Title: 84TH ANNUAL MEETING OF THE AMERICAN THYROID ASSOCIATION
Abstract: ThyroidVol. 24, No. S1 AbstractsFree Access84TH ANNUAL MEETING OF THE AMERICAN THYROID ASSOCIATIONPublished Online:23 Oct 2014https://doi.org/10.1089/thy.2014.2410.abstractsAboutSectionsPDF/EPUB Permissions & CitationsPermissionsDownload CitationsTrack CitationsAdd to favorites Back To Publication ShareShare onFacebookTwitterLinked InRedditEmail WEDNESDAY, OCTOBER 29, 20148:00 a.m. – 4:00 p.m.E. Chester Ridgway (Ridgway) Trainee ConferenceEmpress Hall, Grande Hall Building(Pre-registration required; full agenda available in trainees section of program book) The ATA Trainee Conference is named to memorialize Dr. E. Chester “Chip” Ridgway, for his large contributions to the field of thyroidology, his great devotion to education of fellows over many years, and especially to continue honoring his creation and establishment of a full day seminar led by thyroid experts teaching the full breadth of thyroid-related endocrine subjects that is now expanded to include the ATA trainees track throughout the annual meeting. This fund, supported by colleagues, fellows and friends of Dr. E. Chester Ridgway is to be of continuing support to the ATA Ridgway Trainee Conference.7:00 a.m. – 5:00 p.m.ATA/AACE Endocrine Neck Ultrasound Workshop and PracticumRegent Hall, Grande Hall Building(Satellite program, separate registration required)8:30 a.m. – 2:00 p.m.ATA Board of Directors' MeetingGarden Rom, Victorian Building 2:00 p.m. – 8:30 p.m.Registration OpenWindsor Complex, Victoria Building 5:30 p.m. – 5:45 p.m.Welcome to the 84th Annual Meeting of the ATACrown Room, Victorian BuildingHossein Gharib, ATA President John C. Morris, ATA Secretary/COO R. Michael Tuttle, ATA Program Committee Co-Chair Fredric E. Wondisford, ATA Program Committee Co-Chair5:45 p.m. – 7:30 p.m.Opening Session: Recent Developments and FutureCrown Room, Victorian BuildingChallenges in Thyroidology Chairs: R. Michael Tuttle and Fredric E. Wondisford Basic Review Peter A. Kopp Clinical Endocrine Review Douglas S. Ross Surgical Review Herbert Chen7:30 p.m. – 9:00 p.m.ATA Welcome ReceptionWindsor Lawn(Meeting registration/badge required for entry) Join us for a relaxed time with old friends and a chance to greet new ATA members. (Note: ATA Exhibit Hall is the inclement weather alternate location)8:30 p.m. – 9:30 p.m.ATA Trainees' Welcome ReceptionSun Deck(Open to all trainees; meeting registration/badge required for entry)THURSDAY, OCTOBER 30, 20146:30 a.m. – 5:30 p.m.Registration OpenWindsor Complex, Victorian Building 6:30 a.m. – 7:30 a.m.Early Riser Symposium Continental BreakfastCarousel Room, Victorian Building 6:45 a.m. – 8:00 a.m.Early Riser Symposium: Medullary Thyroid CancerCrown Room, Victorian BuildingChair: Jennifer A. Sipos Prophylactic Thyroidectomy in MEN2: When and Why? Steven G. Waguespack Management of Persistent/Recurrent Disease in the Neck Jeffrey F. Moley Management of Persistent/Recurrent Disease in Distant Sites Manisha H. Shah8:05 a.m. – 8:10 a.m.Welcome and AnnouncementsCrown Room, Victorian BuildingHossein Gharib, John C. Morris, R. Michael Tuttle and Fredric E. Wondisford8:10 a.m. – 8:55 a.m.Crown Room, Victorian BuildingPlenary Lecture: Clinical, Ethical and Legal Implications of Incidental Germ Line Findings Discovered as Part of Sequencing Studies Mark E. Robson Introduction: R. Michael Tuttle9:00 a.m. – 10:00 a.m.Highlighted Oral Abstract Session (4 total)Crown Room, Victorian BuildingChairs: R. Michael Tuttle and Fredric E. Wondisford Highlighted Oral,Autoimmunity,Clinical DOUBLE VISION IS THE MOST COMMON INDICATION FOR THERAPY IN MODERATE TO SEVERE GRAVES' ORBITOPATHY BUT IT CORRELATES NEGATIVELY WITH INFLAMMATORY SIGNS AND PROPTOSIS. A