Publication Information

{'id': 'https://openalex.org/W2613984714', 'doi': None, 'title': 'Autophagy machinery genes are differentially required for autophagy and Parkin-mediated mitophagy', 'display_name': 'Autophagy machinery genes are differentially required for autophagy and Parkin-mediated mitophagy', 'publication_year': 2016, 'publication_date': '2016-12-01', 'ids': {'openalex': 'https://openalex.org/W2613984714', 'mag': '2613984714'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'http://authors.library.caltech.edu/75602/', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': [], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5029896547', 'display_name': 'C. Wang', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'C. Wang', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042018199', 'display_name': 'Catherine L. Nezich', 'orcid': 'https://orcid.org/0000-0002-1849-6038'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'C. Nezich', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016723424', 'display_name': 'Richard J. Youle', 'orcid': 'https://orcid.org/0000-0001-9117-5241'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'R. J. Youle', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5010064823', 'display_name': 'Changlin Zhen', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'C. Zhen', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 66}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10587', 'display_name': 'Role of Autophagy in Disease and Health', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10587', 'display_name': 'Role of Autophagy in Disease and Health', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/atg8', 'display_name': 'ATG8', 'score': 0.8736261}, {'id': 'https://openalex.org/keywords/autophagy-related-protein-13', 'display_name': 'Autophagy-related protein 13', 'score': 0.77811843}, {'id': 'https://openalex.org/keywords/autophagy', 'display_name': 'Autophagy', 'score': 0.615114}, {'id': 'https://openalex.org/keywords/pink1', 'display_name': 'PINK1', 'score': 0.58900803}, {'id': 'https://openalex.org/keywords/ulk1', 'display_name': 'ULK1', 'score': 0.5728154}, {'id': 'https://openalex.org/keywords/mitophagy', 'display_name': 'Mitophagy', 'score': 0.553896}, {'id': 'https://openalex.org/keywords/atg12', 'display_name': 'ATG12', 'score': 0.54707724}, {'id': 'https://openalex.org/keywords/atg16l1', 'display_name': 'ATG16L1', 'score': 0.4934198}, {'id': 'https://openalex.org/keywords/bag3', 'display_name': 'BAG3', 'score': 0.48676848}, {'id': 'https://openalex.org/keywords/optineurin', 'display_name': 'Optineurin', 'score': 0.46250862}], 'concepts': [{'id': 'https://openalex.org/C2781000418', 'wikidata': 'https://www.wikidata.org/wiki/Q18034312', 'display_name': 'ATG5', 'level': 4, 'score': 0.93097156}, {'id': 'https://openalex.org/C203522944', 'wikidata': 'https://www.wikidata.org/wiki/Q288322', 'display_name': 'Autophagy', 'level': 3, 'score': 0.912284}, {'id': 'https://openalex.org/C2780042272', 'wikidata': 'https://www.wikidata.org/wiki/Q27548992', 'display_name': 'ATG8', 'level': 4, 'score': 0.8736261}, {'id': 'https://openalex.org/C2779324830', 'wikidata': 'https://www.wikidata.org/wiki/Q1806192', 'display_name': 'Mitophagy', 'level': 4, 'score': 0.809346}, {'id': 'https://openalex.org/C171896709', 'wikidata': 'https://www.wikidata.org/wiki/Q18034663', 'display_name': 'Autophagy-related protein 13', 'level': 5, 'score': 0.77811843}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.74106324}, {'id': 'https://openalex.org/C2777668072', 'wikidata': 'https://www.wikidata.org/wiki/Q2472777', 'display_name': 'Parkin', 'level': 4, 'score': 0.6897682}, {'id': 'https://openalex.org/C2776804853', 'wikidata': 'https://www.wikidata.org/wiki/Q18045837', 'display_name': 'PINK1', 'level': 5, 'score': 0.58900803}, {'id': 'https://openalex.org/C71680706', 'wikidata': 'https://www.wikidata.org/wiki/Q18032908', 'display_name': 'ULK1', 'level': 5, 'score': 0.5728154}, {'id': 'https://openalex.org/C2780329694', 'wikidata': 'https://www.wikidata.org/wiki/Q18033863', 'display_name': 'ATG12', 'level': 5, 'score': 0.54707724}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5102496}, {'id': 'https://openalex.org/C187092789', 'wikidata': 'https://www.wikidata.org/wiki/Q4654662', 'display_name': 'ATG16L1', 'level': 4, 'score': 0.4934198}, {'id': 'https://openalex.org/C99089365', 'wikidata': 'https://www.wikidata.org/wiki/Q18034356', 'display_name': 'BAG3', 'level': 4, 'score': 0.48676848}, {'id': 'https://openalex.org/C2777801377', 'wikidata': 'https://www.wikidata.org/wiki/Q18035056', 'display_name': 'Optineurin', 'level': 4, 'score': 0.46250862}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.24754715}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.23833355}, {'id': 'https://openalex.org/C97029542', 'wikidata': 'https://www.wikidata.org/wiki/Q281417', 'display_name': 'Protein kinase A', 'level': 3, 'score': 0.1803163}, {'id': 'https://openalex.org/C87325107', 'wikidata': 'https://www.wikidata.org/wiki/Q7251493', 'display_name': 'Protein