 'last_page': '43247'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11319', 'display_name': 'Bioavailability and Health Effects of Curcumin', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/1313', 'display_name': 'Molecular Medicine'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11319', 'display_name': 'Bioavailability and Health Effects of Curcumin', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/1313', 'display_name': 'Molecular Medicine'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10966', 'display_name': 'Mechanisms and Treatment of Liver Fibrosis', 'score': 0.9949, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10570', 'display_name': 'Mechanisms of Multidrug Resistance in Cancer', 'score': 0.9903, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/abcg2', 'display_name': 'Abcg2', 'score': 0.6072925}, {'id': 'https://openalex.org/keywords/atp-dependent-transporters', 'display_name': 'ATP-dependent Transporters', 'score': 0.446882}], 'concepts': [{'id': 'https://openalex.org/C2778227246', 'wikidata': 'https://www.wikidata.org/wiki/Q1365309', 'display_name': 'Glioma', 'level': 2, 'score': 0.6736529}, {'id': 'https://openalex.org/C512196', 'wikidata': 'https://www.wikidata.org/wiki/Q4650095', 'display_name': 'Abcg2', 'level': 5, 'score': 0.6072925}, {'id': 'https://openalex.org/C190232843', 'wikidata': 'https://www.wikidata.org/wiki/Q1950808', 'display_name': 'Small hairpin RNA', 'level': 4, 'score': 0.58948284}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.57605994}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.49570024}, {'id': 'https://openalex.org/C127561419', 'wikidata': 'https://www.wikidata.org/wiki/Q224527', 'display_name': 'Downregulation and upregulation', 'level': 3, 'score': 0.4383806}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.405663}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.4022573}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.357142}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.33572146}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.32871443}, {'id': 'https://openalex.org/C149011108', 'wikidata': 'https://www.wikidata.org/wiki/Q652985', 'display_name': 'Transporter', 'level': 3, 'score': 0.25189167}, {'id': 'https://openalex.org/C44312359', 'wikidata': 'https://www.wikidata.org/wiki/Q286958', 'display_name': 'ATP-binding cassette transporter', 'level': 4, 'score': 0.1981878}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.12927964}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.09480697}, {'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000070997', 'descriptor_name': 'ATP Binding Cassette Transporter, Subfamily G, Member 2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D003474', 'descriptor_name': 'Curcumin', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D005909', 'descriptor_name': 'Glioblastoma', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D005909', 'descriptor_name': 'Glioblastoma', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000070997', 'descriptor_name': 'ATP Binding Cassette Transporter, Subfamily G, Member 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003474', 'descriptor_name': 'Curcumin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D003474', 'descriptor_name': 'Curcumin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D036381', 'descriptor_name': 'Diarylheptanoids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015536', 'descriptor_name': 'Down-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005909', 'descriptor_name': 'Glioblastoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005909', 'descriptor_name': 'Glioblastoma', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008819', 'descriptor_name': 'Mice, Nude', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D011897', 'descriptor_name': 'Random Allocation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D023041', 'descriptor_name': 'Xenograft Model Antitumor Assays', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.18018', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=18018&path%5B%5D=57712', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5522142', 'pdf_url': 'https://europepmc.org/articles/pmc5522142?