SINGLE CENTER PROSPECTIVE COHORT STUDY (N=215) WITH OBJECTIVE QUANTITATION OF DIPLOPIA P. Laurberg, D.C. Berman, I.B. Pedersen, S. Andersen, A. Carlé Highlighted Oral 2,Autoimmunity,Translational CRYSTAL STRUCTURE OF A TSH RECEPTOR MONOCLONAL ANTIBODY PROVIDES EVIDENCE THAT A TRIMER OF THE SHED RECEPTOR A-SUBUNIT IS THE CRITICAL IMMUNOGEN IN GRAVES' DISEASE C.R. Chen, P. Hubbard, S.M. McLachlan, R. Murali, B. Rapoport Highlighted Oral 3,Autoimmunity,Translational DEVELOPMENT OF A UNIQUE MOUSE MODEL FOR GRAVES' DISEASE THAT SPONTANEOUSLY DEVELOPS PATHOGENIC TSH RECEPTOR ANTIBODIES S.M. McLachlan, H. Aliesky, B. Banuelos, B. Rapoport Highlighted Oral 4,Thyroid & Development,Basic DIFFERENTIATION OF HUMAN EMBRYONIC STEM (HES) CELLS INTO THYROID CELLS R. Ma, R. Latif, T.F. Davies9:00 a.m. – 10:30 a.m.Ridgway Trainee Conference: Case Discussions–Thyroid Nodules Erik K. AlexanderEmpress Hall, Grande Hall Building(Open to all trainees; cases submitted by trainees for discussion) Stephanie L. Lee10:00 a.m. – 4:30 p.m.Exhibit Hall OpenBallroom & Coronet, Victorian Bldg. 10:00 a.m. – 11:00 a.m.Poster Review Session and Break in the Exhibit HallBallroom & Coronet, Victorian Bldg. 11:00 a.m. – 12:00 p.m.Meet the Professor Workshops (Pre-registered selections available with mailing badge)Garden Room, Victorian BuildingThyroid Disease and Pregnancy Robin P. PeetersCrown Room, Victorian BuildingManagement of Persistent/Recurrent Differentiated Thyroid Mona M. Sabra Cancer: When to Treat, When to Watch? Gary L. ClaymanEdison Complex, Grande Hall Bldg.TSH Suppression in Thyroid Cancer: Optimizing Risks vs. Benefits Anne R. CappolaIrwin L. KleinSpreckels Complex, Grande Hall Bldg.Fukushima Daiichi Accident and Thyroid Cancer Shigenobu NagatakiHanover Room, Victorian BuildingGenome Wide Analysis of Signaling Laurent SachsWilder Complex, Grande Hall Bldg.In Vivo Modulation of Thyroid Hormone Action by Cofactors Anthony N. Hollenberg12:00 p.m. – 12:55 p.m.Poster Review and Lunch on your Own12:00 p.m. – 12:55 p.m.ATA Committee Meetings/Luncheon (For Active 2014 ATA Committee Members – see governance listing in program book for room assignments)12:00 p.m. – 12:55 p.m.Ridgway Trainee Conference Lunch Session: Career TracksWilder Complex, Grande Hall Bldg.(Designed for basic trainees; open to all trainees – lunch ticket required for meal) Editor Jennifer Sargent Laboratory Director Honey V. Reddi Professor Frances E. Carr Research Director Laurent Sachs12:00 p.m. – 12:55 p.m.Ridgway Trainee Conference Lunch Session: Trainees' Jacqueline KungEmpress Hall, Grande Hall BuildingCorner Review (Open to all trainees - lunch ticket required for meal)12:00 p.m. – 12:55 p.m.Carousel Room, Victorian BuildingATA Expo Theater Presentation with Bayer Healthcare/Onyx Pharmaceuticals – NEXAVAR® (sorafenib) in Patients with Locally Recurrent or Metastatic, Progressive, Differentiated Thyroid Cancer Refractory to Radioactive Iodine Treatment: The Phase 3 DECISION Trial (Open to all attendees; space limited, first come, first served) Ezra Cohen1:00 p.m. – 1:45 p.m.Sidney H. Ingbar Award Lecture Graham R. WilliamsCrown Room, Victorian BuildingRole of Thyroid Hormones in Skeletal Development and Bone Maintenance Introduction: Sheue-yann Cheng Endowed by contributions to honor the memory of Sidney H. Ingbar, the Sidney H. Ingbar Distinguished Lectureship Award recognizes outstanding academic achievements in thyroidology, in keeping with the innovation and vision that epitomized Dr. Ingbar's brilliant investigative career. The Ingbar award is conferred upon an established investigator who has made major contributions to thyroid-related research over many years.1:00 p.m. – 5:00 p.m.Ridgway Trainee Conference: Thyroid Ultrasound