phosphorylation', 'level': 4, 'score': 0.106040865}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C2780124434', 'wikidata': 'https://www.wikidata.org/wiki/Q12357464', 'display_name': 'AMPK', 'level': 4, 'score': 0.0}, {'id': 'https://openalex.org/C2779734285', 'wikidata': 'https://www.wikidata.org/wiki/Q11085', 'display_name': "Parkinson's disease", 'level': 3, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'http://authors.library.caltech.edu/75602/', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Zero hunger', 'id': 'https://metadata.un.org/sdg/2', 'score': 0.62}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3199033091', 'https://openalex.org/W3179218579', 'https://openalex.org/W3009513276', 'https://openalex.org/W2999850725', 'https://openalex.org/W2979081339', 'https://openalex.org/W2970743598', 'https://openalex.org/W2951431277', 'https://openalex.org/W2950208982', 'https://openalex.org/W2939270943', 'https://openalex.org/W2885829694', 'https://openalex.org/W2768302637', 'https://openalex.org/W2536244266', 'https://openalex.org/W2521191706', 'https://openalex.org/W2330972395', 'https://openalex.org/W2275587382', 'https://openalex.org/W2195310994', 'https://openalex.org/W2147305920', 'https://openalex.org/W2041947125', 'https://openalex.org/W1989212506', 'https://openalex.org/W1963715674'], 'abstract_inverted_index': {'Autophagy': [0], 'is': [1, 40], 'a': [2, 74, 261], 'highly': [3], 'conserved': [4], 'process': [5], 'from': [6, 239], 'yeast': [7], 'to': [8, 17, 62, 77, 90, 93, 109, 139, 143, 223, 234], 'mammals': [9, 39], 'that': [10, 50, 72, 135, 164, 254], 'recycles': [11], 'proteins': [12], 'and': [13, 30, 154, 176, 181, 191, 199, 214, 248, 252, 266], 'organelles': [14], 'in': [15, 38, 44, 159, 166], 'response': [16], 'various': [18], 'stresses': [19], 'such': [20, 86], 'as': [21, 87, 227], 'nutrition': [22], 'depletion,': [23], 'unfolded': [24], 'protein': [25, 27], 'or': [26], 'aggregation': [28], 'formation': [29], 'pathogen': [31], 'infections.': [32], 'ULK1': [33, 100], 'complex': [34, 54, 101, 259, 262], 'consisting': [35], 'of': [36, 60, 97, 123, 206, 220, 245, 257, 264], 'ULK1/ATG13/ATG101/FIP200': [37], 'the': [41, 45, 82, 95, 98, 104, 217, 224, 242], 'key': [42], 'component': [43], 'most': [46], 'upstream': [47], 'initiation': [48], 'pathway': [49, 137], 'triggers': [51], 'downstream': [52], 'PI3K': [53], 'activation': [55], '(containing': [56], 'Vps34/Beclin1/ATG14/p150)': [57], 'through': [58], 'phosphorylation': [59], 'Beclin1': [61], 'induce': [63], 'autophagy': [64, 125, 175, 238, 251, 265], 'membrane': [65], 'initiation.': [66], 'Active': [67], 'Vps34': [68], 'then': [69], 'generates': [70], 'PI(3)P': [71], 'becomes': [73], 'docking': [75], 'point': [76], '\r\nrecruit': [78], 'other': [79, 240], 'proteins,': [80], 'mainly': [81], 'uniquitin‐like': [83], 'conjugation': [84], 'system': [85], 'ATG12‐ATG5': [88], 'conjugates': [89], 'lipidate': [91], 'ATG8/LC3': [92], 'complete': [94], 'closure': [96], 'autophagysomes.': [99], 'also': [102, 202], 'phosphorylates': [103], 'only': [105], 'membrane‐spanning': [106], 'member': [107], 'ATG9A': [108, 180], 'assist': [110], 'efficient': [111], 'LC3': [112], 'recruitment.': [113], 'Genetic': [114], 'studies': [115, 133], 'with': [116], 'knockout': [117], 'mice': [118], 'have': [119], 'suggested': [120, 134], 'essential': [121], 'roles': [122], 'each': [124, 129, 136], 'machinery': [126], 'genes': [127], '\r\nat': [128], 'step.': [130], 'However,': [131], 'recently': [132], 'seems': [138], 'be': [140, 235], 'independently': [141], 'recruited': [142], 'mitochondria': [144], 'during': [145, 188], 'Parkin‐mediated': [146], 'mitophagy.': [147, 177], 'By': [148], 'generating': [149], 'ATG5,': [150, 179], 'ATG9A,': [151, 197], 'ATG13,': [152, 246], 'ATG14': [153, 192, 200], 'FIP200': [155, 182, 215, 249], 'single,': [156], 'double,': [157], 'pentaKO': [158], 'HeLa': [160], 'cells,': [161], 'we': [162], 'found': [163], 'unlike': [165], 'mouse,': [167], 'different': [168], 'ATG': [169], '\r\ngenes': [170], 'are': [171, 255], 'differentially': [172], 'required': [173], 'for': [174, 237, 250], 'While': [178, 230], 'KO': [183, 193, 201, 210], 'completely': [184], 'block': [185, 213, 219], 'p62': [186], 'degradation': [187], 'starvation,': [189], 'ATG13': [190, 198], 'exhibits': [194], 'mild': [195, 204], 'inhibition.': [196], 'display': [203], 'inhibition': [205], 'mitophagy,': [207, 221], 'while': [208], 'ATG5': [209], 'shows': [211], 'moderate': [212], 'exhibit': [216], 'strongest': [218], 'almost': [222], 'same': [225], 'extent': [226], '\r\nATG5/9A/13/14': [228], 'QKO.': [229], 'ULK1/ULK2': [231], 'both': [232], 'seem': [233], 'dispensable': [236], 'studies,': [241], 'differential': [243], 'requirement': [244], 'ULK1/2': [247], 'mitophagy': [253, 267], 'components': [256], 'the\r\nsame': [258], 'suggest': [260], 'regulation': [263], 'than': [268], 'previously': [269], 'believed.': [270]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2613984714', 'counts_by_year': [], 'updated_date': '2024-09-30T08:28:14.148812', 'created_date': '2017-05-19'}