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522142', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28591733', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.18018', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=18018&path%5B%5D=57712', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 31, 'referenced_works': ['https://openalex.org/W1534586188', 'https://openalex.org/W1765254582', 'https://openalex.org/W1967718470', 'https://openalex.org/W1969092519', 'https://openalex.org/W1978711046', 'https://openalex.org/W1987831830', 'https://openalex.org/W1990045802', 'https://openalex.org/W1994901446', 'https://openalex.org/W2014427634', 'https://openalex.org/W2024184580', 'https://openalex.org/W2043870205', 'https://openalex.org/W2046767433', 'https://openalex.org/W2087280539', 'https://openalex.org/W2090414990', 'https://openalex.org/W2096724244', 'https://openalex.org/W2112932851', 'https://openalex.org/W2115494253', 'https://openalex.org/W2119867861', 'https://openalex.org/W2158647372', 'https://openalex.org/W2160407679', 'https://openalex.org/W2167241157', 'https://openalex.org/W2171819006', 'https://openalex.org/W2199488492', 'https://openalex.org/W2281584862', 'https://openalex.org/W2337102724', 'https://openalex.org/W2337636620', 'https://openalex.org/W2338137957', 'https://openalex.org/W2415423685', 'https://openalex.org/W2511742209', 'https://openalex.org/W4249802268', 'https://openalex.org/W4319308340'], 'related_works': ['https://openalex.org/W4252330135', 'https://openalex.org/W4247240726', 'https://openalex.org/W4225773383', 'https://openalex.org/W4225126408', 'https://openalex.org/W3164029755', 'https://openalex.org/W2592007767', 'https://openalex.org/W2531151975', 'https://openalex.org/W2055026383', 'https://openalex.org/W1588556397', 'https://openalex.org/W1531932519'], 'abstract_inverted_index': {'//': [0], 'Long': [1], 'Chen': [2], '1,': [3], '2,': [4, 14], '*': [5, 10, 15, 77], ',': [6, 11], 'Lei': [7, 88], 'Shi': [8], '3,': [9], 'Wenhua': [12], 'Wang': [13], 'and': [16, 178, 188, 213, 227, 258], 'Youxin': [17, 92], 'Zhou': [18], '1': [19, 20], 'Department': [21, 37, 59], 'of': [22, 28, 38, 44, 49, 60, 66, 123, 132, 155, 162], 'Neurosurgery,': [23, 39, 61], 'The': [24, 62], 'First': [25, 63], 'Affiliated': [26, 46, 68], 'Hospital': [27, 43, 65], 'Soochow': [29], 'University,': [30, 71], 'Suzhou': [31, 53, 72], '215006,': [32], 'P.': [33, 55, 74], 'R.': [34, 56, 75], 'China': [35, 57, 76], '2': [36], 'Traditional': [40, 50], 'Chinese': [41, 51], 'Medicine': [42], 'Kunshan,': [45], 'Nanjing': [47], 'University': [48], 'Medicine,': [52], '215300,': [54, 73], '3': [58], "People's": [64], 'Kunshan': [67], 'with': [69, 206, 219, 234], 'Jiangsu': [70], 'These': [78, 245], 'authors': [79], 'have': [80], 'contributed': [81], 'equally': [82], 'to': [83, 137], 'this': [84], 'work': [85], 'Correspondence': [86], 'to:': [87], 'Shi,': [89], 'email:': [90, 94], '[email protected]': [91], 'Zhou,': [93], '[email protected]': [95], 'Keywords:': [96], 'glioma': [97, 133], 'stem': [98, 134], 'cells,': [99], 'demethoxycurcumin,': [100], 'reactive': [101, 199], 'oxygen': [102, 200], 'species,': [103], 'caspase-3,': [104], 'ABCG2': [105, 144, 156, 163, 170, 176, 184, 220, 224, 236, 249], 'Received:': [106], 'February': [107], '20,': [108], '2017': [109, 113, 117], 'Accepted:': [110], 'April': [111], '06,': [112], 'Published:': [114], 'May': [115], '19,': [116], 'ABSTRACT': [118], 'We': [119, 140], 'analyzed': [120], 'the': [121, 130, 228, 239], 'role': [122], 'ABCG2,': [124], 'a': [125, 166, 260], 'drug': [126], 'transporter,': [127], 'in': [128, 149, 158, 193, 203, 209, 256], 'determining': [129], 'sensitivity': [131], 'cells': [135], '(GSCs)': [136], 'demethoxycurcumin': [138], '(DMC).': [139], 'first': [141], 'demonstrated': [142], 'that': [143, 248], 'is': [145, 251, 259], 'more': [146], 'highly': [147], 'expressed': [148], 'GSCs': [150, 159, 204, 217, 257], 'than': [151], 'primary': [152], 'astrocytes.': [153], 'Modulation': [154], 'levels': [157, 177, 198], 'by': [160], 'transfection': [161], 'shRNA': [164, 221], 'or': [165, 222], 'lentiviral': [167], 'vector': [168], 'encoding': [169], 'revealed': [171], 'an': [172], 'inverse': [173], 'relation': [174], 'between': [175], 'DMC-induced': [179, 186], 'GSC': [180], 'growth': [181], 'inhibition.': [182], 'Suppressing': [183], 'increased': [185, 197, 210], 'apoptosis': [187], 'G0/G1': [189], 'cell': [190], 'cycle': [191], 'arrest': [192], 'GSCs.': [194], 'It': [195], 'also': [196], 'species': [201], '(ROS)': [202], 'treated': [205, 233], 'DMC,': [207, 235], 'resulting': [208], 'cytochrome': [211], 'C': [212], 'caspase-3': [214], 'activity.': [215], 'When': [216], 'transfected': [218], 'overexpressing': [223], 'were': [225, 232], 'xenografted': [226], 'tumor-bearing,': [229], 'immunodeficient': [230], 'mice': [231], 'expression': [237, 250], 'suppressed': [238], 'tumor': [240], 'proliferation': [241], 'rate': [242], '(T/C': [243], '%).': [244], 'findings': [246], 'demonstrate': [247], 'critical': [252], 'for': [253, 264], 'DMC': [254], 'resistance': [255], 'potential': [261], 'therapeutic': [262], 'target': [263], 'GBM.': [265]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2614589553', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 3}], 'updated_date': '2024-09-19T09:33:35.640821', 'created_date': '2017-05-26'}