CourseEmpress Hall, Grande Hall Building(For Clinical Trainees' Grant participants only, space limited) Introduction to Thyroid Ultrasound Andrew G. Gianoukakis Advanced Thyroid Ultrasound Stephanie A. Fish Thyroid Cytology Nicole A. Massoll Practicum Victor J. Bernet, James V. Hennessey, Joshua P. Klopper, Jennifer A. Sipos, Jacqueline Kung, Stephanie A. Fish and Andrew G. Gianoukakis1:50 p.m. – 3:20 p.m.Basic Oral Abstract SessionGarden Room, Victorian BuildingChairs: Ronald J. Koenig and Yun-Bo Shi Oral 5,Thyroid Cancer,Basic KRASG12D MEDIATED ONCOGENIC TRANSFORMATION OF THYROID FOLLICULAR CELLS REQUIRES LONG-TERM TSH STIMULATION AND IS REGULATED BY SPRY1 Y. Shi, M. Zou, E. Baitei, R. Al-Rijjal, R. Parhar, F. Al-Mohanna, S. Kimura, C. Pritchard, A. Alzahrani, A. Assiri, B. Meyer Oral 6,Thyroid Cancer,Basic SEX HORMONES REGULATE THYROID CANCER INITIATION AND PROGRESSION BY MODIFYING TUMOR SUPPRESSOR GENE EXPRESSION AND TUMOR IMMUNITY L.J. Zhang, Y. Xiong, N. Nilubol, M. He, S. Bommareddi, X. Zhu, L. Jia, Z. Xiao, J. Park, X. Xu, D. Patel, M.C. Willingham, S. Cheng, E. Kebebew Oral 7,Thyroid Cancer,Basic COOPERATIVE ACTIVATION OF TERT BY BRAF V600E AND TERT PROMOTER MUTATIONS: A NOVEL MOLECULAR MECHANISM IN THYROID TUMORIGENESIS R. Liu, M. Xing Oral 8,Iodine Uptake & Metabolism,Basic EFFECTIVE 131I THERAPY OF METASTATIC COLON CANCER AFTER MESENCHYMAL STEM CELL-MEDIATED TUMOR STROMA TARGETING OF THE SODIUM IODIDE SYMPORTER K. Knoop, N. Schwenk, K.A. Schmohl, A. Mueller, C. Zach, C. Cyran, J. Carlsen, G. Böning, P. Bartenstein, B. Göke, E. Wagner, P.J. Nelson, C. Spitzweg Oral 9,Thyroid Cancer,Basic BRAF ACTIVATES AND PHYSICALLY INTERACTS WITH PAK TO REGULATE CELL MOTILITY S.K. McCarty, M. Saji, X. Zhang, L.S. Kirschner, S. Fernandez, M.D. Ringel Oral 10,Thyroid Cancer,Basic BRAFV600E-DRIVEN MURINE ANAPLASTIC THYROID CANCERS RECUR AFTER WITHDRAWAL OF THE ONCOPROTEIN, AND REACTIVATE MAPK SIGNALING IN A BRAFV600E-INDEPENDENT MANNER J.A. Knauf, K. Chen, R.A. Ghossein, J. Fagin1:50 p.m. – 3:20 p.m.Clinical Oral Abstract SessionCrown Room, Victorian BuildingChairs: Naifa L. Busaidy and Wendy Sacks Oral 11,Thyroid Cancer,Clinical LONG-TERM MODERATE THYROID HORMONE SUPPRESSION THERAPY IS ASSOCIATED WITH IMPROVED OUTCOMES IN DIFFERENTIATED THYROID CARCINOMA: NATIONAL THYROID CANCER TREATMENT COOPERATIVE STUDY GROUP REGISTRY ANALYSIS 1987–2012 A. Carhill, D.R. Litofsky, K. Ain, J. Brierley, D.S. Cooper, H. Fein, B. Haugen, J. Jonklaas, P. Ladenson, J. Magner, D. Ross, M. Skarulis, D. Steward, M. Xing, H. Maxon, S.I. Sherman Oral 12,Autoimmunity,Clinical INDUCTION OF PAINLESS THYROIDITIS IN PATIENTS RECEIVING PROGRAMMED DEATH 1 RECEPTOR IMMUNOTHERAPY FOR METASTATIC MALIGNANCIES S. Orlov, F. Salari, L. Kashat, J. Alfaifi, P.G. Walfish Oral 13,Thyroid Cancer,Clinical PROGNOSTIC AND PREDICTIVE FACTORS CORRELATED WITH TREATMENT OUTCOMES FOR RADIOACTIVE IODINE-REFRACTORY DIFFERENTIATED THYROID CANCER (RAI-RDTC) PATIENTS RECEIVING SORAFENIB OR PLACEBO ON THE PHASE III DECISION TRIAL M. Schlumberger, R. Elisei, F. Pacini, B. Jarzab, L. Giannetta, L. Bastholt, C. De la Fouchardiere, R. Paschke, F. Worden, Y. Shong, J. Smit, C. Kappeler, I. Molnar, M.S. Brose Oral 14,Thyroid Cancer,Clinical IS PREOPERATIVE VITAMIN D DEFICIENCY A RISK FACTOR FOR POSTOPERATIVE SYMPTOMATIC HYPOCALCEMIA IN THYROID CANCER PATIENTS UNDERGOING TOTAL THYROIDECTOMY PLUS CENTRAL COMPARTMENT NECK DISSECTION? W. Kim, J. Jeong, S. Jung, C. Lee, S. Kang, J. Lee, J. Jung, K.H. Nam, W. Chung, C. Park Oral 15,Thyroid Cancer,Clinical IMPACT OF RADIOACTIVE IODINE ON SURVIVAL IN PAPILLARY THYROID CARCINOMA D. Boone, P. Suman, R. Prinz, T. Moo-Young, D.J. Winchester Oral 16,Thyroid Cancer,Clinical POSTOPERATIVE NOMOGRAM FOR PREDICTING CANCER-SPECIFIC MORTALITY IN MEDULLARY THYROID CANCER A.S. Ho, L. Wang, F.L. Palmer, C. Yu, A. Toset, S.G. Patel, M.W. Kattan, M.R. Tuttle, I. Ganly3:20 p.m. – 3:50 p.m.Ballroom & Coronet, Victorian Bldg.Poster Review Session and Break in the Exhibit Hall3:50 p.m. – 5:05 p.m.Clinical: Voice Symposium, Surgically RelatedCrown Room, Victorian BuildingChair: Amy Y. Chen Getting the Most Out of the New Guidelines (ATA & AAO-HNSF) David J. Terris Novel Ways to Image Vocal Cord Function Denise Carneiro-Pla State of the Science: Use of Intraoperative Nerve Monitoring and Prediction of Long Term Outcomes Quan-Yang Duh3:50 p.m. – 5:05 p.m.Basic: Thyroid Cell BiologyGarden Room, Victorian BuildingDedicated to the Memory of Paul Kim Chair: Fredric E. Wondisford To Be or Not to Be: How Thyroglobulin Mutations and Folding Peter Arvan Affect Thyroid Survival and Growth Unraveling the Mysteries of the Sodium Iodide Symporter (NIS) Nancy Carrasco Physiology and Pathophysiology of the Dual Oxidases DUOX1 and 2 Xavier De Deken5:10 p.m. – 6:25 p.m.Crown Room, Victorian BuildingSymposium: Intersecting Autoimmunity, Immuno-Modulators and Thyroid Dysfunction – Updates and Emerging Themes Chair: Terry F. Davies Thyroid Dysfunction as a Component of Autoimmune George J. Kahaly Polyendocrinopathy Syndrome Thyroid Dysfunction Associated with Other Autoimmune Diseases Kristien Boelaert Thyroid Dysfunction Associated with Immune Modulating Therapies Mabel M. Ryder6:30 p.m. – 7:30 p.m.ATA Annual Business MeetingGarden Room, Victorian Building(For Active and senior ATA members only) The annual business meeting will feature election results, committee reports, revised bylaws vote and discussion of important member issues.FRIDAY, OCTOBER 31, 20146:30 a.m. – 5:30 p.m.Registration OpenWindsor Complex, Victorian Building 6:30 a.m. – 7:30 a.m.Early Riser Symposium Continental BreakfastCarousel Room, Victorian Building 6:45 a.m. – 8:00 a.m.Early Riser Symposium: Radioactive Iodine RemnantCrown Room, Victorian BuildingAblation: Selecting the Proper Patients, Preparation Method and Administered Activity Chair: Laura Boucai Risk Stratification in Differentiated Thyroid Cancer Fabian Pitoia Guidelines for Patient Selection for Radioactive Iodine Ablation Leonard Wartofsky ESTIMBL and Hi-Lo: What Did We Learn, What Is Next? Ujjal Mallick8:05 a.m. – 8:10 a.m.AnnouncementsCrown Room, Victorian BuildingProgram Chairs R. Michael Tuttle and Fredric E. Wondisford8:10 a.m. – 8:55 a.m.Van Meter Lecture (announced onsite at time of lecture)Crown Room, Victorian BuildingEstablished in 1930, the Van Meter Award Lecture recognizes outstanding contributions to research on the thyroid gland or related subjects. The award is given each year to an investigator who is not older than the age of 45 in the year of the award. The Van Meter award winner is kept secret until the time of the award lecture during the annual meeting. Funded by support from Mary Ann Liebert, Inc., Publishers; and a Van Meter endowment in memory of Jacob (Jack) Robbins created by Jean Robbins in 2014.9:00 a.m. – 10:15 a.m.Clinical: ICCIDD Iodine Deficiency SymposiumCrown Room, Victorian BuildingDedicated to the Memory of Gerard “Jerry” Burrow Chairs: Elizabeth N. Pearce and Angela M. Leung Iodine in Veterinary Populations Charlene H. Edinboro David Marine and the Elimination of Endemic Goiter in the United States J. Woody Sistrunk9:00 a.m. – 10:15 a.m.Basic: Thyroid Hormone Regulation of Growth and DevelopmentGarden Room, Victorian BuildingChair: Anthony N. Hollenberg Thyroid Hormone and the Auditory System Douglas Forrest The Role of Thyroid Hormone on Cerebral Cortex Development Beatriz Morte Molina Roles of Thyroid Hormone Receptors in the Regulation of Thyroid Growth Sheue-yann Cheng9:00 a.m. – 10:30 a.m.Ridgway Trainee Conference: Case Discussions–Thyroid Function Mary H. SamuelsEmpress Hall, Grande Hall Building(Open to all trainees; cases submitted by trainees for discussion) Peter A. Singer10:00 a.m. – 4:30 p.m.Exhibit Hall OpenBallroom & Coronet, Victorian Bldg. 10:15 a.m. – 11:15 a.m.Poster Review Session and Break in the Exhibit HallBallroom & Coronet, Victorian Bldg. 11:15 a.m. – 12:30 p.m.Crown Room, Victorian BuildingArthur Bauman Clinical Symposium: Behind the Scenes –Difficult Decisions, Controversies and Logic in Developing ATA Guidelines Chair: Glenn D. Braunstein Thyroid Nodules and Differentiated Thyroid Cancer Guidelines Bryan R. Haugen Medullary Thyroid Cancer Guidelines Samuel A. Wells Hypothyroidism Guidelines: To T3 or Not to T3 and Other Jacqueline Jonklaas Questions about the Treatment of Hypothyroidism 11:15 a.m. – 12:30 p.m.Basic: The Journey of Thyroid Hormone into the Cell NucleusGarden Room, Victorian BuildingChair: Sheue-yann Cheng Cell Membrane Transporter Heike Heuer Cellular Deiodinase Regulation Elizabeth McAninch Role of Transthyretin in Placental Thyroid Hormone Transport Kerry Richard12:30 p.m. – 1:25 p.m.Poster Review and Lunch on your Own12:30 p.m. – 1:25 p.m.Women in Thyroidology: Communicating and Networking Mary H. SamuelsViceroy Hall, Grande Hall Building(Pre-registration required; ticket required for entry) Women in Thyroidology of the Year Awardee: Rebecca S. Bahn12:30 p.m. – 1:25 p.m.Empress Hall, Grande Hall BuildingRidgway Trainee Conference Lunch Session: How to Get Your Work Published (Open to all trainees – lunch ticket required for meal) Peter A. Kopp12:30 p.m. – 1:25 p.m.ATA Expo Theater Presentation with Veracyte, Inc. – The Giulia C. KennedyRichard T. KloosCarousel Room, Victorian BuildingScientific Story Behind Afirma® Thyroid FNA Analysis (Open to all attendees; space limited – first come, first served)1:30 p.m. – 2:15 p.m.Lewis E. Braverman Award Lecture Leonard WartofskyCrown Room, Victorian BuildingA Tale of Two Iodines – And the Braverman/Wartofsky Intersection Introduction: Elizabeth N. Pearce The Lewis E. Braverman Lectureship Award recognizes an individual who has demonstrated excellence and passion for mentoring fellows, students and junior faculty; has a long history of productive thyroid research; and is devoted to the ATA. The award is endowed by contributions to honor Dr. Lewis E. Braverman.2:20 p.m. – 3:20 p.m.Meet the Professor Workshops (Pre-registered selections available with mailing badge)Crown Room, Victorian BuildingSerum Thyroglobulin in the Management of Differentiated Thyroid Cancer: An Update in 2014 Carole A. SpencerRobert C. SmallridgeGarden Room, Victorian BuildingEvaluation of Thyroid Nodules: What is the Role of Molecular Markers? Julie Ann SosaAnna M. SawkaSpreckels Complex, Grande Hall Bldg.Evaluation and Management of Thyroid Nodules and Thyroid Stephen Huang Cancer in the Pediatric PopulationHanover Room, Victorian BuildingATA Basic Research Guidelines: How to Manipulate Thyroid Tania Ortiga-Carvalho Status in Animal ModelsEdison Complex, Grande Hall Bldg.Role of TRs in Cell Differentiation and Senescence Ana Aranda3:25 p.m. – 3:50 p.m.Clark T. Sawin Historical Vignette Peter A. KoppCrown Room, Victorian BuildingTheodor Kocher (1841–1917) – A Lasting Legacy Introduction: Jeffrey R. Garber The Clark T. Sawin History Resource Center supports this historical lecture and memorializes the work of Dr. Sawin, who served as chair of the history and archives committee for many years; and as the presenter of the historical vignette at ATA annual meetings from 1993 – 2003; and as president of the ATA 2003–2004.3:30 p.m. – 5:00 p.m.Ridgway Trainee Conference: Setting Up a Thyroid PracticeEmpress Hall, Grande Hall Building(Open to all trainees) General Brittany Bohinc/ J. Woody Sistrunk Nuclear Medicine J. Woody Sistrunk Ultrasound Brittany Bohinc3:50 p.m. – 4:20 p.m.Poster Review Session and Break in the Exhibit HallBallroom & Coronet, Victorian Bldg. 4:20 p.m. – 5:05 p.m.Research Grants SymposiumCrown Room, Victorian BuildingChair: Mingzhao Xing An Investigation of the LDLR-Independent Serum Lipid Stephen Ayers Modulation by Thyroid Hormone Type 3 Deiodinase in Dilated Heart Failure Ari J. Wassner Sorafenib and Quinacrine as Potential Combination for Anaplastic Thyroid Carcinoma Niklas K. Finnberg5:10 p.m. – 6:40 p.m.Basic Oral Abstract SessionGarden Room, Victorian BuildingChairs: Terry F. Davies and Theo J. Visser Oral 115,Thyroid Cancer,Basic MICRORNA-339-5P MODULATES NA+/I- SYMPORTER-MEDIATED RADIOIODIDE UPTAKE A. Lakshmanan, A. Wojcicka, M. Kotlarek, K. Jazdzewski, S.M. Jhiang Oral 116,Thyroid Cancer,Basic TARGETED DELIVERY OF A NOVEL HISTONE DEACETYLASE INHIBITOR, AB3, USING UNIMOLECULAR MICELLES TO IMPROVE ANTITUMOR EFFECT IN MEDULLARY THYROID CANCER R. Jaskula-Sztul, G. Chen, A.D. Harrison, A. Dammalapati, R. Nair, G. Winston-McPherson, C. Scheinebeck, W. Tang, S. Gong, H. Chen Oral 117,Autoimmunity,Basic STANDARDIZATION OF A FDA-CLEARED BIOASSAY CONVERTS THYROID-STIMULATING ANTIBODY LEVELS INTO INTERNATIONAL UNITS ENABLING COMPARISON AMONG LABORATORIES T. Diana, M. Kanitz, M. Lehmann, J. Franken, G.J. Kahaly Oral 118,Thyroid Hormone Action,Basic THYROID HORMONE INTERACTS WITH ALPHA2C ADRENERGIC RECEPTOR SIGNALING TO REGULATE THE EPIPHYSIAL GROWTH PLATE MORPHOLOGY AND BONE GROWTH M.M. Rodrigues, M.V. Silva, P.C. Brum, C.H. Gouveia Oral 119,Disorders of Thyroid Function,Basic TSH RECEPTOR ENDOCYTIC CARGO DETERMINES THYROCYTE CELL FATE S. A. Morshed, R. Ma, R. Latif, T.F. Davies Oral 120,Thyroid Hormone Metabolism & Regulation,Basic PHARMACOLOGICAL ACTIVATION OF THYROID HORMONE RECEPTORS ELICITS A FUNCTIONAL CONVERSION OF WHITE TO BROWN FAT K. Phillips, J.Z. Lin, A.J. Martagón, S.L. Cimini, D.D. Gonzalez, S.M. Hartig, A. Biter, N. Zhang, J.D. Baxter, P. Webb, J. Gustafsson5:10 p.m. – 6:40 p.m.Clinical Oral Abstract SessionCrown Room, Victorian BuildingChairs: Kenneth B. Ain and Brian W. Kim Oral 121,Thyroid Cancer,Translational TUMOR SUPPRESSOR MIR-30A-5P INHIBITS LOX EXPRESSION AND CANCER PROGRESSION IN THYROID CANCER M. Boufraqech, N. nilubol, L. Zhang, S. gara, S. Sadowski, A. Mehta, M. He, S. davis, J. Dreiling, J.A. Copland, R.C. Smallridge, M. Quezado, E. Kebebew Oral 122,Thyroid Cancer,Translational DETECTION OF CIRCULATING BRAFV600E IN PATIENTS WITH PAPILLARY THYROID CARCINOMA C.C. Lubitz, S. Parangi, M. Bernasconi, A.P. Schalck, D.T. Frederick, H. Suh, S.E. Donovan, L. Wirth, R.J. Sullivan, D.J. Panka Oral 123,Thyroid Cancer,Clinical HIGHLY ACCURATE DIAGNOSIS OF CANCER IN THYROID NODULES WITH FOLLICULAR NEOPLASM/SUSPICIOUS FOR A FOLLICULAR NEOPLASM CYTOLOGY BY THYROSEQ V2 NEXT GENERATION SEQUENCING ASSAY Y. Nikiforov, S.E. Carty, S.I. Chiosea, C. Coyne, U. Duvvuri, R.L. Ferris, S. Hodak, S.O. LeBeau, N. Ohori, R.R. Seethala, M.E. Tublin, L. Yip, M. Nikiforova Oral 124,Thyroid Cancer,Translational MUTATIONAL ANALYSIS OF KINOME IN DIFFERENTIATED THYROID CANCER T.H. Kim, J. Park, D. Park, K. Lee, J. Moon, K. Kim, K. Yi, D. Park, Y. Park Oral 125,Thyroid Cancer,Clinical DEVELOPMENT OF A CLINICAL TARGETED NEXT-GENERATION SEQUENCING TEST FOR INDETERMINATE THYROID NODULES S.M. Cheng, D. Lew, C. Barlan, F.M. Hantash, J.J. Catanese, A. Grupe, D. Ross, R.E. Reitz, F.M. Waldman Oral 126,Thyroid Cancer,Translational IDENTIFICATION OF IODINE METABOLISM-ASSOCIATED LARGE NON-CODING RNA (LINCRNA) DIFFERENTIALLY EXPRESSED IN BRAFV600E-POSITIVE PAPILLARY THYROID CANCER VERSUS NORMAL THYROID TISSUE M. Duquette, A. Fischer, E. Puxeddu, J. Lawler, P. Pandolfi, C. Nucera7:30 p.m. – 11:00 p.m.ATA Annual Reception and Banquet – Halloween Style!Viceroy/Regent HallsGrande Hall Building(Admission by ticket only; Bring your costume and your festive spirit as this year's event will be a scream!) ATA Distinguished Service Award 2014 Awardee: In recognition and honor of a member who has made important and continuing contributions to the Association. Alan P. Farwell John B. Stanbury Thyroid Pathophysiology Medal 2014 Awardee: In recognition of outstanding research contributions, either conceptual or technical, to the understanding of thyroid physiology or the pathophysiology of thyroid disease, as evidenced by having a major impact on research or clinical practice related to thyroid diseases. Valerie Ann GaltonSATURDAY, NOVEMBER 1, 20146:30 a.m. – 5:30 p.m.Registration OpenGroup Registration Desk Victorian Building 6:30 a.m. – 7:30 a.m.Early Riser Symposium Continental BreakfastCarousel Room, Victorian Building 6:45 a.m. – 8:00 a.m.Early Riser Symposium: Management of Advanced RadioactiveCrown Room, Victorian BuildingIodine Refractory Thyroid Cancer Chair: Maria E. Cabanillas What is the Definition of Radioactive Iodine Refractory? Stephanie L. Lee Opportunities for the Use of Locoregional/Directed Therapies in Radioiodine-Refractory Thyroid Cancers Keith C. Bible Initiation of Systemic Therapy: Which Agents and When? Rossella Elisei8:05 a.m. – 8:10 a.m.AnnouncementsCrown Room, Victorian BuildingProgram Chairs R. Michael Tuttle and Fredric E. Wondisford8:10 a.m. – 8:55 a.m.Plenary Lecture: Excess Thyroid Hormone and Thyrotroph Rolf KarlstromCrown Room, Victorian BuildingCell Death Introduction: Yun-Bo Shi9:00 a.m. – 10:00 a.m.Ridgway Trainee Conference: How to Communicate About the ThyroidEmpress Hall, Grande Hall Building(Open to all trainees) Surgeon's Perspective Gerard M. Doherty Pathologist's Perspective Sylvia L. Asa Endocrinologist's Perspective Stephanie A. Fish9:00 a.m. – 10:30 a.m.Short Call Oral AbstractsCrown Room, Victorian BuildingChairs: Elizabeth N. Pearce and Antonio C. Bianco Short Call Oral 1,Thyroid Cancer,Translational TERT PROMOTER AND BRAF MUTATIONS COOPERATIVELY PROMOTE PAPILLARY THYROID CANCER-RELATED MORTALITY M. Xing, R. Liu, J. Bishop Short Call Oral 2,Thyroid Cancer,Basic NF2/MERLIN IS A NOVEL THYROID TUMOR SUPPRESSOR GENE WHOSE LOSS PROMOTES ONCOGENIC RAS-INDUCED THYROID CANCERS VIA YAP-DEPENDENT TRANSACTIVATION OF MUTANT RAS AND SENSITIZES THEM TO MEK INHIBITION M.E. Garcia-Rendueles, J. Ricarte Filho, B.R. Untch, J.A. Knauf, V. Smith, E. Lundsmith, B. Taylor, G. Oler, S.C. Jhanwar, A. Viale, F. Giancotti, Y. Fang, A. Heguy, K.H. Huberman, M. Ryder, R.A. Ghossein, J. Fagin Short Call Oral 3,Thyroid Cancer,Translational TARGETING OF ONCOGENIC HRAS IN MURINE AGGRESSIVE THYROID CANCERS WITH MEK AND FARNESYLTRANSFERASE INHIBITION B.R. Untch, J.A. Knauf, M.E. Garcia-Rendueles, R.A. Ghossein, A.L. Ho, J. Fagin Short Call Oral 4,Autoimmunity,Translational MUTATIONS IN NOX3 AS GENETIC CAUSE OF FAMILIAL AGRANULOCYTOSIS DURING THYROSTATIC TREATMENT OF GRAVES' DISEASE T.S. Plantinga, P. Arts, G.H. Knarren, A.H. Mulder, I.M. Wakelkamp, A. Hoischen, M. Netea, J. Smit, R.T. Netea-Maier Short Call Oral 5,Thyroid Cancer,Translational IDENTIFICATION OF NOVEL GENE FUSIONS BY TARGETED NEXT-GEN SEQUENCING IN THYROID FNA SAMPLES M. Nikiforova, S. Zhong, A. Wald, L. Kelly, Y. Nikiforov Short Call Oral 6,Thyroid Hormone Action,Basic A ROLE FOR THYROID HORMONE ACTIVATION IN THE TREATMENT OF X-LINKED ADRENOLEUKODYSTROPHY (X-ALD) M.D. Hartley, T. Banerji, T.S. Scanlan9:30 a.m. – 1:30 p.m.Exhibit Hall OpenBallroom & Coronet, Victorian Bldg. 10:00 a.m. – 11:30 a.m.Ridgway Trainee Conference: Case Discussions–Thyroid Cancer R. Michael TuttleEmpress Hall, Grande Hall Building(Open to all trainees; cases submitted by trainees for discussion) Ian D. HayJames D. Brierley10:30 a.m. – 11:30 a.m.Poster Review Session and Break in the Exhibit HallBallroom & Coronet, Victorian Bldg. 11:30 a.m. – 12:30 p.m.Meet the Professor Workshops (Pre-registered selections available with mailing badge)Spreckels Complex, Grande Hall Bldg.Radioactive Iodine Therapy in Benign Goiter Laszlo HegedusGarden Room, Victorian BuildingCorrelating Outcomes with the Histological Description of Follicular Cell Derived Thyroid Cancers: What Is the Clinical Relevance? Ronald A. GhosseinVictor J. BernetCrown Room, Victorian BuildingShould BRAF Status Influence Initial Management Decisions Sally E. CartyKepal Patel In Differentiated Thyroid Cancer? Edison Complex, Grande Hall Bldg.What is New for Thyroid Hormone Transporters Theo J. VisserHanover Room, Victorian BuildingATA Basic Science Handbook Antonio C. Bianco12:30 p.m. – 1:25 p.m.Poster Review and Lunch on your Own12:30 p.m. – 1:25 p.m.Ridgway Trainee Conference Lunch Session: EnhancingWilder Complex, Grande Hall Bldg.Your CV (Designed for basic trainees; open to all trainees – lunch ticket required for meal) Vice President for Research Donald St. Germain Chief Scientific Officer Giulia C. Kennedy Deputy Editor Sarah Linklater12:30 p.m. – 1:25 p.m.Empress Hall, Grande Hall BuildingRidgway Trainee Conference Lunch Session: Clinical Career Tracks(Open to all trainees – lunch ticket required for meal) Private Practice Susan A. Sherman Managed Care Shireen Fatemi Academic (Clinical) Elizabeth N. Pearce Industry James A. Magner12:30 p.m. – 1:25 p.m.Carousel Room, Victorian BuildingATA Expo Theater Presentation with MedImmune, Specialty Care Division of AstraZeneca- Clinical Considerations in Advanced Medullary Thyroid Cancer (MTC) Patient Management (Only U.S. health care professionals are permitted to attend this program; space limited – first come, first served; lunch included) Kate Newbold1:00 p.m. – 3:00 p.m.ATA Alliance for Patient Education Public ForumRegent Hall, Grande Hall Building(Open to the general public and all meeting attendees) Sponsored by the ATA Alliance members: American Thyroid Association, Bite Me Cancer, Graves' Disease and Thyroid Foundation, Light of Life Foundation, ThyCa: Thyroid Cancer Survivors' Association, Inc., Thyroid Cancer Canada and Thyroid Federation International1:30 p.m.Exhibit Hall Closes1:30 p.m. – 2:15 p.m.Paul Starr Award Lecture Gilbert H. DanielsCrown Room, Victorian BuildingWhat Can a Clinician Contribute? Introduction: Gregory W. Randolph The Paul Starr Lectureship Award is in recognition of an outstanding contributor to clinical thyroidology.2:20 p.m. – 3:20 p.m.Basic Oral Abstract SessionGarden Room, Victorian BuildingChairs: Sandra M. McLachlan and Yaron Tomer Oral 215,Thyroid Hormone Action,Basic ROLES OF THYROID HORMONE-TARGET GENE HISTONE H3K79 METHYLTRANSFERASE DOT1L DURING EMBRYOGENESIS AND ADULT STEM CELL DEVELOPMENT Y.B. Shi Oral 216,Thyroid & Development,Basic THYROID HORMONE DRIVING LARVAL CELLS MAD: THE ROLE OF C-MYC GENE FAMILY IN THYROID HORMONE-DEPENDENT INTESTINAL STEM CELL DEVELOPMENT T.C. Miller, M. Okada, Y. Shi Oral 217,Thyroid & Development,Basic THE HISTONE METHYLTRANSFERASE PRMT1 REGULATES ADULT INTESTINAL STEM CELL DEVELOPMENT IN MICE J. Rodiger, Y. Zhang, Y. Shi Oral 218,Disorders of Thyroid Function,Basic XB130 DEFICIENCY RESULTS IN MOUSE THYROID HORMONE SYNTHESIS DISORDER H. Shimizu, Y. Wang, H. Toba, H. Cho, X. Bai, S.L. Asa, X. Liao, S. Refetoff, M. Liu2:20 p.m. – 3:20 p.m.Clinical Oral Abstract SessionCrown Room, Victorian BuildingChairs: Giuseppe